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MAP 2 - 188 004

A major microtubule associated protein
Polyclonal Guinea pig antiserum
Cat. No.: 188 004
Amount: 100 µl
Price: $375.00
Cat. No. 188 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) (see remarks) gallery  
IP: not tested yet
ICC: 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 200 up to 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 2 to 314 from human MAP2-4 hu (UniProt Id: P11137-4)
Reactivity Reacts with: human (P11137), rat (P15146), mouse (P20357).
Other species not tested yet.
Specificity Specific for MAP 2; recognizes all four isoforms.
Matching control protein/peptide 188-0P
Remarks

WB: Due to its large size, MAP 2 requires special gel-electrophoresis and Western blot protocols for visualization by immunoblotting. Excellent results can be obtained with the 4-12% TRIS-glycine gradient gels from anamed or NuPAGE 3-8% TRIS-Acetate gradient gels from invitrogen.

Data sheet 188_004.pdf

References for MAP 2 - 188 004

A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.
Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera FU, Willems E, Piper DR, Scampavia L, Rumbaugh G, Spicer TP
Scientific reports (2019) 91: 9000. 188 004 WB, ICC; tested species: human
MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling.
Nakashima H, Tsujimura K, Irie K, Imamura T, Trujillo CA, Ishizu M, Uesaka M, Pan M, Noguchi H, Okada K, Aoyagi K, et al.
Cell reports (2021) 357: 109124. 188 004 ICC; tested species: human,mouse
Activity-regulated synaptic targeting of lncRNA ADEPTR mediates structural plasticity by localizing Sptn1 and AnkB in dendrites.
Grinman E, Nakahata Y, Avchalumov Y, Espadas I, Swarnkar S, Yasuda R, Puthanveettil SV
Science advances (2021) 716: . 188 004 ICC; tested species: mouse
Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.
Raj N, McEachin ZT, Harousseau W, Zhou Y, Zhang F, Merritt-Garza ME, Taliaferro JM, Kalinowska M, Marro SG, Hales CM, Berry-Kravis E, et al.
Cell reports (2021) 352: 108991. 188 004 ICC; tested species: human
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak G, Rybak-Wolf A, Lisowski P, Pentimalli TM, Jüttner R, Glažar P, Uppal K, Bottani E, Brunetti D, Secker C, Zink A, et al.
Nature communications (2021) 121: 1929. 188 004 ICC; tested species: human
Progressive myoclonus epilepsy KCNC1 variant causes a developmental dendritopathy.
Carpenter JC, Männikkö R, Heffner C, Heneine J, Sampedro-Castañeda M, Lignani G, Schorge S
Epilepsia (2021) : . 188 004 ICC; tested species: mouse
Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD.
Coyne AN, Rothstein JD
Acta neuropathologica communications (2021) 91: 45. 188 004 ICC, IHC-P; tested species: human
Loss of nuclear UBE3A activity is the predominant cause of Angelman syndrome in individuals carrying UBE3A missense mutations.
Bossuyt SNV, Punt AM, de Graaf IJ, van den Burg J, Williams MG, Heussler H, Elgersma Y, Distel B
Human molecular genetics (2021) : . 188 004 ICC; tested species: mouse
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 188 004 ICC; tested species: mouse
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.
Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 188 004 ICC; tested species: rat
Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype.
Frega M, Selten M, Mossink B, Keller JM, Linda K, Moerschen R, Qu J, Koerner P, Jansen S, Oudakker A, Kleefstra T, et al.
Cell reports (2020) 301: 173-186.e6. 188 004 ICC; tested species: rat
Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like Symptoms.
Koch N, Koch D, Krueger S, Tröger J, Sabanov V, Ahmed T, McMillan LE, Wolf D, Montag D, Kessels MM, Balschun D, et al.
Cerebral cortex (New York, N.Y. : 1991) (2020) : . 188 004 ICC; tested species: mouse
Monosomes actively translate synaptic mRNAs in neuronal processes.
Biever A, Glock C, Tushev G, Ciirdaeva E, Dalmay T, Langer JD, Schuman EM
Science (New York, N.Y.) (2020) 3676477: . 188 004 ICC; tested species: rat
Exposure to carbon black nanoparticles increases seizure susceptibility in male mice.
He M, Jiang X, Zou Z, Qin X, Zhang S, Guo Y, Wang X, Tian X, Chen C
Nanotoxicology (2020) : 1-17. 188 004 ICC; tested species: mouse
Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK.
Zieger HL, Kunde SA, Rademacher N, Schmerl B, Shoichet SA
Scientific reports (2020) 101: 5709. 188 004 ICC; tested species: rat
Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening.
Li B, Suutari BS, Sun SD, Luo Z, Wei C, Chenouard N, Mandelberg NJ, Zhang G, Wamsley B, Tian G, Sanchez S, et al.
Cell (2020) : . 188 004 ICC; tested species: rat
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, et al.
Neuron (2020) : . 188 004 ICC; tested species: human
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing.
Medina C, de la Fuente V, Tom Dieck S, Nassim-Assir B, Dalmay T, Bartnik I, Lunardi P, de Oliveira Alvares L, Schuman EM, Letzkus JJ, Romano A, et al.
Neurobiology of learning and memory (2020) : 107275. 188 004 ICC, IHC; tested species: mouse
Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms.
Zampeta IF, Sonzogni M, Niggl E, Lendemeijer B, Smeenk H, de Vrij FMS, Kushner SA, Distel B, Elgersma Y
Human molecular genetics (2020) : . 188 004 ICC; tested species: mouse
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.
Khan TA, Revah O, Gordon A, Yoon SJ, Krawisz AK, Goold C, Sun Y, Kim CH, Tian Y, Li MY, Schaepe JM, et al.
Nature medicine (2020) : . 188 004 ICC; tested species: human
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 188 004 ICC; tested species: rat
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium.
Jacob F, Pather SR, Huang WK, Zhang F, Wong SZH, Zhou H, Cubitt B, Fan W, Chen CZ, Xu M, Pradhan M, et al.
Cell stem cell (2020) 276: 937-950.e9. 188 004 ICC; tested species: human
Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses.
Deshpande D, Higelin J, Schoen M, Vomhof T, Boeckers TM, Demestre M, Michaelis J
Frontiers in cellular neuroscience (2019) 13: 256. 188 004 ICC; tested species: rat
Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome.
Ivankovic D, Drew J, Lesept F, White IJ, López Doménech G, Tooze SA, Kittler JT
Autophagy (2019) : 1-17. 188 004 ICC; tested species: mouse
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.
Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera FU, Willems E, Piper DR, Scampavia L, Rumbaugh G, Spicer TP
Scientific reports (2019) 91: 9000. 188 004 WB, ICC; tested species: human
NMDA Receptors Regulate Neuregulin 2 Binding to ER-PM Junctions and Ectodomain Release.
Vullhorst D, Buonanno A
Molecular neurobiology (2019) : . 188 004 ICC; tested species: rat
Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome.
Avagliano Trezza R, Sonzogni M, Bossuyt SNV, Zampeta FI, Punt AM, van den Berg M, Rotaru DC, Koene LMC, Munshi ST, Stedehouder J, Kros JM, et al.
Nature neuroscience (2019) 228: 1235-1247. 188 004 ICC, IHC; tested species: human,mouse
A genetically encodable cell-type-specific protein synthesis inhibitor.
Heumüller M, Glock C, Rangaraju V, Biever A, Schuman EM
Nature methods (2019) : . 188 004 ICC; tested species: rat
How mRNA Localization and Protein Synthesis Sites Influence Dendritic Protein Distribution and Dynamics.
Fonkeu Y, Kraynyukova N, Hafner AS, Kochen L, Sartori F, Schuman EM, Tchumatchenko T
Neuron (2019) : . 188 004 ICC; tested species: rat
Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-point accumulation for imaging in nanoscale topography.
Böger C, Hafner AS, Schlichthärle T, Strauss MT, Malkusch S, Endesfelder U, Jungmann R, Schuman EM, Heilemann M
Neurophotonics (2019) 63: 035008. 188 004 ICC; tested species: rat
Generation of a knock-in MAP2-tdTomato reporter human embryonic stem cell line with inducible expression of NEUROG2/1 (NYGCe001-A).
Lu C, Sanjana NE
Stem cell research (2019) 41: 101643. 188 004 ICC; tested species: human
Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.
Frega M, Linda K, Keller JM, Gümüş-Akay G, Mossink B, van Rhijn JR, Negwer M, Klein Gunnewiek T, Foreman K, Kompier N, Schoenmaker C, et al.
Nature communications (2019) 101: 4928. 188 004 ICC; tested species: human
Loss of Neurofascin-186 Disrupts Alignment of AnkyrinG Relative to Its Binding Partners in the Axon Initial Segment.
Alpizar SA, Baker AL, Gulledge AT, Hoppa MB
Frontiers in cellular neuroscience (2019) 13: 1. 188 004 ICC; tested species: rat
The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons.
Tonazzini I, Van Woerden GM, Masciullo C, Mientjes EJ, Elgersma Y, Cecchini M
Molecular autism (2019) 10: 41. 188 004 ICC; tested species: mouse
STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, et al.
Brain, behavior, and immunity (2019) 81: 228-246. 188 004 ICC, IHC; tested species: mouse
Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
Livingstone RW, Elder MK, Barrett MC, Westlake CM, Peppercorn K, Tate WP, Abraham WC, Williams JM
Frontiers in molecular neuroscience (2019) 12: 198. 188 004 ICC; tested species: rat
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, et al.
Acta neuropathologica (2019) : . 188 004 ICC, IHC; tested species: human,mouse
Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha.
Mockett BG, Guévremont D, Elder MK, Parfitt KD, Peppercorn K, Morrissey J, Singh A, Hintz TJ, Kochen L, Tom Dieck S, Schuman E, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3917: 3188-3203. 188 004 ICC; tested species: rat
Intramolecular domain dynamics regulate synaptic MAGUK protein interactions.
Rademacher N, Kuropka B, Kunde SA, Wahl MC, Freund C, Shoichet SA
eLife (2019) 8: . 188 004 ICC; tested species: cos cells
Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression.
Heisler FF, Pechmann Y, Wieser I, Altmeppen HC, Veenendaal L, Muhia M, Schweizer M, Glatzel M, Krasemann S, Kneussel M
Neuron (2018) : . 188 004 ICC; tested species: mouse
Local and global influences on protein turnover in neurons and glia.
Dörrbaum AR, Kochen L, Langer JD, Schuman EM
eLife (2018) 7: . 188 004 ICC; tested species: rat
Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain.
Murao N, Matsubara S, Matsuda T, Noguchi H, Mutoh T, Mutoh M, Koseki H, Namihira M, Nakashima K
Neuroscience research (2018) : . 188 004 ICC; tested species: mouse
Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression.
Nakashima H, Tsujimura K, Irie K, Ishizu M, Pan M, Kameda T, Nakashima K
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3820: 4791-4810. 188 004 ICC; tested species: mouse
A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability.
Chia PH, Zhong FL, Niwa S, Bonnard C, Utami KH, Zeng R, Lee H, Eskin A, Nelson SF, Xie WH, Al-Tawalbeh S, et al.
eLife (2018) 7: . 188 004 ICC; tested species: human
Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity.
Rangaraju V, Lauterbach M, Schuman EM
Cell (2018) : . 188 004 ICC; tested species: rat
Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration.
Bieri G, Lucin KM, O'Brien CE, Zhang H, Villeda SA, Wyss-Coray T
Molecular neurodegeneration (2018) 131: 68. 188 004 ICC; tested species: mouse
Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms.
Swarnkar S, Avchalumov Y, Raveendra BL, Grinman E, Puthanveettil SV
Scientific reports (2018) 81: 17419. 188 004 ICC; tested species: mouse
Biofunctionalized 3D nanopillar arrays fostering cell-guidance and promoting synapse stability and neuronal activity in networks.
Amin H, Dipalo M, De Angelis F, Berdondini L
ACS applied materials & interfaces (2018) : . 188 004 ICC; tested species: rat
Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments.
Tushev G, Glock C, Heumüller M, Biever A, Jovanovic M, Schuman EM
Neuron (2018) 983: 495-511.e6. 188 004 ICC, IHC; tested species: mouse
A new photocaged puromycin for an efficient labelling of newly translated proteins in living neurons.
Schwalbe H, Elamri I, Heumüller M, Herzig LM, Stirnal E, Wachtveitl J, Schuman E
Chembiochem : a European journal of chemical biology (2018) : . 188 004 ICC; tested species: rat
The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function.
Onori MP, Koopal B, Everman DB, Worthington JD, Jones JR, Ploeg MA, Mientjes E, van Bon BW, Kleefstra T, Schulman H, Kushner SA, et al.
Human mutation (2018) : . 188 004 ICC; tested species: mouse
Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.
Zhang K, Daigle JG, Cunningham KM, Coyne AN, Ruan K, Grima JC, Bowen KE, Wadhwa H, Yang P, Rigo F, Taylor JP, et al.
Cell (2018) : . 188 004 ICC; tested species: human
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.
Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ
Journal of neuroinflammation (2018) 151: 7. 188 004 ICC, FACS; tested species: rat
Heterogeneity of the Axon Initial Segment in Interneurons and Pyramidal Cells of Rodent Visual Cortex.
Höfflin F, Jack A, Riedel C, Mack-Bucher J, Roos J, Corcelli C, Schultz C, Wahle P, Engelhardt M
Frontiers in cellular neuroscience (2017) 11: 332. 188 004 ICC; tested species: mouse
A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy.
Kankowski S, Förstera B, Winkelmann A, Knauff P, Wanker EE, You XA, Semtner M, Hetsch F, Meier JC
Frontiers in molecular neuroscience (2017) 10: 439. 188 004 ICC; tested species: rat
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo A, van den Bruck D, Ciolli Mattioli C, Franke V, Imami K, McShane E, Moreno-Estelles M, Calviello L, Filipchyk A, Peguero-Sanchez E, Müller T, et al.
Nature communications (2017) 81: 583. 188 004 ICC; tested species: mouse
The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.
Riemann D, Wallrafen R, Dresbach T
Scientific reports (2017) 71: 15791. 188 004 ICC; tested species: rat
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, Tarallo V, Puchkov D, Kochlamazashvili G, Brachs S, Varela L, et al.
Nature neuroscience (2017) 208: 1096-1103. 188 004 ICC; tested species: mouse
Mutant Huntingtin Disrupts the Nuclear Pore Complex.
Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, et al.
Neuron (2017) 941: 93-107.e6. 188 004 ICC; tested species: human,mouse
Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics.
Amin H, Marinaro F, De Pietri Tonelli D, Berdondini L
Scientific reports (2017) 71: 15752. 188 004 ICC; tested species: mouse
High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies.
Amin H, Nieus T, Lonardoni D, Maccione A, Berdondini L
Scientific reports (2017) 71: 2460. 188 004 ICC; tested species: rat
MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons.
Gumy LF, Katrukha EA, Grigoriev I, Jaarsma D, Kapitein LC, Akhmanova A, Hoogenraad CC
Neuron (2017) 942: 347-362.e7. 188 004 ICC
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, et al.
PLoS genetics (2017) 133: e1006684. 188 004 ICC
Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term Cultures.
Lam RS, Töpfer FM, Wood PG, Busskamp V, Bamberg E
PloS one (2017) 121: e0169506. 188 004 ICC
Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V
Neuron (2017) 934: 854-866.e4. 188 004 ICC; tested species: mouse
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, et al.
Stem cell reports (2017) 96: 1745-1753. 188 004 ICC
Electrical Responses and Spontaneous Activity of Human iPS-Derived Neuronal Networks Characterized for 3-month Culture with 4096-Electrode Arrays.
Amin H, Maccione A, Marinaro F, Zordan S, Nieus T, Berdondini L
Frontiers in neuroscience (2016) 10: 121. 188 004 ICC; tested species: human
mGlu5 Receptors and Relapse to Cocaine-Seeking: The Role of Receptor Trafficking in Postrelapse Extinction Learning Deficits.
Knackstedt LA, Schwendt M
Neural plasticity (2016) 2016: 9312508. 188 004 ICC
Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1.
Brahic M, Bousset L, Bieri G, Melki R, Gitler AD
Acta neuropathologica (2016) 1314: 539-48. 188 004 ICC
Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission.
Katsurabayashi S, Kawano H, Ii M, Nakano S, Tatsumi C, Kubota K, Takasaki K, Mishima K, Fujiwara M, Iwasaki K
Physiological reports (2016) 41: . 188 004 ICC
Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration.
Sun Q, Weinger JG, Mao F, Liu G
Neuropharmacology (2016) 108: 426-39. 188 004 ICC; tested species: rat
Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons.
Harrill JA, Chen H, Streifel KM, Yang D, Mundy WR, Lein PJ
Molecular brain (2015) 8: 10. 188 004 ICC
Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathways.
Erdmann F, Kügler S, Blaesse P, Lange MD, Skryabin BV, Pape HC, Jüngling K
PloS one (2015) 102: e0117319. 188 004 ICC
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.
Bavamian S, Mellios N, Lalonde J, Fass DM, Wang J, Sheridan SD, Madison JM, Zhou F, Rueckert EH, Barker D, Perlis RH, et al.
Molecular psychiatry (2015) 205: 573-84. 188 004 ICC
Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.
Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN
Molecular pharmacology (2015) 874: 595-605. 188 004 ICC
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 188 004 ICC; tested species: rat
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.
Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, et al.
Nature (2015) 5257567: 56-61. 188 004 ICC; tested species: human
Shutdown of achaete-scute homolog-1 expression by heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia.
Kasim M, Benko E, Winkelmann A, Mrowka R, Staudacher JJ, Persson PB, Scholz H, Meier JC, Fähling M
The Journal of biological chemistry (2014) 28939: 26973-88. 188 004 ICC; tested species: rat
Inefficient type I interferon-mediated antiviral protection of primary mouse neurons is associated with the lack of apolipoprotein l9 expression.
Kreit M, Paul S, Knoops L, De Cock A, Sorgeloos F, Michiels T
Journal of virology (2014) 887: 3874-84. 188 004 ICC; tested species: mouse
TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors.
Pribiag H, Stellwagen D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3340: 15879-93. 188 004 ICC; tested species: rat
Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury.
Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM
PloS one (2013) 85: e64423. 188 004 ICC; tested species: mouse
Nongenomic, glucocorticoid receptor-mediated regulation of serotonin transporter cell surface expression in embryonic stem cell derived serotonergic neurons.
Lau T, Heimann F, Bartsch D, Schloss P, Weber T
Neuroscience letters (2013) 554: 115-20. 188 004 ICC; tested species: mouse
Long-term culture of astrocytes attenuates the readily releasable pool of synaptic vesicles.
Kawano H, Katsurabayashi S, Kakazu Y, Yamashita Y, Kubo N, Kubo M, Okuda H, Takasaki K, Kubota K, Mishima K, Fujiwara M, et al.
PloS one (2012) 710: e48034. 188 004 ICC
A novel tau-based rhesus monkey model of Alzheimer's pathogenesis.
Beckman D, Chakrabarty P, Ott S, Dao A, Zhou E, Janssen WG, Donis-Cox K, Muller S, Kordower JH, Morrison JH
Alzheimer's & dementia : the journal of the Alzheimer's Association (2021) : . 188 004 IHC; tested species: monkey
Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking.
Schiweck J, Murk K, Ledderose J, Münster-Wandowski A, Ornaghi M, Vida I, Eickholt BJ
Nature communications (2021) 121: 1490. 188 004 IHC; tested species: mouse
Characterization of starvation-induced autophagy in cerebellar Purkinje cells of pHluorin-mKate2-human LC3B transgenic mice.
Oliva Trejo JA, Tanida I, Suzuki C, Kakuta S, Tada N, Uchiyama Y
Scientific reports (2020) 101: 9643. 188 004 IHC; tested species: mouse
Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.
Zhou X, Chen Q, Huang H, Zhang J, Wang J, Chen Y, Peng Y, Zhang H, Zeng J, Feng Z, Xu Z, et al.
Molecular medicine reports (2020) 226: 5348-5357. 188 004 IHC; tested species: rat
Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model.
Fernández-Pérez EJ, Gallegos S, Armijo-Weingart L, Araya A, Riffo-Lepe NO, Cayuman F, Aguayo LG
Scientific reports (2020) 101: 19606. 188 004 IHC; tested species: mouse
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells.
Miura Y, Li MY, Birey F, Ikeda K, Revah O, Thete MV, Park JY, Puno A, Lee SH, Porteus MH, Pașca SP, et al.
Nature biotechnology (2020) 3812: 1421-1430. 188 004 IHC; tested species: human
Olfactomedin-3 Enhances Seizure Activity by Interacting With AMPA Receptors in Epilepsy Models.
Tang S, Wang T, Zhang X, Guo Y, Xu P, Zeng J, Luo Z, Li D, Zheng Y, Luo Y, Yu C, et al.
Frontiers in cell and developmental biology (2020) 8: 722. 188 004 IHC; tested species: human,mouse
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing.
Medina C, de la Fuente V, Tom Dieck S, Nassim-Assir B, Dalmay T, Bartnik I, Lunardi P, de Oliveira Alvares L, Schuman EM, Letzkus JJ, Romano A, et al.
Neurobiology of learning and memory (2020) : 107275. 188 004 ICC, IHC; tested species: mouse
STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, et al.
Brain, behavior, and immunity (2019) 81: 228-246. 188 004 ICC, IHC; tested species: mouse
Atlastin-1 modulates seizure activity and neuronal excitability.
Lu X, Yang M, Yang Y, Wang XF
CNS neuroscience & therapeutics (2019) : . 188 004 IHC; tested species: human,mouse
TIP60/KAT5 is required for neuronal viability in hippocampal CA1.
Urban I, Kerimoglu C, Sakib MS, Wang H, Benito E, Thaller C, Zhou X, Yan J, Fischer A, Eichele G
Scientific reports (2019) 91: 16173. 188 004 IHC; tested species: mouse
Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus.
Yang Q, Huang Z, Luo Y, Zheng F, Hu Y, Liu H, Zhu S, He M, Xu D, Li Y, Yang M, et al.
EBioMedicine (2019) : . 188 004 IHC; tested species: mouse
Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome.
Avagliano Trezza R, Sonzogni M, Bossuyt SNV, Zampeta FI, Punt AM, van den Berg M, Rotaru DC, Koene LMC, Munshi ST, Stedehouder J, Kros JM, et al.
Nature neuroscience (2019) 228: 1235-1247. 188 004 ICC, IHC; tested species: human,mouse
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, et al.
Acta neuropathologica (2019) : . 188 004 ICC, IHC; tested species: human,mouse
Biochemical autoregulatory gene therapy for focal epilepsy.
Lieb A, Qiu Y, Dixon CL, Heller JP, Walker MC, Schorge S, Kullmann DM
Nature medicine (2018) : . 188 004 IHC; tested species: rat
Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments.
Tushev G, Glock C, Heumüller M, Biever A, Jovanovic M, Schuman EM
Neuron (2018) 983: 495-511.e6. 188 004 ICC, IHC; tested species: mouse
GPR40 modulates epileptic seizure and NMDA receptor function.
Yang Y, Tian X, Xu D, Zheng F, Lu X, Zhang Y, Ma Y, Li Y, Xu X, Zhu B, Wang X, et al.
Science advances (2018) 410: eaau2357. 188 004 IHC; tested species: human,mouse
Differential regulation of chloride homeostasis and GABAergic transmission in the thalamus.
Schmidt T, Ghaffarian N, Philippot C, Seifert G, Steinhäuser C, Pape HC, Blaesse P
Scientific reports (2018) 81: 13929. 188 004 IHC; tested species: mouse
ZDHHC8 critically regulates seizure susceptibility in epilepsy.
Yang Q, Zheng F, Hu Y, Yang Y, Li Y, Chen G, Wang W, He M, Zhou R, Ma Y, Xu D, et al.
Cell death & disease (2018) 98: 795. 188 004 IHC; tested species: human,mouse
A-type K+ currents in intralaminar thalamocortical relay neurons.
Kanyshkova T, Broicher T, Meuth SG, Pape HC, Budde T
Pflugers Archiv : European journal of physiology (2011) 4615: 545-56. 188 004 IHC
Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD.
Coyne AN, Rothstein JD
Acta neuropathologica communications (2021) 91: 45. 188 004 ICC, IHC-P; tested species: human
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease.
Shih YH, Tu LH, Chang TY, Ganesan K, Chang WW, Chang PS, Fang YS, Lin YT, Jin LW, Chen YR
Nature communications (2020) 111: 5950. 188 004 IHC-P; tested species: human
The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, et al.
Acta neuropathologica (2018) : . 188 004 IHC-P; tested species: mouse
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.
Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ
Journal of neuroinflammation (2018) 151: 7. 188 004 ICC, FACS; tested species: rat
Cat. No.: 188 004
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A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.
Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera FU, Willems E, Piper DR, Scampavia L, Rumbaugh G, Spicer TP
Scientific reports (2019) 91: 9000. 188 004 WB, ICC; tested species: human
MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling.
Nakashima H, Tsujimura K, Irie K, Imamura T, Trujillo CA, Ishizu M, Uesaka M, Pan M, Noguchi H, Okada K, Aoyagi K, et al.
Cell reports (2021) 357: 109124. 188 004 ICC; tested species: human,mouse
Activity-regulated synaptic targeting of lncRNA ADEPTR mediates structural plasticity by localizing Sptn1 and AnkB in dendrites.
Grinman E, Nakahata Y, Avchalumov Y, Espadas I, Swarnkar S, Yasuda R, Puthanveettil SV
Science advances (2021) 716: . 188 004 ICC; tested species: mouse
Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.
Raj N, McEachin ZT, Harousseau W, Zhou Y, Zhang F, Merritt-Garza ME, Taliaferro JM, Kalinowska M, Marro SG, Hales CM, Berry-Kravis E, et al.
Cell reports (2021) 352: 108991. 188 004 ICC; tested species: human
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak G, Rybak-Wolf A, Lisowski P, Pentimalli TM, Jüttner R, Glažar P, Uppal K, Bottani E, Brunetti D, Secker C, Zink A, et al.
Nature communications (2021) 121: 1929. 188 004 ICC; tested species: human
Progressive myoclonus epilepsy KCNC1 variant causes a developmental dendritopathy.
Carpenter JC, Männikkö R, Heffner C, Heneine J, Sampedro-Castañeda M, Lignani G, Schorge S
Epilepsia (2021) : . 188 004 ICC; tested species: mouse
Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD.
Coyne AN, Rothstein JD
Acta neuropathologica communications (2021) 91: 45. 188 004 ICC, IHC-P; tested species: human
Loss of nuclear UBE3A activity is the predominant cause of Angelman syndrome in individuals carrying UBE3A missense mutations.
Bossuyt SNV, Punt AM, de Graaf IJ, van den Burg J, Williams MG, Heussler H, Elgersma Y, Distel B
Human molecular genetics (2021) : . 188 004 ICC; tested species: mouse
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 188 004 ICC; tested species: mouse
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.
Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 188 004 ICC; tested species: rat
Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype.
Frega M, Selten M, Mossink B, Keller JM, Linda K, Moerschen R, Qu J, Koerner P, Jansen S, Oudakker A, Kleefstra T, et al.
Cell reports (2020) 301: 173-186.e6. 188 004 ICC; tested species: rat
Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like Symptoms.
Koch N, Koch D, Krueger S, Tröger J, Sabanov V, Ahmed T, McMillan LE, Wolf D, Montag D, Kessels MM, Balschun D, et al.
Cerebral cortex (New York, N.Y. : 1991) (2020) : . 188 004 ICC; tested species: mouse
Monosomes actively translate synaptic mRNAs in neuronal processes.
Biever A, Glock C, Tushev G, Ciirdaeva E, Dalmay T, Langer JD, Schuman EM
Science (New York, N.Y.) (2020) 3676477: . 188 004 ICC; tested species: rat
Exposure to carbon black nanoparticles increases seizure susceptibility in male mice.
He M, Jiang X, Zou Z, Qin X, Zhang S, Guo Y, Wang X, Tian X, Chen C
Nanotoxicology (2020) : 1-17. 188 004 ICC; tested species: mouse
Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK.
Zieger HL, Kunde SA, Rademacher N, Schmerl B, Shoichet SA
Scientific reports (2020) 101: 5709. 188 004 ICC; tested species: rat
Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening.
Li B, Suutari BS, Sun SD, Luo Z, Wei C, Chenouard N, Mandelberg NJ, Zhang G, Wamsley B, Tian G, Sanchez S, et al.
Cell (2020) : . 188 004 ICC; tested species: rat
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, et al.
Neuron (2020) : . 188 004 ICC; tested species: human
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing.
Medina C, de la Fuente V, Tom Dieck S, Nassim-Assir B, Dalmay T, Bartnik I, Lunardi P, de Oliveira Alvares L, Schuman EM, Letzkus JJ, Romano A, et al.
Neurobiology of learning and memory (2020) : 107275. 188 004 ICC, IHC; tested species: mouse
Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms.
Zampeta IF, Sonzogni M, Niggl E, Lendemeijer B, Smeenk H, de Vrij FMS, Kushner SA, Distel B, Elgersma Y
Human molecular genetics (2020) : . 188 004 ICC; tested species: mouse
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.
Khan TA, Revah O, Gordon A, Yoon SJ, Krawisz AK, Goold C, Sun Y, Kim CH, Tian Y, Li MY, Schaepe JM, et al.
Nature medicine (2020) : . 188 004 ICC; tested species: human
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 188 004 ICC; tested species: rat
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium.
Jacob F, Pather SR, Huang WK, Zhang F, Wong SZH, Zhou H, Cubitt B, Fan W, Chen CZ, Xu M, Pradhan M, et al.
Cell stem cell (2020) 276: 937-950.e9. 188 004 ICC; tested species: human
Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses.
Deshpande D, Higelin J, Schoen M, Vomhof T, Boeckers TM, Demestre M, Michaelis J
Frontiers in cellular neuroscience (2019) 13: 256. 188 004 ICC; tested species: rat
Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome.
Ivankovic D, Drew J, Lesept F, White IJ, López Doménech G, Tooze SA, Kittler JT
Autophagy (2019) : 1-17. 188 004 ICC; tested species: mouse
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.
Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera FU, Willems E, Piper DR, Scampavia L, Rumbaugh G, Spicer TP
Scientific reports (2019) 91: 9000. 188 004 WB, ICC; tested species: human
NMDA Receptors Regulate Neuregulin 2 Binding to ER-PM Junctions and Ectodomain Release.
Vullhorst D, Buonanno A
Molecular neurobiology (2019) : . 188 004 ICC; tested species: rat
Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome.
Avagliano Trezza R, Sonzogni M, Bossuyt SNV, Zampeta FI, Punt AM, van den Berg M, Rotaru DC, Koene LMC, Munshi ST, Stedehouder J, Kros JM, et al.
Nature neuroscience (2019) 228: 1235-1247. 188 004 ICC, IHC; tested species: human,mouse
A genetically encodable cell-type-specific protein synthesis inhibitor.
Heumüller M, Glock C, Rangaraju V, Biever A, Schuman EM
Nature methods (2019) : . 188 004 ICC; tested species: rat
How mRNA Localization and Protein Synthesis Sites Influence Dendritic Protein Distribution and Dynamics.
Fonkeu Y, Kraynyukova N, Hafner AS, Kochen L, Sartori F, Schuman EM, Tchumatchenko T
Neuron (2019) : . 188 004 ICC; tested species: rat
Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-point accumulation for imaging in nanoscale topography.
Böger C, Hafner AS, Schlichthärle T, Strauss MT, Malkusch S, Endesfelder U, Jungmann R, Schuman EM, Heilemann M
Neurophotonics (2019) 63: 035008. 188 004 ICC; tested species: rat
Generation of a knock-in MAP2-tdTomato reporter human embryonic stem cell line with inducible expression of NEUROG2/1 (NYGCe001-A).
Lu C, Sanjana NE
Stem cell research (2019) 41: 101643. 188 004 ICC; tested species: human
Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.
Frega M, Linda K, Keller JM, Gümüş-Akay G, Mossink B, van Rhijn JR, Negwer M, Klein Gunnewiek T, Foreman K, Kompier N, Schoenmaker C, et al.
Nature communications (2019) 101: 4928. 188 004 ICC; tested species: human
Loss of Neurofascin-186 Disrupts Alignment of AnkyrinG Relative to Its Binding Partners in the Axon Initial Segment.
Alpizar SA, Baker AL, Gulledge AT, Hoppa MB
Frontiers in cellular neuroscience (2019) 13: 1. 188 004 ICC; tested species: rat
The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons.
Tonazzini I, Van Woerden GM, Masciullo C, Mientjes EJ, Elgersma Y, Cecchini M
Molecular autism (2019) 10: 41. 188 004 ICC; tested species: mouse
STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, et al.
Brain, behavior, and immunity (2019) 81: 228-246. 188 004 ICC, IHC; tested species: mouse
Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
Livingstone RW, Elder MK, Barrett MC, Westlake CM, Peppercorn K, Tate WP, Abraham WC, Williams JM
Frontiers in molecular neuroscience (2019) 12: 198. 188 004 ICC; tested species: rat
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, et al.
Acta neuropathologica (2019) : . 188 004 ICC, IHC; tested species: human,mouse
Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha.
Mockett BG, Guévremont D, Elder MK, Parfitt KD, Peppercorn K, Morrissey J, Singh A, Hintz TJ, Kochen L, Tom Dieck S, Schuman E, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3917: 3188-3203. 188 004 ICC; tested species: rat
Intramolecular domain dynamics regulate synaptic MAGUK protein interactions.
Rademacher N, Kuropka B, Kunde SA, Wahl MC, Freund C, Shoichet SA
eLife (2019) 8: . 188 004 ICC; tested species: cos cells
Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression.
Heisler FF, Pechmann Y, Wieser I, Altmeppen HC, Veenendaal L, Muhia M, Schweizer M, Glatzel M, Krasemann S, Kneussel M
Neuron (2018) : . 188 004 ICC; tested species: mouse
Local and global influences on protein turnover in neurons and glia.
Dörrbaum AR, Kochen L, Langer JD, Schuman EM
eLife (2018) 7: . 188 004 ICC; tested species: rat
Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain.
Murao N, Matsubara S, Matsuda T, Noguchi H, Mutoh T, Mutoh M, Koseki H, Namihira M, Nakashima K
Neuroscience research (2018) : . 188 004 ICC; tested species: mouse
Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression.
Nakashima H, Tsujimura K, Irie K, Ishizu M, Pan M, Kameda T, Nakashima K
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3820: 4791-4810. 188 004 ICC; tested species: mouse
A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability.
Chia PH, Zhong FL, Niwa S, Bonnard C, Utami KH, Zeng R, Lee H, Eskin A, Nelson SF, Xie WH, Al-Tawalbeh S, et al.
eLife (2018) 7: . 188 004 ICC; tested species: human
Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity.
Rangaraju V, Lauterbach M, Schuman EM
Cell (2018) : . 188 004 ICC; tested species: rat
Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration.
Bieri G, Lucin KM, O'Brien CE, Zhang H, Villeda SA, Wyss-Coray T
Molecular neurodegeneration (2018) 131: 68. 188 004 ICC; tested species: mouse
Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms.
Swarnkar S, Avchalumov Y, Raveendra BL, Grinman E, Puthanveettil SV
Scientific reports (2018) 81: 17419. 188 004 ICC; tested species: mouse
Biofunctionalized 3D nanopillar arrays fostering cell-guidance and promoting synapse stability and neuronal activity in networks.
Amin H, Dipalo M, De Angelis F, Berdondini L
ACS applied materials & interfaces (2018) : . 188 004 ICC; tested species: rat
Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments.
Tushev G, Glock C, Heumüller M, Biever A, Jovanovic M, Schuman EM
Neuron (2018) 983: 495-511.e6. 188 004 ICC, IHC; tested species: mouse
A new photocaged puromycin for an efficient labelling of newly translated proteins in living neurons.
Schwalbe H, Elamri I, Heumüller M, Herzig LM, Stirnal E, Wachtveitl J, Schuman E
Chembiochem : a European journal of chemical biology (2018) : . 188 004 ICC; tested species: rat
The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function.
Onori MP, Koopal B, Everman DB, Worthington JD, Jones JR, Ploeg MA, Mientjes E, van Bon BW, Kleefstra T, Schulman H, Kushner SA, et al.
Human mutation (2018) : . 188 004 ICC; tested species: mouse
Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.
Zhang K, Daigle JG, Cunningham KM, Coyne AN, Ruan K, Grima JC, Bowen KE, Wadhwa H, Yang P, Rigo F, Taylor JP, et al.
Cell (2018) : . 188 004 ICC; tested species: human
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.
Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ
Journal of neuroinflammation (2018) 151: 7. 188 004 ICC, FACS; tested species: rat
Heterogeneity of the Axon Initial Segment in Interneurons and Pyramidal Cells of Rodent Visual Cortex.
Höfflin F, Jack A, Riedel C, Mack-Bucher J, Roos J, Corcelli C, Schultz C, Wahle P, Engelhardt M
Frontiers in cellular neuroscience (2017) 11: 332. 188 004 ICC; tested species: mouse
A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy.
Kankowski S, Förstera B, Winkelmann A, Knauff P, Wanker EE, You XA, Semtner M, Hetsch F, Meier JC
Frontiers in molecular neuroscience (2017) 10: 439. 188 004 ICC; tested species: rat
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo A, van den Bruck D, Ciolli Mattioli C, Franke V, Imami K, McShane E, Moreno-Estelles M, Calviello L, Filipchyk A, Peguero-Sanchez E, Müller T, et al.
Nature communications (2017) 81: 583. 188 004 ICC; tested species: mouse
The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.
Riemann D, Wallrafen R, Dresbach T
Scientific reports (2017) 71: 15791. 188 004 ICC; tested species: rat
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, Tarallo V, Puchkov D, Kochlamazashvili G, Brachs S, Varela L, et al.
Nature neuroscience (2017) 208: 1096-1103. 188 004 ICC; tested species: mouse
Mutant Huntingtin Disrupts the Nuclear Pore Complex.
Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, et al.
Neuron (2017) 941: 93-107.e6. 188 004 ICC; tested species: human,mouse
Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics.
Amin H, Marinaro F, De Pietri Tonelli D, Berdondini L
Scientific reports (2017) 71: 15752. 188 004 ICC; tested species: mouse
High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies.
Amin H, Nieus T, Lonardoni D, Maccione A, Berdondini L
Scientific reports (2017) 71: 2460. 188 004 ICC; tested species: rat
MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons.
Gumy LF, Katrukha EA, Grigoriev I, Jaarsma D, Kapitein LC, Akhmanova A, Hoogenraad CC
Neuron (2017) 942: 347-362.e7. 188 004 ICC
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, et al.
PLoS genetics (2017) 133: e1006684. 188 004 ICC
Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term Cultures.
Lam RS, Töpfer FM, Wood PG, Busskamp V, Bamberg E
PloS one (2017) 121: e0169506. 188 004 ICC
Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V
Neuron (2017) 934: 854-866.e4. 188 004 ICC; tested species: mouse
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, et al.
Stem cell reports (2017) 96: 1745-1753. 188 004 ICC
Electrical Responses and Spontaneous Activity of Human iPS-Derived Neuronal Networks Characterized for 3-month Culture with 4096-Electrode Arrays.
Amin H, Maccione A, Marinaro F, Zordan S, Nieus T, Berdondini L
Frontiers in neuroscience (2016) 10: 121. 188 004 ICC; tested species: human
mGlu5 Receptors and Relapse to Cocaine-Seeking: The Role of Receptor Trafficking in Postrelapse Extinction Learning Deficits.
Knackstedt LA, Schwendt M
Neural plasticity (2016) 2016: 9312508. 188 004 ICC
Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1.
Brahic M, Bousset L, Bieri G, Melki R, Gitler AD
Acta neuropathologica (2016) 1314: 539-48. 188 004 ICC
Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission.
Katsurabayashi S, Kawano H, Ii M, Nakano S, Tatsumi C, Kubota K, Takasaki K, Mishima K, Fujiwara M, Iwasaki K
Physiological reports (2016) 41: . 188 004 ICC
Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration.
Sun Q, Weinger JG, Mao F, Liu G
Neuropharmacology (2016) 108: 426-39. 188 004 ICC; tested species: rat
Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons.
Harrill JA, Chen H, Streifel KM, Yang D, Mundy WR, Lein PJ
Molecular brain (2015) 8: 10. 188 004 ICC
Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathways.
Erdmann F, Kügler S, Blaesse P, Lange MD, Skryabin BV, Pape HC, Jüngling K
PloS one (2015) 102: e0117319. 188 004 ICC
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.
Bavamian S, Mellios N, Lalonde J, Fass DM, Wang J, Sheridan SD, Madison JM, Zhou F, Rueckert EH, Barker D, Perlis RH, et al.
Molecular psychiatry (2015) 205: 573-84. 188 004 ICC
Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.
Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN
Molecular pharmacology (2015) 874: 595-605. 188 004 ICC
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 188 004 ICC; tested species: rat
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.
Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, et al.
Nature (2015) 5257567: 56-61. 188 004 ICC; tested species: human
Shutdown of achaete-scute homolog-1 expression by heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia.
Kasim M, Benko E, Winkelmann A, Mrowka R, Staudacher JJ, Persson PB, Scholz H, Meier JC, Fähling M
The Journal of biological chemistry (2014) 28939: 26973-88. 188 004 ICC; tested species: rat
Inefficient type I interferon-mediated antiviral protection of primary mouse neurons is associated with the lack of apolipoprotein l9 expression.
Kreit M, Paul S, Knoops L, De Cock A, Sorgeloos F, Michiels T
Journal of virology (2014) 887: 3874-84. 188 004 ICC; tested species: mouse
TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors.
Pribiag H, Stellwagen D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3340: 15879-93. 188 004 ICC; tested species: rat
Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury.
Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM
PloS one (2013) 85: e64423. 188 004 ICC; tested species: mouse
Nongenomic, glucocorticoid receptor-mediated regulation of serotonin transporter cell surface expression in embryonic stem cell derived serotonergic neurons.
Lau T, Heimann F, Bartsch D, Schloss P, Weber T
Neuroscience letters (2013) 554: 115-20. 188 004 ICC; tested species: mouse
Long-term culture of astrocytes attenuates the readily releasable pool of synaptic vesicles.
Kawano H, Katsurabayashi S, Kakazu Y, Yamashita Y, Kubo N, Kubo M, Okuda H, Takasaki K, Kubota K, Mishima K, Fujiwara M, et al.
PloS one (2012) 710: e48034. 188 004 ICC
A novel tau-based rhesus monkey model of Alzheimer's pathogenesis.
Beckman D, Chakrabarty P, Ott S, Dao A, Zhou E, Janssen WG, Donis-Cox K, Muller S, Kordower JH, Morrison JH
Alzheimer's & dementia : the journal of the Alzheimer's Association (2021) : . 188 004 IHC; tested species: monkey
Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking.
Schiweck J, Murk K, Ledderose J, Münster-Wandowski A, Ornaghi M, Vida I, Eickholt BJ
Nature communications (2021) 121: 1490. 188 004 IHC; tested species: mouse
Characterization of starvation-induced autophagy in cerebellar Purkinje cells of pHluorin-mKate2-human LC3B transgenic mice.
Oliva Trejo JA, Tanida I, Suzuki C, Kakuta S, Tada N, Uchiyama Y
Scientific reports (2020) 101: 9643. 188 004 IHC; tested species: mouse
Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.
Zhou X, Chen Q, Huang H, Zhang J, Wang J, Chen Y, Peng Y, Zhang H, Zeng J, Feng Z, Xu Z, et al.
Molecular medicine reports (2020) 226: 5348-5357. 188 004 IHC; tested species: rat
Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model.
Fernández-Pérez EJ, Gallegos S, Armijo-Weingart L, Araya A, Riffo-Lepe NO, Cayuman F, Aguayo LG
Scientific reports (2020) 101: 19606. 188 004 IHC; tested species: mouse
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells.
Miura Y, Li MY, Birey F, Ikeda K, Revah O, Thete MV, Park JY, Puno A, Lee SH, Porteus MH, Pașca SP, et al.
Nature biotechnology (2020) 3812: 1421-1430. 188 004 IHC; tested species: human
Olfactomedin-3 Enhances Seizure Activity by Interacting With AMPA Receptors in Epilepsy Models.
Tang S, Wang T, Zhang X, Guo Y, Xu P, Zeng J, Luo Z, Li D, Zheng Y, Luo Y, Yu C, et al.
Frontiers in cell and developmental biology (2020) 8: 722. 188 004 IHC; tested species: human,mouse
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing.
Medina C, de la Fuente V, Tom Dieck S, Nassim-Assir B, Dalmay T, Bartnik I, Lunardi P, de Oliveira Alvares L, Schuman EM, Letzkus JJ, Romano A, et al.
Neurobiology of learning and memory (2020) : 107275. 188 004 ICC, IHC; tested species: mouse
STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, et al.
Brain, behavior, and immunity (2019) 81: 228-246. 188 004 ICC, IHC; tested species: mouse
Atlastin-1 modulates seizure activity and neuronal excitability.
Lu X, Yang M, Yang Y, Wang XF
CNS neuroscience & therapeutics (2019) : . 188 004 IHC; tested species: human,mouse
TIP60/KAT5 is required for neuronal viability in hippocampal CA1.
Urban I, Kerimoglu C, Sakib MS, Wang H, Benito E, Thaller C, Zhou X, Yan J, Fischer A, Eichele G
Scientific reports (2019) 91: 16173. 188 004 IHC; tested species: mouse
Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus.
Yang Q, Huang Z, Luo Y, Zheng F, Hu Y, Liu H, Zhu S, He M, Xu D, Li Y, Yang M, et al.
EBioMedicine (2019) : . 188 004 IHC; tested species: mouse
Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome.
Avagliano Trezza R, Sonzogni M, Bossuyt SNV, Zampeta FI, Punt AM, van den Berg M, Rotaru DC, Koene LMC, Munshi ST, Stedehouder J, Kros JM, et al.
Nature neuroscience (2019) 228: 1235-1247. 188 004 ICC, IHC; tested species: human,mouse
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, et al.
Acta neuropathologica (2019) : . 188 004 ICC, IHC; tested species: human,mouse
Biochemical autoregulatory gene therapy for focal epilepsy.
Lieb A, Qiu Y, Dixon CL, Heller JP, Walker MC, Schorge S, Kullmann DM
Nature medicine (2018) : . 188 004 IHC; tested species: rat
Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments.
Tushev G, Glock C, Heumüller M, Biever A, Jovanovic M, Schuman EM
Neuron (2018) 983: 495-511.e6. 188 004 ICC, IHC; tested species: mouse
GPR40 modulates epileptic seizure and NMDA receptor function.
Yang Y, Tian X, Xu D, Zheng F, Lu X, Zhang Y, Ma Y, Li Y, Xu X, Zhu B, Wang X, et al.
Science advances (2018) 410: eaau2357. 188 004 IHC; tested species: human,mouse
Differential regulation of chloride homeostasis and GABAergic transmission in the thalamus.
Schmidt T, Ghaffarian N, Philippot C, Seifert G, Steinhäuser C, Pape HC, Blaesse P
Scientific reports (2018) 81: 13929. 188 004 IHC; tested species: mouse
ZDHHC8 critically regulates seizure susceptibility in epilepsy.
Yang Q, Zheng F, Hu Y, Yang Y, Li Y, Chen G, Wang W, He M, Zhou R, Ma Y, Xu D, et al.
Cell death & disease (2018) 98: 795. 188 004 IHC; tested species: human,mouse
A-type K+ currents in intralaminar thalamocortical relay neurons.
Kanyshkova T, Broicher T, Meuth SG, Pape HC, Budde T
Pflugers Archiv : European journal of physiology (2011) 4615: 545-56. 188 004 IHC
Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD.
Coyne AN, Rothstein JD
Acta neuropathologica communications (2021) 91: 45. 188 004 ICC, IHC-P; tested species: human
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease.
Shih YH, Tu LH, Chang TY, Ganesan K, Chang WW, Chang PS, Fang YS, Lin YT, Jin LW, Chen YR
Nature communications (2020) 111: 5950. 188 004 IHC-P; tested species: human
The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, et al.
Acta neuropathologica (2018) : . 188 004 IHC-P; tested species: mouse
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.
Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ
Journal of neuroinflammation (2018) 151: 7. 188 004 ICC, FACS; tested species: rat
Background

There are two major classes of heat stable microtubule associated proteins (MAPs): MAP 2, and tau. Both protein classes are involved in the regulation of microtubule polymerization in cells.
Four differentially regulated isoforms of MAP 2 have been described so far.