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Homer1b/c antibody - 160 023

Homer1 , 2 and 3 are post synaptic density (PSD) proteins involved in the targeting of glutamate receptors
Rabbit polyclonal purified antibody
Cat. No.: 160 023
Amount: 50 µg
Price: $460.00
Cat. No. 160 023 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 200 up to 1 : 500 gallery  
IHC-P: not tested yet
EM: yes
Immunogen Recombinant protein corresponding to the c-terminal half of human Homer 1b (UniProt Id: Q86YM7-1)
Reactivity Reacts with: human (Q86YM7-1), rat (Q9Z214-2, Q9Z214-1), mouse.
Other species not tested yet.
Specificity Specific for homer 1b and 1c; no cross-reactivity to homer 1a.
Matching control protein/peptide 160-02P
Data sheet 160_023.pdf

References for Homer1b/c - 160 023

A single 24 h maternal separation at PND 9 promotes behavioral resilience of female C57BL/6J mice and the possible role of hippocampal Homer1a.
Hao Y, Niu Y, Shi F, Zhang L, Peng C, Yan Z, Chen X, Xu H
Heliyon (2024) 105: e27037. 160 023 WB; tested species: mouse
Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.
Tao-Cheng JH, Thein S, Yang Y, Reese TS, Gallant PE
Neuroscience (2014) 266: 80-90. 160 023 WB, EM; tested species: rat
Dysregulated postsynaptic density and endocytic zone in the amygdala of human heroin and cocaine abusers.
Okvist A, Fagergren P, Whittard J, Garcia-Osta A, Drakenberg K, Horvath MC, Schmidt CJ, Keller E, Bannon MJ, Hurd YL
Biological psychiatry (2011) 693: 245-52. 160 023 WB; tested species: human
Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
Roselli F, Hutzler P, Wegerich Y, Livrea P, Almeida OF
PloS one (2009) 46: e6011. 160 023 WB; tested species: rat
Axonal plasticity in response to active forces generated through magnetic nano-pulling.
Falconieri A, De Vincentiis S, Cappello V, Convertino D, Das R, Ghignoli S, Figoli S, Luin S, Català-Castro F, Marchetti L, Borello U, et al.
Cell reports (2022) 421: 111912. 160 023 ICC; tested species: mouse
Kainate Receptor Activation Shapes Short-Term Synaptic Plasticity by Controlling Receptor Lateral Mobility at Glutamatergic Synapses.
Polenghi A, Nieus T, Guazzi S, Gorostiza P, Petrini EM, Barberis A
Cell reports (2020) 3110: 107735. 160 023 ICC; tested species: mouse
Preparation of dissociated mouse primary neuronal cultures from long-term cryopreserved brain tissue.
Cano-Jaimez M, Tagliatti E, Mendonca P, Nicholson E, Vivekananda U, Kullmann DM, Volynski KE
Journal of neuroscience methods (2019) : 108452. 160 023 ICC; tested species: mouse
NMDA-induced accumulation of Shank at the postsynaptic density is mediated by CaMKII.
Tao-Cheng JH, Yang Y, Bayer KU, Reese TS, Dosemeci A
Biochemical and biophysical research communications (2014) 4501: 808-11. 160 023 ICC
Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing.
Ibrahim LA, Wamsley B, Alghamdi N, Yusuf N, Sevier E, Hairston A, Sherer M, Jaglin XH, Xu Q, Guo L, Khodadadi-Jamayran A, et al.
eLife (2023) 12: . 160 023 IHC; tested species: mouse
Loss of miR-183/96 alters synaptic strength via pre- and postsynaptic mechanisms at a central synapse.
Krohs C, Körber C, Ebbers L, Altaf F, Hollje G, Hoppe S, Dörflinger Y, Prosser HM, Nothwang HG
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 160 023 IHC; tested species: mouse
GABA-receptive microglia selectively sculpt developing inhibitory circuits.
Favuzzi E, Huang S, Saldi GA, Binan L, Ibrahim LA, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, et al.
Cell (2021) 18415: 4048-4063.e32. 160 023 IHC; tested species: mouse
Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS.
Bączyk M, Alami NO, Delestrée N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N, Frankel W, Manuel M, Roselli F, et al.
The Journal of experimental medicine (2020) 2178: . 160 023 IHC; tested species: mouse
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 160 023 IHC; tested species: rat
Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus.
Heise C, Schroeder JC, Schoen M, Halbedl S, Reim D, Woelfle S, Kreutz MR, Schmeisser MJ, Boeckers TM
Frontiers in cellular neuroscience (2016) 10: 106. 160 023 IHC
Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.
Tao-Cheng JH, Thein S, Yang Y, Reese TS, Gallant PE
Neuroscience (2014) 266: 80-90. 160 023 WB, EM; tested species: rat
Cat. No.: 160 023
Amount: 50 µg
Price: $460.00
A single 24 h maternal separation at PND 9 promotes behavioral resilience of female C57BL/6J mice and the possible role of hippocampal Homer1a.
Hao Y, Niu Y, Shi F, Zhang L, Peng C, Yan Z, Chen X, Xu H
Heliyon (2024) 105: e27037. 160 023 WB; tested species: mouse
Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.
Tao-Cheng JH, Thein S, Yang Y, Reese TS, Gallant PE
Neuroscience (2014) 266: 80-90. 160 023 WB, EM; tested species: rat
Dysregulated postsynaptic density and endocytic zone in the amygdala of human heroin and cocaine abusers.
Okvist A, Fagergren P, Whittard J, Garcia-Osta A, Drakenberg K, Horvath MC, Schmidt CJ, Keller E, Bannon MJ, Hurd YL
Biological psychiatry (2011) 693: 245-52. 160 023 WB; tested species: human
Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
Roselli F, Hutzler P, Wegerich Y, Livrea P, Almeida OF
PloS one (2009) 46: e6011. 160 023 WB; tested species: rat
Axonal plasticity in response to active forces generated through magnetic nano-pulling.
Falconieri A, De Vincentiis S, Cappello V, Convertino D, Das R, Ghignoli S, Figoli S, Luin S, Català-Castro F, Marchetti L, Borello U, et al.
Cell reports (2022) 421: 111912. 160 023 ICC; tested species: mouse
Kainate Receptor Activation Shapes Short-Term Synaptic Plasticity by Controlling Receptor Lateral Mobility at Glutamatergic Synapses.
Polenghi A, Nieus T, Guazzi S, Gorostiza P, Petrini EM, Barberis A
Cell reports (2020) 3110: 107735. 160 023 ICC; tested species: mouse
Preparation of dissociated mouse primary neuronal cultures from long-term cryopreserved brain tissue.
Cano-Jaimez M, Tagliatti E, Mendonca P, Nicholson E, Vivekananda U, Kullmann DM, Volynski KE
Journal of neuroscience methods (2019) : 108452. 160 023 ICC; tested species: mouse
NMDA-induced accumulation of Shank at the postsynaptic density is mediated by CaMKII.
Tao-Cheng JH, Yang Y, Bayer KU, Reese TS, Dosemeci A
Biochemical and biophysical research communications (2014) 4501: 808-11. 160 023 ICC
Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing.
Ibrahim LA, Wamsley B, Alghamdi N, Yusuf N, Sevier E, Hairston A, Sherer M, Jaglin XH, Xu Q, Guo L, Khodadadi-Jamayran A, et al.
eLife (2023) 12: . 160 023 IHC; tested species: mouse
Loss of miR-183/96 alters synaptic strength via pre- and postsynaptic mechanisms at a central synapse.
Krohs C, Körber C, Ebbers L, Altaf F, Hollje G, Hoppe S, Dörflinger Y, Prosser HM, Nothwang HG
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 160 023 IHC; tested species: mouse
GABA-receptive microglia selectively sculpt developing inhibitory circuits.
Favuzzi E, Huang S, Saldi GA, Binan L, Ibrahim LA, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, et al.
Cell (2021) 18415: 4048-4063.e32. 160 023 IHC; tested species: mouse
Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS.
Bączyk M, Alami NO, Delestrée N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N, Frankel W, Manuel M, Roselli F, et al.
The Journal of experimental medicine (2020) 2178: . 160 023 IHC; tested species: mouse
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 160 023 IHC; tested species: rat
Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus.
Heise C, Schroeder JC, Schoen M, Halbedl S, Reim D, Woelfle S, Kreutz MR, Schmeisser MJ, Boeckers TM
Frontiers in cellular neuroscience (2016) 10: 106. 160 023 IHC
Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.
Tao-Cheng JH, Thein S, Yang Y, Reese TS, Gallant PE
Neuroscience (2014) 266: 80-90. 160 023 WB, EM; tested species: rat
Background

Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.