Cat. No.: 162 013
Amount: 50 µg
Price:
$455.00
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| Cat. No. 162 013 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 397 to 619 from rat Shank1 (UniProt Id: Q9WV48) |
| Reactivity |
Reacts with: rat (Q9WV48), mouse (D3YZU1). Other species not tested yet. |
| Specificity | Specific for shank 1 with weak cross reactivity to shank 2 and 3 due to high sequence homology. K.O. validated PubMed: 25816842 |
| Remarks |
ICC: Methanol fixation is recommended. |
| Data sheet | 162_013.pdf |
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Shank1, 2 and 3 are major proteins of the postsynaptic density (PSD). They are composed of several protein-protein interaction domains like PDZ-, homer- and ABP1-binding domains which allow them to crosslink ionotopic and metabotropic glutamate receptor complexes with each other and to the actin-cytoskeleton.