Cat. No.: 160 111AbOR
Amount: 100 µg
Price:
$465.00
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| Cat. No. 160 111AbOR |
100 µg purified IgG, lyophilized, fluorescence-labeled with
abberior STAR ORANGE.
Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Either add 1:1 (v/v) glycerol, then aliquot and store at -20°C until use, or store aliquots at -80°C without additives. Reconstitute immediately upon receipt! Avoid bright light when working with the antibody to minimize photo bleeching of the fluorescent dye. |
| Applications | |
| Label | abberior STAR ORANGE |
| Clone | SY-72G2 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Recombinant protein corresponding to the c-terminal half of human Homer1b (UniProt Id: Q86YM7-1) |
| Reactivity |
Reacts with: mouse (Q9Z2Y3), rat (Q9Z214), human (Q86YM7-1). Other species not tested yet. |
| Specificity | Specific for Homer1b and 1c; no cross-reactivity to Homer1a |
| Remarks |
ICC: This antibody conjugate is especially suitable for high resolution STED microscopy. |
| Data sheet | 160_111abor.pdf |
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Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.