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- will be discontinued soon
Polyclonal antibodies are a finite resource. We have now started to sell the last lots of our well received Guinea pig polyclonal TRIM46 antibody 377 005. It will be replaced by our new Guinea pig monoclonal recombinant IgG TRIM46 antibody 377 308.

TRIM46 antibody - 377 005

TRIM46 is involved in establishing neuronal polarity
Guinea pig polyclonal purified antibody
Cat. No.: 377 005
Amount: 50 µg
Price: $460.00
Cat. No. 377 005 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 561 from rat Trim46 (UniProt Id: A0A0G2JXN2)
Reactivity Reacts with: rat (A0A0G2JXN2), mouse (Q7TNM2).
Other species not tested yet.
Data sheet 377_005.pdf

References for TRIM46 - 377 005

Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.
Lindhout FW, Portegies S, Kooistra R, Herstel LJ, Stucchi R, Hummel JJA, Scheefhals N, Katrukha EA, Altelaar M, MacGillavry HD, Wierenga CJ, et al.
The EMBO journal (2021) : e106798. 377 005 WB, ICC; tested species: human,rat
The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling.
Dorrego-Rivas A, Ezan J, Moreau MM, Poirault-Chassac S, Aubailly N, De Neve J, Blanchard C, Castets F, Fréal A, Battefeld A, Sans N, et al.
Science advances (2022) 836: eabo6333. 377 005 ICC; tested species: rat
Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.
Lindhout FW, Portegies S, Kooistra R, Herstel LJ, Stucchi R, Hummel JJA, Scheefhals N, Katrukha EA, Altelaar M, MacGillavry HD, Wierenga CJ, et al.
The EMBO journal (2021) : e106798. 377 005 WB, ICC; tested species: human,rat
Cat. No.: 377 005
Amount: 50 µg
Price: $460.00
Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.
Lindhout FW, Portegies S, Kooistra R, Herstel LJ, Stucchi R, Hummel JJA, Scheefhals N, Katrukha EA, Altelaar M, MacGillavry HD, Wierenga CJ, et al.
The EMBO journal (2021) : e106798. 377 005 WB, ICC; tested species: human,rat
The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling.
Dorrego-Rivas A, Ezan J, Moreau MM, Poirault-Chassac S, Aubailly N, De Neve J, Blanchard C, Castets F, Fréal A, Battefeld A, Sans N, et al.
Science advances (2022) 836: eabo6333. 377 005 ICC; tested species: rat
Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.
Lindhout FW, Portegies S, Kooistra R, Herstel LJ, Stucchi R, Hummel JJA, Scheefhals N, Katrukha EA, Altelaar M, MacGillavry HD, Wierenga CJ, et al.
The EMBO journal (2021) : e106798. 377 005 WB, ICC; tested species: human,rat
Background
The tripartite motif containing protein TRIM 46, also referred to as TRIFIC, is a member of the C-I TRIM family, a subfamily of the RBCC (N-terminal RING finger/B-box/coiled coil)/TRIM superfamily.
TRIM 46 localizes to newly specified axons and, at later stages, to the axon initial segment (AIS). By forming closely spaced parallel microtubule bundles it plays a crucial role in the initial polarization of neuronal cells.