Cat. No.: 214 008
Amount: 50 µg
Price:
$415.00
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| Cat. No. 214 008 |
50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | Rb351C10 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Full-length recombinant human Calbindin D28k protein (UniProt Id: P05937) |
| Reactivity |
Reacts with: human (P05937), rat (P07171), mouse (P12658), zebrafish, grashopper. Other species not tested yet. |
| Matching control protein/peptide | 214-0P |
| Remarks |
This antibody is a chimeric antibody based on the well known monoclonal mouse antibody clone 351C10. The constant regions of the heavy and light chains have been replaced by rabbit specific sequences. Therefore, the antibody can be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells. |
| Data sheet | 214_008.pdf |
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Two isoforms of the vitamin D-dependent Ca-binding proteins have been described so far: calbindin D28k, also referred to as CALB 1, D-28k, and CAB 27, and calbindin D29k, also known as calretinin. These proteins are expressed in cells that have to handle a high calcium influx such as brain, bone, teeth, inner ear and others. Calbindins are believed to regulate cellular activity by suppressing or buffering intracellur calcium. In the brain calbindin D28k is a useful marker for specific neuronal cell types. It is particularly concentrated in the dendrites and perikarya of cerebellar Purkinje cells, but is also found in many GABAergic interneurons in the cortex.