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alpha-Internexin protein - 167-0P

alpha-Internexin is a type IV intermediate filament of neurons
control protein
Cat. No.: 167-0P
Amount: 100 µg
Price: $90.00
Cat. No. 167-0P 100 µg protein, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Immunogen Recombinant protein corresponding to AA 1 to 499 from human α-Internexin (UniProt Id: Q16352)
Recommended dilution Optimal concentrations should be determined by the end-user.
Matching antibodies 167 002
Remarks

This control protein consists of the recombinant full length human α internexin that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of protein needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.

Data sheet 167-0p.pdf
Cat. No.: 167-0P
Quantity: 100 µg
Price: $90.00
Background
The cytoskeleton of most eukaryotic cells is composed of three distinct components: Actin-based microfilaments, tubulin based microtubules and intermediate filaments (IFs).
α-Internexin is a neuronal intermediate filament of type four. It is assumed to be expressed by all neurons and preceeds the onset of the expression of the heavy medium and light variants of neurofilaments which are major components of the neuronal IFs.
Alterations in the phosphorylation state of IFs have been associated with neurodegenerative diseases like Alzheimer, Parkinson, dementia with Lewy bodies (DLB), and motor neuron disease (MND).
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