Synaptic Systems - Synaptobrevin2

Cat. No.: 104 211

Amount: 50 µg

Price: $430.00

Cat. No. 104 211	50 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 2000 up to 1 : 20000 (AP staining) gallery IP: yes ICC: 1 : 1000 gallery IHC: 1 : 500 up to 1 : 1000 gallery IHC-P: 1 : 500 gallery DNA-PAINT: yes (see remarks) EM: yes ELISA: yes (see remarks) Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section. Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section. Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section. Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section. Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. In antibody-based DNA-PAINT (Point Accumulation in Nanoscale Topography), a short oligomeric docking strand is coupled to a specific antibody. The transient association of the fluorophore to the antibody is mediated by the pairing of a short fluorescently labeled complementary imager DNA strand. DNA-PAINT allows super-resolution imaging and the imaging of a huge number of antibodies on the same biological sample in a single multiplex experiment. For additional experimental details refer to the Remarks section. Electron microscopy (EM) is a microscopy technique that detects the scatter of electrons through thin tissue sections. In Immuno-EM the antigen is usually revealed by colloidal gold conjugated secondary antibodies linking electron dense structures to antigen-bound primary antibodies. Enzyme-linked immunosorbent assay (ELISA); a frequently employed method to quantify target-molecules in solution. The detection of some proteins requires special solubilization steps. For further information, please refer to the „Remarks“ section.
Clone	69.1
Subtype	IgG1 (κ light chain)
Immunogen	Synthetic peptide corresponding to residues near the amino terminus of rat Synaptobrevin2 (UniProt Id: P63045)
Reactivity	Reacts with: human (P63027), rat (P63045), mouse (P63044), hamster. No signal: chicken, zebrafish. Other species not tested yet.
Specificity	K.O. validated PubMed: 26663078
Matching control protein/peptide	104-2P
Remarks	Although the epitope is still present in the Botox B cleavage product (aa 1 - 76), it is not recognized, probably due to conformational masking of the epitope. DNA-PAINT: This antibody has been successfully used for DNA-PAINT application (see Unterauer et al., 2024; PMID: 38552614). ELISA: Suitable capture antibody for sandwich-ELISA with cat. no. 104 102 or 104 203 as detector. The ELISA-protocol for membrane proteins is recommended.
Data sheet	104_211.pdf

References for Synaptobrevin2 - 104 211

Gαo1 and Gαo1/Gαo2 deletion differentially affect hippocampal mossy fiber tract anatomy and neuronal morphogenesis.
Höltje M, Wolkowicz A, Brunk I, Baron J, Ahnert-Hilger G
Journal of neurochemistry (2024) : . 104 211 WB; tested species: mouse

Light-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex.
Lux UT, Meyer J, Jahn O, Davison A, Babai N, Gießl A, Wartenberg A, Sticht H, Brose N, Reim K, Brandstätter JH, et al.
Frontiers in molecular neuroscience (2024) 17: 1308466. 104 211 WB, IHC; tested species: mouse

Expression, purification and application of a recombinant, membrane permeating version of the light chain of botulinum toxin B.
Buzzatto MV, Benegas Guerrero FC, Álvarez PA, Zizzias MP, Polo LM, Tomes CN
Bioscience reports (2024) 447: . 104 211 ICC, WB; tested species: rat,human

Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours.
Shi HJ, Xue YR, Shao H, Wei C, Liu T, He J, Yang YH, Wang HM, Li N, Ren SQ, Chang L, et al.
Brain : a journal of neurology (2024) : . 104 211 WB; tested species: mouse

loHuntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning.
Vitet H, Bruyère J, Xu H, Séris C, Brocard J, Abada YS, Delatour B, Scaramuzzino C, Venance L, Saudou F
eLife (2023) 12: . 104 211 WB; tested species: mouse

Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging.
Uzay B, Houcek A, Ma ZZ, Konradi C, Monteggia LM, Kavalali ET
Cell reports (2023) 422: 112042. 104 211 WB; tested species: human

Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons.
Watson ET, Pauers MM, Seibert MJ, Vevea JD, Chapman ER
eLife (2023) 12: . 104 211 ICC, WB

Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells.
Xu W, Qadir MMF, Nasteska D, Mota de Sa P, Gorvin CM, Blandino-Rosano M, Evans CR, Ho T, Potapenko E, Veluthakal R, Ashford FB, et al.
Cell reports (2023) 425: 112529. 104 211 WB; tested species: rat

Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's disease.
Vidyadhara DJ, Somayaji M, Wade N, Yücel B, Zhao H, Shashaank N, Ribaudo J, Gupta J, Lam TT, Sames D, Greene LE, et al.
Cell reports (2023) 423: 112231. 104 211 WB; tested species: mouse

Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates.
Park D, Wu Y, Wang X, Gowrishankar S, Baublis A, De Camilli P
Nature communications (2023) 141: 455. 104 211 WB, IP, ICC; tested species: mouse

Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons.
Subkhangulova A, Gonzalez-Lozano MA, Groffen AJA, van Weering JRT, Smit AB, Toonen RF, Verhage M
eLife (2023) 12: . 104 211 WB; tested species: mouse

Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions.
Mahoney-Crane CL, Viswanathan M, Russell D, Curtiss RAC, Freire J, Bobba SS, Coyle SD, Kandebo M, Yao L, Wan BL, Hatcher NG, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) 433: 501-521. 104 211 WB; tested species: mouse

Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination.
Pan L, Trimarco A, Zhang AJ, Fujimori K, Urade Y, Sun LO, Taveggia C, Zhang Y
eLife (2023) 12: . 104 211 WB, ICC; tested species: mouse

A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses.
Kim JK, Jha NN, Awano T, Caine C, Gollapalli K, Welby E, Kim SS, Fuentes-Moliz A, Wang X, Feng Z, Sera F, et al.
Neuron (2023) 1119: 1423-1439.e4. 104 211 WB; tested species: mouse

C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction.
Huber N, Hoffmann D, Giniatullina R, Rostalski H, Leskelä S, Takalo M, Natunen T, Solje E, Remes AM, Giniatullin R, Hiltunen M, et al.
Neurobiology of disease (2022) 162: 105584. 104 211 WB; tested species: mouse

Rapid and gentle immunopurification of brain synaptic vesicles.
Bradberry MM, Mishra S, Zhang Z, Wu L, McKetney JM, Vestling MM, Coon JJ, Chapman ER
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) : . 104 211 WB; tested species: mouse

Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins.
Carnazza KE, Komer LE, Xie YX, Pineda A, Briano JA, Gao V, Na Y, Ramlall T, Buchman VL, Eliezer D, Sharma M, et al.
Cell reports (2022) 392: 110675. 104 211 WB, ICC; tested species: mouse

Alpha-Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction.
Ponterio G, Faustini G, El Atiallah I, Sciamanna G, Meringolo M, Tassone A, Imbriani P, Cerri S, Martella G, Bonsi P, Bellucci A, et al.
Movement disorders : official journal of the Movement Disorder Society (2022) : . 104 211 WB; tested species: mouse

Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.
Chen XQ, Zuo X, Becker A, Head E, Mobley WC
Alzheimer's & dementia : the journal of the Alzheimer's Association (2022) : . 104 211 WB; tested species: human,mouse

The lipid transporter ORP2 regulates synaptic neurotransmitter release via two distinct mechanisms.
Weber-Boyvat M, Kroll J, Trimbuch T, Olkkonen VM, Rosenmund C
Cell reports (2022) 4113: 111882. 104 211 WB; tested species: mouse

Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody.
Fabris F, Šoštarić P, Matak I, Binz T, Toffan A, Simonato M, Montecucco C, Pirazzini M, Rossetto O
International journal of molecular sciences (2022) 238: . 104 211 WB, ICC; tested species: rat

VAMPs sensitive to tetanus toxin are required for cortical granule exocytosis in mouse oocytes.
de Paola M, Garrido F, Zanetti MN, Michaut MA
Experimental cell research (2021) 4051: 112629. 104 211 WB, ICC; tested species: mouse

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, et al.
Neuron (2021) : . 104 211 WB; tested species: mouse

The phosphoprotein Synapsin Ia regulates the kinetics of dense-core vesicle release.
Yang HJ, Chen PC, Huang CT, Cheng TL, Hsu SP, Chen CY, Lu JC, Wang CT
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 104 211 WB, ICC

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.
Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, et al.
Nature communications (2021) 121: 1848. 104 211 WB; tested species: mouse

Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease.
Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, Ericsson M, Arthanari H, Selkoe DJ
Cell reports (2021) 361: 109333. 104 211 WB; tested species: mouse

Synapsin Condensates Recruit alpha-Synuclein.
Hoffmann C, Sansevrino R, Morabito G, Logan C, Vabulas RM, Ulusoy A, Ganzella M, Milovanovic D
Journal of molecular biology (2021) 43312: 166961. 104 211 WB; tested species: rat

The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites.
Bakr M, Jullié D, Krapivkina J, Paget-Blanc V, Bouit L, Petersen JD, Retailleau N, Breillat C, Herzog E, Choquet D, Perrais D, et al.
Cell reports (2021) 3610: 109678. 104 211 WB; tested species: rat

Munc13-1 is a Ca2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission.
Lipstein N, Chang S, Lin KH, López-Murcia FJ, Neher E, Taschenberger H, Brose N
Neuron (2021) : . 104 211 WB; tested species: mouse

RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.
Shumate KM, Tas ST, Kavalali ET, Emeson RB
Journal of neurochemistry (2021) 1582: 182-196. 104 211 WB; tested species: mouse

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.
Brzozowski CF, Hijaz BA, Singh V, Gcwensa NZ, Kelly K, Boyden ES, West AB, Sarkar D, Volpicelli-Daley LA
Acta neuropathologica communications (2021) 91: 180. 104 211 WB; tested species: mouse

Microglia modulate gliotransmission through the regulation of VAMP2 proteins in astrocytes.
Takata-Tsuji F, Chounlamountri N, Do LD, Philippot C, Novion Ducassou J, Couté Y, Ben Achour S, Honnorat J, Place C, Pascual O
Glia (2021) 691: 61-72. 104 211 WB; tested species: mouse

Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose.
Qian C, Wu Z, Sun R, Yu H, Zeng J, Rao Y, Li Y
eLife (2021) 10: . 104 211 WB; tested species: mouse

β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins.
Ninkina N, Millership SJ, Peters OM, Connor-Robson N, Chaprov K, Kopylov AT, Montoya A, Kramer H, Withers DJ, Buchman VL
The Journal of biological chemistry (2021) : 101375. 104 211 WB; tested species: mouse

Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies.
Alten B, Zhou Q, Shin OH, Esquivies L, Lin PY, White KI, Sun R, Chung WK, Monteggia LM, Brunger AT, Kavalali ET, et al.
Neuron (2020) : . 104 211 WB; tested species: mouse

LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.
Sclip A, Südhof TC
eLife (2020) 9: . 104 211 WB; tested species: mouse

Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.
Naseri NN, Ergel B, Kharel P, Na Y, Huang Q, Huang R, Dolzhanskaya N, Burré J, Velinov MT, Sharma M
Nature structural & molecular biology (2020) 272: 192-201. 104 211 WB, IP; tested species: mouse

Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.
Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, et al.
Nature communications (2020) 111: 1266. 104 211 WB, ICC; tested species: mouse

VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.
Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 104 211 WB; tested species: rat

Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons.
Hoogstraaten RI, van Keimpema L, Toonen RF, Verhage M
Scientific reports (2020) 101: 10913. 104 211 WB, ICC; tested species: mouse

Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly.
Wang C, Tu J, Zhang S, Cai B, Liu Z, Hou S, Zhong Q, Hu X, Liu W, Li G, Liu Z, et al.
Nature communications (2020) 111: 1531. 104 211 WB, ICC; tested species: human,mouse

Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates.
Wu X, Ganzella M, Zhou J, Zhu S, Jahn R, Zhang M
Molecular cell (2020) : . 104 211 WB

Danish and British dementia ITM2b/BRI2 mutations reduce BRI2 protein stability and impair glutamatergic synaptic transmission.
Yin T, Yao W, Lemenze AD, D'Adamio L
The Journal of biological chemistry (2020) : . 104 211 WB; tested species: mouse

Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: . 104 211 WB; tested species: mouse

Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2.
Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, et al.
eLife (2020) 9: . 104 211 WB; tested species: rat

Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits.
Banks GT, Guillaumin MCC, Heise I, Lau P, Yin M, Bourbia N, Aguilar C, Bowl MR, Esapa C, Brown LA, Hasan S, et al.
Science advances (2020) 633: eabb3567. 104 211 WB, ICC; tested species: mouse

Rho-kinase inhibition by fasudil modulates pre-synaptic vesicle dynamics.
Saal KA, Warth Pérez Arias C, Roser AE, Christoph Koch J, Bähr M, Rizzoli SO, Lingor P
Journal of neurochemistry (2020) : . 104 211 WB, ICC; tested species: rat

A cryptic non-GPI-anchored cytosolic isoform of CD59 controls insulin exocytosis in pancreatic β-cells by interaction with SNARE proteins.
Golec E, Rosberg R, Zhang E, Renström E, Blom AM, King BC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201901007R. 104 211 WB, ICC; tested species: rat

Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, et al.
Science signaling (2019) 12569: . 104 211 WB; tested species: mouse

SNAP-25 isoforms differentially regulate synaptic transmission and long-term synaptic plasticity at central synapses.
Irfan M, Gopaul KR, Miry O, Hökfelt T, Stanton PK, Bark C
Scientific reports (2019) 91: 6403. 104 211 WB; tested species: mouse

Botulinum Neurotoxins A, B, C, E, and F preferentially enter cultured human motor neurons compared to other cultured human neuronal populations.
Pellett S, Tepp WH, Johnson EA
FEBS letters (2019) : . 104 211 WB; tested species: human

Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory.
Navarrete M, Cuartero MI, Palenzuela R, Draffin JE, Konomi A, Serra I, Colié S, Castaño-Castaño S, Hasan MT, Nebreda ÁR, Esteban JA, et al.
Nature communications (2019) 101: 2968. 104 211 WB; tested species: mouse

Invasion by activated macrophages requires delivery of nascent MT1-MMP through late endosomes/lysosomes to the cell surface.
Röhl J, West ZE, Rudolph M, Zaharia A, Van Lonkhuyzen D, Hickey DK, Semmler ABT, Murray RZ
Traffic (Copenhagen, Denmark) (2019) : . 104 211 WB; KD verified; tested species: mouse

Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex.
Lazarevic V, Mantas I, Flais I, Svenningsson P
International journal of molecular sciences (2019) 2017: . 104 211 WB; tested species: rat

In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties.
Kreutzberger AJB, Kiessling V, Stroupe C, Liang B, Preobraschenski J, Ganzella M, Kreutzberger MAB, Nakamoto R, Jahn R, Castle JD, Tamm LK, et al.
Nature communications (2019) 101: 3904. 104 211 WB; tested species: rat

Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson's disease.
Torre-Muruzabal T, Devoght J, Van den Haute C, Brône B, Van der Perren A, Baekelandt V
Acta neuropathologica communications (2019) 71: 160. 104 211 WB; tested species: rat

Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity.
Yagensky O, Kohansal-Nodehi M, Gunaseelan S, Rabe T, Zafar S, Zerr I, Härtig W, Urlaub H, Chua JJ
eLife (2019) 8: . 104 211 WB; tested species: mouse

Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE.
Rathore SS, Liu Y, Yu H, Wan C, Lee M, Yin Q, Stowell MHB, Shen J
Cell reports (2019) 2913: 4583-4592.e3. 104 211 WB

Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.
Raja MK, Preobraschenski J, Del Olmo-Cabrera S, Martinez-Turrillas R, Jahn R, Perez-Otano I, Wesseling JF
eLife (2019) 8: . 104 211 WB; tested species: mouse

The Prion Protein Regulates Synaptic Transmission by Controlling the Expression of Proteins Key to Synaptic Vesicle Recycling and Exocytosis.
Peggion C, Stella R, Chemello F, Massimino ML, Arrigoni G, Cagnin S, Biancotto G, Franchin C, Sorgato MC, Bertoli A
Molecular neurobiology (2018) : . 104 211 WB; tested species: mouse

Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.
Zhang S, Lebreton F, Mansfield MJ, Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martínez-Carranza M, Stenmark P, Gilmore MS, et al.
Cell host & microbe (2018) 232: 169-176.e6. 104 211 WB; tested species: rat

Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes.
Duan MJ, Yan ML, Wang Q, Mao M, Su D, Sun LL, Li KX, Qu Y, Sun Q, Zhang XY, Huang SY, et al.
Cell communication and signaling : CCS (2018) 161: 91. 104 211 WB; tested species: mouse

SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins.
Yu H, Shen C, Liu Y, Menasche BL, Ouyang Y, Stowell MHB, Shen J
Proceedings of the National Academy of Sciences of the United States of America (2018) : . 104 211 WB; tested species: mouse

The N-peptide binding mode is critical to Munc18-1 function in synaptic exocytosis.
Shen C, Liu Y, Yu H, Gulbranson DR, Kogut I, Bilousova G, Zhang C, Stowell MHB, Shen J
The Journal of biological chemistry (2018) : . 104 211 WB; tested species: human

Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system.
Baron J, Bilbao A, Hörtnagl H, Birnbaumer L, Leixner S, Spanagel R, Ahnert-Hilger G, Brunk I
Journal of neurochemistry (2018) : . 104 211 WB; tested species: mouse

Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity.
Farsi Z, Gowrisankaran S, Krunic M, Rammner B, Woehler A, Lafer EM, Mim C, Jahn R, Milosevic I
eLife (2018) 7: . 104 211 WB; tested species: mouse

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.
McInnes J, Wierda K, Snellinx A, Bounti L, Wang YC, Stancu IC, Apóstolo N, Gevaert K, Dewachter I, Spires-Jones TL, De Strooper B, et al.
Neuron (2018) 974: 823-835.e8. 104 211 WB; tested species: mouse

SNAP-25a and SNAP-25b differently mediate interactions with Munc18-1 and Gβγ subunits.
Daraio T, Valladolid-Acebes I, Brismar K, Bark C
Neuroscience letters (2018) 674: 75-80. 104 211 WB; tested species: mouse

Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 104 211 WB

Functional mapping of brain synapses by the enriching activity-marker SynaptoZip.
Ferro M, Lamanna J, Ripamonti M, Racchetti G, Arena A, Spadini S, Montesano G, Cortese R, Zimarino V, Malgaroli A
Nature communications (2017) 81: 1229. 104 211 WB; tested species: rat

Serotonin Transporter Associated Protein Complexes Are Enriched in Synaptic Vesicle Proteins and Proteins Involved in Energy Metabolism and Ion Homeostasis.
Haase J, Grudzinska-Goebel J, Müller HK, Münster-Wandowski A, Chow E, Wynne K, Farsi Z, Zander JF, Ahnert-Hilger G
ACS chemical neuroscience (2017) 85: 1101-1116. 104 211 WB; tested species: mouse,rat

Identification and characterization of a novel botulinum neurotoxin.
Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita SI, Martínez-Carranza M, Dong M, Stenmark P
Nature communications (2017) 8: 14130. 104 211 WB; tested species: mouse

Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway.
Sheehan P, Zhu M, Beskow A, Vollmer C, Waites CL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3633: 8668-86. 104 211 WB, IP, ICC; tested species: rat

Altered sensory processing and dendritic remodeling in hyperexcitable visual cortical networks.
Vannini E, Restani L, Pietrasanta M, Panarese A, Mazzoni A, Rossetto O, Middei S, Micera S, Caleo M
Brain structure & function (2016) 2216: 2919-36. 104 211 WB, IHC

How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
Acuna C, Liu X, Südhof TC
Neuron (2016) 914: 792-807. 104 211 WB

Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure.
Iijima Y, Behr K, Iijima T, Biemans B, Bischofberger J, Scheiffele P
Scientific reports (2016) 6: 27400. 104 211 WB, ICC

Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression.
Rajappa R, Gauthier-Kemper A, Böning D, Hüve J, Klingauf J
Cell reports (2016) 146: 1369-1381. 104 211 ICC, WB; tested species: rat

Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission.
Koo SJ, Kochlamazashvili G, Rost B, Puchkov D, Gimber N, Lehmann M, Tadeus G, Schmoranzer J, Rosenmund C, Haucke V, Maritzen T, et al.
Neuron (2015) 882: 330-44. 104 211 WB; tested species: mouse

Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons.
Grassi D, Plonka FB, Oksdath M, Guil AN, Sosa LJ, Quiroga S
Cell discovery (2015) 1: 15023. 104 211 WB, ICC

SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting.
Zulliger R, Conley SM, Mwoyosvi ML, Stuck MW, Azadi S, Naash MI
PloS one (2015) 109: e0138508. 104 211 WB, IHC

Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice.
Liu Y, Li H, Sugiura Y, Han W, Gallardo G, Khvotchev M, Zhang Y, Kavalali ET, Südhof TC, Lin W
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3533: 11514-31. 104 211 WB

Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss.
Benitez BA, Cairns NJ, Schmidt RE, Morris JC, Norton JB, Cruchaga C, Sands MS
Acta neuropathologica communications (2015) 3: 73. 104 211 WB

Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse.
Chang S, Reim K, Pedersen M, Neher E, Brose N, Taschenberger H
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3521: 8272-90. 104 211 WB

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles.
Bacaj T, Wu D, Burré J, Malenka RC, Liu X, Südhof TC
PLoS biology (2015) 1310: e1002267. 104 211 WB

Vesicular transport system in myotubes: ultrastructural study and signposting with vesicle-associated membrane proteins.
Tajika Y, Takahashi M, Khairani AF, Ueno H, Murakami T, Yorifuji H
Histochemistry and cell biology (2014) 1414: 441-54. 104 211 WB, ICC, EM; tested species: mouse

Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism.
Kioumourtzoglou D, Gould GW, Bryant NJ
Molecular and cellular biology (2014) 347: 1271-9. 104 211 ICC, WB

Vesicle associated membrane protein 8 (VAMP8)-mediated zymogen granule exocytosis is dependent on endosomal trafficking via the constitutive-like secretory pathway.
Messenger SW, Falkowski MA, Thomas DD, Jones EK, Hong W, Gaisano HY, Giasano HY, Boulis NM, Groblewski GE
The Journal of biological chemistry (2014) 28940: 28040-53. 104 211 IHC, WB

Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.
Manca P, Mameli O, Caria MA, Torrejón-Escribano B, Blasi J
Neuroscience (2014) 266: 102-15. 104 211 IHC, EM, WB

KV10.1 opposes activity-dependent increase in Ca2+ influx into the presynaptic terminal of the parallel fibre - Purkinje cell synapse.
Mortensen LS, Schmidt H, Farsi Z, Barrantes-Freer A, Rubio ME, Ufartes R, Eilers J, Sakaba T, Stühmer W, Pardo LA
The Journal of physiology (2014) : . 104 211 WB

BDNF enhances spontaneous and activity-dependent neurotransmitter release at excitatory terminals but not at inhibitory terminals in hippocampal neurons.
Shinoda Y, Ahmed S, Ramachandran B, Bharat V, Brockelt D, Altas B, Dean C
Frontiers in synaptic neuroscience (2014) 6: 27. 104 211 WB, ICC; tested species: rat

Synaptic function of nicastrin in hippocampal neurons.
Lee SH, Sharma M, Südhof TC, Shen J
Proceedings of the National Academy of Sciences of the United States of America (2014) 11124: 8973-8. 104 211 WB; tested species: mouse

SCAMP5 plays a critical role in synaptic vesicle endocytosis during high neuronal activity.
Zhao H, Kim Y, Park J, Park D, Lee SE, Chang I, Chang S
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3430: 10085-95. 104 211 WB; tested species: rat

Calsyntenin-1 regulates targeting of dendritic NMDA receptors and dendritic spine maturation in CA1 hippocampal pyramidal cells during postnatal development.
Ster J, Steuble M, Orlando C, Diep TM, Akhmedov A, Raineteau O, Pernet V, Sonderegger P, Gerber U
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3426: 8716-27. 104 211 WB; tested species: mouse

The SNARE protein vti1a functions in dense-core vesicle biogenesis.
Walter AM, Kurps J, de Wit H, Schöning S, Toft-Bertelsen TL, Lauks J, Ziomkiewicz I, Weiss AN, Schulz A, Fischer von Mollard G, Verhage M, et al.
The EMBO journal (2014) 3315: 1681-97. 104 211 WB, ICC; tested species: mouse

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 104 211 WB, ICC; tested species: rat

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.
Burré J, Sharma M, Südhof TC
Proceedings of the National Academy of Sciences of the United States of America (2014) 11140: E4274-83. 104 211 WB

Mover is a homomeric phospho-protein present on synaptic vesicles.
Ahmed S, Wittenmayer N, Kremer T, Hoeber J, Kiran Akula A, Urlaub H, Islinger M, Kirsch J, Dean C, Dresbach T
PloS one (2013) 85: e63474. 104 211 WB

LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25.
Yun HJ, Park J, Ho DH, Kim H, Kim CH, Oh H, Ga I, Seo H, Chang S, Son I, Seol W, et al.
Experimental & molecular medicine (2013) 45: e36. 104 211 WB; tested species: mouse

Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP.
Kaeser-Woo YJ, Younts TJ, Yang X, Zhou P, Wu D, Castillo PE, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3323: 9769-80. 104 211 WB

Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice.
Yao J, de la Iglesia HO, Bajjalieh SM
PloS one (2013) 87: e68215. 104 211 WB; tested species: mouse

Tumor protein D52 controls trafficking of an apical endolysosomal secretory pathway in pancreatic acinar cells.
Messenger SW, Thomas DD, Falkowski MA, Byrne JA, Gorelick FS, Groblewski GE
American journal of physiology. Gastrointestinal and liver physiology (2013) 3056: G439-52. 104 211 WB, IHC; tested species: rat

Small-scale isolation of synaptic vesicles from mammalian brain.
Ahmed S, Holt M, Riedel D, Jahn R
Nature protocols (2013) 85: 998-1009. 104 211 WB; tested species: mouse

mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.
Wentzel C, Sommer JE, Nair R, Stiefvater A, Sibarita JB, Scheiffele P
Neuron (2013) 786: 1012-23. 104 211 WB; tested species: mouse

Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.
Martineau M, Shi T, Puyal J, Knolhoff AM, Dulong J, Gasnier B, Klingauf J, Sweedler JV, Jahn R, Mothet JP
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 338: 3413-23. 104 211 WB; tested species: rat

Membrane-tethered monomeric neurexin LNS-domain triggers synapse formation.
Gokce O, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3336: 14617-28. 104 211 WB; tested species: mouse

C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosis.
Kaeser-Woo YJ, Yang X, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 328: 2877-85. 104 211 WB; tested species: rat

Tetanus neurotoxin-induced epilepsy in mouse visual cortex.
Mainardi M, Pietrasanta M, Vannini E, Rossetto O, Caleo M
Epilepsia (2012) 537: e132-6. 104 211 WB, ICC; tested species: mouse

Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.
Sadakata T, Sekine Y, Oka M, Itakura M, Takahashi M, Furuichi T
The FEBS journal (2012) 2793: 384-94. 104 211 WB, IP; tested species: mouse

CSPα knockout causes neurodegeneration by impairing SNAP-25 function.
Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Südhof TC
The EMBO journal (2012) 314: 829-41. 104 211 WB; tested species: mouse

Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.
Steuble M, Diep TM, Schätzle P, Ludwig A, Tagaya M, Kunz B, Sonderegger P
Biology open (2012) 18: 761-74. 104 211 WB

Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms.
Oh E, Kalwat MA, Kim MJ, Verhage M, Thurmond DC
The Journal of biological chemistry (2012) 28731: 25821-33. 104 211 WB; tested species: mouse

SV31 is a Zn2+-binding synaptic vesicle protein.
Barth J, Zimmermann H, Volknandt W
Journal of neurochemistry (2011) 1184: 558-70. 104 211 WB

Neurotoxic phospholipases directly affect synaptic vesicle function.
Treppmann P, Brunk I, Afube T, Richter K, Ahnert-Hilger G
Journal of neurochemistry (2011) 1174: 757-64. 104 211 WB; tested species: rat

CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
Sharma M, Burré J, Südhof TC
Nature cell biology (2011) 131: 30-9. 104 211 WB; tested species: mouse

Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation.
Vitureira N, Andrés R, Pérez-Martínez E, Martínez A, Bribián A, Blasi J, Chelliah S, López-Doménech G, De Castro F, Burgaya F, McNagny K, et al.
PloS one (2010) 58: e12003. 104 211 WB

Complexin 2 modulates vesicle-associated membrane protein (VAMP) 2-regulated zymogen granule exocytosis in pancreatic acini.
Falkowski MA, Thomas DD, Groblewski GE
The Journal of biological chemistry (2010) 28546: 35558-66. 104 211 WB, ICC

Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release.
Groffen AJ, Martens S, Díez Arazola R, Cornelisse LN, Lozovaya N, de Jong AP, Goriounova NA, Habets RL, Takai Y, Borst JG, Brose N, et al.
Science (New York, N.Y.) (2010) 3275973: 1614-8. 104 211 WB, ICC; tested species: mouse

CHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complex.
Andreyeva A, Leshchyns'ka I, Knepper M, Betzel C, Redecke L, Sytnyk V, Schachner M
PloS one (2010) 58: e12018. 104 211 WB

Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina.
Morgans CW, Kensel-Hammes P, Hurley JB, Burton K, Idzerda R, McKnight GS, Bajjalieh SM
PloS one (2009) 44: e5230. 104 211 WB; tested species: mouse

Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18.
Camoletto PG, Vara H, Morando L, Connell E, Marletto FP, Giustetto M, Sassoè-Pognetto M, Van Veldhoven PP, Ledesma MD
PloS one (2009) 44: e5310. 104 211 WB; tested species: mouse

Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4.
Reim K, Regus-Leidig H, Ammermüller J, El-Kordi A, Radyushkin K, Ehrenreich H, Brandstätter JH, Brose N
Journal of cell science (2009) 122Pt 9: 1352-61. 104 211 WB, IHC; tested species: mouse

Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms.
Puri N, Roche PA
Proceedings of the National Academy of Sciences of the United States of America (2008) 1057: 2580-5. 104 211 WB; tested species: mouse

Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.
Sander LE, Frank SP, Bolat S, Blank U, Galli T, Bigalke H, Bischoff SC, Lorentz A
European journal of immunology (2008) 383: 855-63. 104 211 WB; tested species: human

Pancreatic acinar cells express vesicle-associated membrane protein 2- and 8-specific populations of zymogen granules with distinct and overlapping roles in secretion.
Weng N, Thomas DD, Groblewski GE
The Journal of biological chemistry (2007) 28213: 9635-45. 104 211 WB, ICC; tested species: rat

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC
Science (New York, N.Y.) (2007) 3185847: 71-6. 104 211 WB; tested species: mouse

Dvl regulates endo- and exocytotic processes through binding to synaptotagmin.
Kishida S, Hamao K, Inoue M, Hasegawa M, Matsuura Y, Mikoshiba K, Fukuda M, Kikuchi A
Genes to cells : devoted to molecular & cellular mechanisms (2007) 121: 49-61. 104 211 WB; tested species: rat

Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease.
Smith R, Klein P, Koc-Schmitz Y, Waldvogel HJ, Faull RL, Brundin P, Plomann M, Li JY
Journal of neurochemistry (2007) 1031: 115-23. 104 211 IHC, WB; tested species: human

Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2.
Yelamanchili SV, Pendyala G, Brunk I, Darna M, Albrecht U, Ahnert-Hilger G
The Journal of biological chemistry (2006) 28123: 15671-9. 104 211 WB; tested species: mouse

Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release.
Ahmad-Annuar A, Ciani L, Simeonidis I, Herreros J, Fredj NB, Rosso SB, Hall A, Brickley S, Salinas PC
The Journal of cell biology (2006) 1741: 127-39. 104 211 WB, ICC; tested species: mouse

Synaptic vesicle chips to assay botulinum neurotoxins.
Ferracci G, Miquelis R, Kozaki S, Seagar M, Lévêque C
The Biochemical journal (2005) 391Pt 3: 659-66. 104 211 WB

Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2005) 956: 1732-45. 104 211 WB; tested species: rat

EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin.
Rüder C, Reimer T, Delgado-Martinez I, Hermosilla R, Engelsberg A, Nehring R, Dörken B, Rehm A
Molecular biology of the cell (2005) 163: 1245-57. 104 211 ICC, WB; tested species: human

Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis.
Knoch KP, Bergert H, Borgonovo B, Saeger HD, Altkrüger A, Verkade P, Solimena M
Nature cell biology (2004) 63: 207-14. 104 211 WB

The synaptophysin/synaptobrevin complex dissociates independently of neuroexocytosis.
Reisinger C, Yelamanchili SV, Hinz B, Mitter D, Becher A, Bigalke H, Ahnert-Hilger G
Journal of neurochemistry (2004) 901: 1-8. 104 211 WB, IP

A common mechanism for the regulation of vesicular SNAREs on phospholipid membranes.
Hu K, Rickman C, Carroll J, Davletov B
The Biochemical journal (2004) 377Pt 3: 781-5. 104 211 WB

Differential distribution of vesicle associated membrane protein isoforms in the mouse retina.
Sherry DM, Wang MM, Frishman LJ
Molecular vision (2003) 9: 673-88. 104 211 WB, IHC

Vesicular localization and activity-dependent trafficking of presynaptic choline transporters.
Ferguson SM, Savchenko V, Apparsundaram S, Zwick M, Wright J, Heilman CJ, Yi H, Levey AI, Blakely RD
The Journal of neuroscience : the official journal of the Society for Neuroscience (2003) 2330: 9697-709. 104 211 WB; tested species: mouse

SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis.
Chamberlain LH, Burgoyne RD, Gould GW
Proceedings of the National Academy of Sciences of the United States of America (2001) 9810: 5619-24. 104 211 WB; tested species: rat

Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 104 211 WB, IHC

Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes.
Redecker P
Cell and tissue research (1996) 2833: 443-54. 104 211 WB, EM, IHC; tested species: rat

Separation of Single Core and Multicore Lytic Granules by Subcellular Fractionation and Immunoisolation.
Schirra C, Alawar N, Becherer U, Chang HF
Methods in molecular biology (Clifton, N.J.) (2023) 2654: 159-167. 104 211 IP; tested species: mouse

The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin.
Hanson PI, Otto H, Barton N, Jahn R
The Journal of biological chemistry (1995) 27028: 16955-61. 104 211 IP

Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer's disease-relevant brain circuits.
Perdok A, Van Acker ZP, Vrancx C, Sannerud R, Vorsters I, Verrengia A, Callaerts-Végh Z, Creemers E, Gutiérrez Fernández S, D'hauw B, Serneels L, et al.
Nature communications (2024) 151: 10412. 104 211 ICC; tested species: mouse

Reduced synaptic depression in human neurons carrying homozygous disease-causing STXBP1 variant L446F.
Öttl M, Toonen RF, Verhage M
Human molecular genetics (2024) : . 104 211 ICC; tested species: stem cells

Apache is a neuronal player in autophagy required for retrograde axonal transport of autophagosomes.
Parisi B, Esposito A, Castroflorio E, Bramini M, Pepe S, Marte A, Guarnieri FC, Valtorta F, Baldelli P, Benfenati F, Fassio A, et al.
Cellular and molecular life sciences : CMLS (2024) 811: 416. 104 211 ICC; tested species: mouse

Actomyosin-mediated inhibition of synaptic vesicle release under CB1R activation.
McFadden MH, Emeritt MB, Xu H, Cui Y, Leterrier C, Zala D, Venance L, Lenkei Z
Translational psychiatry (2024) 141: 335. 104 211 ICC; tested species: rat

Improving morphological and functional properties of enteric neuronal networks in vitro using a novel upside-down culture approach.
Schulte S, Decker D, Nowduri B, Gries M, Christmann A, Meyszner A, Rabe H, Saumer M, Schäfer KH
American journal of physiology. Gastrointestinal and liver physiology (2024) : . 104 211 ICC, IHC; tested species: mouse

Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons.
Watson ET, Pauers MM, Seibert MJ, Vevea JD, Chapman ER
eLife (2023) 12: . 104 211 ICC, WB

Ketamine Reduces the Surface Density of the Astroglial Kir4.1 Channel and Inhibits Voltage-Activated Currents in a Manner Similar to the Action of Ba2+ on K+ Currents.
Božić M, Pirnat S, Fink K, Potokar M, Kreft M, Zorec R, Stenovec M
Cells (2023) 1210: . 104 211 ICC; tested species: rat

AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release.
Ramsay HJ, Gookin SE, Ramsey AM, Kareemo DJ, Crosby KC, Stich DG, Olah SS, Actor-Engel HS, Smith KR, Kennedy MJ
Frontiers in molecular neuroscience (2023) 16: 1232795. 104 211 ICC; tested species: rat

Presynapses contain distinct actin nanostructures.
Bingham D, Jakobs CE, Wernert F, Boroni-Rueda F, Jullien N, Schentarra EM, Friedl K, Da Costa Moura J, van Bommel DM, Caillol G, Ogawa Y, et al.
The Journal of cell biology (2023) 22210: . 104 211 ICC; tested species: rat

Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses.
Song SH, Augustine GJ
Cell reports (2023) 428: 113004. 104 211 ICC; tested species: mouse

Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles.
Longfield SF, Mollazade M, Wallis TP, Gormal RS, Joensuu M, Wark JR, van Waardenberg AJ, Small C, Graham ME, Meunier FA, Martínez-Mármol R, et al.
Nature communications (2023) 141: 7277. 104 211 ICC; tested species: mouse

Dynamin is primed at endocytic sites for ultrafast endocytosis.
Imoto Y, Raychaudhuri S, Ma Y, Fenske P, Sandoval E, Itoh K, Blumrich EM, Matsubayashi HT, Mamer L, Zarebidaki F, Söhl-Kielczynski B, et al.
Neuron (2022) 11017: 2815-2835.e13. 104 211 ICC; tested species: mouse

Dually innervated dendritic spines develop in the absence of excitatory activity and resist plasticity through tonic inhibitory crosstalk.
Kleinjan MS, Buchta WC, Ogelman R, Hwang IW, Kuwajima M, Hubbard DD, Kareemo DJ, Prikhodko O, Olah SL, Gomez Wulschner LE, Abraham WC, et al.
Neuron (2022) : . 104 211 ICC; tested species: mouse

α-Synuclein induced cholesterol lowering increases tonic and reduces depolarization-evoked synaptic vesicle recycling and glutamate release.
Lazarevic V, Yang Y, Paslawski W, Svenningsson P
NPJ Parkinson's disease (2022) 81: 71. 104 211 ICC; tested species: mouse

FEZ1 forms complexes with CRMP1 and DCC to regulate axon and dendrite development.
Chua JY, Ng SJ, Yagensky O, Wanker EE, Chua JJE
eNeuro (2021) : . 104 211 ICC; tested species: rat

Single synapse glutamate imaging reveals multiple levels of release mode regulation in mammalian synapses.
Farsi Z, Walde M, Klementowicz AE, Paraskevopoulou F, Woehler A
iScience (2021) 241: 101909. 104 211 ICC; tested species: rat

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak G, Rybak-Wolf A, Lisowski P, Pentimalli TM, Jüttner R, Glažar P, Uppal K, Bottani E, Brunetti D, Secker C, Zink A, et al.
Nature communications (2021) 121: 1929. 104 211 ICC; tested species: human

The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons.
Mori Y, Takenaka KI, Fukazawa Y, Takamori S
Communications biology (2021) 41: 981. 104 211 ICC; tested species: mouse

Novel vertebrate- and brain-specific driver of neuronal outgrowth.
Jansen EJR, van Bakel NHM, Benedict B, Olde Loohuis NFM, Hafmans TGM, Chim SM, Xu J, Kolk SM, Martens GJM
Progress in neurobiology (2021) 202: 102069. 104 211 ICC; tested species: mouse

Distinct Expression of SLM2 Underlies Splicing-Dependent Trans-Synaptic Signaling of Neurexin Across GABAergic Neuron Subtypes.
Sato Y, Iijima Y, Darwish M, Sato T, Iijima T
Neurochemical research (2021) : . 104 211 ICC; tested species: mouse

Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release.
Dhara M, Mantero Martinez M, Makke M, Schwarz Y, Mohrmann R, Bruns D
eLife (2020) 9: . 104 211 ICC; KO verified; tested species: mouse

Post-tetanic potentiation lowers the energy barrier for synaptic vesicle fusion independently of Synaptotagmin-1.
Huson V, Meijer M, Dekker R, Ter Veer M, Ruiter M, van Weering JR, Verhage M, Cornelisse LN
eLife (2020) 9: . 104 211 ICC; tested species: mouse

Astrocyte Specific Remodeling of Plasmalemmal Cholesterol Composition by Ketamine Indicates a New Mechanism of Antidepressant Action.
Lasič E, Lisjak M, Horvat A, Božić M, Šakanović A, Anderluh G, Verkhratsky A, Vardjan N, Jorgačevski J, Stenovec M, Zorec R, et al.
Scientific reports (2019) 91: 10957. 104 211 ICC; tested species: rat

A connection between reversible tyrosine phosphorylation and SNARE complex-disassembly activity of N-ethylmaleimide-sensitive factor unveiled by the phosphomimetic mutant N-ethylmaleimide-sensitive factor-Y83E.
Ruete MC, Zarelli VEP, Masone D, Paola M, Bustos DM, Tomes CN
Molecular human reproduction (2019) : . 104 211 ICC; tested species: human

Synaptobrevin-2 C-Terminal Flexible Region Regulates the Discharge of Catecholamine Molecules.
Weiss AN
Biophysical journal (2019) 1165: 921-929. 104 211 ICC; KO verified; tested species: mouse

A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function.
Lin AY, Henry S, Reissner C, Neupert C, Kenny C, Missler M, Beffert U, Ho A
Scientific reports (2019) 91: 6024. 104 211 ICC; tested species: mouse

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage.
Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, et al.
Nature communications (2019) 101: 53. 104 211 ICC; tested species: mouse

VPS35 depletion does not impair presynaptic structure and function.
Vazquez-Sanchez S, Bobeldijk S, Dekker MP, van Keimpema L, van Weering JRT
Scientific reports (2018) 81: 2996. 104 211 ICC; tested species: mouse

Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.
Emperador-Melero J, Huson V, van Weering J, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M
Nature communications (2018) 91: 3421. 104 211 ICC; tested species: mouse

The Transmembrane Domain of Synaptobrevin Influences Neurotransmitter Flux Through Synaptic Fusion Pores.
Chiang CW, Chang CW, Jackson MB
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 104 211 ICC; KO verified; tested species: mouse

Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly.
Meijer M, Dörr B, Lammertse HC, Blithikioti C, van Weering JR, Toonen RF, Söllner TH, Verhage M
The EMBO journal (2018) 372: 300-320. 104 211 ICC; tested species: mouse

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Trepte P, Kruse S, Kostova S, Hoffmann S, Buntru A, Tempelmeier A, Secker C, Diez L, Schulz A, Klockmeier K, Zenkner M, et al.
Molecular systems biology (2018) 147: e8071. 104 211 ICC; tested species: mouse

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.
Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, et al.
Nature communications (2018) 91: 712. 104 211 ICC; tested species: rat

Vesicular nucleotide transporter mediates ATP release and migration in neutrophils.
Harada Y, Kato Y, Miyaji T, Omote H, Moriyama Y, Hiasa M
The Journal of biological chemistry (2018) : . 104 211 ICC; tested species: mouse

Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy.
Kovacevic J, Maroteaux G, Schut D, Loos M, Dubey M, Pitsch J, Remmelink E, Koopmans B, Crowley J, Cornelisse LN, Sullivan PF, et al.
Brain : a journal of neurology (2018) : . 104 211 ICC; tested species: mouse

Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.
Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, et al.
The EMBO journal (2018) 371: 139-159. 104 211 ICC; tested species: mouse

Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.
Houy S, Groffen AJ, Ziomkiewicz I, Verhage M, Pinheiro PS, Sørensen JB
eLife (2017) 6: . 104 211 ICC; tested species: mouse

The Atypical Receptor CCRL2 (C-C Chemokine Receptor-Like 2) Does Not Act As a Decoy Receptor in Endothelial Cells.
Mazzotti C, Gagliostro V, Bosisio D, Del Prete A, Tiberio L, Thelen M, Sozzani S
Frontiers in immunology (2017) 8: 1233. 104 211 ICC

Redistribution of soluble N-ethylmaleimide-sensitive-factor attachment protein receptors in mouse sperm membranes prior to the acrosome reaction.
Sharif M, Silva E, Shah STA, Miller DJ
Biology of reproduction (2017) 962: 352-365. 104 211 ICC

A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 104 211 ICC

Dynamin regulates the fusion pore of endo- and exocytotic vesicles as revealed by membrane capacitance measurements.
Lasič E, Stenovec M, Kreft M, Robinson PJ, Zorec R
Biochimica et biophysica acta (2017) 18619: 2293-2303. 104 211 ICC; tested species: rat

ENA/VASP proteins regulate exocytosis by mediating myosin VI-dependent recruitment of secretory granules to the cortical actin network.
Tomatis VM, Josh P, Papadopulos A, Gormal RS, Lanoue V, Martin S, Meunier FA
Molecular and cellular neurosciences (2017) 84: 100-111. 104 211 ICC; tested species: rat

Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.
Geerts CJ, Mancini R, Chen N, Koopmans FTW, Li KW, Smit AB, van Weering JRT, Verhage M, Groffen AJA
PloS one (2017) 127: e0180912. 104 211 ICC; tested species: mouse

Human autoantibodies to amphiphysin induce defective presynaptic vesicle dynamics and composition.
Werner C, Pauli M, Doose S, Weishaupt A, Haselmann H, Grünewald B, Sauer M, Heckmann M, Toyka KV, Asan E, Sommer C, et al.
Brain : a journal of neurology (2016) 139Pt 2: 365-79. 104 211 ICC; tested species: rat

Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion.
Chang CW, Chiang CW, Gaffaney JD, Chapman ER, Jackson MB
The Journal of biological chemistry (2016) 2916: 2848-57. 104 211 ICC; KO verified

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.
Murdoch JD, Rostosky CM, Gowrisankaran S, Arora AS, Soukup SF, Vidal R, Capece V, Freytag S, Fischer A, Verstreken P, Bonn S, et al.
Cell reports (2016) 174: 1071-1086. 104 211 ICC; tested species: mouse

Intracellular TRPA1 mediates Ca2+ release from lysosomes in dorsal root ganglion neurons.
Shang S, Zhu F, Liu B, Chai Z, Wu Q, Hu M, Wang Y, Huang R, Zhang X, Wu X, Sun L, et al.
The Journal of cell biology (2016) 2153: 369-381. 104 211 ICC; tested species: mouse

CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.
Farina M, van de Bospoort R, He E, Persoon CM, van Weering JR, Broeke JH, Verhage M, Toonen RF
eLife (2015) 4: . 104 211 ICC

Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive.
Williams MR, DeSpenza T, Li M, Gulledge AT, Luikart BW
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 353: 943-59. 104 211 ICC; tested species: mouse

A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores.
Chang CW, Hui E, Bai J, Bruns D, Chapman ER, Jackson MB
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3514: 5772-80. 104 211 ICC

Astrocyte VAMP3 vesicles undergo Ca2+ -independent cycling and modulate glutamate transporter trafficking.
Li D, Hérault K, Zylbersztejn K, Lauterbach MA, Guillon M, Oheim M, Ropert N
The Journal of physiology (2015) 59313: 2807-32. 104 211 ICC

The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis.
Shen C, Rathore SS, Yu H, Gulbranson DR, Hua R, Zhang C, Schoppa NE, Shen J
Nature communications (2015) 6: 8852. 104 211 ICC; KD verified; tested species: mouse

Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences.
Giniatullina A, Maroteaux G, Geerts CJ, Koopmans B, Loos M, Klaassen R, Chen N, van der Schors RC, van Nierop P, Li KW, de Jong J, et al.
Neuroscience (2015) 300: 518-38. 104 211 ICC

Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism.
Kioumourtzoglou D, Gould GW, Bryant NJ
Molecular and cellular biology (2014) 347: 1271-9. 104 211 ICC, WB

Atoxic derivative of botulinum neurotoxin A as a prototype molecular vehicle for targeted delivery to the neuronal cytoplasm.
Vazquez-Cintron EJ, Vakulenko M, Band PA, Stanker LH, Johnson EA, Ichtchenko K
PloS one (2014) 91: e85517. 104 211 ICC; tested species: rat

A new probe for super-resolution imaging of membranes elucidates trafficking pathways.
Revelo NH, Kamin D, Truckenbrodt S, Wong AB, Reuter-Jessen K, Reisinger E, Moser T, Rizzoli SO
The Journal of cell biology (2014) 2054: 591-606. 104 211 ICC

Identification of a mammalian vesicular polyamine transporter.
Hiasa M, Miyaji T, Haruna Y, Takeuchi T, Harada Y, Moriyama S, Yamamoto A, Omote H, Moriyama Y
Scientific reports (2014) 4: 6836. 104 211 ICC; tested species: mouse,rat

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC
The Journal of cell biology (2013) 2016: 915-28. 104 211 ICC; tested species: rat

Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356× mutation in synapsin I.
Giannandrea M, Guarnieri FC, Gehring NH, Monzani E, Benfenati F, Kulozik AE, Valtorta F
PloS one (2013) 86: e67724. 104 211 ICC; tested species: rat

Asymmetric N-cadherin expression results in synapse dysfunction, synapse elimination, and axon retraction in cultured mouse neurons.
Pielarski KN, van Stegen B, Andreyeva A, Nieweg K, Jüngling K, Redies C, Gottmann K
PloS one (2013) 81: e54105. 104 211 ICC; tested species: mouse

Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release.
Pinheiro PS, de Wit H, Walter AM, Groffen AJ, Verhage M, Sørensen JB
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3342: 16459-70. 104 211 ICC

Tetanus toxin and botulinum toxin a utilize unique mechanisms to enter neurons of the central nervous system.
Blum FC, Chen C, Kroken AR, Barbieri JT
Infection and immunity (2012) 805: 1662-9. 104 211 ICC

Munc18-1 controls SNARE protein complex assembly during human sperm acrosomal exocytosis.
Rodríguez F, Zanetti MN, Mayorga LS, Tomes CN
The Journal of biological chemistry (2012) 28752: 43825-39. 104 211 ICC; tested species: human

Tetanus neurotoxin-induced epilepsy in mouse visual cortex.
Mainardi M, Pietrasanta M, Vannini E, Rossetto O, Caleo M
Epilepsia (2012) 537: e132-6. 104 211 WB, ICC; tested species: mouse

Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system.
Zheng L, Cedazo-Minguez A, Hallbeck M, Jerhammar F, Marcusson J, Terman A
Translational neurodegeneration (2012) 11: 19. 104 211 ICC; tested species: human

SV2 mediates entry of tetanus neurotoxin into central neurons.
Yeh FL, Dong M, Yao J, Tepp WH, Lin G, Johnson EA, Chapman ER
PLoS pathogens (2010) 611: e1001207. 104 211 ICC; tested species: rat

Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation.
Stan A, Pielarski KN, Brigadski T, Wittenmayer N, Fedorchenko O, Gohla A, Lessmann V, Dresbach T, Gottmann K
Proceedings of the National Academy of Sciences of the United States of America (2010) 10724: 11116-21. 104 211 ICC; tested species: mouse

Synaptic membrane proteins form stable microdomains in early endosomes.
Geumann U, Schäfer C, Riedel D, Jahn R, Rizzoli SO
Microscopy research and technique (2010) 736: 606-17. 104 211 ICC

A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing.
Jiang X, Litkowski PE, Taylor AA, Lin Y, Snider BJ, Moulder KL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 305: 1798-809. 104 211 ICC

Schwann cells modulate short-term plasticity of cholinergic autaptic synapses.
Perez-Gonzalez AP, Albrecht D, Blasi J, Llobet A
The Journal of physiology (2008) 58619: 4675-91. 104 211 ICC; tested species: rat

CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.
Jockusch WJ, Speidel D, Sigler A, Sørensen JB, Varoqueaux F, Rhee JS, Brose N
Cell (2007) 1314: 796-808. 104 211 ICC

Dynamics of SNARE assembly and disassembly during sperm acrosomal exocytosis.
De Blas GA, Roggero CM, Tomes CN, Mayorga LS
PLoS biology (2005) 310: e323. 104 211 ICC; tested species: human

Morphological and molecular heterogeneity in release sites of single neurons.
Morgenthaler FD, Knott GW, Floyd Sarria JC, Wang X, Staple JK, Catsicas S, Hirling H
The European journal of neuroscience (2003) 177: 1365-74. 104 211 ICC

The existence of cells exhibiting characteristics of both Type II and Type III cells in rat taste buds. An immunohistochemical and electron-microscopic study.
Inoko S, Katagiri H, Tsujimura M, Yoshie S
Odontology (2024) : . 104 211 IHC; tested species: rat

Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain.
Singh V, Menard MA, Serrano GE, Beach TG, Zhao HT, Riley-DiPaolo A, Subrahmanian N, LaVoie MJ, Volpicelli-Daley LA
Acta neuropathologica communications (2023) 111: 201. 104 211 IHC; tested species: human,mouse

Proteomic analysis reveals the composition of glutamatergic organelles of auditory inner hair cell.
Cepeda AP, Ninov M, Neef J, Parfentev I, Kusch K, Reisinger E, Jahn R, Moser T, Urlaub H
Molecular & cellular proteomics : MCP (2023) : 100704. 104 211 IHC; tested species: mouse

Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells.
Jun S, Kim M, Park H, Hwang E, Yamamoto Y, Tanaka-Yamamoto K
Cell reports (2023) 429: 113137. 104 211 IHC; tested species: mouse

Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus.
Fabris F, Varani S, Tonellato M, Matak I, Šoštarić P, Meglić P, Caleo M, Megighian A, Rossetto O, Montecucco C, Pirazzini M, et al.
JCI insight (2023) 811: . 104 211 IHC; tested species: mouse,rat

Functional neuronal circuitry and oscillatory dynamics in human brain organoids.
Sharf T, van der Molen T, Glasauer SMK, Guzman E, Buccino AP, Luna G, Cheng Z, Audouard M, Ranasinghe KG, Kudo K, Nagarajan SS, et al.
Nature communications (2022) 131: 4403. 104 211 IHC; tested species: human

Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission.
Imamura Y, Okuzumi A, Yoshinaga S, Hiyama A, Furukawa Y, Miyasaka T, Hattori N, Nukina N
Communications biology (2022) 51: 636. 104 211 IHC; tested species: mouse

Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention.
Vignoli B, Sansevero G, Sasi M, Rimondini R, Blum R, Bonaldo V, Biasini E, Santi S, Berardi N, Lu B, Canossa M, et al.
Communications biology (2021) 41: 1152. 104 211 IHC; tested species: mouse

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo.
Shi Y, Sun L, Wang M, Liu J, Zhong S, Li R, Li P, Guo L, Fang A, Chen R, Ge WP, et al.
PLoS biology (2020) 185: e3000705. 104 211 IHC; tested species: mouse

Spinal Motoneuron TMEM16F Acts at C-boutons to Modulate Motor Resistance and Contributes to ALS Pathogenesis.
Soulard C, Salsac C, Mouzat K, Hilaire C, Roussel J, Mezghrani A, Lumbroso S, Raoul C, Scamps F
Cell reports (2020) 308: 2581-2593.e7. 104 211 IHC; tested species: mouse

Inputs from Sequentially Developed Parallel Fibers Are Required for Cerebellar Organization.
Park H, Kim T, Kim J, Yamamoto Y, Tanaka-Yamamoto K
Cell reports (2019) 2811: 2939-2954.e5. 104 211 IHC; tested species: mouse

Ablation of all synaptobrevin vSNAREs blocks evoked but not spontaneous neurotransmitter release at neuromuscular synapses.
Liu Y, Sugiura Y, Südhof TC, Lin W
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 104 211 IHC; KO verified; tested species: mouse

GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing.
Wolter S, Möhrle D, Schmidt H, Pfeiffer S, Zelle D, Eckert P, Krämer M, Feil R, Pilz PKD, Knipper M, Rüttiger L, et al.
Frontiers in neural circuits (2018) 12: 65. 104 211 IHC; tested species: mouse

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity.
Barthet G, Jordà-Siquier T, Rumi-Masante J, Bernadou F, Müller U, Mulle C
Nature communications (2018) 91: 4780. 104 211 IHC; tested species: mouse

Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission.
Sando R, Bushong E, Zhu Y, Huang M, Considine C, Phan S, Ju S, Uytiepo M, Ellisman M, Maximov A
Neuron (2017) 942: 312-321.e3. 104 211 IHC; tested species: mouse

Immunohistochemical localization of SNARE core proteins in intrapulpal and intradentinal nerve fibers of rat molar teeth.
Honma S, Kadono K, Kawano A, Wakisaka S
Archives of oral biology (2017) 73: 248-252. 104 211 IHC

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.
Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, et al.
Nature neuroscience (2017) 202: 176-188. 104 211 IHC

SPARC triggers a cell-autonomous program of synapse elimination.
López-Murcia FJ, Terni B, Llobet A
Proceedings of the National Academy of Sciences of the United States of America (2015) 11243: 13366-71. 104 211 IHC

Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.
Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M, et al.
PLoS pathogens (2014) 107: e1004177. 104 211 IHC; tested species: mouse

Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.
Cijsouw T, Weber JP, Broeke JH, Broek JA, Schut D, Kroon T, Saarloos I, Verhage M, Toonen RF
The Journal of cell biology (2014) 2045: 759-75. 104 211 IHC; tested species: mouse

The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration.
Hoshino S, Sakamoto K, Vassilopoulos S, Camus SM, Griffin CA, Esk C, Torres JA, Ohkoshi N, Ishii A, Tamaoka A, Funke BH, et al.
PloS one (2013) 810: e77787. 104 211 IHC; tested species: human,muscle

Development of axon-target specificity of ponto-cerebellar afferents.
Kalinovsky A, Boukhtouche F, Blazeski R, Bornmann C, Suzuki N, Mason CA, Scheiffele P
PLoS biology (2011) 92: e1001013. 104 211 IHC; tested species: mouse

SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1.
Iijima T, Wu K, Witte H, Hanno-Iijima Y, Glatter T, Richard S, Scheiffele P
Cell (2011) 1477: 1601-14. 104 211 IHC; tested species: mouse

VAMP2 is expressed in myogenic cells during rat development.
Tajika Y, Murakami T, Sato M, Kubota F, Yorifuji H
Developmental dynamics : an official publication of the American Association of Anatomists (2008) 2377: 1886-92. 104 211 IHC; tested species: rat

Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen.
Johnson PT, Brown MN, Pulliam BC, Anderson DH, Johnson LV
Investigative ophthalmology & visual science (2005) 4612: 4788-95. 104 211 IHC

Brain synaptic junctional proteins at the acrosome of rat testicular germ cells.
Redecker P, Kreutz MR, Bockmann J, Gundelfinger ED, Boeckers TM
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (2003) 516: 809-19. 104 211 IHC

Differential distribution of vesicle associated membrane protein isoforms in the mouse retina.
Sherry DM, Wang MM, Frishman LJ
Molecular vision (2003) 9: 673-88. 104 211 WB, IHC

Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes.
Redecker P
Cell and tissue research (1996) 2833: 443-54. 104 211 WB, EM, IHC; tested species: rat

APP accumulates with presynaptic proteins around amyloid plaques: A role for presynaptic mechanisms in Alzheimer's disease?
Jordà-Siquier T, Petrel M, Kouskoff V, Smailovic U, Cordelières F, Frykman S, Müller U, Mulle C, Barthet G
Alzheimer's & dementia : the journal of the Alzheimer's Association (2022) : . 104 211 IHC-P; tested species: human

Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease.
Haytural H, Jordà-Siquier T, Winblad B, Mulle C, Tjernberg LO, Granholm AC, Frykman S, Barthet G
Brain communications (2021) 32: fcab079. 104 211 IHC-P; tested species: human

Spatial proteomics in neurons at single-protein resolution.
Unterauer EM, Shetab Boushehri S, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, et al.
Cell (2024) 1877: 1785-1800.e16. 104 211 DNA-PAINT; tested species: rat

Cytosolic prion protein in neurons.
Mironov A, Latawiec D, Wille H, Bouzamondo-Bernstein E, Legname G, Williamson RA, Burton D, DeArmond SJ, Prusiner SB, Peters PJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2003) 2318: 7183-93. 104 211 EM; tested species: mouse

Insulin recruits GLUT4 from specialized VAMP2-carrying vesicles as well as from the dynamic endosomal/trans-Golgi network in rat adipocytes.
Ramm G, Slot JW, James DE, Stoorvogel W
Molecular biology of the cell (2000) 1112: 4079-91. 104 211 EM

Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes.
Redecker P
Cell and tissue research (1996) 2833: 443-54. 104 211 WB, EM, IHC; tested species: rat

Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 104 211 ELISA

Endosomal sorting of readily releasable synaptic vesicles.
Hoopmann P, Punge A, Barysch SV, Westphal V, Bückers J, Opazo F, Bethani I, Lauterbach MA, Hell SW, Rizzoli SO
Proceedings of the National Academy of Sciences of the United States of America (2010) 10744: 19055-60. 104 211

Cat. No.: 104 211

Amount: 50 µg

Price: $430.00

Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons.
Watson ET, Pauers MM, Seibert MJ, Vevea JD, Chapman ER
eLife (2023) 12: . 104 211 ICC, WB

LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.
Sclip A, Südhof TC
eLife (2020) 9: . 104 211 WB; tested species: mouse

Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates.
Wu X, Ganzella M, Zhou J, Zhu S, Jahn R, Zhang M
Molecular cell (2020) : . 104 211 WB

How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
Acuna C, Liu X, Südhof TC
Neuron (2016) 914: 792-807. 104 211 WB

Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism.
Kioumourtzoglou D, Gould GW, Bryant NJ
Molecular and cellular biology (2014) 347: 1271-9. 104 211 ICC, WB

Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice.
Yao J, de la Iglesia HO, Bajjalieh SM
PloS one (2013) 87: e68215. 104 211 WB; tested species: mouse

Small-scale isolation of synaptic vesicles from mammalian brain.
Ahmed S, Holt M, Riedel D, Jahn R
Nature protocols (2013) 85: 998-1009. 104 211 WB; tested species: mouse

Tetanus neurotoxin-induced epilepsy in mouse visual cortex.
Mainardi M, Pietrasanta M, Vannini E, Rossetto O, Caleo M
Epilepsia (2012) 537: e132-6. 104 211 WB, ICC; tested species: mouse

SV31 is a Zn2+-binding synaptic vesicle protein.
Barth J, Zimmermann H, Volknandt W
Journal of neurochemistry (2011) 1184: 558-70. 104 211 WB

CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
Sharma M, Burré J, Südhof TC
Nature cell biology (2011) 131: 30-9. 104 211 WB; tested species: mouse

Synaptic vesicle chips to assay botulinum neurotoxins.
Ferracci G, Miquelis R, Kozaki S, Seagar M, Lévêque C
The Biochemical journal (2005) 391Pt 3: 659-66. 104 211 WB

A common mechanism for the regulation of vesicular SNAREs on phospholipid membranes.
Hu K, Rickman C, Carroll J, Davletov B
The Biochemical journal (2004) 377Pt 3: 781-5. 104 211 WB

Differential distribution of vesicle associated membrane protein isoforms in the mouse retina.
Sherry DM, Wang MM, Frishman LJ
Molecular vision (2003) 9: 673-88. 104 211 WB, IHC

Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes.
Redecker P
Cell and tissue research (1996) 2833: 443-54. 104 211 WB, EM, IHC; tested species: rat

Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons.
Watson ET, Pauers MM, Seibert MJ, Vevea JD, Chapman ER
eLife (2023) 12: . 104 211 ICC, WB

Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses.
Song SH, Augustine GJ
Cell reports (2023) 428: 113004. 104 211 ICC; tested species: mouse

FEZ1 forms complexes with CRMP1 and DCC to regulate axon and dendrite development.
Chua JY, Ng SJ, Yagensky O, Wanker EE, Chua JJE
eNeuro (2021) : . 104 211 ICC; tested species: rat

Synaptobrevin-2 C-Terminal Flexible Region Regulates the Discharge of Catecholamine Molecules.
Weiss AN
Biophysical journal (2019) 1165: 921-929. 104 211 ICC; KO verified; tested species: mouse

Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism.
Kioumourtzoglou D, Gould GW, Bryant NJ
Molecular and cellular biology (2014) 347: 1271-9. 104 211 ICC, WB

Tetanus neurotoxin-induced epilepsy in mouse visual cortex.
Mainardi M, Pietrasanta M, Vannini E, Rossetto O, Caleo M
Epilepsia (2012) 537: e132-6. 104 211 WB, ICC; tested species: mouse

SV2 mediates entry of tetanus neurotoxin into central neurons.
Yeh FL, Dong M, Yao J, Tepp WH, Lin G, Johnson EA, Chapman ER
PLoS pathogens (2010) 611: e1001207. 104 211 ICC; tested species: rat

Synaptic membrane proteins form stable microdomains in early endosomes.
Geumann U, Schäfer C, Riedel D, Jahn R, Rizzoli SO
Microscopy research and technique (2010) 736: 606-17. 104 211 ICC

CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.
Jockusch WJ, Speidel D, Sigler A, Sørensen JB, Varoqueaux F, Rhee JS, Brose N
Cell (2007) 1314: 796-808. 104 211 ICC

Dynamics of SNARE assembly and disassembly during sperm acrosomal exocytosis.
De Blas GA, Roggero CM, Tomes CN, Mayorga LS
PLoS biology (2005) 310: e323. 104 211 ICC; tested species: human

Differential distribution of vesicle associated membrane protein isoforms in the mouse retina.
Sherry DM, Wang MM, Frishman LJ
Molecular vision (2003) 9: 673-88. 104 211 WB, IHC

Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes.
Redecker P
Cell and tissue research (1996) 2833: 443-54. 104 211 WB, EM, IHC; tested species: rat

ICC

IHC

IHC-P

Background

Synaptobrevins/VAMPs represents a family of integral membrane proteins of 11-13 kDa with the N-terminal region exposed to the cytoplasm and a C-terminal transmembrane domain. Two isoforms were identified in the mammalian CNS, synaptobrevin1 (VAMP1 or p18-1) and synaptobrevin2 (VAMP2 or p18-2) that differ in their distribution within different brain regions.
Synaptobrevin1 is highly conserved between vertebrates and invertebrates. It is a major constituent of synaptic vesicles and peptidergic secretory granules in all neurons examined so far. In addition, it is present on secretory granules of neuroendocrine cells. Low levels of synaptobrevin2 are present in many other tissues where the protein resides on specialized microvesicles.
In non-neuronal cells the third isoform, cellubrevin (VAMP3), is present where it is localized to an endosomal membrane pool.
Synaptobrevin/VAMP is an essential component of the exocytotic fusion machine, related to a larger protein family referred to as v-SNAREs. It is the sole target for tetanus and several of the botulinal neurotoxins which cleave the protein at single sites in the C-terminal portion of the molecule.

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Protocols

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Membrane proteins

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Synaptobrevin2 antibody - 104 211 K.O.

References for Synaptobrevin2 - 104 211