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Synaptoporin - 102 003

A synaptic vesicle membrane protein enriched in Mossy fibres
Polyclonal rabbit purified antibody
Cat. No.: 102 003
Amount: 50 µg
Price: 450.00 €
Cat. No. 102 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 200 up to 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 250 to 263 from rat Synaptoporin (UniProt Id: P22831)
Reactivity Reacts with: rat (P22831), mouse (Q8BGN8), hamster, human (Q8TBG9).
Other species not tested yet.
Specificity Specific for synaptoporin.
Matching control protein/peptide 102-1P
Data sheet 102_003.pdf

References for Synaptoporin - 102 003

Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation.
De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Recupero AJ, Le Metayer T, Hansen MT, Shim HN, et al.
Cell reports (2020) 3010: 3520-3535.e7. 102 003 IHC; tested species: mouse
Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.
Maus L, Lee C, Altas B, Sertel SM, Weyand K, Rizzoli SO, Rhee J, Brose N, Imig C, Cooper BH
Cell reports (2020) 3011: 3632-3643.e8. 102 003 IHC; tested species: mouse
Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices.
Imig C, López-Murcia FJ, Maus L, García-Plaza IH, Mortensen LS, Schwark M, Schwarze V, Angibaud J, Nägerl UV, Taschenberger H, Brose N, et al.
Neuron (2020) : . 102 003 IHC; tested species: mouse
BACE1 partial deletion induces synaptic plasticity deficit in adult mice.
Lombardo S, Chiacchiaretta M, Tarr A, Kim W, Cao T, Sigal G, Rosahl TW, Xia W, Haydon PG, Kennedy ME, Tesco G, et al.
Scientific reports (2019) 91: 19877. 102 003 IHC; tested species: mouse
Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy.
Janz P, Schwaderlapp N, Heining K, Häussler U, Korvink JG, von Elverfeldt D, Hennig J, Egert U, LeVan P, Haas CA
eLife (2017) 6: . 102 003 IHC; tested species: human
Cat. No.: 102 003
Quantity: 50 µg
Price: 450.00 €
Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation.
De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Recupero AJ, Le Metayer T, Hansen MT, Shim HN, et al.
Cell reports (2020) 3010: 3520-3535.e7. 102 003 IHC; tested species: mouse
Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.
Maus L, Lee C, Altas B, Sertel SM, Weyand K, Rizzoli SO, Rhee J, Brose N, Imig C, Cooper BH
Cell reports (2020) 3011: 3632-3643.e8. 102 003 IHC; tested species: mouse
Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices.
Imig C, López-Murcia FJ, Maus L, García-Plaza IH, Mortensen LS, Schwark M, Schwarze V, Angibaud J, Nägerl UV, Taschenberger H, Brose N, et al.
Neuron (2020) : . 102 003 IHC; tested species: mouse
BACE1 partial deletion induces synaptic plasticity deficit in adult mice.
Lombardo S, Chiacchiaretta M, Tarr A, Kim W, Cao T, Sigal G, Rosahl TW, Xia W, Haydon PG, Kennedy ME, Tesco G, et al.
Scientific reports (2019) 91: 19877. 102 003 IHC; tested species: mouse
Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy.
Janz P, Schwaderlapp N, Heining K, Häussler U, Korvink JG, von Elverfeldt D, Hennig J, Egert U, LeVan P, Haas CA
eLife (2017) 6: . 102 003 IHC; tested species: human
Background

Synaptoporin, also known as synaptophysin 2 and p38-2, is highly homologous to synaptophysin 1 but encoded by a different gene. Like synaptopysin 1, synaptoporin contains four transmembrane regions and a short cytoplasmic tail. Unlike synaptophysin 1, it is not glycosylated.
The distributions of synaptophysin 1 and synaptoporin are different. Synaptophysin 1 is more uniformly expressed whereas synaptoporin is particularly enriched in mossy fiber synapses in the hippocampus. It is thus an excellent marker for subsets of synapses.