Synaptic Systems - beta3-Integrin

Cat. No.: 240 303

Amount: 50 µg

Price: $375.00

WB

Background

Integrins are heterodimers consisting of noncovalently associated α and β subunits. More than 20 different integrin receptors composed of 16 different α and 8 different β subunits have been described so far. Most of these receptors bind components of the extracellular matrix like fibronectin, collagen and vitronectin.
Integrins are transmembrane glycoproteins involved in many normal cellular processes (embryogenesis, hemostasis, tissue repair, immune response) but also in abnormal pathological events like metastatic spread of tumor cells. In humans five isoforms of β1-integrin have been described (β1A-1D, 1C-2). β1-integrin is also known as very late antigen VLA or CD29.
β3-integrin, also referred to a CD 61, is found with the alpha IIb chain in platelets.

1 ) Dingemans AM, Molecular cancer (2010) 9: 152.
2 ) Liu S, Arthritis and rheumatism (2009) 609: 2817-21.
3 ) Loulier K, PLoS biology (2009) 78: e1000176.
4 ) Shi F, Journal of cell science (2008) 121Pt 14: 2360-71.
5 ) Young-Pearse TL, Neural development (2008) 3: 15.

Protocols

WB

OTHER

Preabsorbtion

Other products for this target

Cat. No. 240 303	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 1000 gallery IP: not tested yet ICC: not tested yet IHC: not tested yet IHC-P: not tested yet
Immunogen	Synthetic peptide corresponding to AA 76 to 91 from mouse β3-Integrin (UniProt Id: O54890)
Reactivity	Reacts with: rat (Q8R2H2), mouse (O54890). Other species not tested yet.
Specificity	Specific for β3-integrin.
Matching control protein/peptide	240-3P
Data sheet	240_303.pdf

beta3-Integrin antibody - 240 303