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Home > Products > 101 006

Synaptophysin1 antibody - 101 006

Synaptophysin is a major synaptic vesicle membrane protein and a useful neuroendocrine tumor marker
Chicken polyclonal IgY fraction
Cat. No.: 101 006
Amount: 200 µl
Price: $370.00
Cat. No. 101 006 200 µl antibody, lyophilized. Albumin was added for stabilization. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.
Immunogen Synthetic peptide corresponding to residues near the carboxy terminus of human Synaptophysin (UniProt Id: P08247)
Reactivity Reacts with: human (P08247), rat (P07825), mouse (Q62277).
Other species not tested yet.
Matching control protein/peptide 101-0P
Data sheet 101_006.pdf

References for Synaptophysin1 - 101 006

G6PD deficiency triggers dopamine loss and the initiation of Parkinson's disease pathogenesis.
Stykel MG, Siripala SV, Soubeyrand E, Coackley CL, Lu P, Camargo S, Thevasenan S, Figueroa GB, So RWL, Stuart E, Panchal R, et al.
Cell reports (2025) 441: 115178. 101 006 WB, ICC; tested species: human,mouse,rat
G6PD deficiency triggers dopamine loss and the initiation of Parkinson's disease pathogenesis.
Stykel MG, Siripala SV, Soubeyrand E, Coackley CL, Lu P, Camargo S, Thevasenan S, Figueroa GB, So RWL, Stuart E, Panchal R, et al.
Cell reports (2025) 441: 115178. 101 006 WB, ICC; tested species: human,mouse,rat
Methods for culturing adult CNS neurons reveal a CNS conditioning effect.
van Niekerk EA, Kawaguchi R, Marques de Freria C, Groeniger K, Marchetto MC, Dupraz S, Bradke F, Geschwind DH, Gage FH, Tuszynski MH
Cell reports methods (2022) 27: 100255. 101 006 ICC; tested species: mouse
Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements.
Ibarra IL, Ratnu VS, Gordillo L, Hwang IY, Mariani L, Weinand K, Hammarén HM, Heck J, Bulyk ML, Savitski MM, Zaugg JB, et al.
Molecular systems biology (2022) 188: e10473. 101 006 ICC; tested species: human,mouse
Modulating electrophysiology of motor neural networks via optogenetic stimulation during neurogenesis and synaptogenesis.
Pagan-Diaz GJ, Drnevich J, Ramos-Cruz KP, Sam R, Sengupta P, Bashir R
Scientific reports (2020) 101: 12460. 101 006 ICC; tested species: mouse
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, et al.
Frontiers in immunology (2020) 11: 599771. 101 006 ICC, IHC; tested species: mouse
High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.
Parker SS, Moutal A, Cai S, Chandrasekaran S, Roman MR, Koshy AA, Khanna R, Zinsmaier KE, Mouneimne G
eNeuro () 55: . 101 006 ICC; tested species: mouse
NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway.
Gill AJ, Smith MD, Galleguillos D, Garton T, Mace JW, Gadani SP, Kumar S, Pokharel A, Solem K, Potluri S, Hussein O, et al.
Journal of neuroinflammation (2025) 221: 21. 101 006 IHC; tested species: mouse
Tau association with synaptic mitochondria coincides with energetic dysfunction and excitatory synapse loss in the P301S tauopathy mouse model.
Daniel Estrella L, Trease AJ, Sheldon L, Roland NJ, Fox HS, Stauch KL
Neurobiology of aging (2024) 147: 163-175. 101 006 IHC; tested species: mouse
BDNF-dependent modulation of axonal transport is selectively impaired in ALS.
Tosolini AP, Sleigh JN, Surana S, Rhymes ER, Cahalan SD, Schiavo G
Acta neuropathologica communications (2022) 101: 121. 101 006 IHC; tested species: mouse
Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer's disease animal model.
Györffy BA, Tóth V, Török G, Gulyássy P, Kovács RÁ, Vadászi H, Micsonai A, Tóth ME, Sántha M, Homolya L, Drahos L, et al.
Cellular and molecular life sciences : CMLS (2020) : . 101 006 IHC; tested species: mouse
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, et al.
Frontiers in immunology (2020) 11: 599771. 101 006 ICC, IHC; tested species: mouse
Cat. No.: 101 006
Amount: 200 µl
Price: $370.00
G6PD deficiency triggers dopamine loss and the initiation of Parkinson's disease pathogenesis.
Stykel MG, Siripala SV, Soubeyrand E, Coackley CL, Lu P, Camargo S, Thevasenan S, Figueroa GB, So RWL, Stuart E, Panchal R, et al.
Cell reports (2025) 441: 115178. 101 006 WB, ICC; tested species: human,mouse,rat
G6PD deficiency triggers dopamine loss and the initiation of Parkinson's disease pathogenesis.
Stykel MG, Siripala SV, Soubeyrand E, Coackley CL, Lu P, Camargo S, Thevasenan S, Figueroa GB, So RWL, Stuart E, Panchal R, et al.
Cell reports (2025) 441: 115178. 101 006 WB, ICC; tested species: human,mouse,rat
Methods for culturing adult CNS neurons reveal a CNS conditioning effect.
van Niekerk EA, Kawaguchi R, Marques de Freria C, Groeniger K, Marchetto MC, Dupraz S, Bradke F, Geschwind DH, Gage FH, Tuszynski MH
Cell reports methods (2022) 27: 100255. 101 006 ICC; tested species: mouse
Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements.
Ibarra IL, Ratnu VS, Gordillo L, Hwang IY, Mariani L, Weinand K, Hammarén HM, Heck J, Bulyk ML, Savitski MM, Zaugg JB, et al.
Molecular systems biology (2022) 188: e10473. 101 006 ICC; tested species: human,mouse
Modulating electrophysiology of motor neural networks via optogenetic stimulation during neurogenesis and synaptogenesis.
Pagan-Diaz GJ, Drnevich J, Ramos-Cruz KP, Sam R, Sengupta P, Bashir R
Scientific reports (2020) 101: 12460. 101 006 ICC; tested species: mouse
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, et al.
Frontiers in immunology (2020) 11: 599771. 101 006 ICC, IHC; tested species: mouse
High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.
Parker SS, Moutal A, Cai S, Chandrasekaran S, Roman MR, Koshy AA, Khanna R, Zinsmaier KE, Mouneimne G
eNeuro () 55: . 101 006 ICC; tested species: mouse
NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway.
Gill AJ, Smith MD, Galleguillos D, Garton T, Mace JW, Gadani SP, Kumar S, Pokharel A, Solem K, Potluri S, Hussein O, et al.
Journal of neuroinflammation (2025) 221: 21. 101 006 IHC; tested species: mouse
Tau association with synaptic mitochondria coincides with energetic dysfunction and excitatory synapse loss in the P301S tauopathy mouse model.
Daniel Estrella L, Trease AJ, Sheldon L, Roland NJ, Fox HS, Stauch KL
Neurobiology of aging (2024) 147: 163-175. 101 006 IHC; tested species: mouse
BDNF-dependent modulation of axonal transport is selectively impaired in ALS.
Tosolini AP, Sleigh JN, Surana S, Rhymes ER, Cahalan SD, Schiavo G
Acta neuropathologica communications (2022) 101: 121. 101 006 IHC; tested species: mouse
Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer's disease animal model.
Györffy BA, Tóth V, Török G, Gulyássy P, Kovács RÁ, Vadászi H, Micsonai A, Tóth ME, Sántha M, Homolya L, Drahos L, et al.
Cellular and molecular life sciences : CMLS (2020) : . 101 006 IHC; tested species: mouse
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, et al.
Frontiers in immunology (2020) 11: 599771. 101 006 ICC, IHC; tested species: mouse
WB
ICC
IHC
IHC-P
Background

Synaptophysin1, also referred to as p38-1, is a membrane glycoprotein of synaptic vesicles that is ubiquitously expressed in all neurons and in many endocrine cells. It is currently the most widely used marker for nerve terminals and probably the best marker for the pathologist in differentiating neuroendocrine tumors.
Synaptophysin1 has four transmembrane domains with both N- and C-terminus facing the cytoplasm. It binds to synaptobrevin1 and synaptobrevin2 in detergent extracts but its function has not been elucidated completely. It forms a complex with dynamin at high Ca2+ concentration suggesting an involvement in synaptic vesicle endocytosis. As typical for synaptic vesicle proteins, synaptophysin1 represents a small protein family with two additonal members, synaptoporin (synaptophysin2) and panthophysin. Like synaptophysin1, synaptoporin is widely expressed in neurons and colocalizes with synaptophysin1 on synaptic vesicles whereas panthophysin is expressed in all tissues.
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