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alpha-Internexin antibody - 167 002

alpha-Internexin is a type IV intermediate filament of neurons
Polyclonal rabbit antiserum
Cat. No.: 167 002
Amount: 200 µl
Price: $350.00
Cat. No. 167 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 1 to 499 from human α-Internexin (UniProt Id: Q16352)
Reactivity Reacts with: rat (P23565), mouse (P46660).
Other species not tested yet.
Specificity Specific for α-internexin.
Matching control protein/peptide 167-0P
Remarks

Ice cold methanol fixation is recommended.

Data sheet 167_002.pdf
Cat. No.: 167 002
Quantity: 200 µl
Price: $350.00
Background
The cytoskeleton of most eukaryotic cells is composed of three distinct components: Actin-based microfilaments, tubulin based microtubules and intermediate filaments (IFs).
α-Internexin is a neuronal intermediate filament of type four. It is assumed to be expressed by all neurons and preceeds the onset of the expression of the heavy medium and light variants of neurofilaments which are major components of the neuronal IFs.
Alterations in the phosphorylation state of IFs have been associated with neurodegenerative diseases like Alzheimer, Parkinson, dementia with Lewy bodies (DLB), and motor neuron disease (MND).