Home|||||||Technical Support|

Synaptoporin - 102 002

A synaptic vesicle membrane protein enriched in Mossy fibres
Polyclonal rabbit antiserum
Cat. No.: 102 002
Amount: 200 µl
Price: 350.00 €
Cat. No. 102 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 100 up to 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 250 to 263 from rat Synaptoporin (UniProt Id: P22831)
Reactivity Reacts with: rat (P22831), mouse (Q8BGN8), hamster, human (Q8TBG9).
Other species not tested yet.
Specificity Specific for synaptoporin. K.O. PubMed: 31090538
Matching control protein/peptide 102-1P
Data sheet 102_002.pdf

References for Synaptoporin - 102 002

Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.
Raja MK, Preobraschenski J, Del Olmo-Cabrera S, Martinez-Turrillas R, Jahn R, Perez-Otano I, Wesseling JF
eLife (2019) 8: . 102 002 WB; KO verified; tested species: mouse
Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus.
Basu R, Duan X, Taylor MR, Martin EA, Muralidhar S, Wang Y, Gangi-Wellman L, Das SC, Yamagata M, West PJ, Sanes JR, et al.
Neuron (2017) 961: 160-176.e8. 102 002 WB; tested species: mouse
Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.
Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3516: 6544-53. 102 002 WB, IHC
The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels.
Morciano M, Beckhaus T, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2009) 1083: 662-75. 102 002 WB
B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus.
Armstrong JN, Saganich MJ, Xu NJ, Henkemeyer M, Heinemann SF, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2613: 3474-81. 102 002 WB, IHC
Abnormal dysbindin expression in cerebellar mossy fiber synapses in the mdx mouse model of Duchenne muscular dystrophy.
Sillitoe RV, Benson MA, Blake DJ, Hawkes R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2003) 2316: 6576-85. 102 002 WB
Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase.
Armstrong JN, Brust TB, Lewis RG, MacVicar BA
The Journal of neuroscience : the official journal of the Society for Neuroscience (2002) 2214: 5938-45. 102 002 WB; tested species: rat
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 102 002 WB
Kappa opioid receptors regulate hippocampal synaptic homeostasis and epileptogenesis.
Queenan BN, Dunn RL, Santos VR, Feng Y, Huizenga MN, Hammack RJ, Vicini S, Forcelli PA, Pak DTS
Epilepsia (2018) 591: 106-122. 102 002 ICC; tested species: rat
NeuroD2 regulates the development of hippocampal mossy fiber synapses.
Wilke SA, Hall BJ, Antonios JK, Denardo LA, Otto S, Yuan B, Chen F, Robbins EM, Tiglio K, Williams ME, Qiu Z, et al.
Neural development (2012) 7: 9. 102 002 ICC
The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.
Riccomagno MM, Hurtado A, Wang H, Macopson JG, Griner EM, Betz A, Brose N, Kazanietz MG, Kolodkin AL
Cell (2012) 1497: 1594-606. 102 002 ICC; tested species: mouse
Autaptic cultures of single hippocampal granule cells of mice and rats.
Rost BR, Breustedt J, Schoenherr A, Grosse G, Ahnert-Hilger G, Schmitz D
The European journal of neuroscience (2010) 326: 939-47. 102 002 ICC
Exercise Reverses Behavioral and Synaptic Abnormalities after Maternal Inflammation.
Andoh M, Shibata K, Okamoto K, Onodera J, Morishita K, Miura Y, Ikegaya Y, Koyama R
Cell reports (2019) 2710: 2817-2825.e5. 102 002 IHC; tested species: mouse
Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn.
Chung J, Franklin JF, Lee HJ
Scientific reports (2019) 91: 4273. 102 002 IHC; tested species: rat
Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, et al.
Cell (2019) 1785: 1159-1175.e17. 102 002 IHC; tested species: mouse
Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels.
Xiao S, McKeever PM, Lau A, Robertson J
Acta neuropathologica communications (2019) 71: 161. 102 002 IHC; tested species: mouse
Selective increases in inter-individual variability in response to environmental enrichment in female mice.
Körholz JC, Zocher S, Grzyb AN, Morisse B, Poetzsch A, Ehret F, Schmied C, Kempermann G
eLife (2018) 7: . 102 002 IHC; tested species: mouse
New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation.
Mata A, Gil V, Pérez-Clausell J, Dasilva M, González-Calixto MC, Soriano E, García-Verdugo JM, Sanchez-Vives MV, Del Río JA
Scientific reports (2018) 81: 1381. 102 002 IHC; tested species: mouse
Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission.
Sando R, Bushong E, Zhu Y, Huang M, Considine C, Phan S, Ju S, Uytiepo M, Ellisman M, Maximov A
Neuron (2017) 942: 312-321.e3. 102 002 IHC; tested species: mouse
Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus.
Heise C, Schroeder JC, Schoen M, Halbedl S, Reim D, Woelfle S, Kreutz MR, Schmeisser MJ, Boeckers TM
Frontiers in cellular neuroscience (2016) 10: 106. 102 002 IHC
Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.
Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3516: 6544-53. 102 002 WB, IHC
β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects.
Hitt B, Riordan SM, Kukreja L, Eimer WA, Rajapaksha TW, Vassar R
The Journal of biological chemistry (2012) 28746: 38408-25. 102 002 IHC
Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy.
Volz F, Bock HH, Gierthmuehlen M, Zentner J, Haas CA, Freiman TM
Epilepsia (2011) 529: 1579-89. 102 002 IHC
Continuous neural plasticity in the olfactory intrabulbar circuitry.
Cummings DM, Belluscio L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3027: 9172-80. 102 002 IHC
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, et al.
Cell (2009) 1386: 1222-35. 102 002 IHC
Synaptic integration of adult-generated olfactory bulb granule cells: basal axodendritic centrifugal input precedes apical dendrodendritic local circuits.
Whitman MC, Greer CA
The Journal of neuroscience : the official journal of the Society for Neuroscience (2007) 2737: 9951-61. 102 002 IHC
B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus.
Armstrong JN, Saganich MJ, Xu NJ, Henkemeyer M, Heinemann SF, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2613: 3474-81. 102 002 WB, IHC
Serum response factor controls neuronal circuit assembly in the hippocampus.
Knöll B, Kretz O, Fiedler C, Alberti S, Schütz G, Frotscher M, Nordheim A
Nature neuroscience (2006) 92: 195-204. 102 002 EM; tested species: mouse
Cat. No.: 102 002
Quantity: 200 µl
Price: 350.00 €
Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.
Raja MK, Preobraschenski J, Del Olmo-Cabrera S, Martinez-Turrillas R, Jahn R, Perez-Otano I, Wesseling JF
eLife (2019) 8: . 102 002 WB; KO verified; tested species: mouse
Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus.
Basu R, Duan X, Taylor MR, Martin EA, Muralidhar S, Wang Y, Gangi-Wellman L, Das SC, Yamagata M, West PJ, Sanes JR, et al.
Neuron (2017) 961: 160-176.e8. 102 002 WB; tested species: mouse
Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.
Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3516: 6544-53. 102 002 WB, IHC
The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels.
Morciano M, Beckhaus T, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2009) 1083: 662-75. 102 002 WB
B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus.
Armstrong JN, Saganich MJ, Xu NJ, Henkemeyer M, Heinemann SF, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2613: 3474-81. 102 002 WB, IHC
Abnormal dysbindin expression in cerebellar mossy fiber synapses in the mdx mouse model of Duchenne muscular dystrophy.
Sillitoe RV, Benson MA, Blake DJ, Hawkes R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2003) 2316: 6576-85. 102 002 WB
Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase.
Armstrong JN, Brust TB, Lewis RG, MacVicar BA
The Journal of neuroscience : the official journal of the Society for Neuroscience (2002) 2214: 5938-45. 102 002 WB; tested species: rat
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 102 002 WB
Kappa opioid receptors regulate hippocampal synaptic homeostasis and epileptogenesis.
Queenan BN, Dunn RL, Santos VR, Feng Y, Huizenga MN, Hammack RJ, Vicini S, Forcelli PA, Pak DTS
Epilepsia (2018) 591: 106-122. 102 002 ICC; tested species: rat
NeuroD2 regulates the development of hippocampal mossy fiber synapses.
Wilke SA, Hall BJ, Antonios JK, Denardo LA, Otto S, Yuan B, Chen F, Robbins EM, Tiglio K, Williams ME, Qiu Z, et al.
Neural development (2012) 7: 9. 102 002 ICC
The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.
Riccomagno MM, Hurtado A, Wang H, Macopson JG, Griner EM, Betz A, Brose N, Kazanietz MG, Kolodkin AL
Cell (2012) 1497: 1594-606. 102 002 ICC; tested species: mouse
Autaptic cultures of single hippocampal granule cells of mice and rats.
Rost BR, Breustedt J, Schoenherr A, Grosse G, Ahnert-Hilger G, Schmitz D
The European journal of neuroscience (2010) 326: 939-47. 102 002 ICC
Exercise Reverses Behavioral and Synaptic Abnormalities after Maternal Inflammation.
Andoh M, Shibata K, Okamoto K, Onodera J, Morishita K, Miura Y, Ikegaya Y, Koyama R
Cell reports (2019) 2710: 2817-2825.e5. 102 002 IHC; tested species: mouse
Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn.
Chung J, Franklin JF, Lee HJ
Scientific reports (2019) 91: 4273. 102 002 IHC; tested species: rat
Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, et al.
Cell (2019) 1785: 1159-1175.e17. 102 002 IHC; tested species: mouse
Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels.
Xiao S, McKeever PM, Lau A, Robertson J
Acta neuropathologica communications (2019) 71: 161. 102 002 IHC; tested species: mouse
Selective increases in inter-individual variability in response to environmental enrichment in female mice.
Körholz JC, Zocher S, Grzyb AN, Morisse B, Poetzsch A, Ehret F, Schmied C, Kempermann G
eLife (2018) 7: . 102 002 IHC; tested species: mouse
New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation.
Mata A, Gil V, Pérez-Clausell J, Dasilva M, González-Calixto MC, Soriano E, García-Verdugo JM, Sanchez-Vives MV, Del Río JA
Scientific reports (2018) 81: 1381. 102 002 IHC; tested species: mouse
Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission.
Sando R, Bushong E, Zhu Y, Huang M, Considine C, Phan S, Ju S, Uytiepo M, Ellisman M, Maximov A
Neuron (2017) 942: 312-321.e3. 102 002 IHC; tested species: mouse
Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus.
Heise C, Schroeder JC, Schoen M, Halbedl S, Reim D, Woelfle S, Kreutz MR, Schmeisser MJ, Boeckers TM
Frontiers in cellular neuroscience (2016) 10: 106. 102 002 IHC
Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.
Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3516: 6544-53. 102 002 WB, IHC
β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects.
Hitt B, Riordan SM, Kukreja L, Eimer WA, Rajapaksha TW, Vassar R
The Journal of biological chemistry (2012) 28746: 38408-25. 102 002 IHC
Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy.
Volz F, Bock HH, Gierthmuehlen M, Zentner J, Haas CA, Freiman TM
Epilepsia (2011) 529: 1579-89. 102 002 IHC
Continuous neural plasticity in the olfactory intrabulbar circuitry.
Cummings DM, Belluscio L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3027: 9172-80. 102 002 IHC
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, et al.
Cell (2009) 1386: 1222-35. 102 002 IHC
Synaptic integration of adult-generated olfactory bulb granule cells: basal axodendritic centrifugal input precedes apical dendrodendritic local circuits.
Whitman MC, Greer CA
The Journal of neuroscience : the official journal of the Society for Neuroscience (2007) 2737: 9951-61. 102 002 IHC
B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus.
Armstrong JN, Saganich MJ, Xu NJ, Henkemeyer M, Heinemann SF, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2613: 3474-81. 102 002 WB, IHC
Serum response factor controls neuronal circuit assembly in the hippocampus.
Knöll B, Kretz O, Fiedler C, Alberti S, Schütz G, Frotscher M, Nordheim A
Nature neuroscience (2006) 92: 195-204. 102 002 EM; tested species: mouse
Background

Synaptoporin, also known as synaptophysin 2 and p38-2, is highly homologous to synaptophysin 1 but encoded by a different gene. Like synaptopysin 1, synaptoporin contains four transmembrane regions and a short cytoplasmic tail. Unlike synaptophysin 1, it is not glycosylated.
The distributions of synaptophysin 1 and synaptoporin are different. Synaptophysin 1 is more uniformly expressed whereas synaptoporin is particularly enriched in mossy fiber synapses in the hippocampus. It is thus an excellent marker for subsets of synapses.