Cat. No.: 129 103
Amount: 50 µg
Price:
$375.00
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| Cat. No. 129 103 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: not recommended IHC: not recommended IHC-P: not recommended ELISA: yes (see remarks) |
| Immunogen | Recombinant protein corresponding to AA 710 to 824 from mouse Neuroligin3 (UniProt Id: Q8BYM5) |
| Reactivity |
Reacts with: rat (Q62889), mouse (Q8BYM5). Other species not tested yet. |
| Specificity | Specific for neuroligin 3. Detects other neuroligins when heavily overexpressed. K.O. validated |
| Matching control protein/peptide | 129-1P |
| Remarks |
ELISA: Suitable as detector antibody for sandwich-ELISA with cat. no. 129 011 as capture antibody. The ELISA-protocol for membrane proteins is recommended. |
| Data sheet | 129_103.pdf |
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Neuroligins form a family of postsynaptic cell surface molecules that interact with β-neurexins. They are 110-120 kDa polypeptides with homology to acetylcholine esterase. Neuroligin 1 and neuroligin 3 are specifically localized to post-synaptic densities of excitatory synapses whereas neuroligin 2 is found exclusively on inhibitory synapses.
Mutations in neuroligin 3 and neuroligin 4 have been implicated with a rare, heritable form of autism.