Home|||||||Technical Support|

AiF - 300 003

An oxidoreductase in the inner mitochondrial membrane
Polyclonal rabbit purified antibody
Cat. No.: 300 003
Amount: 50 µg
Price: $370.00
Cat. No. 300 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not recommended
ICC: 1 : 500 gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 514 to 529 from mouse AiF (UniProt Id: Q9Z0X1)
Reactivity Reacts with: human, rat, mouse.
Other species not tested yet.
Specificity Specific for AiF.
Matching control protein/peptide 300-0P
Data sheet 300_003.pdf
Cat. No.: 300 003
Quantity: 50 µg
Price: $370.00
Background
In healthy cells the apoptosis-inducing factor AiF, also referred to as PDCD 8, localizes to the inner membrane of mitochondria where it functions as an oxidoreductase. After permeabilization of the outer mitochondrial membrane, which is common to apoptotic pathways, AiF is released from mitochondria and translocated to the nucleus. There it contributes to apoptotic chromatin condensation and DNA degradation.