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Home > Products > 102 002

Synaptoporin antibody - 102 002 K.O.

Synaptoporin s a synaptic vesicle membrane protein similar to synaptophysin1 enriched in Mossy fibres
Rabbit polyclonal antiserum
Cat. No.: 102 002
Amount: 200 µl
Price: $360.00
Cat. No. 102 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 100 up to 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.
Immunogen Synthetic peptide corresponding to AA 250 to 263 from rat Synaptoporin (UniProt Id: P22831)
Reactivity Reacts with: rat (P22831), mouse (Q8BGN8), hamster, human (Q8TBG9).
Other species not tested yet.
Specificity K.O. validated PubMed: 31090538
Matching control protein/peptide 102-1P
Data sheet 102_002.pdf

References for Synaptoporin - 102 002

Aβ-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation.
Kim DK, Jeong H, Bae J, Cha MY, Kang M, Shin D, Ha S, Hyeon SJ, Kim H, Suh K, Choi MS, et al.
Experimental & molecular medicine (2022) : . 102 002 WB, IHC; tested species: mouse
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer.
Apóstolo N, Smukowski SN, Vanderlinden J, Condomitti G, Rybakin V, Ten Bos J, Trobiani L, Portegies S, Vennekens KM, Gounko NV, Comoletti D, et al.
Nature communications (2020) 111: 5171. 102 002 WB, ICC, IHC; tested species: mouse
Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.
Raja MK, Preobraschenski J, Del Olmo-Cabrera S, Martinez-Turrillas R, Jahn R, Perez-Otano I, Wesseling JF
eLife (2019) 8: . 102 002 WB; KO verified; tested species: mouse
Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus.
Basu R, Duan X, Taylor MR, Martin EA, Muralidhar S, Wang Y, Gangi-Wellman L, Das SC, Yamagata M, West PJ, Sanes JR, et al.
Neuron (2017) 961: 160-176.e8. 102 002 WB; tested species: mouse
Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.
Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3516: 6544-53. 102 002 WB, IHC
The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels.
Morciano M, Beckhaus T, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2009) 1083: 662-75. 102 002 WB
B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus.
Armstrong JN, Saganich MJ, Xu NJ, Henkemeyer M, Heinemann SF, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2613: 3474-81. 102 002 WB, IHC
Abnormal dysbindin expression in cerebellar mossy fiber synapses in the mdx mouse model of Duchenne muscular dystrophy.
Sillitoe RV, Benson MA, Blake DJ, Hawkes R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2003) 2316: 6576-85. 102 002 WB
Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase.
Armstrong JN, Brust TB, Lewis RG, MacVicar BA
The Journal of neuroscience : the official journal of the Society for Neuroscience (2002) 2214: 5938-45. 102 002 WB; tested species: rat
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 102 002 WB
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, et al.
Neuron (2021) : . 102 002 ICC, IHC; tested species: mouse
Going Back and Forth: Episomal Vector Reprogramming of Peripheral Blood Mononuclear Cells to Induced Pluripotent Stem Cells and Subsequent Differentiation into Cardiomyocytes and Neuron-Astrocyte Co-cultures.
de Leeuw VC, van Oostrom CTM, Imholz S, Piersma AH, Hessel EVS, Dollé MET
Cellular reprogramming (2020) : . 102 002 ICC; tested species: human
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer.
Apóstolo N, Smukowski SN, Vanderlinden J, Condomitti G, Rybakin V, Ten Bos J, Trobiani L, Portegies S, Vennekens KM, Gounko NV, Comoletti D, et al.
Nature communications (2020) 111: 5171. 102 002 WB, ICC, IHC; tested species: mouse
Kappa opioid receptors regulate hippocampal synaptic homeostasis and epileptogenesis.
Queenan BN, Dunn RL, Santos VR, Feng Y, Huizenga MN, Hammack RJ, Vicini S, Forcelli PA, Pak DTS
Epilepsia (2018) 591: 106-122. 102 002 ICC; tested species: rat
NeuroD2 regulates the development of hippocampal mossy fiber synapses.
Wilke SA, Hall BJ, Antonios JK, Denardo LA, Otto S, Yuan B, Chen F, Robbins EM, Tiglio K, Williams ME, Qiu Z, et al.
Neural development (2012) 7: 9. 102 002 ICC
The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.
Riccomagno MM, Hurtado A, Wang H, Macopson JG, Griner EM, Betz A, Brose N, Kazanietz MG, Kolodkin AL
Cell (2012) 1497: 1594-606. 102 002 ICC; tested species: mouse
Autaptic cultures of single hippocampal granule cells of mice and rats.
Rost BR, Breustedt J, Schoenherr A, Grosse G, Ahnert-Hilger G, Schmitz D
The European journal of neuroscience (2010) 326: 939-47. 102 002 ICC
Gαo1 and Gαo1/Gαo2 deletion differentially affect hippocampal mossy fiber tract anatomy and neuronal morphogenesis.
Höltje M, Wolkowicz A, Brunk I, Baron J, Ahnert-Hilger G
Journal of neurochemistry (2024) : . 102 002 IHC; tested species: mouse
Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons.
Cabrera OH, Useinovic N, Maksimovic S, Near M, Quillinan N, Todorovic SM, Jevtovic-Todorovic V
Neurobiology of disease (2022) 175: 105923. 102 002 IHC; tested species: mouse
LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits.
Kim J, Park D, Seo NY, Yoon TH, Kim GH, Lee SH, Seo J, Um JW, Lee KJ, Ko J
Proceedings of the National Academy of Sciences of the United States of America (2022) 1193: . 102 002 IHC; tested species: mouse
Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by Regulating Axon Collateral Formation Through CRMP2 in a Rat Model of Epilepsy.
Li Y, Tong F, Zhang Y, Cai Y, Ding J, Wang Q, Wang X
Molecular neurobiology (2022) : . 102 002 IHC; tested species: rat
Adenosine A2A receptors control synaptic remodeling in the adult brain.
Xu X, Beleza RO, Gonçalves FQ, Valbuena S, Alçada-Morais S, Gonçalves N, Magalhães J, Rocha JMM, Ferreira S, Figueira ASG, Lerma J, et al.
Scientific reports (2022) 121: 14690. 102 002 IHC; tested species: rat
Aβ-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation.
Kim DK, Jeong H, Bae J, Cha MY, Kang M, Shin D, Ha S, Hyeon SJ, Kim H, Suh K, Choi MS, et al.
Experimental & molecular medicine (2022) : . 102 002 WB, IHC; tested species: mouse
Substantial outcome improvement using a refined pilocarpine mouse model of temporal lobe epilepsy.
Vigier A, Partouche N, Michel FJ, Crépel V, Marissal T
Neurobiology of disease (2021) : 105547. 102 002 IHC; tested species: mouse
The interplay of seizures-induced axonal sprouting and transcription-dependent Bdnf repositioning in the model of temporal lobe epilepsy.
Skupien-Jaroszek A, Walczak A, Czaban I, Pels KK, Szczepankiewicz AA, Krawczyk K, Ruszczycki B, Wilczynski GM, Dzwonek J, Magalska A
PloS one (2021) 166: e0239111. 102 002 IHC; tested species: rat
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, et al.
Neuron (2021) : . 102 002 ICC, IHC; tested species: mouse
REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis.
Griffin P, Sheehan PW, Dimitry JM, Guo C, Kanan MF, Lee J, Zhang J, Musiek ES
eLife (2020) 9: . 102 002 IHC; tested species: mouse
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer.
Apóstolo N, Smukowski SN, Vanderlinden J, Condomitti G, Rybakin V, Ten Bos J, Trobiani L, Portegies S, Vennekens KM, Gounko NV, Comoletti D, et al.
Nature communications (2020) 111: 5171. 102 002 WB, ICC, IHC; tested species: mouse
Reelin Supplementation Into the Hippocampus Rescues Abnormal Behavior in a Mouse Model of Neurodevelopmental Disorders.
Ibi D, Nakasai G, Koide N, Sawahata M, Kohno T, Takaba R, Nagai T, Hattori M, Nabeshima T, Yamada K, Hiramatsu M, et al.
Frontiers in cellular neuroscience (2020) 14: 285. 102 002 IHC; tested species: mouse
Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels.
Xiao S, McKeever PM, Lau A, Robertson J
Acta neuropathologica communications (2019) 71: 161. 102 002 IHC; tested species: mouse
Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, et al.
Cell (2019) 1785: 1159-1175.e17. 102 002 IHC; tested species: mouse
Exercise Reverses Behavioral and Synaptic Abnormalities after Maternal Inflammation.
Andoh M, Shibata K, Okamoto K, Onodera J, Morishita K, Miura Y, Ikegaya Y, Koyama R
Cell reports (2019) 2710: 2817-2825.e5. 102 002 IHC; tested species: mouse
Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn.
Chung J, Franklin JF, Lee HJ
Scientific reports (2019) 91: 4273. 102 002 IHC; tested species: rat
Selective increases in inter-individual variability in response to environmental enrichment in female mice.
Körholz JC, Zocher S, Grzyb AN, Morisse B, Poetzsch A, Ehret F, Schmied C, Kempermann G
eLife (2018) 7: . 102 002 IHC; tested species: mouse
New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation.
Mata A, Gil V, Pérez-Clausell J, Dasilva M, González-Calixto MC, Soriano E, García-Verdugo JM, Sanchez-Vives MV, Del Río JA
Scientific reports (2018) 81: 1381. 102 002 IHC; tested species: mouse
Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity.
Barthet G, Jordà-Siquier T, Rumi-Masante J, Bernadou F, Müller U, Mulle C
Nature communications (2018) 91: 4780. 102 002 IHC; tested species: mouse
Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission.
Sando R, Bushong E, Zhu Y, Huang M, Considine C, Phan S, Ju S, Uytiepo M, Ellisman M, Maximov A
Neuron (2017) 942: 312-321.e3. 102 002 IHC; tested species: mouse
Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus.
Heise C, Schroeder JC, Schoen M, Halbedl S, Reim D, Woelfle S, Kreutz MR, Schmeisser MJ, Boeckers TM
Frontiers in cellular neuroscience (2016) 10: 106. 102 002 IHC
Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.
Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3516: 6544-53. 102 002 WB, IHC
β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects.
Hitt B, Riordan SM, Kukreja L, Eimer WA, Rajapaksha TW, Vassar R
The Journal of biological chemistry (2012) 28746: 38408-25. 102 002 IHC
Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy.
Volz F, Bock HH, Gierthmuehlen M, Zentner J, Haas CA, Freiman TM
Epilepsia (2011) 529: 1579-89. 102 002 IHC
Continuous neural plasticity in the olfactory intrabulbar circuitry.
Cummings DM, Belluscio L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3027: 9172-80. 102 002 IHC
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, et al.
Cell (2009) 1386: 1222-35. 102 002 IHC
Synaptic integration of adult-generated olfactory bulb granule cells: basal axodendritic centrifugal input precedes apical dendrodendritic local circuits.
Whitman MC, Greer CA
The Journal of neuroscience : the official journal of the Society for Neuroscience (2007) 2737: 9951-61. 102 002 IHC
B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus.
Armstrong JN, Saganich MJ, Xu NJ, Henkemeyer M, Heinemann SF, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2613: 3474-81. 102 002 WB, IHC
Aberrant hippocampal mossy fibers in temporal lobe epilepsy target excitatory and inhibitory neurons.
Puhahn-Schmeiser B, Leicht K, Gessler F, Freiman TM
Epilepsia (2021) : . 102 002 EM; tested species: human
Serum response factor controls neuronal circuit assembly in the hippocampus.
Knöll B, Kretz O, Fiedler C, Alberti S, Schütz G, Frotscher M, Nordheim A
Nature neuroscience (2006) 92: 195-204. 102 002 EM; tested species: mouse
Cat. No.: 102 002
Amount: 200 µl
Price: $360.00
Aβ-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation.
Kim DK, Jeong H, Bae J, Cha MY, Kang M, Shin D, Ha S, Hyeon SJ, Kim H, Suh K, Choi MS, et al.
Experimental & molecular medicine (2022) : . 102 002 WB, IHC; tested species: mouse
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer.
Apóstolo N, Smukowski SN, Vanderlinden J, Condomitti G, Rybakin V, Ten Bos J, Trobiani L, Portegies S, Vennekens KM, Gounko NV, Comoletti D, et al.
Nature communications (2020) 111: 5171. 102 002 WB, ICC, IHC; tested species: mouse
Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.
Raja MK, Preobraschenski J, Del Olmo-Cabrera S, Martinez-Turrillas R, Jahn R, Perez-Otano I, Wesseling JF
eLife (2019) 8: . 102 002 WB; KO verified; tested species: mouse
Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus.
Basu R, Duan X, Taylor MR, Martin EA, Muralidhar S, Wang Y, Gangi-Wellman L, Das SC, Yamagata M, West PJ, Sanes JR, et al.
Neuron (2017) 961: 160-176.e8. 102 002 WB; tested species: mouse
Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.
Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3516: 6544-53. 102 002 WB, IHC
The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels.
Morciano M, Beckhaus T, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2009) 1083: 662-75. 102 002 WB
B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus.
Armstrong JN, Saganich MJ, Xu NJ, Henkemeyer M, Heinemann SF, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2613: 3474-81. 102 002 WB, IHC
Abnormal dysbindin expression in cerebellar mossy fiber synapses in the mdx mouse model of Duchenne muscular dystrophy.
Sillitoe RV, Benson MA, Blake DJ, Hawkes R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2003) 2316: 6576-85. 102 002 WB
Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase.
Armstrong JN, Brust TB, Lewis RG, MacVicar BA
The Journal of neuroscience : the official journal of the Society for Neuroscience (2002) 2214: 5938-45. 102 002 WB; tested species: rat
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 102 002 WB
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, et al.
Neuron (2021) : . 102 002 ICC, IHC; tested species: mouse
Going Back and Forth: Episomal Vector Reprogramming of Peripheral Blood Mononuclear Cells to Induced Pluripotent Stem Cells and Subsequent Differentiation into Cardiomyocytes and Neuron-Astrocyte Co-cultures.
de Leeuw VC, van Oostrom CTM, Imholz S, Piersma AH, Hessel EVS, Dollé MET
Cellular reprogramming (2020) : . 102 002 ICC; tested species: human
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer.
Apóstolo N, Smukowski SN, Vanderlinden J, Condomitti G, Rybakin V, Ten Bos J, Trobiani L, Portegies S, Vennekens KM, Gounko NV, Comoletti D, et al.
Nature communications (2020) 111: 5171. 102 002 WB, ICC, IHC; tested species: mouse
Kappa opioid receptors regulate hippocampal synaptic homeostasis and epileptogenesis.
Queenan BN, Dunn RL, Santos VR, Feng Y, Huizenga MN, Hammack RJ, Vicini S, Forcelli PA, Pak DTS
Epilepsia (2018) 591: 106-122. 102 002 ICC; tested species: rat
NeuroD2 regulates the development of hippocampal mossy fiber synapses.
Wilke SA, Hall BJ, Antonios JK, Denardo LA, Otto S, Yuan B, Chen F, Robbins EM, Tiglio K, Williams ME, Qiu Z, et al.
Neural development (2012) 7: 9. 102 002 ICC
The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.
Riccomagno MM, Hurtado A, Wang H, Macopson JG, Griner EM, Betz A, Brose N, Kazanietz MG, Kolodkin AL
Cell (2012) 1497: 1594-606. 102 002 ICC; tested species: mouse
Autaptic cultures of single hippocampal granule cells of mice and rats.
Rost BR, Breustedt J, Schoenherr A, Grosse G, Ahnert-Hilger G, Schmitz D
The European journal of neuroscience (2010) 326: 939-47. 102 002 ICC
Gαo1 and Gαo1/Gαo2 deletion differentially affect hippocampal mossy fiber tract anatomy and neuronal morphogenesis.
Höltje M, Wolkowicz A, Brunk I, Baron J, Ahnert-Hilger G
Journal of neurochemistry (2024) : . 102 002 IHC; tested species: mouse
Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons.
Cabrera OH, Useinovic N, Maksimovic S, Near M, Quillinan N, Todorovic SM, Jevtovic-Todorovic V
Neurobiology of disease (2022) 175: 105923. 102 002 IHC; tested species: mouse
LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits.
Kim J, Park D, Seo NY, Yoon TH, Kim GH, Lee SH, Seo J, Um JW, Lee KJ, Ko J
Proceedings of the National Academy of Sciences of the United States of America (2022) 1193: . 102 002 IHC; tested species: mouse
Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by Regulating Axon Collateral Formation Through CRMP2 in a Rat Model of Epilepsy.
Li Y, Tong F, Zhang Y, Cai Y, Ding J, Wang Q, Wang X
Molecular neurobiology (2022) : . 102 002 IHC; tested species: rat
Adenosine A2A receptors control synaptic remodeling in the adult brain.
Xu X, Beleza RO, Gonçalves FQ, Valbuena S, Alçada-Morais S, Gonçalves N, Magalhães J, Rocha JMM, Ferreira S, Figueira ASG, Lerma J, et al.
Scientific reports (2022) 121: 14690. 102 002 IHC; tested species: rat
Aβ-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation.
Kim DK, Jeong H, Bae J, Cha MY, Kang M, Shin D, Ha S, Hyeon SJ, Kim H, Suh K, Choi MS, et al.
Experimental & molecular medicine (2022) : . 102 002 WB, IHC; tested species: mouse
Substantial outcome improvement using a refined pilocarpine mouse model of temporal lobe epilepsy.
Vigier A, Partouche N, Michel FJ, Crépel V, Marissal T
Neurobiology of disease (2021) : 105547. 102 002 IHC; tested species: mouse
The interplay of seizures-induced axonal sprouting and transcription-dependent Bdnf repositioning in the model of temporal lobe epilepsy.
Skupien-Jaroszek A, Walczak A, Czaban I, Pels KK, Szczepankiewicz AA, Krawczyk K, Ruszczycki B, Wilczynski GM, Dzwonek J, Magalska A
PloS one (2021) 166: e0239111. 102 002 IHC; tested species: rat
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, et al.
Neuron (2021) : . 102 002 ICC, IHC; tested species: mouse
REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis.
Griffin P, Sheehan PW, Dimitry JM, Guo C, Kanan MF, Lee J, Zhang J, Musiek ES
eLife (2020) 9: . 102 002 IHC; tested species: mouse
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer.
Apóstolo N, Smukowski SN, Vanderlinden J, Condomitti G, Rybakin V, Ten Bos J, Trobiani L, Portegies S, Vennekens KM, Gounko NV, Comoletti D, et al.
Nature communications (2020) 111: 5171. 102 002 WB, ICC, IHC; tested species: mouse
Reelin Supplementation Into the Hippocampus Rescues Abnormal Behavior in a Mouse Model of Neurodevelopmental Disorders.
Ibi D, Nakasai G, Koide N, Sawahata M, Kohno T, Takaba R, Nagai T, Hattori M, Nabeshima T, Yamada K, Hiramatsu M, et al.
Frontiers in cellular neuroscience (2020) 14: 285. 102 002 IHC; tested species: mouse
Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels.
Xiao S, McKeever PM, Lau A, Robertson J
Acta neuropathologica communications (2019) 71: 161. 102 002 IHC; tested species: mouse
Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, et al.
Cell (2019) 1785: 1159-1175.e17. 102 002 IHC; tested species: mouse
Exercise Reverses Behavioral and Synaptic Abnormalities after Maternal Inflammation.
Andoh M, Shibata K, Okamoto K, Onodera J, Morishita K, Miura Y, Ikegaya Y, Koyama R
Cell reports (2019) 2710: 2817-2825.e5. 102 002 IHC; tested species: mouse
Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn.
Chung J, Franklin JF, Lee HJ
Scientific reports (2019) 91: 4273. 102 002 IHC; tested species: rat
Selective increases in inter-individual variability in response to environmental enrichment in female mice.
Körholz JC, Zocher S, Grzyb AN, Morisse B, Poetzsch A, Ehret F, Schmied C, Kempermann G
eLife (2018) 7: . 102 002 IHC; tested species: mouse
New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation.
Mata A, Gil V, Pérez-Clausell J, Dasilva M, González-Calixto MC, Soriano E, García-Verdugo JM, Sanchez-Vives MV, Del Río JA
Scientific reports (2018) 81: 1381. 102 002 IHC; tested species: mouse
Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity.
Barthet G, Jordà-Siquier T, Rumi-Masante J, Bernadou F, Müller U, Mulle C
Nature communications (2018) 91: 4780. 102 002 IHC; tested species: mouse
Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission.
Sando R, Bushong E, Zhu Y, Huang M, Considine C, Phan S, Ju S, Uytiepo M, Ellisman M, Maximov A
Neuron (2017) 942: 312-321.e3. 102 002 IHC; tested species: mouse
Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus.
Heise C, Schroeder JC, Schoen M, Halbedl S, Reim D, Woelfle S, Kreutz MR, Schmeisser MJ, Boeckers TM
Frontiers in cellular neuroscience (2016) 10: 106. 102 002 IHC
Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.
Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3516: 6544-53. 102 002 WB, IHC
β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects.
Hitt B, Riordan SM, Kukreja L, Eimer WA, Rajapaksha TW, Vassar R
The Journal of biological chemistry (2012) 28746: 38408-25. 102 002 IHC
Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy.
Volz F, Bock HH, Gierthmuehlen M, Zentner J, Haas CA, Freiman TM
Epilepsia (2011) 529: 1579-89. 102 002 IHC
Continuous neural plasticity in the olfactory intrabulbar circuitry.
Cummings DM, Belluscio L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3027: 9172-80. 102 002 IHC
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, et al.
Cell (2009) 1386: 1222-35. 102 002 IHC
Synaptic integration of adult-generated olfactory bulb granule cells: basal axodendritic centrifugal input precedes apical dendrodendritic local circuits.
Whitman MC, Greer CA
The Journal of neuroscience : the official journal of the Society for Neuroscience (2007) 2737: 9951-61. 102 002 IHC
B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus.
Armstrong JN, Saganich MJ, Xu NJ, Henkemeyer M, Heinemann SF, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2613: 3474-81. 102 002 WB, IHC
Aberrant hippocampal mossy fibers in temporal lobe epilepsy target excitatory and inhibitory neurons.
Puhahn-Schmeiser B, Leicht K, Gessler F, Freiman TM
Epilepsia (2021) : . 102 002 EM; tested species: human
Serum response factor controls neuronal circuit assembly in the hippocampus.
Knöll B, Kretz O, Fiedler C, Alberti S, Schütz G, Frotscher M, Nordheim A
Nature neuroscience (2006) 92: 195-204. 102 002 EM; tested species: mouse
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Background

Synaptoporin, also known as synaptophysin 2 and p38-2, is highly homologous to synaptophysin 1 but encoded by a different gene. Like synaptopysin 1, synaptoporin contains four transmembrane regions and a short cytoplasmic tail. Unlike synaptophysin 1, it is not glycosylated.
The distributions of synaptophysin 1 and synaptoporin are different. Synaptophysin 1 is more uniformly expressed whereas synaptoporin is particularly enriched in mossy fiber synapses in the hippocampus. It is thus an excellent marker for subsets of synapses.
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