Tailor-made Antibodies
and Tools for Life Science
quick order | cart
?
|
login
Home|||||Technical Support
Home > Products > 188 004

MAP2 antibody - 188 004

MAP2 is a major microtubule associated protein in neurons
Guinea pig polyclonal antiserum
Cat. No.: 188 004
Amount: 100 µl
Price: $400.00
Cat. No. 188 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) (see remarks) gallery  
IP: not tested yet
ICC: 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 200 up to 1 : 500 gallery  

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.
Immunogen Recombinant protein corresponding to residues near the amino terminus of human Map2 (UniProt Id: P11137-4)
Reactivity Reacts with: human (P11137), rat (P15146), mouse (P20357).
Other species not tested yet.
Specificity Specific for MAP 2; recognizes all four isoforms.
Matching control protein/peptide 188-0P
Remarks

WB: Due to its large size, MAP2 requires special gel-electrophoresis and Western blot protocols for visualization by immunoblotting. Excellent results can be obtained with the 4-12% TRIS-glycine gradient gels from anamed or NuPAGE 3-8% TRIS-Acetate gradient gels from invitrogen.
Data sheet 188_004.pdf

References for MAP2 - 188 004

Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons.
Xie J, Wu S, Szadowski H, Min S, Yang Y, Bowman AB, Rochet JC, Freeman JL, Yuan C
The Journal of biological chemistry (2023) : 105023. 188 004 WB, ICC; tested species: human
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.
Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera FU, Willems E, Piper DR, Scampavia L, Rumbaugh G, Spicer TP
Scientific reports (2019) 91: 9000. 188 004 WB, ICC; tested species: human
Functional specificity of liquid-liquid phase separation at the synapse.
Guzikowski NJ, Kavalali ET
Nature communications (2024) 151: 10103. 188 004 ICC; tested species: rat
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.
Hacisuleyman E, Hale CR, Noble N, Luo JD, Fak JJ, Saito M, Chen J, Weissman JS, Darnell RB
Nature neuroscience (2024) : . 188 004 ICC; tested species: mouse
Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development.
Hennegan J, Bryant AH, Griffiths L, Trigano M, Bartley OJM, Bartlett JJ, Minahan C, Abreu de Oliveira WA, Yutuc E, Ntikas S, Bartsocas CS, et al.
iScience (2024) 271: 108670. 188 004 ICC; tested species: human
Synaptic homeostasis transiently leverages Hebbian mechanisms for a multiphasic response to inactivity.
Sun SED, Levenstein D, Li B, Mandelberg N, Chenouard N, Suutari BS, Sanchez S, Tian G, Rinzel J, Buzsáki G, Tsien RW, et al.
Cell reports (2024) 434: 113839. 188 004 ICC; tested species: mouse
EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation.
Ji Y, Izadi-Seitz M, Landmann A, Schwintzer L, Qualmann B, Kessels MM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2024) 446: . 188 004 ICC; tested species: rat
Functional properties of measles virus proteins derived from a subacute sclerosing panencephalitis patient who received repeated remdesivir treatments.
Schmitz KS, Handrejk K, Liepina L, Bauer L, Haas GD, van Puijfelik F, Veldhuis Kroeze EJB, Riekstina M, Strautmanis J, Cao H, Verdijk RM, et al.
Journal of virology (2024) : e0187423. 188 004 ICC; tested species: human
Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons.
Wu S, Xie J, Zhao H, Zhao X, Sánchez OF, Rochet JC, Freeman JL, Yuan C
Environment international (2024) 190: 108914. 188 004 ICC; tested species: human
Human Pluripotent Stem Cell-Derived Astrocyte Functionality Compares Favorably with Primary Rat Astrocytes.
Lendemeijer B, Unkel M, Smeenk H, Mossink B, Hijazi S, Gordillo-Sampedro S, Shpak G, Slump DE, van den Hout MCGN, van IJcken WFJ, Bindels EMJ, et al.
eNeuro (2024) 119: . 188 004 ICC; tested species: human
A Screen of Plant-Based Natural Products Revealed That Quercetin Prevents Pyroglutamylated Amyloid-β (Aβ3(pE)-42) Uptake in Astrocytes As Well As Resulting Astrogliosis and Synaptic Dysfunction.
Arndt H, Bachurski M, Yuanxiang P, Franke K, Wessjohann LA, Kreutz MR, Grochowska KM
Molecular neurobiology (2024) : . 188 004 ICC; tested species: rat
Differential susceptibility of human motor neurons to infection with Usutu and West Nile virus.
Marshall EM, Bauer L, Nelemans T, Sooksawasdi Na Ayudhya S, Benavides F, Lanko K, de Vrij FMS, Kushner SA, Koopmans M, van Riel D, Rockx B, et al.
Journal of neuroinflammation (2024) 211: 236. 188 004 ICC; tested species: human
Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity.
Rosenberg EC, Chamberland S, Bazelot M, Nebet ER, Wang X, McKenzie S, Jain S, Greenhill S, Wilson M, Marley N, Salah A, et al.
Neuron (2023) : . 188 004 ICC; tested species: rat
An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses.
Sun C, Desch K, Nassim-Assir B, Giandomenico SL, Nemcova P, Langer JD, Schuman EM
Science (New York, N.Y.) (2023) 3806647: eadf2018. 188 004 ICC; tested species: rat
The Rab5 effector FERRY links early endosomes with mRNA localization.
Schuhmacher JS, Tom Dieck S, Christoforidis S, Landerer C, Davila Gallesio J, Hersemann L, Seifert S, Schäfer R, Giner A, Toth-Petroczy A, Kalaidzidis Y, et al.
Molecular cell (2023) 8311: 1839-1855.e13. 188 004 ICC; tested species: rat
Profiling of purified autophagic vesicle degradome in the maturing and aging brain.
Kallergi E, Siva Sankar D, Matera A, Kolaxi A, Paolicelli RC, Dengjel J, Nikoletopoulou V
Neuron (2023) : . 188 004 ICC; tested species: mouse
Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons.
Xie J, Wu S, Szadowski H, Min S, Yang Y, Bowman AB, Rochet JC, Freeman JL, Yuan C
The Journal of biological chemistry (2023) : 105023. 188 004 WB, ICC; tested species: human
Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses.
Andres-Alonso M, Borgmeyer M, Mirzapourdelavar H, Lormann J, Klein K, Schweizer M, Hoffmeister-Ullerich S, Oelschlegel AM, Dityatev A, Kreutz MR
Cell reports (2023) 427: 112692. 188 004 ICC; tested species: mouse
Sialic acid biosynthesis pathway blockade disturbs neuronal network formation in human iPSC-derived excitatory neurons.
Mijdam R, Bijnagte-Schoenmaker C, Dyke E, Moons SJ, Boltje TJ, Nadif Kasri N, Lefeber DJ
Journal of neurochemistry (2023) : . 188 004 ICC; tested species: human
Super-resolution imaging of synaptic scaffold proteins in rat hippocampal neurons.
Guzikowski NJ, Kavalali ET
STAR protocols (2023) 41: 102080. 188 004 ICC; tested species: rat
Synaptojanin1 modifies endolysosomal parameters in cultured ventral midbrain neurons.
Zhu X, Prakash SS, McAuliffe G, Pan PY
eNeuro (2023) : . 188 004 ICC; tested species: mouse
Neuroproteomic Analysis after SARS-CoV-2 Infection Reveals Overrepresented Neurodegeneration Pathways and Disrupted Metabolic Pathways.
Basak I, Harfoot R, Palmer JE, Kumar A, Quiñones-Mateu ME, Schweitzer L, Hughes SM
Biomolecules (2023) 1311: . 188 004 ICC; tested species: human
Tonic activin signaling shapes cellular and synaptic properties of CA1 neurons mainly in dorsal hippocampus.
Dahlmanns M, Valero-Aracama MJ, Dahlmanns JK, Zheng F, Alzheimer C
iScience (2023) 2610: 108001. 188 004 ICC; tested species: mouse
ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks.
Teunissen MWA, Lewerissa E, van Hugte EJH, Wang S, Ockeloen CW, Koolen DA, Pfundt R, Marcelis CLM, Brilstra E, Howe JL, Scherer SW, et al.
Human molecular genetics (2023) 3214: 2373-2385. 188 004 ICC; tested species: human
Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal.
Grochowska KM, Sperveslage M, Raman R, Failla AV, Głów D, Schulze C, Laprell L, Fehse B, Kreutz MR
Cell reports (2023) 428: 112998. 188 004 ICC; tested species: rat
Oxidized linoleic acid metabolites regulate neuronal morphogenesis in vitro.
da Costa Souza F, Grodzki ACG, Morgan RK, Zhang Z, Taha AY, Lein PJ
Neurochemistry international (2023) 164: 105506. 188 004 ICC; tested species: rat
Combinatorial selective ER-phagy remodels the ER during neurogenesis.
Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F, Schulman BA, et al.
bioRxiv : the preprint server for biology (2023) : . 188 004 ICC; tested species: human
Essential transcription factors for induced neuron differentiation.
Lu C, Garipler G, Dai C, Roush T, Salome-Correa J, Martin A, Liscovitch-Brauer N, Mazzoni EO, Sanjana NE
Nature communications (2023) 141: 8362. 188 004 ICC; tested species: human
Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles.
Longfield SF, Mollazade M, Wallis TP, Gormal RS, Joensuu M, Wark JR, van Waardenberg AJ, Small C, Graham ME, Meunier FA, Martínez-Mármol R, et al.
Nature communications (2023) 141: 7277. 188 004 ICC; tested species: mouse
An in silico and in vitro human neuronal network model reveals cellular mechanisms beyond NaV1.1 underlying Dravet syndrome.
Doorn N, van Hugte EJH, Ciptasari U, Mordelt A, Meijer HGE, Schubert D, Frega M, Nadif Kasri N, van Putten MJAM
Stem cell reports (2023) 188: 1686-1700. 188 004 ICC; tested species: human
Muscleblind-like proteins use modular domains to localize RNAs by riding kinesins and docking to membranes.
Hildebrandt RP, Moss KR, Janusz-Kaminska A, Knudson LA, Denes LT, Saxena T, Boggupalli DP, Li Z, Lin K, Bassell GJ, Wang ET, et al.
Nature communications (2023) 141: 3427. 188 004 ICC; tested species: mouse
SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity.
Martínez-Mármol R, Giordano-Santini R, Kaulich E, Cho AN, Przybyla M, Riyadh MA, Robinson E, Chew KY, Amor R, Meunier FA, Balistreri G, et al.
Science advances (2023) 923: eadg2248. 188 004 ICC; tested species: mouse
Nano-organization of spontaneous GABAergic transmission directs its autonomous function in neuronal signaling.
Guzikowski NJ, Kavalali ET
Cell reports (2022) 406: 111172. 188 004 ICC; tested species: rat
miR-124-dependent tagging of synapses by synaptopodin enables input-specific homeostatic plasticity.
Dubes S, Soula A, Benquet S, Tessier B, Poujol C, Favereaux A, Thoumine O, Letellier M
The EMBO journal (2022) : e109012. 188 004 ICC; tested species: rat
Bidirectional regulation of synaptic SUMOylation by Group 1 metabotropic glutamate receptors.
Pronot M, Poupon G, Pizzamiglio L, Prieto M, Chato-Astrain I, Lacagne I, Schorova L, Folci A, Brau F, Martin S
Cellular and molecular life sciences : CMLS (2022) 797: 378. 188 004 ICC; tested species: rat
Pre-differentiation exposure of PFOA induced persistent changes in DNA methylation and mitochondrial morphology in human dopaminergic-like neurons.
Zhao H, Xie J, Wu S, Sánchez OF, Zhang X, Freeman JL, Yuan C
Environmental pollution (Barking, Essex : 1987) (2022) 308: 119684. 188 004 ICC; tested species: human
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.
Gleixner AM, Verdone BM, Otte CG, Anderson EN, Ramesh N, Shapiro OR, Gale JR, Mauna JC, Mann JR, Copley KE, Daley EL, et al.
Nature communications (2022) 131: 3380. 188 004 ICC; tested species: human
Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.
Azarnia Tehran D, Kochlamazashvili G, Pampaloni NP, Sposini S, Shergill JK, Lehmann M, Pashkova N, Schmidt C, Löwe D, Napieczynska H, Heuser A, et al.
Science advances (2022) 821: eabl5032. 188 004 ICC; tested species: mouse
Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission.
Liu GT, Kochlamazashvili G, Puchkov D, Müller R, Schultz C, Mackintosh AI, Vollweiter D, Haucke V, Soykan T
The EMBO journal (2022) : e109352. 188 004 ICC; tested species: rat
The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth.
Schrötter S, Yuskaitis CJ, MacArthur MR, Mitchell SJ, Hosios AM, Osipovich M, Torrence ME, Mitchell JR, Hoxhaj G, Sahin M, Manning BD, et al.
Cell reports (2022) 397: 110824. 188 004 ICC; tested species: mouse
MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy.
Li MR, Lei CT, Tang H, Yin XJ, Hao Z, Qiu Y, Xie YR, Zeng JY, Su H, Zhang C
International journal of biological sciences (2022) 185: 1896-1911. 188 004 ICC; tested species: rat
Engineering brain assembloids to interrogate human neural circuits.
Miura Y, Li MY, Revah O, Yoon SJ, Narazaki G, Pașca SP
Nature protocols (2022) 171: 15-35. 188 004 ICC; tested species: human
The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses.
Schmerl B, Gimber N, Kuropka B, Stumpf A, Rentsch J, Kunde SA, von Sivers J, Ewers H, Schmitz D, Freund C, Schmoranzer J, et al.
PLoS biology (2022) 203: e3001503. 188 004 ICC; tested species: rat
Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice.
Kallergi E, Daskalaki AD, Kolaxi A, Camus C, Ioannou E, Mercaldo V, Haberkant P, Stein F, Sidiropoulou K, Dalezios Y, Savitski MM, et al.
Nature communications (2022) 131: 680. 188 004 ICC; tested species: mouse
Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.
López-Hernández T, Takenaka KI, Mori Y, Kongpracha P, Nagamori S, Haucke V, Takamori S
eLife (2022) 11: . 188 004 ICC; tested species: mouse
Targeted proteoform mapping uncovers specific Neurexin-3 variants required for dendritic inhibition.
Hauser D, Behr K, Konno K, Schreiner D, Schmidt A, Watanabe M, Bischofberger J, Scheiffele P
Neuron (2022) 11013: 2094-2109.e10. 188 004 ICC; tested species: mouse
High-content analysis of neuronal morphology in human iPSC-derived neurons.
Lickfett S, Menacho C, Zink A, Telugu NS, Beller M, Diecke S, Cambridge S, Prigione A
STAR protocols (2022) 33: 101567. 188 004 ICC; tested species: human
Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes in vivo.
Ghazale H, Park E, Vasan L, Mester J, Saleh F, Trevisiol A, Zinyk D, Chinchalongporn V, Liu M, Fleming T, Prokopchuk O, et al.
Frontiers in neuroscience (2022) 16: 917071. 188 004 ICC; tested species: mouse
Establishment of autaptic culture with human-induced pluripotent stem cell-derived astrocytes.
Uchino K, Tanaka Y, Kawaguchi S, Kubota K, Watanabe T, Katsurabayashi S, Hirose S, Iwasaki K
iScience (2022) 258: 104762. 188 004 ICC; tested species: human
Spinal cord synaptic plasticity by GlyRβ release from receptor fields and syndapin I-dependent uptake.
Tröger J, Seemann E, Heintzmann R, Kessels MM, Qualmann B
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) 4235: 6706-23. 188 004 ICC; tested species: mouse
Synaptic neurofilaments and GluN1-NfL interaction in experimental models of α-synucleinopathies.
Imarisio A, Ferrari E, Pilotto A, Di Luca M, Padovani A, Gardoni F
Neuro-degenerative diseases (2022) : . 188 004 ICC; tested species: mouse
Secreted Amyloid Precursor Protein Alpha, a Neuroprotective Protein in the Brain Has Widespread Effects on the Transcriptome and Proteome of Human Inducible Pluripotent Stem Cell-Derived Glutamatergic Neurons Related to Memory Mechanisms.
Peppercorn K, Kleffmann T, Jones O, Hughes S, Tate W
Frontiers in neuroscience (2022) 16: 858524. 188 004 ICC; tested species: human
In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants.
Bauer L, Rissmann M, Benavides FFW, Leijten L, van Run P, Begeman L, Veldhuis Kroeze EJB, Lendemeijer B, Smeenk H, de Vrij FMS, Kushner SA, et al.
Acta neuropathologica communications (2022) 101: 124. 188 004 ICC; tested species: human
Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis.
Zhang S, Cooper-Knock J, Weimer AK, Shi M, Moll T, Marshall JNG, Harvey C, Nezhad HG, Franklin J, Souza CDS, Ning K, et al.
Neuron (2022) 1106: 992-1008.e11. 188 004 ICC; tested species: human
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.
Gerosa L, Mazzoleni S, Rusconi F, Longaretti A, Lewerissa E, Pelucchi S, Murru L, Giannelli SG, Broccoli V, Marcello E, Kasri NN, et al.
Cell reports (2022) 398: 110857. 188 004 ICC; tested species: rat
Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2.
Rodriguez CM, Bechek SC, Jones GL, Nakayama L, Akiyama T, Kim G, Solow-Cordero DE, Strittmatter SM, Gitler AD
Cell reports (2022) 414: 111505. 188 004 ICC; tested species: mouse
An atlas of endogenous DNA double-strand breaks arising during human neural cell fate determination.
Ballarino R, Bouwman BAM, Agostini F, Harbers L, Diekmann C, Wernersson E, Bienko M, Crosetto N
Scientific data (2022) 91: 400. 188 004 ICC; tested species: human
Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2.
Kim G, Nakayama L, Blum JA, Akiyama T, Boeynaems S, Chakraborty M, Couthouis J, Tassoni-Tsuchida E, Rodriguez CM, Bassik MC, Gitler AD, et al.
Cell reports (2022) 414: 111508. 188 004 ICC; tested species: mouse
Plasticity-Related Gene 5 Is Expressed in a Late Phase of Neurodifferentiation After Neuronal Cell-Fate Determination.
Gross I, Brandt N, Vonk D, Köper F, Wöhlbrand L, Rabus R, Witt M, Heep A, Plösch T, Hipp MS, Bräuer AU, et al.
Frontiers in cellular neuroscience (2022) 16: 797588. 188 004 ICC; tested species: mouse
Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts.
Mazille M, Buczak K, Scheiffele P, Mauger O
The EMBO journal (2022) : e110192. 188 004 ICC; tested species: mouse
Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements.
Ibarra IL, Ratnu VS, Gordillo L, Hwang IY, Mariani L, Weinand K, Hammarén HM, Heck J, Bulyk ML, Savitski MM, Zaugg JB, et al.
Molecular systems biology (2022) 188: e10473. 188 004 ICC; tested species: human,mouse
Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders.
Linda K, Lewerissa EI, Verboven AHA, Gabriele M, Frega M, Klein Gunnewiek TM, Devilee L, Ulferts E, Hommersom M, Oudakker A, Schoenmaker C, et al.
Autophagy (2021) : 1-20. 188 004 ICC; tested species: human
Biallelic variants in TMEM222 cause a new autosomal recessive neurodevelopmental disorder.
Polla DL, Farazi Fard MA, Tabatabaei Z, Habibzadeh P, Levchenko OA, Nikuei P, Makrythanasis P, Hussain M, von Hardenberg S, Zeinali S, Fallah MS, et al.
Genetics in medicine : official journal of the American College of Medical Genetics (2021) 237: 1246-1254. 188 004 ICC; tested species: human
Primate cell fusion disentangles gene regulatory divergence in neurodevelopment.
Agoglia RM, Sun D, Birey F, Yoon SJ, Miura Y, Sabatini K, Pașca SP, Fraser HB
Nature (2021) 5927854: 421-427. 188 004 ICC; tested species: human
SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis.
Castelli LM, Cutillo L, Souza CDS, Sanchez-Martinez A, Granata I, Lin YH, Myszczynska MA, Heath PR, Livesey MR, Ning K, Azzouz M, et al.
Molecular neurodegeneration (2021) 161: 53. 188 004 ICC; tested species: human
Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome.
Parrini M, Naskar S, Alberti M, Colombi I, Morelli G, Rocchi A, Nanni M, Piccardi F, Charles S, Ronzitti G, Mingozzi F, et al.
Molecular therapy : the journal of the American Society of Gene Therapy (2021) : . 188 004 ICC; tested species: mouse
The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity.
Sun C, Nold A, Fusco CM, Rangaraju V, Tchumatchenko T, Heilemann M, Schuman EM
Science advances (2021) 738: eabj0790. 188 004 ICC; tested species: rat
Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca2+-Permeable AMPA Receptors.
Livingstone RW, Elder MK, Singh A, Westlake CM, Tate WP, Abraham WC, Williams JM
Frontiers in molecular neuroscience (2021) 14: 660208. 188 004 ICC; tested species: rat
Synaptic disruption and CREB-regulated transcription are restored by K+ channel blockers in ALS.
Catanese A, Rajkumar S, Sommer D, Freisem D, Wirth A, Aly A, Massa-López D, Olivieri A, Torelli F, Ioannidis V, Lipecka J, et al.
EMBO molecular medicine (2021) 137: e13131. 188 004 ICC; tested species: human,rat
ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function.
Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, Sakai J, et al.
iScience (2021) 247: 102758. 188 004 ICC; tested species: mouse
An altered secretome is an early marker of the pathogenesis of CLN6 Batten disease.
Best HL, Clare AJ, McDonald KO, Wicky HE, Hughes SM
Journal of neurochemistry (2021) 1573: 764-780. 188 004 ICC; tested species: mouse
Inhibitory synaptic transmission is impaired at higher extracellular Ca2+ concentrations in Scn1a+/- mouse model of Dravet syndrome.
Uchino K, Kawano H, Tanaka Y, Adaniya Y, Asahara A, Deshimaru M, Kubota K, Watanabe T, Katsurabayashi S, Iwasaki K, Hirose S, et al.
Scientific reports (2021) 111: 10634. 188 004 ICC; tested species: mouse
The novel mitochondria activator, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), promotes the development of hippocampal neuronal morphology.
Katsurabayashi S, Oyabu K, Kubota K, Watanabe T, Nagamatsu T, Akaike N, Iwasaki K
Biochemical and biophysical research communications (2021) 560: 146-151. 188 004 ICC; tested species: mouse
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5. 188 004 ICC; tested species: rat
Isolation and culturing of primary mouse astrocytes for the analysis of focal adhesion dynamics.
Güler BE, Krzysko J, Wolfrum U
STAR protocols (2021) 24: 100954. 188 004 ICC; tested species: mouse
Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans.
Courtland JL, Bradshaw TW, Waitt G, Soderblom EJ, Ho T, Rajab A, Vancini R, Kim IH, Soderling SH
eLife (2021) 10: . 188 004 ICC; tested species: mouse
Subcellular sequencing of single neurons reveals the dendritic transcriptome of GABAergic interneurons.
Perez JD, Dieck ST, Alvarez-Castelao B, Tushev G, Chan IC, Schuman EM
eLife (2021) 10: . 188 004 ICC; tested species: mouse
Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural Models.
Bauer L, Lendemeijer B, Leijten L, Embregts CWE, Rockx B, Kushner SA, de Vrij FMS, van Riel D
mSphere (2021) 63: e0027021. 188 004 ICC; tested species: human
Activity-regulated synaptic targeting of lncRNA ADEPTR mediates structural plasticity by localizing Sptn1 and AnkB in dendrites.
Grinman E, Nakahata Y, Avchalumov Y, Espadas I, Swarnkar S, Yasuda R, Puthanveettil SV
Science advances (2021) 716: . 188 004 ICC; tested species: mouse
MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling.
Nakashima H, Tsujimura K, Irie K, Imamura T, Trujillo CA, Ishizu M, Uesaka M, Pan M, Noguchi H, Okada K, Aoyagi K, et al.
Cell reports (2021) 357: 109124. 188 004 ICC; tested species: human,mouse
Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.
Raj N, McEachin ZT, Harousseau W, Zhou Y, Zhang F, Merritt-Garza ME, Taliaferro JM, Kalinowska M, Marro SG, Hales CM, Berry-Kravis E, et al.
Cell reports (2021) 352: 108991. 188 004 ICC; tested species: human
Progressive myoclonus epilepsy KCNC1 variant causes a developmental dendritopathy.
Carpenter JC, Männikkö R, Heffner C, Heneine J, Sampedro-Castañeda M, Lignani G, Schorge S
Epilepsia (2021) : . 188 004 ICC; tested species: mouse
Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD.
Coyne AN, Rothstein JD
Acta neuropathologica communications (2021) 91: 45. 188 004 ICC, IHC-P; tested species: human
Loss of nuclear UBE3A activity is the predominant cause of Angelman syndrome in individuals carrying UBE3A missense mutations.
Bossuyt SNV, Punt AM, de Graaf IJ, van den Burg J, Williams MG, Heussler H, Elgersma Y, Distel B
Human molecular genetics (2021) : . 188 004 ICC; tested species: mouse
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak G, Rybak-Wolf A, Lisowski P, Pentimalli TM, Jüttner R, Glažar P, Uppal K, Bottani E, Brunetti D, Secker C, Zink A, et al.
Nature communications (2021) 121: 1929. 188 004 ICC; tested species: human
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 188 004 ICC; tested species: mouse
Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype.
Frega M, Selten M, Mossink B, Keller JM, Linda K, Moerschen R, Qu J, Koerner P, Jansen S, Oudakker A, Kleefstra T, et al.
Cell reports (2020) 301: 173-186.e6. 188 004 ICC; tested species: rat
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.
Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 188 004 ICC; tested species: rat
Monosomes actively translate synaptic mRNAs in neuronal processes.
Biever A, Glock C, Tushev G, Ciirdaeva E, Dalmay T, Langer JD, Schuman EM
Science (New York, N.Y.) (2020) 3676477: . 188 004 ICC; tested species: rat
Exposure to carbon black nanoparticles increases seizure susceptibility in male mice.
He M, Jiang X, Zou Z, Qin X, Zhang S, Guo Y, Wang X, Tian X, Chen C
Nanotoxicology (2020) : 1-17. 188 004 ICC; tested species: mouse
Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK.
Zieger HL, Kunde SA, Rademacher N, Schmerl B, Shoichet SA
Scientific reports (2020) 101: 5709. 188 004 ICC; tested species: rat
Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening.
Li B, Suutari BS, Sun SD, Luo Z, Wei C, Chenouard N, Mandelberg NJ, Zhang G, Wamsley B, Tian G, Sanchez S, et al.
Cell (2020) : . 188 004 ICC; tested species: rat
Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms.
Zampeta IF, Sonzogni M, Niggl E, Lendemeijer B, Smeenk H, de Vrij FMS, Kushner SA, Distel B, Elgersma Y
Human molecular genetics (2020) : . 188 004 ICC; tested species: mouse
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, et al.
Neuron (2020) : . 188 004 ICC; tested species: human
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing.
Medina C, de la Fuente V, Tom Dieck S, Nassim-Assir B, Dalmay T, Bartnik I, Lunardi P, de Oliveira Alvares L, Schuman EM, Letzkus JJ, Romano A, et al.
Neurobiology of learning and memory (2020) : 107275. 188 004 ICC, IHC; tested species: mouse
Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like Symptoms.
Koch N, Koch D, Krueger S, Tröger J, Sabanov V, Ahmed T, McMillan LE, Wolf D, Montag D, Kessels MM, Balschun D, et al.
Cerebral cortex (New York, N.Y. : 1991) (2020) : . 188 004 ICC; tested species: mouse
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.
Khan TA, Revah O, Gordon A, Yoon SJ, Krawisz AK, Goold C, Sun Y, Kim CH, Tian Y, Li MY, Schaepe JM, et al.
Nature medicine (2020) : . 188 004 ICC; tested species: human
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 188 004 ICC; tested species: rat
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium.
Jacob F, Pather SR, Huang WK, Zhang F, Wong SZH, Zhou H, Cubitt B, Fan W, Chen CZ, Xu M, Pradhan M, et al.
Cell stem cell (2020) 276: 937-950.e9. 188 004 ICC; tested species: human
A genetically encodable cell-type-specific protein synthesis inhibitor.
Heumüller M, Glock C, Rangaraju V, Biever A, Schuman EM
Nature methods (2019) : . 188 004 ICC; tested species: rat
Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome.
Avagliano Trezza R, Sonzogni M, Bossuyt SNV, Zampeta FI, Punt AM, van den Berg M, Rotaru DC, Koene LMC, Munshi ST, Stedehouder J, Kros JM, et al.
Nature neuroscience (2019) 228: 1235-1247. 188 004 ICC, IHC; tested species: human,mouse
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, et al.
Acta neuropathologica (2019) : . 188 004 ICC, IHC; tested species: human,mouse
Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha.
Mockett BG, Guévremont D, Elder MK, Parfitt KD, Peppercorn K, Morrissey J, Singh A, Hintz TJ, Kochen L, Tom Dieck S, Schuman E, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3917: 3188-3203. 188 004 ICC; tested species: rat
NMDA Receptors Regulate Neuregulin 2 Binding to ER-PM Junctions and Ectodomain Release.
Vullhorst D, Buonanno A
Molecular neurobiology (2019) : . 188 004 ICC; tested species: rat
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.
Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera FU, Willems E, Piper DR, Scampavia L, Rumbaugh G, Spicer TP
Scientific reports (2019) 91: 9000. 188 004 WB, ICC; tested species: human
Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome.
Ivankovic D, Drew J, Lesept F, White IJ, López Doménech G, Tooze SA, Kittler JT
Autophagy (2019) : 1-17. 188 004 ICC; tested species: mouse
Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses.
Deshpande D, Higelin J, Schoen M, Vomhof T, Boeckers TM, Demestre M, Michaelis J
Frontiers in cellular neuroscience (2019) 13: 256. 188 004 ICC; tested species: rat
How mRNA Localization and Protein Synthesis Sites Influence Dendritic Protein Distribution and Dynamics.
Fonkeu Y, Kraynyukova N, Hafner AS, Kochen L, Sartori F, Schuman EM, Tchumatchenko T
Neuron (2019) : . 188 004 ICC; tested species: rat
Intramolecular domain dynamics regulate synaptic MAGUK protein interactions.
Rademacher N, Kuropka B, Kunde SA, Wahl MC, Freund C, Shoichet SA
eLife (2019) 8: . 188 004 ICC; tested species: cos cells
Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.
Frega M, Linda K, Keller JM, Gümüş-Akay G, Mossink B, van Rhijn JR, Negwer M, Klein Gunnewiek T, Foreman K, Kompier N, Schoenmaker C, et al.
Nature communications (2019) 101: 4928. 188 004 ICC; tested species: human
Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-point accumulation for imaging in nanoscale topography.
Böger C, Hafner AS, Schlichthärle T, Strauss MT, Malkusch S, Endesfelder U, Jungmann R, Schuman EM, Heilemann M
Neurophotonics (2019) 63: 035008. 188 004 ICC; tested species: rat
The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons.
Tonazzini I, Van Woerden GM, Masciullo C, Mientjes EJ, Elgersma Y, Cecchini M
Molecular autism (2019) 10: 41. 188 004 ICC; tested species: mouse
Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
Livingstone RW, Elder MK, Barrett MC, Westlake CM, Peppercorn K, Tate WP, Abraham WC, Williams JM
Frontiers in molecular neuroscience (2019) 12: 198. 188 004 ICC; tested species: rat
Loss of Neurofascin-186 Disrupts Alignment of AnkyrinG Relative to Its Binding Partners in the Axon Initial Segment.
Alpizar SA, Baker AL, Gulledge AT, Hoppa MB
Frontiers in cellular neuroscience (2019) 13: 1. 188 004 ICC; tested species: rat
STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, et al.
Brain, behavior, and immunity (2019) 81: 228-246. 188 004 ICC, IHC; tested species: mouse
Generation of a knock-in MAP2-tdTomato reporter human embryonic stem cell line with inducible expression of NEUROG2/1 (NYGCe001-A).
Lu C, Sanjana NE
Stem cell research (2019) 41: 101643. 188 004 ICC; tested species: human
Local and global influences on protein turnover in neurons and glia.
Dörrbaum AR, Kochen L, Langer JD, Schuman EM
eLife (2018) 7: . 188 004 ICC; tested species: rat
Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms.
Swarnkar S, Avchalumov Y, Raveendra BL, Grinman E, Puthanveettil SV
Scientific reports (2018) 81: 17419. 188 004 ICC; tested species: mouse
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.
Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ
Journal of neuroinflammation (2018) 151: 7. 188 004 ICC, FACS; tested species: rat
Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.
Zhang K, Daigle JG, Cunningham KM, Coyne AN, Ruan K, Grima JC, Bowen KE, Wadhwa H, Yang P, Rigo F, Taylor JP, et al.
Cell (2018) : . 188 004 ICC; tested species: human
Biofunctionalized 3D nanopillar arrays fostering cell-guidance and promoting synapse stability and neuronal activity in networks.
Amin H, Dipalo M, De Angelis F, Berdondini L
ACS applied materials & interfaces (2018) : . 188 004 ICC; tested species: rat
Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain.
Murao N, Matsubara S, Matsuda T, Noguchi H, Mutoh T, Mutoh M, Koseki H, Namihira M, Nakashima K
Neuroscience research (2018) : . 188 004 ICC; tested species: mouse
Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression.
Heisler FF, Pechmann Y, Wieser I, Altmeppen HC, Veenendaal L, Muhia M, Schweizer M, Glatzel M, Krasemann S, Kneussel M
Neuron (2018) : . 188 004 ICC; tested species: mouse
The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function.
Onori MP, Koopal B, Everman DB, Worthington JD, Jones JR, Ploeg MA, Mientjes E, van Bon BW, Kleefstra T, Schulman H, Kushner SA, et al.
Human mutation (2018) : . 188 004 ICC; tested species: mouse
A new photocaged puromycin for an efficient labelling of newly translated proteins in living neurons.
Schwalbe H, Elamri I, Heumüller M, Herzig LM, Stirnal E, Wachtveitl J, Schuman E
Chembiochem : a European journal of chemical biology (2018) : . 188 004 ICC; tested species: rat
Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments.
Tushev G, Glock C, Heumüller M, Biever A, Jovanovic M, Schuman EM
Neuron (2018) 983: 495-511.e6. 188 004 ICC, IHC; tested species: mouse
Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration.
Bieri G, Lucin KM, O'Brien CE, Zhang H, Villeda SA, Wyss-Coray T
Molecular neurodegeneration (2018) 131: 68. 188 004 ICC; tested species: mouse
A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability.
Chia PH, Zhong FL, Niwa S, Bonnard C, Utami KH, Zeng R, Lee H, Eskin A, Nelson SF, Xie WH, Al-Tawalbeh S, et al.
eLife (2018) 7: . 188 004 ICC; tested species: human
Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity.
Rangaraju V, Lauterbach M, Schuman EM
Cell (2018) : . 188 004 ICC; tested species: rat
Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression.
Nakashima H, Tsujimura K, Irie K, Ishizu M, Pan M, Kameda T, Nakashima K
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3820: 4791-4810. 188 004 ICC; tested species: mouse
Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term Cultures.
Lam RS, Töpfer FM, Wood PG, Busskamp V, Bamberg E
PloS one (2017) 121: e0169506. 188 004 ICC
Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V
Neuron (2017) 934: 854-866.e4. 188 004 ICC; tested species: mouse
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, et al.
PLoS genetics (2017) 133: e1006684. 188 004 ICC
MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons.
Gumy LF, Katrukha EA, Grigoriev I, Jaarsma D, Kapitein LC, Akhmanova A, Hoogenraad CC
Neuron (2017) 942: 347-362.e7. 188 004 ICC
High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies.
Amin H, Nieus T, Lonardoni D, Maccione A, Berdondini L
Scientific reports (2017) 71: 2460. 188 004 ICC; tested species: rat
The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.
Riemann D, Wallrafen R, Dresbach T
Scientific reports (2017) 71: 15791. 188 004 ICC; tested species: rat
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, Tarallo V, Puchkov D, Kochlamazashvili G, Brachs S, Varela L, et al.
Nature neuroscience (2017) 208: 1096-1103. 188 004 ICC; tested species: mouse
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, et al.
Stem cell reports (2017) 96: 1745-1753. 188 004 ICC
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo A, van den Bruck D, Ciolli Mattioli C, Franke V, Imami K, McShane E, Moreno-Estelles M, Calviello L, Filipchyk A, Peguero-Sanchez E, Müller T, et al.
Nature communications (2017) 81: 583. 188 004 ICC; tested species: mouse
A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy.
Kankowski S, Förstera B, Winkelmann A, Knauff P, Wanker EE, You XA, Semtner M, Hetsch F, Meier JC
Frontiers in molecular neuroscience (2017) 10: 439. 188 004 ICC; tested species: rat
Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics.
Amin H, Marinaro F, De Pietri Tonelli D, Berdondini L
Scientific reports (2017) 71: 15752. 188 004 ICC; tested species: mouse
Heterogeneity of the Axon Initial Segment in Interneurons and Pyramidal Cells of Rodent Visual Cortex.
Höfflin F, Jack A, Riedel C, Mack-Bucher J, Roos J, Corcelli C, Schultz C, Wahle P, Engelhardt M
Frontiers in cellular neuroscience (2017) 11: 332. 188 004 ICC; tested species: mouse
Mutant Huntingtin Disrupts the Nuclear Pore Complex.
Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, et al.
Neuron (2017) 941: 93-107.e6. 188 004 ICC; tested species: human,mouse
Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration.
Sun Q, Weinger JG, Mao F, Liu G
Neuropharmacology (2016) 108: 426-39. 188 004 ICC; tested species: rat
mGlu5 Receptors and Relapse to Cocaine-Seeking: The Role of Receptor Trafficking in Postrelapse Extinction Learning Deficits.
Knackstedt LA, Schwendt M
Neural plasticity (2016) 2016: 9312508. 188 004 ICC
Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission.
Katsurabayashi S, Kawano H, Ii M, Nakano S, Tatsumi C, Kubota K, Takasaki K, Mishima K, Fujiwara M, Iwasaki K
Physiological reports (2016) 41: . 188 004 ICC
Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1.
Brahic M, Bousset L, Bieri G, Melki R, Gitler AD
Acta neuropathologica (2016) 1314: 539-48. 188 004 ICC
Electrical Responses and Spontaneous Activity of Human iPS-Derived Neuronal Networks Characterized for 3-month Culture with 4096-Electrode Arrays.
Amin H, Maccione A, Marinaro F, Zordan S, Nieus T, Berdondini L
Frontiers in neuroscience (2016) 10: 121. 188 004 ICC; tested species: human
Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons.
Harrill JA, Chen H, Streifel KM, Yang D, Mundy WR, Lein PJ
Molecular brain (2015) 8: 10. 188 004 ICC
Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.
Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN
Molecular pharmacology (2015) 874: 595-605. 188 004 ICC
Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathways.
Erdmann F, Kügler S, Blaesse P, Lange MD, Skryabin BV, Pape HC, Jüngling K
PloS one (2015) 102: e0117319. 188 004 ICC
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.
Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, et al.
Nature (2015) 5257567: 56-61. 188 004 ICC; tested species: human
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.
Bavamian S, Mellios N, Lalonde J, Fass DM, Wang J, Sheridan SD, Madison JM, Zhou F, Rueckert EH, Barker D, Perlis RH, et al.
Molecular psychiatry (2015) 205: 573-84. 188 004 ICC
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 188 004 ICC; tested species: rat
Shutdown of achaete-scute homolog-1 expression by heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia.
Kasim M, Benko E, Winkelmann A, Mrowka R, Staudacher JJ, Persson PB, Scholz H, Meier JC, Fähling M
The Journal of biological chemistry (2014) 28939: 26973-88. 188 004 ICC; tested species: rat
Inefficient type I interferon-mediated antiviral protection of primary mouse neurons is associated with the lack of apolipoprotein l9 expression.
Kreit M, Paul S, Knoops L, De Cock A, Sorgeloos F, Michiels T
Journal of virology (2014) 887: 3874-84. 188 004 ICC; tested species: mouse
Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury.
Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM
PloS one (2013) 85: e64423. 188 004 ICC; tested species: mouse
Nongenomic, glucocorticoid receptor-mediated regulation of serotonin transporter cell surface expression in embryonic stem cell derived serotonergic neurons.
Lau T, Heimann F, Bartsch D, Schloss P, Weber T
Neuroscience letters (2013) 554: 115-20. 188 004 ICC; tested species: mouse
TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors.
Pribiag H, Stellwagen D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3340: 15879-93. 188 004 ICC; tested species: rat
Long-term culture of astrocytes attenuates the readily releasable pool of synaptic vesicles.
Kawano H, Katsurabayashi S, Kakazu Y, Yamashita Y, Kubo N, Kubo M, Okuda H, Takasaki K, Kubota K, Mishima K, Fujiwara M, et al.
PloS one (2012) 710: e48034. 188 004 ICC
Neurovirulence of Usutu virus in human fetal organotypic brain slice cultures partially resembles Zika and West Nile virus.
Marshall EM, Rashidi AS, van Gent M, Rockx B, Verjans GMGM
Scientific reports (2024) 141: 20095. 188 004 IHC, IHC-P; tested species: human
Host circuit engagement of human cortical organoids transplanted in rodents.
Kelley KW, Revah O, Gore F, Kaganovsky K, Chen X, Deisseroth K, Pașca SP
Nature protocols (2024) : . 188 004 IHC; tested species: human
Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer's disease.
Beckman D, Diniz GB, Ott S, Hobson B, Chaudhari AJ, Muller S, Chu Y, Takano A, Schwarz AJ, Yeh CL, McQuade P, et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association (2024) : . 188 004 IHC; tested species: monkey
Integrated proteogenomic characterization of glioblastoma evolution.
Kim KH, Migliozzi S, Koo H, Hong JH, Park SM, Kim S, Kwon HJ, Ha S, Garofano L, Oh YT, D'Angelo F, et al.
Cancer cell (2024) 423: 358-377.e8. 188 004 IHC; tested species: mouse
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.
Taylor LW, Simzer EM, Pimblett C, Lacey-Solymar OTT, McGeachan RI, Meftah S, Rose JL, Spires-Jones MP, Holt K, Catterson JH, Koch H, et al.
Acta neuropathologica (2024) 1471: 7. 188 004 IHC; tested species: human
A cost-effective and efficient ex vivo, ex situ human whole brain perfusion protocol for immunohistochemistry.
Hade AC, Philips MA, Promet L, Jagomäe T, Hanumantharaju A, Salumäe L, Reimann E, Plaas M, Vasar E, Väli M
Journal of neuroscience methods (2024) 404: 110059. 188 004 IHC; tested species: human
Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development.
Tagliatti E, Desiato G, Mancinelli S, Bizzotto M, Gagliani MC, Faggiani E, Hernández-Soto R, Cugurra A, Poliseno P, Miotto M, Argüello RJ, et al.
Immunity (2023) : . 188 004 IHC; tested species: mouse
Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function.
Adams JM, Rege SV, Liu AT, Vu NV, Raina S, Kirsher DY, Nguyen AL, Harish R, Szoke B, Leone DP, Czirr E, et al.
Science advances (2023) 946: eadf8764. 188 004 IHC; tested species: mouse
Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity.
Barone I, Gilette NM, Hawks-Mayer H, Handy J, Zhang KJ, Chifamba FF, Mostafa E, Johnson-Venkatesh EM, Sun Y, Gibson JM, Rotenberg A, et al.
Science advances (2023) 943: eadj1010. 188 004 IHC; tested species: mouse
Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations.
Oliveira AR, Martins S, Cammarata G, Martins M, Cardoso AM, Almeida MR, do Carmo Macário M, Santana I, Peça J, Cardoso AL
Biomedicines (2022) 108: . 188 004 IHC; tested species: human
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.
Boutin ME, Strong CE, Van Hese B, Hu X, Itkin Z, Chen YC, LaCroix A, Gordon R, Guicherit O, Carromeu C, Kundu S, et al.
SLAS discovery : advancing life sciences R & D (2022) : . 188 004 IHC; tested species: human
CXCL14 exacerbates seizures by inhibiting GABA metabolism in epileptic mice.
Chen M, He W, Ding X, Wang S, Zhang M, Cao X, Tan J, Jiang G
American journal of translational research (2022) 149: 6222-6233. 188 004 IHC; tested species: mouse
Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros.
Zywitza V, Frahm S, Krüger N, Weise A, Göritz F, Hermes R, Holtze S, Colleoni S, Galli C, Drukker M, Hildebrandt TB, et al.
iScience (2022) 2511: 105414. 188 004 IHC
The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity.
Grzejda D, Mach J, Schweizer JA, Hummel B, Rezansoff AM, Eggenhofer F, Panhale A, Lalioti ME, Cabezas Wallscheid N, Backofen R, Felsenberg J, et al.
Science advances (2022) 839: eabo5578. 188 004 IHC; tested species: mouse
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19.
Beckman D, Bonillas A, Diniz GB, Ott S, Roh JW, Elizaldi SR, Schmidt BA, Sammak RL, Van Rompay KKA, Iyer SS, Morrison JH, et al.
Cell reports (2022) 415: 111573. 188 004 IHC; tested species: monkey
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Li D, Zhang L, Tuo J, Zhang F, Tai Z, Liu X, Qiu X, Zhang H, Yang J, Wang J, Luo Z, et al.
Neurochemical research (2022) : . 188 004 IHC; tested species: rat
Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment.
Borgmeyer M, Coman C, Has C, Schött HF, Li T, Westhoff P, Cheung YFH, Hoffmann N, Yuanxiang P, Behnisch T, Gomes GM, et al.
Cell reports (2021) 371: 109797. 188 004 IHC; tested species: mouse
The translatome of neuronal cell bodies, dendrites, and axons.
Glock C, Biever A, Tushev G, Nassim-Assir B, Kao A, Bartnik I, Tom Dieck S, Schuman EM
Proceedings of the National Academy of Sciences of the United States of America (2021) 11843: . 188 004 IHC; tested species: rat
Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking.
Schiweck J, Murk K, Ledderose J, Münster-Wandowski A, Ornaghi M, Vida I, Eickholt BJ
Nature communications (2021) 121: 1490. 188 004 IHC; tested species: mouse
A novel tau-based rhesus monkey model of Alzheimer's pathogenesis.
Beckman D, Chakrabarty P, Ott S, Dao A, Zhou E, Janssen WG, Donis-Cox K, Muller S, Kordower JH, Morrison JH
Alzheimer's & dementia : the journal of the Alzheimer's Association (2021) : . 188 004 IHC; tested species: monkey
Long-term maturation of human cortical organoids matches key early postnatal transitions.
Gordon A, Yoon SJ, Tran SS, Makinson CD, Park JY, Andersen J, Valencia AM, Horvath S, Xiao X, Huguenard JR, Pașca SP, et al.
Nature neuroscience (2021) 243: 331-342. 188 004 IHC; tested species: human
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, et al.
Science (New York, N.Y.) (2020) 3676477: 528-537. 188 004 IHC; tested species: mouse
Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.
Zhou X, Chen Q, Huang H, Zhang J, Wang J, Chen Y, Peng Y, Zhang H, Zeng J, Feng Z, Xu Z, et al.
Molecular medicine reports (2020) 226: 5348-5357. 188 004 IHC; tested species: rat
Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model.
Fernández-Pérez EJ, Gallegos S, Armijo-Weingart L, Araya A, Riffo-Lepe NO, Cayuman F, Aguayo LG
Scientific reports (2020) 101: 19606. 188 004 IHC; tested species: mouse
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells.
Miura Y, Li MY, Birey F, Ikeda K, Revah O, Thete MV, Park JY, Puno A, Lee SH, Porteus MH, Pașca SP, et al.
Nature biotechnology (2020) 3812: 1421-1430. 188 004 IHC; tested species: human
Olfactomedin-3 Enhances Seizure Activity by Interacting With AMPA Receptors in Epilepsy Models.
Tang S, Wang T, Zhang X, Guo Y, Xu P, Zeng J, Luo Z, Li D, Zheng Y, Luo Y, Yu C, et al.
Frontiers in cell and developmental biology (2020) 8: 722. 188 004 IHC; tested species: human,mouse
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing.
Medina C, de la Fuente V, Tom Dieck S, Nassim-Assir B, Dalmay T, Bartnik I, Lunardi P, de Oliveira Alvares L, Schuman EM, Letzkus JJ, Romano A, et al.
Neurobiology of learning and memory (2020) : 107275. 188 004 ICC, IHC; tested species: mouse
Characterization of starvation-induced autophagy in cerebellar Purkinje cells of pHluorin-mKate2-human LC3B transgenic mice.
Oliva Trejo JA, Tanida I, Suzuki C, Kakuta S, Tada N, Uchiyama Y
Scientific reports (2020) 101: 9643. 188 004 IHC; tested species: mouse
TIP60/KAT5 is required for neuronal viability in hippocampal CA1.
Urban I, Kerimoglu C, Sakib MS, Wang H, Benito E, Thaller C, Zhou X, Yan J, Fischer A, Eichele G
Scientific reports (2019) 91: 16173. 188 004 IHC; tested species: mouse
Atlastin-1 modulates seizure activity and neuronal excitability.
Lu X, Yang M, Yang Y, Wang XF
CNS neuroscience & therapeutics (2019) : . 188 004 IHC; tested species: human,mouse
STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, et al.
Brain, behavior, and immunity (2019) 81: 228-246. 188 004 ICC, IHC; tested species: mouse
Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus.
Yang Q, Huang Z, Luo Y, Zheng F, Hu Y, Liu H, Zhu S, He M, Xu D, Li Y, Yang M, et al.
EBioMedicine (2019) : . 188 004 IHC; tested species: mouse
Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome.
Avagliano Trezza R, Sonzogni M, Bossuyt SNV, Zampeta FI, Punt AM, van den Berg M, Rotaru DC, Koene LMC, Munshi ST, Stedehouder J, Kros JM, et al.
Nature neuroscience (2019) 228: 1235-1247. 188 004 ICC, IHC; tested species: human,mouse
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, et al.
Acta neuropathologica (2019) : . 188 004 ICC, IHC; tested species: human,mouse
Differential regulation of chloride homeostasis and GABAergic transmission in the thalamus.
Schmidt T, Ghaffarian N, Philippot C, Seifert G, Steinhäuser C, Pape HC, Blaesse P
Scientific reports (2018) 81: 13929. 188 004 IHC; tested species: mouse
ZDHHC8 critically regulates seizure susceptibility in epilepsy.
Yang Q, Zheng F, Hu Y, Yang Y, Li Y, Chen G, Wang W, He M, Zhou R, Ma Y, Xu D, et al.
Cell death & disease (2018) 98: 795. 188 004 IHC; tested species: human,mouse
Biochemical autoregulatory gene therapy for focal epilepsy.
Lieb A, Qiu Y, Dixon CL, Heller JP, Walker MC, Schorge S, Kullmann DM
Nature medicine (2018) : . 188 004 IHC; tested species: rat
GPR40 modulates epileptic seizure and NMDA receptor function.
Yang Y, Tian X, Xu D, Zheng F, Lu X, Zhang Y, Ma Y, Li Y, Xu X, Zhu B, Wang X, et al.
Science advances (2018) 410: eaau2357. 188 004 IHC; tested species: human,mouse
Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments.
Tushev G, Glock C, Heumüller M, Biever A, Jovanovic M, Schuman EM
Neuron (2018) 983: 495-511.e6. 188 004 ICC, IHC; tested species: mouse
A-type K+ currents in intralaminar thalamocortical relay neurons.
Kanyshkova T, Broicher T, Meuth SG, Pape HC, Budde T
Pflugers Archiv : European journal of physiology (2011) 4615: 545-56. 188 004 IHC
Herpes simplex virus infection induces necroptosis of neurons and astrocytes in human fetal organotypic brain slice cultures.
Rashidi AS, Tran DN, Peelen CR, van Gent M, Ouwendijk WJD, Verjans GMGM
Journal of neuroinflammation (2024) 211: 38. 188 004 IHC-P; tested species: human
Neurovirulence of Usutu virus in human fetal organotypic brain slice cultures partially resembles Zika and West Nile virus.
Marshall EM, Rashidi AS, van Gent M, Rockx B, Verjans GMGM
Scientific reports (2024) 141: 20095. 188 004 IHC, IHC-P; tested species: human
Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD.
Coyne AN, Rothstein JD
Acta neuropathologica communications (2021) 91: 45. 188 004 ICC, IHC-P; tested species: human
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease.
Shih YH, Tu LH, Chang TY, Ganesan K, Chang WW, Chang PS, Fang YS, Lin YT, Jin LW, Chen YR
Nature communications (2020) 111: 5950. 188 004 IHC-P; tested species: human
The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, et al.
Acta neuropathologica (2018) : . 188 004 IHC-P; tested species: mouse
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.
Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ
Journal of neuroinflammation (2018) 151: 7. 188 004 ICC, FACS; tested species: rat
Cat. No.: 188 004
Amount: 100 µl
Price: $400.00
Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons.
Xie J, Wu S, Szadowski H, Min S, Yang Y, Bowman AB, Rochet JC, Freeman JL, Yuan C
The Journal of biological chemistry (2023) : 105023. 188 004 WB, ICC; tested species: human
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.
Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera FU, Willems E, Piper DR, Scampavia L, Rumbaugh G, Spicer TP
Scientific reports (2019) 91: 9000. 188 004 WB, ICC; tested species: human
Functional specificity of liquid-liquid phase separation at the synapse.
Guzikowski NJ, Kavalali ET
Nature communications (2024) 151: 10103. 188 004 ICC; tested species: rat
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.
Hacisuleyman E, Hale CR, Noble N, Luo JD, Fak JJ, Saito M, Chen J, Weissman JS, Darnell RB
Nature neuroscience (2024) : . 188 004 ICC; tested species: mouse
Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development.
Hennegan J, Bryant AH, Griffiths L, Trigano M, Bartley OJM, Bartlett JJ, Minahan C, Abreu de Oliveira WA, Yutuc E, Ntikas S, Bartsocas CS, et al.
iScience (2024) 271: 108670. 188 004 ICC; tested species: human
Synaptic homeostasis transiently leverages Hebbian mechanisms for a multiphasic response to inactivity.
Sun SED, Levenstein D, Li B, Mandelberg N, Chenouard N, Suutari BS, Sanchez S, Tian G, Rinzel J, Buzsáki G, Tsien RW, et al.
Cell reports (2024) 434: 113839. 188 004 ICC; tested species: mouse
EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation.
Ji Y, Izadi-Seitz M, Landmann A, Schwintzer L, Qualmann B, Kessels MM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2024) 446: . 188 004 ICC; tested species: rat
Functional properties of measles virus proteins derived from a subacute sclerosing panencephalitis patient who received repeated remdesivir treatments.
Schmitz KS, Handrejk K, Liepina L, Bauer L, Haas GD, van Puijfelik F, Veldhuis Kroeze EJB, Riekstina M, Strautmanis J, Cao H, Verdijk RM, et al.
Journal of virology (2024) : e0187423. 188 004 ICC; tested species: human
Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons.
Wu S, Xie J, Zhao H, Zhao X, Sánchez OF, Rochet JC, Freeman JL, Yuan C
Environment international (2024) 190: 108914. 188 004 ICC; tested species: human
Human Pluripotent Stem Cell-Derived Astrocyte Functionality Compares Favorably with Primary Rat Astrocytes.
Lendemeijer B, Unkel M, Smeenk H, Mossink B, Hijazi S, Gordillo-Sampedro S, Shpak G, Slump DE, van den Hout MCGN, van IJcken WFJ, Bindels EMJ, et al.
eNeuro (2024) 119: . 188 004 ICC; tested species: human
A Screen of Plant-Based Natural Products Revealed That Quercetin Prevents Pyroglutamylated Amyloid-β (Aβ3(pE)-42) Uptake in Astrocytes As Well As Resulting Astrogliosis and Synaptic Dysfunction.
Arndt H, Bachurski M, Yuanxiang P, Franke K, Wessjohann LA, Kreutz MR, Grochowska KM
Molecular neurobiology (2024) : . 188 004 ICC; tested species: rat
Differential susceptibility of human motor neurons to infection with Usutu and West Nile virus.
Marshall EM, Bauer L, Nelemans T, Sooksawasdi Na Ayudhya S, Benavides F, Lanko K, de Vrij FMS, Kushner SA, Koopmans M, van Riel D, Rockx B, et al.
Journal of neuroinflammation (2024) 211: 236. 188 004 ICC; tested species: human
Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity.
Rosenberg EC, Chamberland S, Bazelot M, Nebet ER, Wang X, McKenzie S, Jain S, Greenhill S, Wilson M, Marley N, Salah A, et al.
Neuron (2023) : . 188 004 ICC; tested species: rat
An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses.
Sun C, Desch K, Nassim-Assir B, Giandomenico SL, Nemcova P, Langer JD, Schuman EM
Science (New York, N.Y.) (2023) 3806647: eadf2018. 188 004 ICC; tested species: rat
The Rab5 effector FERRY links early endosomes with mRNA localization.
Schuhmacher JS, Tom Dieck S, Christoforidis S, Landerer C, Davila Gallesio J, Hersemann L, Seifert S, Schäfer R, Giner A, Toth-Petroczy A, Kalaidzidis Y, et al.
Molecular cell (2023) 8311: 1839-1855.e13. 188 004 ICC; tested species: rat
Profiling of purified autophagic vesicle degradome in the maturing and aging brain.
Kallergi E, Siva Sankar D, Matera A, Kolaxi A, Paolicelli RC, Dengjel J, Nikoletopoulou V
Neuron (2023) : . 188 004 ICC; tested species: mouse
Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons.
Xie J, Wu S, Szadowski H, Min S, Yang Y, Bowman AB, Rochet JC, Freeman JL, Yuan C
The Journal of biological chemistry (2023) : 105023. 188 004 WB, ICC; tested species: human
Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses.
Andres-Alonso M, Borgmeyer M, Mirzapourdelavar H, Lormann J, Klein K, Schweizer M, Hoffmeister-Ullerich S, Oelschlegel AM, Dityatev A, Kreutz MR
Cell reports (2023) 427: 112692. 188 004 ICC; tested species: mouse
Sialic acid biosynthesis pathway blockade disturbs neuronal network formation in human iPSC-derived excitatory neurons.
Mijdam R, Bijnagte-Schoenmaker C, Dyke E, Moons SJ, Boltje TJ, Nadif Kasri N, Lefeber DJ
Journal of neurochemistry (2023) : . 188 004 ICC; tested species: human
Super-resolution imaging of synaptic scaffold proteins in rat hippocampal neurons.
Guzikowski NJ, Kavalali ET
STAR protocols (2023) 41: 102080. 188 004 ICC; tested species: rat
Synaptojanin1 modifies endolysosomal parameters in cultured ventral midbrain neurons.
Zhu X, Prakash SS, McAuliffe G, Pan PY
eNeuro (2023) : . 188 004 ICC; tested species: mouse
Neuroproteomic Analysis after SARS-CoV-2 Infection Reveals Overrepresented Neurodegeneration Pathways and Disrupted Metabolic Pathways.
Basak I, Harfoot R, Palmer JE, Kumar A, Quiñones-Mateu ME, Schweitzer L, Hughes SM
Biomolecules (2023) 1311: . 188 004 ICC; tested species: human
Tonic activin signaling shapes cellular and synaptic properties of CA1 neurons mainly in dorsal hippocampus.
Dahlmanns M, Valero-Aracama MJ, Dahlmanns JK, Zheng F, Alzheimer C
iScience (2023) 2610: 108001. 188 004 ICC; tested species: mouse
ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks.
Teunissen MWA, Lewerissa E, van Hugte EJH, Wang S, Ockeloen CW, Koolen DA, Pfundt R, Marcelis CLM, Brilstra E, Howe JL, Scherer SW, et al.
Human molecular genetics (2023) 3214: 2373-2385. 188 004 ICC; tested species: human
Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal.
Grochowska KM, Sperveslage M, Raman R, Failla AV, Głów D, Schulze C, Laprell L, Fehse B, Kreutz MR
Cell reports (2023) 428: 112998. 188 004 ICC; tested species: rat
Oxidized linoleic acid metabolites regulate neuronal morphogenesis in vitro.
da Costa Souza F, Grodzki ACG, Morgan RK, Zhang Z, Taha AY, Lein PJ
Neurochemistry international (2023) 164: 105506. 188 004 ICC; tested species: rat
Combinatorial selective ER-phagy remodels the ER during neurogenesis.
Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F, Schulman BA, et al.
bioRxiv : the preprint server for biology (2023) : . 188 004 ICC; tested species: human
Essential transcription factors for induced neuron differentiation.
Lu C, Garipler G, Dai C, Roush T, Salome-Correa J, Martin A, Liscovitch-Brauer N, Mazzoni EO, Sanjana NE
Nature communications (2023) 141: 8362. 188 004 ICC; tested species: human
Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles.
Longfield SF, Mollazade M, Wallis TP, Gormal RS, Joensuu M, Wark JR, van Waardenberg AJ, Small C, Graham ME, Meunier FA, Martínez-Mármol R, et al.
Nature communications (2023) 141: 7277. 188 004 ICC; tested species: mouse
An in silico and in vitro human neuronal network model reveals cellular mechanisms beyond NaV1.1 underlying Dravet syndrome.
Doorn N, van Hugte EJH, Ciptasari U, Mordelt A, Meijer HGE, Schubert D, Frega M, Nadif Kasri N, van Putten MJAM
Stem cell reports (2023) 188: 1686-1700. 188 004 ICC; tested species: human
Muscleblind-like proteins use modular domains to localize RNAs by riding kinesins and docking to membranes.
Hildebrandt RP, Moss KR, Janusz-Kaminska A, Knudson LA, Denes LT, Saxena T, Boggupalli DP, Li Z, Lin K, Bassell GJ, Wang ET, et al.
Nature communications (2023) 141: 3427. 188 004 ICC; tested species: mouse
SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity.
Martínez-Mármol R, Giordano-Santini R, Kaulich E, Cho AN, Przybyla M, Riyadh MA, Robinson E, Chew KY, Amor R, Meunier FA, Balistreri G, et al.
Science advances (2023) 923: eadg2248. 188 004 ICC; tested species: mouse
Nano-organization of spontaneous GABAergic transmission directs its autonomous function in neuronal signaling.
Guzikowski NJ, Kavalali ET
Cell reports (2022) 406: 111172. 188 004 ICC; tested species: rat
miR-124-dependent tagging of synapses by synaptopodin enables input-specific homeostatic plasticity.
Dubes S, Soula A, Benquet S, Tessier B, Poujol C, Favereaux A, Thoumine O, Letellier M
The EMBO journal (2022) : e109012. 188 004 ICC; tested species: rat
Bidirectional regulation of synaptic SUMOylation by Group 1 metabotropic glutamate receptors.
Pronot M, Poupon G, Pizzamiglio L, Prieto M, Chato-Astrain I, Lacagne I, Schorova L, Folci A, Brau F, Martin S
Cellular and molecular life sciences : CMLS (2022) 797: 378. 188 004 ICC; tested species: rat
Pre-differentiation exposure of PFOA induced persistent changes in DNA methylation and mitochondrial morphology in human dopaminergic-like neurons.
Zhao H, Xie J, Wu S, Sánchez OF, Zhang X, Freeman JL, Yuan C
Environmental pollution (Barking, Essex : 1987) (2022) 308: 119684. 188 004 ICC; tested species: human
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.
Gleixner AM, Verdone BM, Otte CG, Anderson EN, Ramesh N, Shapiro OR, Gale JR, Mauna JC, Mann JR, Copley KE, Daley EL, et al.
Nature communications (2022) 131: 3380. 188 004 ICC; tested species: human
Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.
Azarnia Tehran D, Kochlamazashvili G, Pampaloni NP, Sposini S, Shergill JK, Lehmann M, Pashkova N, Schmidt C, Löwe D, Napieczynska H, Heuser A, et al.
Science advances (2022) 821: eabl5032. 188 004 ICC; tested species: mouse
Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission.
Liu GT, Kochlamazashvili G, Puchkov D, Müller R, Schultz C, Mackintosh AI, Vollweiter D, Haucke V, Soykan T
The EMBO journal (2022) : e109352. 188 004 ICC; tested species: rat
The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth.
Schrötter S, Yuskaitis CJ, MacArthur MR, Mitchell SJ, Hosios AM, Osipovich M, Torrence ME, Mitchell JR, Hoxhaj G, Sahin M, Manning BD, et al.
Cell reports (2022) 397: 110824. 188 004 ICC; tested species: mouse
MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy.
Li MR, Lei CT, Tang H, Yin XJ, Hao Z, Qiu Y, Xie YR, Zeng JY, Su H, Zhang C
International journal of biological sciences (2022) 185: 1896-1911. 188 004 ICC; tested species: rat
Engineering brain assembloids to interrogate human neural circuits.
Miura Y, Li MY, Revah O, Yoon SJ, Narazaki G, Pașca SP
Nature protocols (2022) 171: 15-35. 188 004 ICC; tested species: human
The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses.
Schmerl B, Gimber N, Kuropka B, Stumpf A, Rentsch J, Kunde SA, von Sivers J, Ewers H, Schmitz D, Freund C, Schmoranzer J, et al.
PLoS biology (2022) 203: e3001503. 188 004 ICC; tested species: rat
Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice.
Kallergi E, Daskalaki AD, Kolaxi A, Camus C, Ioannou E, Mercaldo V, Haberkant P, Stein F, Sidiropoulou K, Dalezios Y, Savitski MM, et al.
Nature communications (2022) 131: 680. 188 004 ICC; tested species: mouse
Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.
López-Hernández T, Takenaka KI, Mori Y, Kongpracha P, Nagamori S, Haucke V, Takamori S
eLife (2022) 11: . 188 004 ICC; tested species: mouse
Targeted proteoform mapping uncovers specific Neurexin-3 variants required for dendritic inhibition.
Hauser D, Behr K, Konno K, Schreiner D, Schmidt A, Watanabe M, Bischofberger J, Scheiffele P
Neuron (2022) 11013: 2094-2109.e10. 188 004 ICC; tested species: mouse
High-content analysis of neuronal morphology in human iPSC-derived neurons.
Lickfett S, Menacho C, Zink A, Telugu NS, Beller M, Diecke S, Cambridge S, Prigione A
STAR protocols (2022) 33: 101567. 188 004 ICC; tested species: human
Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes in vivo.
Ghazale H, Park E, Vasan L, Mester J, Saleh F, Trevisiol A, Zinyk D, Chinchalongporn V, Liu M, Fleming T, Prokopchuk O, et al.
Frontiers in neuroscience (2022) 16: 917071. 188 004 ICC; tested species: mouse
Establishment of autaptic culture with human-induced pluripotent stem cell-derived astrocytes.
Uchino K, Tanaka Y, Kawaguchi S, Kubota K, Watanabe T, Katsurabayashi S, Hirose S, Iwasaki K
iScience (2022) 258: 104762. 188 004 ICC; tested species: human
Spinal cord synaptic plasticity by GlyRβ release from receptor fields and syndapin I-dependent uptake.
Tröger J, Seemann E, Heintzmann R, Kessels MM, Qualmann B
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) 4235: 6706-23. 188 004 ICC; tested species: mouse
Synaptic neurofilaments and GluN1-NfL interaction in experimental models of α-synucleinopathies.
Imarisio A, Ferrari E, Pilotto A, Di Luca M, Padovani A, Gardoni F
Neuro-degenerative diseases (2022) : . 188 004 ICC; tested species: mouse
Secreted Amyloid Precursor Protein Alpha, a Neuroprotective Protein in the Brain Has Widespread Effects on the Transcriptome and Proteome of Human Inducible Pluripotent Stem Cell-Derived Glutamatergic Neurons Related to Memory Mechanisms.
Peppercorn K, Kleffmann T, Jones O, Hughes S, Tate W
Frontiers in neuroscience (2022) 16: 858524. 188 004 ICC; tested species: human
In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants.
Bauer L, Rissmann M, Benavides FFW, Leijten L, van Run P, Begeman L, Veldhuis Kroeze EJB, Lendemeijer B, Smeenk H, de Vrij FMS, Kushner SA, et al.
Acta neuropathologica communications (2022) 101: 124. 188 004 ICC; tested species: human
Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis.
Zhang S, Cooper-Knock J, Weimer AK, Shi M, Moll T, Marshall JNG, Harvey C, Nezhad HG, Franklin J, Souza CDS, Ning K, et al.
Neuron (2022) 1106: 992-1008.e11. 188 004 ICC; tested species: human
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.
Gerosa L, Mazzoleni S, Rusconi F, Longaretti A, Lewerissa E, Pelucchi S, Murru L, Giannelli SG, Broccoli V, Marcello E, Kasri NN, et al.
Cell reports (2022) 398: 110857. 188 004 ICC; tested species: rat
Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2.
Rodriguez CM, Bechek SC, Jones GL, Nakayama L, Akiyama T, Kim G, Solow-Cordero DE, Strittmatter SM, Gitler AD
Cell reports (2022) 414: 111505. 188 004 ICC; tested species: mouse
An atlas of endogenous DNA double-strand breaks arising during human neural cell fate determination.
Ballarino R, Bouwman BAM, Agostini F, Harbers L, Diekmann C, Wernersson E, Bienko M, Crosetto N
Scientific data (2022) 91: 400. 188 004 ICC; tested species: human
Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2.
Kim G, Nakayama L, Blum JA, Akiyama T, Boeynaems S, Chakraborty M, Couthouis J, Tassoni-Tsuchida E, Rodriguez CM, Bassik MC, Gitler AD, et al.
Cell reports (2022) 414: 111508. 188 004 ICC; tested species: mouse
Plasticity-Related Gene 5 Is Expressed in a Late Phase of Neurodifferentiation After Neuronal Cell-Fate Determination.
Gross I, Brandt N, Vonk D, Köper F, Wöhlbrand L, Rabus R, Witt M, Heep A, Plösch T, Hipp MS, Bräuer AU, et al.
Frontiers in cellular neuroscience (2022) 16: 797588. 188 004 ICC; tested species: mouse
Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts.
Mazille M, Buczak K, Scheiffele P, Mauger O
The EMBO journal (2022) : e110192. 188 004 ICC; tested species: mouse
Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements.
Ibarra IL, Ratnu VS, Gordillo L, Hwang IY, Mariani L, Weinand K, Hammarén HM, Heck J, Bulyk ML, Savitski MM, Zaugg JB, et al.
Molecular systems biology (2022) 188: e10473. 188 004 ICC; tested species: human,mouse
Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders.
Linda K, Lewerissa EI, Verboven AHA, Gabriele M, Frega M, Klein Gunnewiek TM, Devilee L, Ulferts E, Hommersom M, Oudakker A, Schoenmaker C, et al.
Autophagy (2021) : 1-20. 188 004 ICC; tested species: human
Biallelic variants in TMEM222 cause a new autosomal recessive neurodevelopmental disorder.
Polla DL, Farazi Fard MA, Tabatabaei Z, Habibzadeh P, Levchenko OA, Nikuei P, Makrythanasis P, Hussain M, von Hardenberg S, Zeinali S, Fallah MS, et al.
Genetics in medicine : official journal of the American College of Medical Genetics (2021) 237: 1246-1254. 188 004 ICC; tested species: human
Primate cell fusion disentangles gene regulatory divergence in neurodevelopment.
Agoglia RM, Sun D, Birey F, Yoon SJ, Miura Y, Sabatini K, Pașca SP, Fraser HB
Nature (2021) 5927854: 421-427. 188 004 ICC; tested species: human
SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis.
Castelli LM, Cutillo L, Souza CDS, Sanchez-Martinez A, Granata I, Lin YH, Myszczynska MA, Heath PR, Livesey MR, Ning K, Azzouz M, et al.
Molecular neurodegeneration (2021) 161: 53. 188 004 ICC; tested species: human
Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome.
Parrini M, Naskar S, Alberti M, Colombi I, Morelli G, Rocchi A, Nanni M, Piccardi F, Charles S, Ronzitti G, Mingozzi F, et al.
Molecular therapy : the journal of the American Society of Gene Therapy (2021) : . 188 004 ICC; tested species: mouse
The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity.
Sun C, Nold A, Fusco CM, Rangaraju V, Tchumatchenko T, Heilemann M, Schuman EM
Science advances (2021) 738: eabj0790. 188 004 ICC; tested species: rat
Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca2+-Permeable AMPA Receptors.
Livingstone RW, Elder MK, Singh A, Westlake CM, Tate WP, Abraham WC, Williams JM
Frontiers in molecular neuroscience (2021) 14: 660208. 188 004 ICC; tested species: rat
Synaptic disruption and CREB-regulated transcription are restored by K+ channel blockers in ALS.
Catanese A, Rajkumar S, Sommer D, Freisem D, Wirth A, Aly A, Massa-López D, Olivieri A, Torelli F, Ioannidis V, Lipecka J, et al.
EMBO molecular medicine (2021) 137: e13131. 188 004 ICC; tested species: human,rat
ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function.
Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, Sakai J, et al.
iScience (2021) 247: 102758. 188 004 ICC; tested species: mouse
An altered secretome is an early marker of the pathogenesis of CLN6 Batten disease.
Best HL, Clare AJ, McDonald KO, Wicky HE, Hughes SM
Journal of neurochemistry (2021) 1573: 764-780. 188 004 ICC; tested species: mouse
Inhibitory synaptic transmission is impaired at higher extracellular Ca2+ concentrations in Scn1a+/- mouse model of Dravet syndrome.
Uchino K, Kawano H, Tanaka Y, Adaniya Y, Asahara A, Deshimaru M, Kubota K, Watanabe T, Katsurabayashi S, Iwasaki K, Hirose S, et al.
Scientific reports (2021) 111: 10634. 188 004 ICC; tested species: mouse
The novel mitochondria activator, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), promotes the development of hippocampal neuronal morphology.
Katsurabayashi S, Oyabu K, Kubota K, Watanabe T, Nagamatsu T, Akaike N, Iwasaki K
Biochemical and biophysical research communications (2021) 560: 146-151. 188 004 ICC; tested species: mouse
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5. 188 004 ICC; tested species: rat
Isolation and culturing of primary mouse astrocytes for the analysis of focal adhesion dynamics.
Güler BE, Krzysko J, Wolfrum U
STAR protocols (2021) 24: 100954. 188 004 ICC; tested species: mouse
Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans.
Courtland JL, Bradshaw TW, Waitt G, Soderblom EJ, Ho T, Rajab A, Vancini R, Kim IH, Soderling SH
eLife (2021) 10: . 188 004 ICC; tested species: mouse
Subcellular sequencing of single neurons reveals the dendritic transcriptome of GABAergic interneurons.
Perez JD, Dieck ST, Alvarez-Castelao B, Tushev G, Chan IC, Schuman EM
eLife (2021) 10: . 188 004 ICC; tested species: mouse
Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural Models.
Bauer L, Lendemeijer B, Leijten L, Embregts CWE, Rockx B, Kushner SA, de Vrij FMS, van Riel D
mSphere (2021) 63: e0027021. 188 004 ICC; tested species: human
Activity-regulated synaptic targeting of lncRNA ADEPTR mediates structural plasticity by localizing Sptn1 and AnkB in dendrites.
Grinman E, Nakahata Y, Avchalumov Y, Espadas I, Swarnkar S, Yasuda R, Puthanveettil SV
Science advances (2021) 716: . 188 004 ICC; tested species: mouse
MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling.
Nakashima H, Tsujimura K, Irie K, Imamura T, Trujillo CA, Ishizu M, Uesaka M, Pan M, Noguchi H, Okada K, Aoyagi K, et al.
Cell reports (2021) 357: 109124. 188 004 ICC; tested species: human,mouse
Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.
Raj N, McEachin ZT, Harousseau W, Zhou Y, Zhang F, Merritt-Garza ME, Taliaferro JM, Kalinowska M, Marro SG, Hales CM, Berry-Kravis E, et al.
Cell reports (2021) 352: 108991. 188 004 ICC; tested species: human
Progressive myoclonus epilepsy KCNC1 variant causes a developmental dendritopathy.
Carpenter JC, Männikkö R, Heffner C, Heneine J, Sampedro-Castañeda M, Lignani G, Schorge S
Epilepsia (2021) : . 188 004 ICC; tested species: mouse
Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD.
Coyne AN, Rothstein JD
Acta neuropathologica communications (2021) 91: 45. 188 004 ICC, IHC-P; tested species: human
Loss of nuclear UBE3A activity is the predominant cause of Angelman syndrome in individuals carrying UBE3A missense mutations.
Bossuyt SNV, Punt AM, de Graaf IJ, van den Burg J, Williams MG, Heussler H, Elgersma Y, Distel B
Human molecular genetics (2021) : . 188 004 ICC; tested species: mouse
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak G, Rybak-Wolf A, Lisowski P, Pentimalli TM, Jüttner R, Glažar P, Uppal K, Bottani E, Brunetti D, Secker C, Zink A, et al.
Nature communications (2021) 121: 1929. 188 004 ICC; tested species: human
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 188 004 ICC; tested species: mouse
Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype.
Frega M, Selten M, Mossink B, Keller JM, Linda K, Moerschen R, Qu J, Koerner P, Jansen S, Oudakker A, Kleefstra T, et al.
Cell reports (2020) 301: 173-186.e6. 188 004 ICC; tested species: rat
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.
Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 188 004 ICC; tested species: rat
Monosomes actively translate synaptic mRNAs in neuronal processes.
Biever A, Glock C, Tushev G, Ciirdaeva E, Dalmay T, Langer JD, Schuman EM
Science (New York, N.Y.) (2020) 3676477: . 188 004 ICC; tested species: rat
Exposure to carbon black nanoparticles increases seizure susceptibility in male mice.
He M, Jiang X, Zou Z, Qin X, Zhang S, Guo Y, Wang X, Tian X, Chen C
Nanotoxicology (2020) : 1-17. 188 004 ICC; tested species: mouse
Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK.
Zieger HL, Kunde SA, Rademacher N, Schmerl B, Shoichet SA
Scientific reports (2020) 101: 5709. 188 004 ICC; tested species: rat
Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening.
Li B, Suutari BS, Sun SD, Luo Z, Wei C, Chenouard N, Mandelberg NJ, Zhang G, Wamsley B, Tian G, Sanchez S, et al.
Cell (2020) : . 188 004 ICC; tested species: rat
Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms.
Zampeta IF, Sonzogni M, Niggl E, Lendemeijer B, Smeenk H, de Vrij FMS, Kushner SA, Distel B, Elgersma Y
Human molecular genetics (2020) : . 188 004 ICC; tested species: mouse
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, et al.
Neuron (2020) : . 188 004 ICC; tested species: human
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing.
Medina C, de la Fuente V, Tom Dieck S, Nassim-Assir B, Dalmay T, Bartnik I, Lunardi P, de Oliveira Alvares L, Schuman EM, Letzkus JJ, Romano A, et al.
Neurobiology of learning and memory (2020) : 107275. 188 004 ICC, IHC; tested species: mouse
Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like Symptoms.
Koch N, Koch D, Krueger S, Tröger J, Sabanov V, Ahmed T, McMillan LE, Wolf D, Montag D, Kessels MM, Balschun D, et al.
Cerebral cortex (New York, N.Y. : 1991) (2020) : . 188 004 ICC; tested species: mouse
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.
Khan TA, Revah O, Gordon A, Yoon SJ, Krawisz AK, Goold C, Sun Y, Kim CH, Tian Y, Li MY, Schaepe JM, et al.
Nature medicine (2020) : . 188 004 ICC; tested species: human
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 188 004 ICC; tested species: rat
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium.
Jacob F, Pather SR, Huang WK, Zhang F, Wong SZH, Zhou H, Cubitt B, Fan W, Chen CZ, Xu M, Pradhan M, et al.
Cell stem cell (2020) 276: 937-950.e9. 188 004 ICC; tested species: human
A genetically encodable cell-type-specific protein synthesis inhibitor.
Heumüller M, Glock C, Rangaraju V, Biever A, Schuman EM
Nature methods (2019) : . 188 004 ICC; tested species: rat
Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome.
Avagliano Trezza R, Sonzogni M, Bossuyt SNV, Zampeta FI, Punt AM, van den Berg M, Rotaru DC, Koene LMC, Munshi ST, Stedehouder J, Kros JM, et al.
Nature neuroscience (2019) 228: 1235-1247. 188 004 ICC, IHC; tested species: human,mouse
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, et al.
Acta neuropathologica (2019) : . 188 004 ICC, IHC; tested species: human,mouse
Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha.
Mockett BG, Guévremont D, Elder MK, Parfitt KD, Peppercorn K, Morrissey J, Singh A, Hintz TJ, Kochen L, Tom Dieck S, Schuman E, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3917: 3188-3203. 188 004 ICC; tested species: rat
NMDA Receptors Regulate Neuregulin 2 Binding to ER-PM Junctions and Ectodomain Release.
Vullhorst D, Buonanno A
Molecular neurobiology (2019) : . 188 004 ICC; tested species: rat
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.
Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera FU, Willems E, Piper DR, Scampavia L, Rumbaugh G, Spicer TP
Scientific reports (2019) 91: 9000. 188 004 WB, ICC; tested species: human
Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome.
Ivankovic D, Drew J, Lesept F, White IJ, López Doménech G, Tooze SA, Kittler JT
Autophagy (2019) : 1-17. 188 004 ICC; tested species: mouse
Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses.
Deshpande D, Higelin J, Schoen M, Vomhof T, Boeckers TM, Demestre M, Michaelis J
Frontiers in cellular neuroscience (2019) 13: 256. 188 004 ICC; tested species: rat
How mRNA Localization and Protein Synthesis Sites Influence Dendritic Protein Distribution and Dynamics.
Fonkeu Y, Kraynyukova N, Hafner AS, Kochen L, Sartori F, Schuman EM, Tchumatchenko T
Neuron (2019) : . 188 004 ICC; tested species: rat
Intramolecular domain dynamics regulate synaptic MAGUK protein interactions.
Rademacher N, Kuropka B, Kunde SA, Wahl MC, Freund C, Shoichet SA
eLife (2019) 8: . 188 004 ICC; tested species: cos cells
Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.
Frega M, Linda K, Keller JM, Gümüş-Akay G, Mossink B, van Rhijn JR, Negwer M, Klein Gunnewiek T, Foreman K, Kompier N, Schoenmaker C, et al.
Nature communications (2019) 101: 4928. 188 004 ICC; tested species: human
Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-point accumulation for imaging in nanoscale topography.
Böger C, Hafner AS, Schlichthärle T, Strauss MT, Malkusch S, Endesfelder U, Jungmann R, Schuman EM, Heilemann M
Neurophotonics (2019) 63: 035008. 188 004 ICC; tested species: rat
The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons.
Tonazzini I, Van Woerden GM, Masciullo C, Mientjes EJ, Elgersma Y, Cecchini M
Molecular autism (2019) 10: 41. 188 004 ICC; tested species: mouse
Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
Livingstone RW, Elder MK, Barrett MC, Westlake CM, Peppercorn K, Tate WP, Abraham WC, Williams JM
Frontiers in molecular neuroscience (2019) 12: 198. 188 004 ICC; tested species: rat
Loss of Neurofascin-186 Disrupts Alignment of AnkyrinG Relative to Its Binding Partners in the Axon Initial Segment.
Alpizar SA, Baker AL, Gulledge AT, Hoppa MB
Frontiers in cellular neuroscience (2019) 13: 1. 188 004 ICC; tested species: rat
STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, et al.
Brain, behavior, and immunity (2019) 81: 228-246. 188 004 ICC, IHC; tested species: mouse
Generation of a knock-in MAP2-tdTomato reporter human embryonic stem cell line with inducible expression of NEUROG2/1 (NYGCe001-A).
Lu C, Sanjana NE
Stem cell research (2019) 41: 101643. 188 004 ICC; tested species: human
Local and global influences on protein turnover in neurons and glia.
Dörrbaum AR, Kochen L, Langer JD, Schuman EM
eLife (2018) 7: . 188 004 ICC; tested species: rat
Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms.
Swarnkar S, Avchalumov Y, Raveendra BL, Grinman E, Puthanveettil SV
Scientific reports (2018) 81: 17419. 188 004 ICC; tested species: mouse
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.
Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ
Journal of neuroinflammation (2018) 151: 7. 188 004 ICC, FACS; tested species: rat
Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.
Zhang K, Daigle JG, Cunningham KM, Coyne AN, Ruan K, Grima JC, Bowen KE, Wadhwa H, Yang P, Rigo F, Taylor JP, et al.
Cell (2018) : . 188 004 ICC; tested species: human
Biofunctionalized 3D nanopillar arrays fostering cell-guidance and promoting synapse stability and neuronal activity in networks.
Amin H, Dipalo M, De Angelis F, Berdondini L
ACS applied materials & interfaces (2018) : . 188 004 ICC; tested species: rat
Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain.
Murao N, Matsubara S, Matsuda T, Noguchi H, Mutoh T, Mutoh M, Koseki H, Namihira M, Nakashima K
Neuroscience research (2018) : . 188 004 ICC; tested species: mouse
Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression.
Heisler FF, Pechmann Y, Wieser I, Altmeppen HC, Veenendaal L, Muhia M, Schweizer M, Glatzel M, Krasemann S, Kneussel M
Neuron (2018) : . 188 004 ICC; tested species: mouse
The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function.
Onori MP, Koopal B, Everman DB, Worthington JD, Jones JR, Ploeg MA, Mientjes E, van Bon BW, Kleefstra T, Schulman H, Kushner SA, et al.
Human mutation (2018) : . 188 004 ICC; tested species: mouse
A new photocaged puromycin for an efficient labelling of newly translated proteins in living neurons.
Schwalbe H, Elamri I, Heumüller M, Herzig LM, Stirnal E, Wachtveitl J, Schuman E
Chembiochem : a European journal of chemical biology (2018) : . 188 004 ICC; tested species: rat
Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments.
Tushev G, Glock C, Heumüller M, Biever A, Jovanovic M, Schuman EM
Neuron (2018) 983: 495-511.e6. 188 004 ICC, IHC; tested species: mouse
Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration.
Bieri G, Lucin KM, O'Brien CE, Zhang H, Villeda SA, Wyss-Coray T
Molecular neurodegeneration (2018) 131: 68. 188 004 ICC; tested species: mouse
A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability.
Chia PH, Zhong FL, Niwa S, Bonnard C, Utami KH, Zeng R, Lee H, Eskin A, Nelson SF, Xie WH, Al-Tawalbeh S, et al.
eLife (2018) 7: . 188 004 ICC; tested species: human
Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity.
Rangaraju V, Lauterbach M, Schuman EM
Cell (2018) : . 188 004 ICC; tested species: rat
Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression.
Nakashima H, Tsujimura K, Irie K, Ishizu M, Pan M, Kameda T, Nakashima K
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3820: 4791-4810. 188 004 ICC; tested species: mouse
Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term Cultures.
Lam RS, Töpfer FM, Wood PG, Busskamp V, Bamberg E
PloS one (2017) 121: e0169506. 188 004 ICC
Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V
Neuron (2017) 934: 854-866.e4. 188 004 ICC; tested species: mouse
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, et al.
PLoS genetics (2017) 133: e1006684. 188 004 ICC
MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons.
Gumy LF, Katrukha EA, Grigoriev I, Jaarsma D, Kapitein LC, Akhmanova A, Hoogenraad CC
Neuron (2017) 942: 347-362.e7. 188 004 ICC
High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies.
Amin H, Nieus T, Lonardoni D, Maccione A, Berdondini L
Scientific reports (2017) 71: 2460. 188 004 ICC; tested species: rat
The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.
Riemann D, Wallrafen R, Dresbach T
Scientific reports (2017) 71: 15791. 188 004 ICC; tested species: rat
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, Tarallo V, Puchkov D, Kochlamazashvili G, Brachs S, Varela L, et al.
Nature neuroscience (2017) 208: 1096-1103. 188 004 ICC; tested species: mouse
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, et al.
Stem cell reports (2017) 96: 1745-1753. 188 004 ICC
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo A, van den Bruck D, Ciolli Mattioli C, Franke V, Imami K, McShane E, Moreno-Estelles M, Calviello L, Filipchyk A, Peguero-Sanchez E, Müller T, et al.
Nature communications (2017) 81: 583. 188 004 ICC; tested species: mouse
A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy.
Kankowski S, Förstera B, Winkelmann A, Knauff P, Wanker EE, You XA, Semtner M, Hetsch F, Meier JC
Frontiers in molecular neuroscience (2017) 10: 439. 188 004 ICC; tested species: rat
Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics.
Amin H, Marinaro F, De Pietri Tonelli D, Berdondini L
Scientific reports (2017) 71: 15752. 188 004 ICC; tested species: mouse
Heterogeneity of the Axon Initial Segment in Interneurons and Pyramidal Cells of Rodent Visual Cortex.
Höfflin F, Jack A, Riedel C, Mack-Bucher J, Roos J, Corcelli C, Schultz C, Wahle P, Engelhardt M
Frontiers in cellular neuroscience (2017) 11: 332. 188 004 ICC; tested species: mouse
Mutant Huntingtin Disrupts the Nuclear Pore Complex.
Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, et al.
Neuron (2017) 941: 93-107.e6. 188 004 ICC; tested species: human,mouse
Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration.
Sun Q, Weinger JG, Mao F, Liu G
Neuropharmacology (2016) 108: 426-39. 188 004 ICC; tested species: rat
mGlu5 Receptors and Relapse to Cocaine-Seeking: The Role of Receptor Trafficking in Postrelapse Extinction Learning Deficits.
Knackstedt LA, Schwendt M
Neural plasticity (2016) 2016: 9312508. 188 004 ICC
Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission.
Katsurabayashi S, Kawano H, Ii M, Nakano S, Tatsumi C, Kubota K, Takasaki K, Mishima K, Fujiwara M, Iwasaki K
Physiological reports (2016) 41: . 188 004 ICC
Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1.
Brahic M, Bousset L, Bieri G, Melki R, Gitler AD
Acta neuropathologica (2016) 1314: 539-48. 188 004 ICC
Electrical Responses and Spontaneous Activity of Human iPS-Derived Neuronal Networks Characterized for 3-month Culture with 4096-Electrode Arrays.
Amin H, Maccione A, Marinaro F, Zordan S, Nieus T, Berdondini L
Frontiers in neuroscience (2016) 10: 121. 188 004 ICC; tested species: human
Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons.
Harrill JA, Chen H, Streifel KM, Yang D, Mundy WR, Lein PJ
Molecular brain (2015) 8: 10. 188 004 ICC
Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.
Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN
Molecular pharmacology (2015) 874: 595-605. 188 004 ICC
Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathways.
Erdmann F, Kügler S, Blaesse P, Lange MD, Skryabin BV, Pape HC, Jüngling K
PloS one (2015) 102: e0117319. 188 004 ICC
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.
Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, et al.
Nature (2015) 5257567: 56-61. 188 004 ICC; tested species: human
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.
Bavamian S, Mellios N, Lalonde J, Fass DM, Wang J, Sheridan SD, Madison JM, Zhou F, Rueckert EH, Barker D, Perlis RH, et al.
Molecular psychiatry (2015) 205: 573-84. 188 004 ICC
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 188 004 ICC; tested species: rat
Shutdown of achaete-scute homolog-1 expression by heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia.
Kasim M, Benko E, Winkelmann A, Mrowka R, Staudacher JJ, Persson PB, Scholz H, Meier JC, Fähling M
The Journal of biological chemistry (2014) 28939: 26973-88. 188 004 ICC; tested species: rat
Inefficient type I interferon-mediated antiviral protection of primary mouse neurons is associated with the lack of apolipoprotein l9 expression.
Kreit M, Paul S, Knoops L, De Cock A, Sorgeloos F, Michiels T
Journal of virology (2014) 887: 3874-84. 188 004 ICC; tested species: mouse
Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury.
Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM
PloS one (2013) 85: e64423. 188 004 ICC; tested species: mouse
Nongenomic, glucocorticoid receptor-mediated regulation of serotonin transporter cell surface expression in embryonic stem cell derived serotonergic neurons.
Lau T, Heimann F, Bartsch D, Schloss P, Weber T
Neuroscience letters (2013) 554: 115-20. 188 004 ICC; tested species: mouse
TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors.
Pribiag H, Stellwagen D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3340: 15879-93. 188 004 ICC; tested species: rat
Long-term culture of astrocytes attenuates the readily releasable pool of synaptic vesicles.
Kawano H, Katsurabayashi S, Kakazu Y, Yamashita Y, Kubo N, Kubo M, Okuda H, Takasaki K, Kubota K, Mishima K, Fujiwara M, et al.
PloS one (2012) 710: e48034. 188 004 ICC
Neurovirulence of Usutu virus in human fetal organotypic brain slice cultures partially resembles Zika and West Nile virus.
Marshall EM, Rashidi AS, van Gent M, Rockx B, Verjans GMGM
Scientific reports (2024) 141: 20095. 188 004 IHC, IHC-P; tested species: human
Host circuit engagement of human cortical organoids transplanted in rodents.
Kelley KW, Revah O, Gore F, Kaganovsky K, Chen X, Deisseroth K, Pașca SP
Nature protocols (2024) : . 188 004 IHC; tested species: human
Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer's disease.
Beckman D, Diniz GB, Ott S, Hobson B, Chaudhari AJ, Muller S, Chu Y, Takano A, Schwarz AJ, Yeh CL, McQuade P, et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association (2024) : . 188 004 IHC; tested species: monkey
Integrated proteogenomic characterization of glioblastoma evolution.
Kim KH, Migliozzi S, Koo H, Hong JH, Park SM, Kim S, Kwon HJ, Ha S, Garofano L, Oh YT, D'Angelo F, et al.
Cancer cell (2024) 423: 358-377.e8. 188 004 IHC; tested species: mouse
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.
Taylor LW, Simzer EM, Pimblett C, Lacey-Solymar OTT, McGeachan RI, Meftah S, Rose JL, Spires-Jones MP, Holt K, Catterson JH, Koch H, et al.
Acta neuropathologica (2024) 1471: 7. 188 004 IHC; tested species: human
A cost-effective and efficient ex vivo, ex situ human whole brain perfusion protocol for immunohistochemistry.
Hade AC, Philips MA, Promet L, Jagomäe T, Hanumantharaju A, Salumäe L, Reimann E, Plaas M, Vasar E, Väli M
Journal of neuroscience methods (2024) 404: 110059. 188 004 IHC; tested species: human
Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development.
Tagliatti E, Desiato G, Mancinelli S, Bizzotto M, Gagliani MC, Faggiani E, Hernández-Soto R, Cugurra A, Poliseno P, Miotto M, Argüello RJ, et al.
Immunity (2023) : . 188 004 IHC; tested species: mouse
Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function.
Adams JM, Rege SV, Liu AT, Vu NV, Raina S, Kirsher DY, Nguyen AL, Harish R, Szoke B, Leone DP, Czirr E, et al.
Science advances (2023) 946: eadf8764. 188 004 IHC; tested species: mouse
Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity.
Barone I, Gilette NM, Hawks-Mayer H, Handy J, Zhang KJ, Chifamba FF, Mostafa E, Johnson-Venkatesh EM, Sun Y, Gibson JM, Rotenberg A, et al.
Science advances (2023) 943: eadj1010. 188 004 IHC; tested species: mouse
Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations.
Oliveira AR, Martins S, Cammarata G, Martins M, Cardoso AM, Almeida MR, do Carmo Macário M, Santana I, Peça J, Cardoso AL
Biomedicines (2022) 108: . 188 004 IHC; tested species: human
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.
Boutin ME, Strong CE, Van Hese B, Hu X, Itkin Z, Chen YC, LaCroix A, Gordon R, Guicherit O, Carromeu C, Kundu S, et al.
SLAS discovery : advancing life sciences R & D (2022) : . 188 004 IHC; tested species: human
CXCL14 exacerbates seizures by inhibiting GABA metabolism in epileptic mice.
Chen M, He W, Ding X, Wang S, Zhang M, Cao X, Tan J, Jiang G
American journal of translational research (2022) 149: 6222-6233. 188 004 IHC; tested species: mouse
Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros.
Zywitza V, Frahm S, Krüger N, Weise A, Göritz F, Hermes R, Holtze S, Colleoni S, Galli C, Drukker M, Hildebrandt TB, et al.
iScience (2022) 2511: 105414. 188 004 IHC
The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity.
Grzejda D, Mach J, Schweizer JA, Hummel B, Rezansoff AM, Eggenhofer F, Panhale A, Lalioti ME, Cabezas Wallscheid N, Backofen R, Felsenberg J, et al.
Science advances (2022) 839: eabo5578. 188 004 IHC; tested species: mouse
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19.
Beckman D, Bonillas A, Diniz GB, Ott S, Roh JW, Elizaldi SR, Schmidt BA, Sammak RL, Van Rompay KKA, Iyer SS, Morrison JH, et al.
Cell reports (2022) 415: 111573. 188 004 IHC; tested species: monkey
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Li D, Zhang L, Tuo J, Zhang F, Tai Z, Liu X, Qiu X, Zhang H, Yang J, Wang J, Luo Z, et al.
Neurochemical research (2022) : . 188 004 IHC; tested species: rat
Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment.
Borgmeyer M, Coman C, Has C, Schött HF, Li T, Westhoff P, Cheung YFH, Hoffmann N, Yuanxiang P, Behnisch T, Gomes GM, et al.
Cell reports (2021) 371: 109797. 188 004 IHC; tested species: mouse
The translatome of neuronal cell bodies, dendrites, and axons.
Glock C, Biever A, Tushev G, Nassim-Assir B, Kao A, Bartnik I, Tom Dieck S, Schuman EM
Proceedings of the National Academy of Sciences of the United States of America (2021) 11843: . 188 004 IHC; tested species: rat
Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking.
Schiweck J, Murk K, Ledderose J, Münster-Wandowski A, Ornaghi M, Vida I, Eickholt BJ
Nature communications (2021) 121: 1490. 188 004 IHC; tested species: mouse
A novel tau-based rhesus monkey model of Alzheimer's pathogenesis.
Beckman D, Chakrabarty P, Ott S, Dao A, Zhou E, Janssen WG, Donis-Cox K, Muller S, Kordower JH, Morrison JH
Alzheimer's & dementia : the journal of the Alzheimer's Association (2021) : . 188 004 IHC; tested species: monkey
Long-term maturation of human cortical organoids matches key early postnatal transitions.
Gordon A, Yoon SJ, Tran SS, Makinson CD, Park JY, Andersen J, Valencia AM, Horvath S, Xiao X, Huguenard JR, Pașca SP, et al.
Nature neuroscience (2021) 243: 331-342. 188 004 IHC; tested species: human
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, et al.
Science (New York, N.Y.) (2020) 3676477: 528-537. 188 004 IHC; tested species: mouse
Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.
Zhou X, Chen Q, Huang H, Zhang J, Wang J, Chen Y, Peng Y, Zhang H, Zeng J, Feng Z, Xu Z, et al.
Molecular medicine reports (2020) 226: 5348-5357. 188 004 IHC; tested species: rat
Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model.
Fernández-Pérez EJ, Gallegos S, Armijo-Weingart L, Araya A, Riffo-Lepe NO, Cayuman F, Aguayo LG
Scientific reports (2020) 101: 19606. 188 004 IHC; tested species: mouse
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells.
Miura Y, Li MY, Birey F, Ikeda K, Revah O, Thete MV, Park JY, Puno A, Lee SH, Porteus MH, Pașca SP, et al.
Nature biotechnology (2020) 3812: 1421-1430. 188 004 IHC; tested species: human
Olfactomedin-3 Enhances Seizure Activity by Interacting With AMPA Receptors in Epilepsy Models.
Tang S, Wang T, Zhang X, Guo Y, Xu P, Zeng J, Luo Z, Li D, Zheng Y, Luo Y, Yu C, et al.
Frontiers in cell and developmental biology (2020) 8: 722. 188 004 IHC; tested species: human,mouse
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing.
Medina C, de la Fuente V, Tom Dieck S, Nassim-Assir B, Dalmay T, Bartnik I, Lunardi P, de Oliveira Alvares L, Schuman EM, Letzkus JJ, Romano A, et al.
Neurobiology of learning and memory (2020) : 107275. 188 004 ICC, IHC; tested species: mouse
Characterization of starvation-induced autophagy in cerebellar Purkinje cells of pHluorin-mKate2-human LC3B transgenic mice.
Oliva Trejo JA, Tanida I, Suzuki C, Kakuta S, Tada N, Uchiyama Y
Scientific reports (2020) 101: 9643. 188 004 IHC; tested species: mouse
TIP60/KAT5 is required for neuronal viability in hippocampal CA1.
Urban I, Kerimoglu C, Sakib MS, Wang H, Benito E, Thaller C, Zhou X, Yan J, Fischer A, Eichele G
Scientific reports (2019) 91: 16173. 188 004 IHC; tested species: mouse
Atlastin-1 modulates seizure activity and neuronal excitability.
Lu X, Yang M, Yang Y, Wang XF
CNS neuroscience & therapeutics (2019) : . 188 004 IHC; tested species: human,mouse
STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, et al.
Brain, behavior, and immunity (2019) 81: 228-246. 188 004 ICC, IHC; tested species: mouse
Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus.
Yang Q, Huang Z, Luo Y, Zheng F, Hu Y, Liu H, Zhu S, He M, Xu D, Li Y, Yang M, et al.
EBioMedicine (2019) : . 188 004 IHC; tested species: mouse
Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome.
Avagliano Trezza R, Sonzogni M, Bossuyt SNV, Zampeta FI, Punt AM, van den Berg M, Rotaru DC, Koene LMC, Munshi ST, Stedehouder J, Kros JM, et al.
Nature neuroscience (2019) 228: 1235-1247. 188 004 ICC, IHC; tested species: human,mouse
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, et al.
Acta neuropathologica (2019) : . 188 004 ICC, IHC; tested species: human,mouse
Differential regulation of chloride homeostasis and GABAergic transmission in the thalamus.
Schmidt T, Ghaffarian N, Philippot C, Seifert G, Steinhäuser C, Pape HC, Blaesse P
Scientific reports (2018) 81: 13929. 188 004 IHC; tested species: mouse
ZDHHC8 critically regulates seizure susceptibility in epilepsy.
Yang Q, Zheng F, Hu Y, Yang Y, Li Y, Chen G, Wang W, He M, Zhou R, Ma Y, Xu D, et al.
Cell death & disease (2018) 98: 795. 188 004 IHC; tested species: human,mouse
Biochemical autoregulatory gene therapy for focal epilepsy.
Lieb A, Qiu Y, Dixon CL, Heller JP, Walker MC, Schorge S, Kullmann DM
Nature medicine (2018) : . 188 004 IHC; tested species: rat
GPR40 modulates epileptic seizure and NMDA receptor function.
Yang Y, Tian X, Xu D, Zheng F, Lu X, Zhang Y, Ma Y, Li Y, Xu X, Zhu B, Wang X, et al.
Science advances (2018) 410: eaau2357. 188 004 IHC; tested species: human,mouse
Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments.
Tushev G, Glock C, Heumüller M, Biever A, Jovanovic M, Schuman EM
Neuron (2018) 983: 495-511.e6. 188 004 ICC, IHC; tested species: mouse
A-type K+ currents in intralaminar thalamocortical relay neurons.
Kanyshkova T, Broicher T, Meuth SG, Pape HC, Budde T
Pflugers Archiv : European journal of physiology (2011) 4615: 545-56. 188 004 IHC
Herpes simplex virus infection induces necroptosis of neurons and astrocytes in human fetal organotypic brain slice cultures.
Rashidi AS, Tran DN, Peelen CR, van Gent M, Ouwendijk WJD, Verjans GMGM
Journal of neuroinflammation (2024) 211: 38. 188 004 IHC-P; tested species: human
Neurovirulence of Usutu virus in human fetal organotypic brain slice cultures partially resembles Zika and West Nile virus.
Marshall EM, Rashidi AS, van Gent M, Rockx B, Verjans GMGM
Scientific reports (2024) 141: 20095. 188 004 IHC, IHC-P; tested species: human
Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD.
Coyne AN, Rothstein JD
Acta neuropathologica communications (2021) 91: 45. 188 004 ICC, IHC-P; tested species: human
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease.
Shih YH, Tu LH, Chang TY, Ganesan K, Chang WW, Chang PS, Fang YS, Lin YT, Jin LW, Chen YR
Nature communications (2020) 111: 5950. 188 004 IHC-P; tested species: human
The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, et al.
Acta neuropathologica (2018) : . 188 004 IHC-P; tested species: mouse
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.
Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ
Journal of neuroinflammation (2018) 151: 7. 188 004 ICC, FACS; tested species: rat
WB
ICC
IHC
IHC-P
Background

There are two major classes of heat stable microtubule associated proteins (MAPs): MAP2, and tau. Both protein classes are involved in the regulation of microtubule polymerization in cells.
Four differentially regulated isoforms of MAP2 have been described so far.
Other products for this target