Kv7.3 peptide - 368-0P

Kv7.3 is a potassium channel widely expressed throughout the brain

control peptide

Cat. No.: 368-0P

Amount: 100 µg

Price: $105.00

Cat. No. 368-0P	100 µg peptide, lyophilized. For reconstitution add 100 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Control peptides should be stored at -20°C when still lyophilized!
Applications
Immunogen	Synthetic peptide corresponding to AA 858 to 873 from rat Kv7.3 (UniProt Id: O88944-1)
Recommended dilution	Optimal concentrations should be determined by the end-user.
Matching antibodies	368 003
Remarks	This control peptide consists of the synthetic peptide (aa 858-873 of rat Kv7.3) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of peptide needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.
Data sheet	368-0p.pdf

Cat. No.: 368-0P

Amount: 100 µg

Price: $105.00

Background

Five voltage gated potassium channels Kv7, encoded by the genes KCNQ 1-5, have been described in mammals so far. They are integral membrane proteins and show distinct distribution patterns. Kv7.2, Kv7.3 and Kv7.5 are widely expressed in different brain regions whereas Kv7.1 and Kv7.4 show more restricted expression profiles.
Kv7.3 forms the M channel with either Kv7.2 or Kv7.5. This ion channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability.

1 ) Stewart AP et al., J. Biol. Chem. (2012)
2 ) Cooper EC et al., Proc. Natl. Acad. Sci. U.S.A. (2000)
3 ) Selyanko AA et al., J. Neurosci. (1999)
4 ) Singh NA et al., Nat. Genet. (1998)

Protocols

OTHER

Preadsorbtion

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