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Synaptophysin 1 - 101 006

Major synaptic vesicle membrane protein; neuroendocrine tumor marker
Polyclonal chicken IgY fraction
Cat. No.: 101 006
Amount: 200 µl
Price: $350.00
Cat. No. 101 006 200 µl antibody, lyophilized. Albumin was added for stabilization. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 301 to 313 from human Synaptophysin1 (UniProt Id: P08247)
Reactivity Reacts with: human (P08247), rat (P07825), mouse (Q62277).
Other species not tested yet.
Specificity Specific for synaptophysin 1, no cross-reactivity to other synaptophysins.
Matching control protein/peptide 101-0P
Data sheet 101_006.pdf

References for Synaptophysin 1 - 101 006

Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, et al.
Frontiers in immunology (2020) 11: 599771. 101 006 ICC, IHC; tested species: mouse
Modulating electrophysiology of motor neural networks via optogenetic stimulation during neurogenesis and synaptogenesis.
Pagan-Diaz GJ, Drnevich J, Ramos-Cruz KP, Sam R, Sengupta P, Bashir R
Scientific reports (2020) 101: 12460. 101 006 ICC; tested species: mouse
High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.
Parker SS, Moutal A, Cai S, Chandrasekaran S, Roman MR, Koshy AA, Khanna R, Zinsmaier KE, Mouneimne G
eNeuro () 55: . 101 006 ICC; tested species: mouse
Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer's disease animal model.
Györffy BA, Tóth V, Török G, Gulyássy P, Kovács RÁ, Vadászi H, Micsonai A, Tóth ME, Sántha M, Homolya L, Drahos L, et al.
Cellular and molecular life sciences : CMLS (2020) : . 101 006 IHC; tested species: mouse
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, et al.
Frontiers in immunology (2020) 11: 599771. 101 006 ICC, IHC; tested species: mouse
Cat. No.: 101 006
Quantity: 200 µl
Price: $350.00
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, et al.
Frontiers in immunology (2020) 11: 599771. 101 006 ICC, IHC; tested species: mouse
Modulating electrophysiology of motor neural networks via optogenetic stimulation during neurogenesis and synaptogenesis.
Pagan-Diaz GJ, Drnevich J, Ramos-Cruz KP, Sam R, Sengupta P, Bashir R
Scientific reports (2020) 101: 12460. 101 006 ICC; tested species: mouse
High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.
Parker SS, Moutal A, Cai S, Chandrasekaran S, Roman MR, Koshy AA, Khanna R, Zinsmaier KE, Mouneimne G
eNeuro () 55: . 101 006 ICC; tested species: mouse
Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer's disease animal model.
Györffy BA, Tóth V, Török G, Gulyássy P, Kovács RÁ, Vadászi H, Micsonai A, Tóth ME, Sántha M, Homolya L, Drahos L, et al.
Cellular and molecular life sciences : CMLS (2020) : . 101 006 IHC; tested species: mouse
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, et al.
Frontiers in immunology (2020) 11: 599771. 101 006 ICC, IHC; tested species: mouse
Background

Synaptophysin 1, also referred to as p38-1, is a membrane glycoprotein of synaptic vesicles that is ubiquitously expressed in all neurons and in many endocrine cells. It is currently the most widely used marker for nerve terminals and probably the best marker for the pathologist in differentiating neuroendocrine tumors.
Synaptophysin 1 has four transmembrane domains with both N- and C-terminus facing the cytoplasm. It binds to synaptobrevin 1 and synaptobrevin 2 in detergent extracts but its function has not been elucidated completely. It forms a complex with dynamin at high Ca2+ concentration suggesting an involvement in synaptic vesicle endocytosis. As typical for synaptic vesicle proteins, synaptophysin 1 represents a small protein family with two additonal members, synaptoporin (synaptophysin 2) and panthophysin. Like synaptophysin 1, synaptoporin is widely expressed in neurons and colocalizes with synaptophysin 1 on synaptic vesicles whereas panthophysin is expressed in all tissues.