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beta-Catenin - 281 003

Cadherin binding partners
Polyclonal rabbit purified antibody
Cat. No.: 281 003
Amount: 50 µg
Price: $370.00
Cat. No. 281 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 1000 gallery  
IHC: 1 : 1000 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 768 to 782 from mouse β-Catenin (UniProt Id: Q02248)
Reactivity Reacts with: human (P35222), rat (Q9WU82), mouse (Q02248), zebrafish, grashopper.
Other species not tested yet.
Specificity Specific for β-catenin
Matching control protein/peptide 281-0P
Data sheet 281_003.pdf

References for beta-Catenin - 281 003

Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory, Spatial Working Memory, and Dendritic Structure in Mice.
Wang HL, Li JT, Wang H, Sun YX, Liu R, Wang XD, Su YA, Si TM
Neuroscience bulletin (2020) : . 281 003 WB; tested species: mouse
Cat. No.: 281 003
Quantity: 50 µg
Price: $370.00
Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory, Spatial Working Memory, and Dendritic Structure in Mice.
Wang HL, Li JT, Wang H, Sun YX, Liu R, Wang XD, Su YA, Si TM
Neuroscience bulletin (2020) : . 281 003 WB; tested species: mouse
Background
α, β and γ-catenin are intracellular proteins that link cadherins to the actin cytosceleton. Cadherins are cell-surface proteins that are involved in cell-cell adhesion.
α-N-catenin is expressed mainly in the nervous system. It is a cytoplasmic protein that interacts with N-cadherin and functions in cell-cell adhesion. It is a regulator for the stability of synaptic contacts and is important for cerebellar and hippocampal lamination. There are two isoforms which are differentially expressed during development.
The major part of β-catenin localizes to the cell membrane and is part of E-cadherin/catenin adhesion complexes.