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Synaptophysin 1 - 101 002

Major synaptic vesicle membrane protein; neuroendocrine tumor marker
Polyclonal rabbit antiserum
Cat. No.: 101 002
Amount: 200 µl
Price: $375.00
Cat. No. 101 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 10000 (AP staining) gallery  
IP: yes
ICC: 1 : 100 up to 1 : 500 gallery  
IHC: 1 : 500      gallery  
IHC-P/FFPE: 1 : 200 gallery  
EM: yes
ELISA: yes (see remarks)
Immunogen Synthetic peptide corresponding to AA 301 to 313 from human Synaptophysin1 (UniProt Id: P08247)
Reactivity Reacts with: human (P08247), rat (P07825), mouse (Q62277), hamster, cow, chicken, frog, zebrafish.
Other species not tested yet.
Specificity Specific for synaptophysin 1, no cross-reactivity to other synaptophysins.
Matching control protein/peptide 101-0P
Remarks

ELISA: Suitable as detector antibody for sandwich-ELISA with cat. no. 101 011 as capture antibody. The ELISA-protocol for membrane proteins is recommended.

Data sheet 101_002.pdf

References for Synaptophysin 1 - 101 002

Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.
Ivanova D, Dobson KL, Gajbhiye A, Davenport EC, Hacker D, Ultanir SK, Trost M, Cousin MA
Science advances (2021) 718: . 101 002 WB; tested species: mouse
The phosphoprotein Synapsin Ia regulates the kinetics of dense-core vesicle release.
Yang HJ, Chen PC, Huang CT, Cheng TL, Hsu SP, Chen CY, Lu JC, Wang CT
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 101 002 WB, ICC
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 101 002 WB; tested species: mouse
Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: . 101 002 WB; tested species: mouse
Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
Pintér A, Hevesi Z, Zahola P, Alpár A, Hanics J
Cellular signalling (2020) 74: 109710. 101 002 WB; tested species: rat
Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.
Santa-Marinha L, Castanho I, Silva RR, Bravo FV, Miranda AM, Meira T, Morais-Ribeiro R, Marques F, Xu Y, Point du Jour K, Wenk M, et al.
Cell reports (2020) 3012: 4197-4208.e6. 101 002 WB; tested species: mouse
Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.
Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, et al.
Nature communications (2020) 111: 1266. 101 002 WB; tested species: mouse
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert S, Gimber N, Deuschel D, Stuhlmann T, Puchkov D, Farsi Z, Ludwig CF, Novarino G, López-Cayuqueo KI, Planells-Cases R, Jentsch TJ, et al.
The EMBO journal (2020) : e103358. 101 002 WB, IHC; tested species: mouse
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.
Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, et al.
Acta neuropathologica (2019) : . 101 002 WB; tested species: mouse
Monitoring translation in synaptic fractions using a ribosome profiling strategy.
Simbriger K, Amorim IS, Chalkiadaki K, Lach G, Jafarnejad SM, Khoutorsky A, Gkogkas CG
Journal of neuroscience methods (2019) : 108456. 101 002 WB; tested species: mouse
Cyclophillin A deficiency accelerates RML-induced prion disease.
Bouybayoune I, Comerio L, Pasetto L, Bertani I, Bonetto V, Chiesa R
Neurobiology of disease (2019) : 104498. 101 002 WB; tested species: mouse
Isolation of Synaptic Vesicles from Genetically Engineered Cultured Neurons.
McKenzie C, Spanova M, Johnson A, Kainrath S, Zheden V, Sitte HH, Janovjak H
Journal of neuroscience methods (2018) : . 101 002 WB; tested species: rat
Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress.
Alpár A, Zahola P, Hanics J, Hevesi Z, Korchynska S, Benevento M, Pifl C, Zachar G, Perugini J, Severi I, Leitgeb P, et al.
The EMBO journal (2018) : . 101 002 WB; tested species: mouse
Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling.
Richter M, Murtaza N, Scharrenberg R, White SH, Johanns O, Walker S, Yuen RKC, Schwanke B, Bedürftig B, Henis M, Scharf S, et al.
Molecular psychiatry (2018) : . 101 002 WB; tested species: mouse
Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.
Fasano C, Rocchetti J, Pietrajtis K, Zander JF, Manseau F, Sakae DY, Marcus-Sells M, Ramet L, Morel LJ, Carrel D, Dumas S, et al.
Frontiers in cellular neuroscience (2017) 11: 140. 101 002 WB, IP; tested species: mouse
PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery.
Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni RI, Prestigio C, Giovedì S, Onofri F, Mura E, Guarnieri FC, et al.
Cell reports (2016) 151: 117-31. 101 002 WB
Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression.
Rajappa R, Gauthier-Kemper A, Böning D, Hüve J, Klingauf J
Cell reports (2016) 146: 1369-1381. 101 002 WB, ICC; tested species: rat
The GTPase Rab26 links synaptic vesicles to the autophagy pathway.
Binotti B, Pavlos NJ, Riedel D, Wenzel D, Vorbrüggen G, Schalk AM, Kühnel K, Boyken J, Erck C, Martens H, Chua JJ, et al.
eLife (2015) 4: e05597. 101 002 WB, ICC
Differential spatial expression and subcellular localization of CtBP family members in rodent brain.
Hübler D, Rankovic M, Richter K, Lazarevic V, Altrock WD, Fischer KD, Gundelfinger ED, Fejtova A
PloS one (2012) 76: e39710. 101 002 WB; tested species: mouse
N-cofilin can compensate for the loss of ADF in excitatory synapses.
Görlich A, Wolf M, Zimmermann AM, Gurniak CB, Al Banchaabouchi M, Sassoè-Pognetto M, Witke W, Friauf E, Rust MB
PloS one (2011) 610: e26789. 101 002 WB; tested species: mouse
Activity-dependent shedding of the NMDA receptor glycine binding site by matrix metalloproteinase 3: a PUTATIVE mechanism of postsynaptic plasticity.
Pauly T, Ratliff M, Pietrowski E, Neugebauer R, Schlicksupp A, Kirsch J, Kuhse J
PloS one (2008) 37: e2681. 101 002 WB, ICC; tested species: rat
Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.
Baldelli P, Fassio A, Valtorta F, Benfenati F
The Journal of neuroscience : the official journal of the Society for Neuroscience (2007) 2749: 13520-31. 101 002 WB; tested species: mouse
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 101 002 WB, IHC
Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.
Fasano C, Rocchetti J, Pietrajtis K, Zander JF, Manseau F, Sakae DY, Marcus-Sells M, Ramet L, Morel LJ, Carrel D, Dumas S, et al.
Frontiers in cellular neuroscience (2017) 11: 140. 101 002 WB, IP; tested species: mouse
The phosphoprotein Synapsin Ia regulates the kinetics of dense-core vesicle release.
Yang HJ, Chen PC, Huang CT, Cheng TL, Hsu SP, Chen CY, Lu JC, Wang CT
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 101 002 WB, ICC
Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells.
Park D, Wu Y, Lee SE, Kim G, Jeong S, Milovanovic D, Camilli P, Chang S
Nature communications (2021) 121: 263. 101 002 ICC; tested species: monkey
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids.
Renner H, Grabos M, Becker KJ, Kagermeier TE, Wu J, Otto M, Peischard S, Zeuschner D, TsyTsyura Y, Disse P, Klingauf J, et al.
eLife (2020) 9: . 101 002 ICC; tested species: human
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 101 002 ICC; tested species: mouse
Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.
Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, et al.
Neuron (2020) : . 101 002 ICC; tested species: mouse
Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron (2018) 973: 727. 101 002 ICC; tested species: mouse
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.
Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, et al.
Nature communications (2018) 91: 712. 101 002 ICC; tested species: rat
Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron (2017) 934: 897-913.e7. 101 002 ICC; tested species: mouse
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 101 002 ICC; tested species: mouse
Cross-talk between metabotropic glutamate receptor 7 and beta adrenergic receptor signaling at cerebrocortical nerve terminals.
Ferrero JJ, Ramírez-Franco J, Martín R, Bartolomé-Martín D, Torres M, Sánchez-Prieto J
Neuropharmacology (2016) 101: 412-25. 101 002 ICC; tested species: mouse
Evidence for a role of glycoprotein M6a in dendritic spine formation and synaptogenesis.
Formoso K, Garcia MD, Frasch AC, Scorticati C
Molecular and cellular neurosciences (2016) 77: 95-104. 101 002 ICC; tested species: mouse
Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression.
Rajappa R, Gauthier-Kemper A, Böning D, Hüve J, Klingauf J
Cell reports (2016) 146: 1369-1381. 101 002 WB, ICC; tested species: rat
The GTPase Rab26 links synaptic vesicles to the autophagy pathway.
Binotti B, Pavlos NJ, Riedel D, Wenzel D, Vorbrüggen G, Schalk AM, Kühnel K, Boyken J, Erck C, Martens H, Chua JJ, et al.
eLife (2015) 4: e05597. 101 002 WB, ICC
Vesicular glutamate transporter expression level affects synaptic vesicle release probability at hippocampal synapses in culture.
Herman MA, Ackermann F, Trimbuch T, Rosenmund C
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3435: 11781-91. 101 002 ICC; tested species: mouse
β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.
Ferrero JJ, Alvarez AM, Ramírez-Franco J, Godino MC, Bartolomé-Martín D, Aguado C, Torres M, Luján R, Ciruela F, Sánchez-Prieto J
The Journal of biological chemistry (2013) 28843: 31370-85. 101 002 ICC; tested species: mouse
Tetanus toxin and botulinum toxin a utilize unique mechanisms to enter neurons of the central nervous system.
Blum FC, Chen C, Kroken AR, Barbieri JT
Infection and immunity (2012) 805: 1662-9. 101 002 ICC
Isolation of a novel rat neural progenitor clone that expresses Dlx family transcription factors and gives rise to functional GABAergic neurons in culture.
Li H, Hader AT, Han YR, Wong JA, Babiarz J, Ricupero CL, Godfrey SB, Corradi JP, Fennell M, Hart RP, Plummer MR, et al.
Developmental neurobiology (2012) 726: 805-20. 101 002 ICC; tested species: rat
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 101 002 ICC
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J
PloS one (2010) 59: . 101 002 ICC; tested species: mouse
Activity-dependent shedding of the NMDA receptor glycine binding site by matrix metalloproteinase 3: a PUTATIVE mechanism of postsynaptic plasticity.
Pauly T, Ratliff M, Pietrowski E, Neugebauer R, Schlicksupp A, Kirsch J, Kuhse J
PloS one (2008) 37: e2681. 101 002 WB, ICC; tested species: rat
Schwann cells modulate short-term plasticity of cholinergic autaptic synapses.
Perez-Gonzalez AP, Albrecht D, Blasi J, Llobet A
The Journal of physiology (2008) 58619: 4675-91. 101 002 ICC; tested species: rat
Morphological and molecular heterogeneity in release sites of single neurons.
Morgenthaler FD, Knott GW, Floyd Sarria JC, Wang X, Staple JK, Catsicas S, Hirling H
The European journal of neuroscience (2003) 177: 1365-74. 101 002 ICC
A phosphorylation site regulates sorting of the vesicular acetylcholine transporter to dense core vesicles.
Krantz DE, Waites C, Oorschot V, Liu Y, Wilson RI, Tan PK, Klumperman J, Edwards RH
The Journal of cell biology (2000) 1492: 379-96. 101 002 ICC, EM
Polysialic acid in the rat brainstem and thoracolumbar spinal cord: Distribution, cellular location, and comparison with mouse.
Shahbazian S, Bokiniec P, Berning BA, McMullan S, Goodchild AK
The Journal of comparative neurology (2021) 5294: 811-827. 101 002 IHC; tested species: mouse
Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS.
Kao CS, van Bruggen R, Kim JR, Chen XXL, Chan C, Lee J, Cho WI, Zhao M, Arndt C, Maksimovic K, Khan M, et al.
Nature communications (2020) 111: 5304. 101 002 IHC; tested species: mouse
Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS.
Bączyk M, Alami NO, Delestrée N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N, Frankel W, Manuel M, Roselli F, et al.
The Journal of experimental medicine (2020) 2178: . 101 002 IHC; tested species: mouse
Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease.
Wang S, Yao H, Xu Y, Hao R, Zhang W, Liu H, Huang Y, Guo W, Lu B
Theranostics (2020) 1015: 6854-6874. 101 002 IHC; tested species: mouse
Automated highly multiplexed super-resolution imaging of protein nano-architecture in cells and tissues.
Klevanski M, Herrmannsdoerfer F, Sass S, Venkataramani V, Heilemann M, Kuner T
Nature communications (2020) 111: 1552. 101 002 IHC; tested species: rat
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert S, Gimber N, Deuschel D, Stuhlmann T, Puchkov D, Farsi Z, Ludwig CF, Novarino G, López-Cayuqueo KI, Planells-Cases R, Jentsch TJ, et al.
The EMBO journal (2020) : e103358. 101 002 WB, IHC; tested species: mouse
Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy.
Zhou H, Meng J, Malerba A, Catapano F, Sintusek P, Jarmin S, Feng L, Lu-Nguyen N, Sun L, Mariot V, Dumonceaux J, et al.
Journal of cachexia, sarcopenia and muscle (2020) : . 101 002 IHC; tested species: mouse
Microtubule and Actin Differentially Regulate Synaptic Vesicle Cycling to Maintain High-frequency Neurotransmission.
Piriya Ananda Babu L, Wang HY, Eguchi K, Guillaud L, Takahashi T
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 101 002 IHC; tested species: rat
Neuronal preservation and reactive gliosis attenuation following neonatal sciatic nerve axotomy by a fluorinated cannabidiol derivative.
Perez M, Cartarozzi LP, Chiarotto GB, Alves de Oliveira S, Guimarães FS, Rodrigues de Oliveira AL
Neuropharmacology (2018) : . 101 002 IHC; tested species: rat
Mitochondrial abnormalities and disruption of the neuromuscular junction precede the clinical phenotype and motor neuron loss in hFUSWT transgenic mice.
So E, Mitchell JC, Memmi C, Chennell G, Vizcay-Barrena G, Allison L, Shaw CE, Vance C
Human molecular genetics (2018) 273: 463-474. 101 002 IHC; tested species: mouse
Blocking p62/SQSTM1-dependent SMN degradation ameliorates Spinal Muscular Atrophy disease phenotypes.
Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL
The Journal of clinical investigation (2018) : . 101 002 IHC; tested species: mouse
Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation.
Bhattacharya S, Herrera-Molina R, Sabanov V, Ahmed T, Iscru E, Stöber F, Richter K, Fischer KD, Angenstein F, Goldschmidt J, Beesley PW, et al.
Biological psychiatry (2017) 812: 124-135. 101 002 IHC
The excitatory/inhibitory input to orexin/hypocretin neuron soma undergoes day/night reorganization.
Laperchia C, Imperatore R, Azeez IA, Del Gallo F, Bertini G, Grassi-Zucconi G, Cristino L, Bentivoglio M
Brain structure & function (2017) 2228: 3847-3859. 101 002 IHC; tested species: mouse
The Gut-Associated Lymphoid Tissues in the Small Intestine, Not the Large Intestine, Play a Major Role in Oral Prion Disease Pathogenesis.
Donaldson DS, Else KJ, Mabbott NA
Journal of virology (2015) 8918: 9532-47. 101 002 IHC
Synaptic reorganization in the adult rat's ventral cochlear nucleus following its total sensory deafferentation.
Hildebrandt H, Hoffmann NA, Illing RB
PloS one (2011) 68: e23686. 101 002 IHC; tested species: rat
Neural proliferation and restoration of neurochemical phenotypes and compromised functions following capsaicin-induced neuronal damage in the nodose ganglion of the adult rat.
Gallaher ZR, Ryu V, Larios RM, Sprunger LK, Czaja K
Frontiers in neuroscience (2011) 5: 12. 101 002 IHC; tested species: mouse
Expression of the axonal membrane glycoprotein M6a is regulated by chronic stress.
Cooper B, Fuchs E, Flügge G
PloS one (2009) 41: e3659. 101 002 IHC; tested species: rat
The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.
Bottos A, Destro E, Rissone A, Graziano S, Cordara G, Assenzio B, Cera MR, Mascia L, Bussolino F, Arese M
Proceedings of the National Academy of Sciences of the United States of America (2009) 10649: 20782-7. 101 002 IHC; tested species: chicken
Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular junctions.
Kawashima S, Imamura Y, Chandana EP, Noda T, Takahashi R, Adachi E, Takahashi C, Noda M
Journal of neurochemistry (2008) 1042: 376-85. 101 002 IHC; tested species: mouse
Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease.
Kirvell SL, Esiri M, Francis PT
Journal of neurochemistry (2006) 983: 939-50. 101 002 IHC
Donut-like topology of synaptic vesicles with a central cluster of mitochondria wrapped into membrane protrusions: a novel structure-function module of the adult calyx of Held.
Wimmer VC, Horstmann H, Groh A, Kuner T
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 261: 109-16. 101 002 IHC
The expression pattern and assembly profile of synaptic membrane proteins in ribbon synapses of the developing mouse retina.
von Kriegstein K, Schmitz F
Cell and tissue research (2003) 3112: 159-73. 101 002 IHC
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 101 002 WB, IHC
Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease.
Frahm S, Melis V, Horsley D, Rickard JE, Riedel G, Fadda P, Scherma M, Harrington CR, Wischik CM, Theuring F, Schwab K, et al.
Behavioural brain research (2018) 339: 153-168. 101 002 IHC-P; tested species: mouse
A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation.
Oorschot V, de Wit H, Annaert WG, Klumperman J
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (2002) 508: 1067-80. 101 002 EM
A phosphorylation site regulates sorting of the vesicular acetylcholine transporter to dense core vesicles.
Krantz DE, Waites C, Oorschot V, Liu Y, Wilson RI, Tan PK, Klumperman J, Edwards RH
The Journal of cell biology (2000) 1492: 379-96. 101 002 ICC, EM
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 101 002 ELISA
Cat. No.: 101 002
Quantity: 200 µl
Price: $375.00
Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.
Ivanova D, Dobson KL, Gajbhiye A, Davenport EC, Hacker D, Ultanir SK, Trost M, Cousin MA
Science advances (2021) 718: . 101 002 WB; tested species: mouse
The phosphoprotein Synapsin Ia regulates the kinetics of dense-core vesicle release.
Yang HJ, Chen PC, Huang CT, Cheng TL, Hsu SP, Chen CY, Lu JC, Wang CT
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 101 002 WB, ICC
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 101 002 WB; tested species: mouse
Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: . 101 002 WB; tested species: mouse
Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
Pintér A, Hevesi Z, Zahola P, Alpár A, Hanics J
Cellular signalling (2020) 74: 109710. 101 002 WB; tested species: rat
Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.
Santa-Marinha L, Castanho I, Silva RR, Bravo FV, Miranda AM, Meira T, Morais-Ribeiro R, Marques F, Xu Y, Point du Jour K, Wenk M, et al.
Cell reports (2020) 3012: 4197-4208.e6. 101 002 WB; tested species: mouse
Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.
Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, et al.
Nature communications (2020) 111: 1266. 101 002 WB; tested species: mouse
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert S, Gimber N, Deuschel D, Stuhlmann T, Puchkov D, Farsi Z, Ludwig CF, Novarino G, López-Cayuqueo KI, Planells-Cases R, Jentsch TJ, et al.
The EMBO journal (2020) : e103358. 101 002 WB, IHC; tested species: mouse
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.
Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, et al.
Acta neuropathologica (2019) : . 101 002 WB; tested species: mouse
Monitoring translation in synaptic fractions using a ribosome profiling strategy.
Simbriger K, Amorim IS, Chalkiadaki K, Lach G, Jafarnejad SM, Khoutorsky A, Gkogkas CG
Journal of neuroscience methods (2019) : 108456. 101 002 WB; tested species: mouse
Cyclophillin A deficiency accelerates RML-induced prion disease.
Bouybayoune I, Comerio L, Pasetto L, Bertani I, Bonetto V, Chiesa R
Neurobiology of disease (2019) : 104498. 101 002 WB; tested species: mouse
Isolation of Synaptic Vesicles from Genetically Engineered Cultured Neurons.
McKenzie C, Spanova M, Johnson A, Kainrath S, Zheden V, Sitte HH, Janovjak H
Journal of neuroscience methods (2018) : . 101 002 WB; tested species: rat
Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress.
Alpár A, Zahola P, Hanics J, Hevesi Z, Korchynska S, Benevento M, Pifl C, Zachar G, Perugini J, Severi I, Leitgeb P, et al.
The EMBO journal (2018) : . 101 002 WB; tested species: mouse
Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling.
Richter M, Murtaza N, Scharrenberg R, White SH, Johanns O, Walker S, Yuen RKC, Schwanke B, Bedürftig B, Henis M, Scharf S, et al.
Molecular psychiatry (2018) : . 101 002 WB; tested species: mouse
Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.
Fasano C, Rocchetti J, Pietrajtis K, Zander JF, Manseau F, Sakae DY, Marcus-Sells M, Ramet L, Morel LJ, Carrel D, Dumas S, et al.
Frontiers in cellular neuroscience (2017) 11: 140. 101 002 WB, IP; tested species: mouse
PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery.
Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni RI, Prestigio C, Giovedì S, Onofri F, Mura E, Guarnieri FC, et al.
Cell reports (2016) 151: 117-31. 101 002 WB
Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression.
Rajappa R, Gauthier-Kemper A, Böning D, Hüve J, Klingauf J
Cell reports (2016) 146: 1369-1381. 101 002 WB, ICC; tested species: rat
The GTPase Rab26 links synaptic vesicles to the autophagy pathway.
Binotti B, Pavlos NJ, Riedel D, Wenzel D, Vorbrüggen G, Schalk AM, Kühnel K, Boyken J, Erck C, Martens H, Chua JJ, et al.
eLife (2015) 4: e05597. 101 002 WB, ICC
Differential spatial expression and subcellular localization of CtBP family members in rodent brain.
Hübler D, Rankovic M, Richter K, Lazarevic V, Altrock WD, Fischer KD, Gundelfinger ED, Fejtova A
PloS one (2012) 76: e39710. 101 002 WB; tested species: mouse
N-cofilin can compensate for the loss of ADF in excitatory synapses.
Görlich A, Wolf M, Zimmermann AM, Gurniak CB, Al Banchaabouchi M, Sassoè-Pognetto M, Witke W, Friauf E, Rust MB
PloS one (2011) 610: e26789. 101 002 WB; tested species: mouse
Activity-dependent shedding of the NMDA receptor glycine binding site by matrix metalloproteinase 3: a PUTATIVE mechanism of postsynaptic plasticity.
Pauly T, Ratliff M, Pietrowski E, Neugebauer R, Schlicksupp A, Kirsch J, Kuhse J
PloS one (2008) 37: e2681. 101 002 WB, ICC; tested species: rat
Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.
Baldelli P, Fassio A, Valtorta F, Benfenati F
The Journal of neuroscience : the official journal of the Society for Neuroscience (2007) 2749: 13520-31. 101 002 WB; tested species: mouse
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 101 002 WB, IHC
Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.
Fasano C, Rocchetti J, Pietrajtis K, Zander JF, Manseau F, Sakae DY, Marcus-Sells M, Ramet L, Morel LJ, Carrel D, Dumas S, et al.
Frontiers in cellular neuroscience (2017) 11: 140. 101 002 WB, IP; tested species: mouse
The phosphoprotein Synapsin Ia regulates the kinetics of dense-core vesicle release.
Yang HJ, Chen PC, Huang CT, Cheng TL, Hsu SP, Chen CY, Lu JC, Wang CT
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 101 002 WB, ICC
Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells.
Park D, Wu Y, Lee SE, Kim G, Jeong S, Milovanovic D, Camilli P, Chang S
Nature communications (2021) 121: 263. 101 002 ICC; tested species: monkey
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids.
Renner H, Grabos M, Becker KJ, Kagermeier TE, Wu J, Otto M, Peischard S, Zeuschner D, TsyTsyura Y, Disse P, Klingauf J, et al.
eLife (2020) 9: . 101 002 ICC; tested species: human
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 101 002 ICC; tested species: mouse
Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.
Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, et al.
Neuron (2020) : . 101 002 ICC; tested species: mouse
Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron (2018) 973: 727. 101 002 ICC; tested species: mouse
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.
Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, et al.
Nature communications (2018) 91: 712. 101 002 ICC; tested species: rat
Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron (2017) 934: 897-913.e7. 101 002 ICC; tested species: mouse
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 101 002 ICC; tested species: mouse
Cross-talk between metabotropic glutamate receptor 7 and beta adrenergic receptor signaling at cerebrocortical nerve terminals.
Ferrero JJ, Ramírez-Franco J, Martín R, Bartolomé-Martín D, Torres M, Sánchez-Prieto J
Neuropharmacology (2016) 101: 412-25. 101 002 ICC; tested species: mouse
Evidence for a role of glycoprotein M6a in dendritic spine formation and synaptogenesis.
Formoso K, Garcia MD, Frasch AC, Scorticati C
Molecular and cellular neurosciences (2016) 77: 95-104. 101 002 ICC; tested species: mouse
Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression.
Rajappa R, Gauthier-Kemper A, Böning D, Hüve J, Klingauf J
Cell reports (2016) 146: 1369-1381. 101 002 WB, ICC; tested species: rat
The GTPase Rab26 links synaptic vesicles to the autophagy pathway.
Binotti B, Pavlos NJ, Riedel D, Wenzel D, Vorbrüggen G, Schalk AM, Kühnel K, Boyken J, Erck C, Martens H, Chua JJ, et al.
eLife (2015) 4: e05597. 101 002 WB, ICC
Vesicular glutamate transporter expression level affects synaptic vesicle release probability at hippocampal synapses in culture.
Herman MA, Ackermann F, Trimbuch T, Rosenmund C
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3435: 11781-91. 101 002 ICC; tested species: mouse
β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.
Ferrero JJ, Alvarez AM, Ramírez-Franco J, Godino MC, Bartolomé-Martín D, Aguado C, Torres M, Luján R, Ciruela F, Sánchez-Prieto J
The Journal of biological chemistry (2013) 28843: 31370-85. 101 002 ICC; tested species: mouse
Tetanus toxin and botulinum toxin a utilize unique mechanisms to enter neurons of the central nervous system.
Blum FC, Chen C, Kroken AR, Barbieri JT
Infection and immunity (2012) 805: 1662-9. 101 002 ICC
Isolation of a novel rat neural progenitor clone that expresses Dlx family transcription factors and gives rise to functional GABAergic neurons in culture.
Li H, Hader AT, Han YR, Wong JA, Babiarz J, Ricupero CL, Godfrey SB, Corradi JP, Fennell M, Hart RP, Plummer MR, et al.
Developmental neurobiology (2012) 726: 805-20. 101 002 ICC; tested species: rat
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 101 002 ICC
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J
PloS one (2010) 59: . 101 002 ICC; tested species: mouse
Activity-dependent shedding of the NMDA receptor glycine binding site by matrix metalloproteinase 3: a PUTATIVE mechanism of postsynaptic plasticity.
Pauly T, Ratliff M, Pietrowski E, Neugebauer R, Schlicksupp A, Kirsch J, Kuhse J
PloS one (2008) 37: e2681. 101 002 WB, ICC; tested species: rat
Schwann cells modulate short-term plasticity of cholinergic autaptic synapses.
Perez-Gonzalez AP, Albrecht D, Blasi J, Llobet A
The Journal of physiology (2008) 58619: 4675-91. 101 002 ICC; tested species: rat
Morphological and molecular heterogeneity in release sites of single neurons.
Morgenthaler FD, Knott GW, Floyd Sarria JC, Wang X, Staple JK, Catsicas S, Hirling H
The European journal of neuroscience (2003) 177: 1365-74. 101 002 ICC
A phosphorylation site regulates sorting of the vesicular acetylcholine transporter to dense core vesicles.
Krantz DE, Waites C, Oorschot V, Liu Y, Wilson RI, Tan PK, Klumperman J, Edwards RH
The Journal of cell biology (2000) 1492: 379-96. 101 002 ICC, EM
Polysialic acid in the rat brainstem and thoracolumbar spinal cord: Distribution, cellular location, and comparison with mouse.
Shahbazian S, Bokiniec P, Berning BA, McMullan S, Goodchild AK
The Journal of comparative neurology (2021) 5294: 811-827. 101 002 IHC; tested species: mouse
Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS.
Kao CS, van Bruggen R, Kim JR, Chen XXL, Chan C, Lee J, Cho WI, Zhao M, Arndt C, Maksimovic K, Khan M, et al.
Nature communications (2020) 111: 5304. 101 002 IHC; tested species: mouse
Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS.
Bączyk M, Alami NO, Delestrée N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N, Frankel W, Manuel M, Roselli F, et al.
The Journal of experimental medicine (2020) 2178: . 101 002 IHC; tested species: mouse
Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease.
Wang S, Yao H, Xu Y, Hao R, Zhang W, Liu H, Huang Y, Guo W, Lu B
Theranostics (2020) 1015: 6854-6874. 101 002 IHC; tested species: mouse
Automated highly multiplexed super-resolution imaging of protein nano-architecture in cells and tissues.
Klevanski M, Herrmannsdoerfer F, Sass S, Venkataramani V, Heilemann M, Kuner T
Nature communications (2020) 111: 1552. 101 002 IHC; tested species: rat
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert S, Gimber N, Deuschel D, Stuhlmann T, Puchkov D, Farsi Z, Ludwig CF, Novarino G, López-Cayuqueo KI, Planells-Cases R, Jentsch TJ, et al.
The EMBO journal (2020) : e103358. 101 002 WB, IHC; tested species: mouse
Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy.
Zhou H, Meng J, Malerba A, Catapano F, Sintusek P, Jarmin S, Feng L, Lu-Nguyen N, Sun L, Mariot V, Dumonceaux J, et al.
Journal of cachexia, sarcopenia and muscle (2020) : . 101 002 IHC; tested species: mouse
Microtubule and Actin Differentially Regulate Synaptic Vesicle Cycling to Maintain High-frequency Neurotransmission.
Piriya Ananda Babu L, Wang HY, Eguchi K, Guillaud L, Takahashi T
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 101 002 IHC; tested species: rat
Neuronal preservation and reactive gliosis attenuation following neonatal sciatic nerve axotomy by a fluorinated cannabidiol derivative.
Perez M, Cartarozzi LP, Chiarotto GB, Alves de Oliveira S, Guimarães FS, Rodrigues de Oliveira AL
Neuropharmacology (2018) : . 101 002 IHC; tested species: rat
Mitochondrial abnormalities and disruption of the neuromuscular junction precede the clinical phenotype and motor neuron loss in hFUSWT transgenic mice.
So E, Mitchell JC, Memmi C, Chennell G, Vizcay-Barrena G, Allison L, Shaw CE, Vance C
Human molecular genetics (2018) 273: 463-474. 101 002 IHC; tested species: mouse
Blocking p62/SQSTM1-dependent SMN degradation ameliorates Spinal Muscular Atrophy disease phenotypes.
Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL
The Journal of clinical investigation (2018) : . 101 002 IHC; tested species: mouse
Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation.
Bhattacharya S, Herrera-Molina R, Sabanov V, Ahmed T, Iscru E, Stöber F, Richter K, Fischer KD, Angenstein F, Goldschmidt J, Beesley PW, et al.
Biological psychiatry (2017) 812: 124-135. 101 002 IHC
The excitatory/inhibitory input to orexin/hypocretin neuron soma undergoes day/night reorganization.
Laperchia C, Imperatore R, Azeez IA, Del Gallo F, Bertini G, Grassi-Zucconi G, Cristino L, Bentivoglio M
Brain structure & function (2017) 2228: 3847-3859. 101 002 IHC; tested species: mouse
The Gut-Associated Lymphoid Tissues in the Small Intestine, Not the Large Intestine, Play a Major Role in Oral Prion Disease Pathogenesis.
Donaldson DS, Else KJ, Mabbott NA
Journal of virology (2015) 8918: 9532-47. 101 002 IHC
Synaptic reorganization in the adult rat's ventral cochlear nucleus following its total sensory deafferentation.
Hildebrandt H, Hoffmann NA, Illing RB
PloS one (2011) 68: e23686. 101 002 IHC; tested species: rat
Neural proliferation and restoration of neurochemical phenotypes and compromised functions following capsaicin-induced neuronal damage in the nodose ganglion of the adult rat.
Gallaher ZR, Ryu V, Larios RM, Sprunger LK, Czaja K
Frontiers in neuroscience (2011) 5: 12. 101 002 IHC; tested species: mouse
Expression of the axonal membrane glycoprotein M6a is regulated by chronic stress.
Cooper B, Fuchs E, Flügge G
PloS one (2009) 41: e3659. 101 002 IHC; tested species: rat
The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.
Bottos A, Destro E, Rissone A, Graziano S, Cordara G, Assenzio B, Cera MR, Mascia L, Bussolino F, Arese M
Proceedings of the National Academy of Sciences of the United States of America (2009) 10649: 20782-7. 101 002 IHC; tested species: chicken
Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular junctions.
Kawashima S, Imamura Y, Chandana EP, Noda T, Takahashi R, Adachi E, Takahashi C, Noda M
Journal of neurochemistry (2008) 1042: 376-85. 101 002 IHC; tested species: mouse
Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease.
Kirvell SL, Esiri M, Francis PT
Journal of neurochemistry (2006) 983: 939-50. 101 002 IHC
Donut-like topology of synaptic vesicles with a central cluster of mitochondria wrapped into membrane protrusions: a novel structure-function module of the adult calyx of Held.
Wimmer VC, Horstmann H, Groh A, Kuner T
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 261: 109-16. 101 002 IHC
The expression pattern and assembly profile of synaptic membrane proteins in ribbon synapses of the developing mouse retina.
von Kriegstein K, Schmitz F
Cell and tissue research (2003) 3112: 159-73. 101 002 IHC
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 101 002 WB, IHC
Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease.
Frahm S, Melis V, Horsley D, Rickard JE, Riedel G, Fadda P, Scherma M, Harrington CR, Wischik CM, Theuring F, Schwab K, et al.
Behavioural brain research (2018) 339: 153-168. 101 002 IHC-P; tested species: mouse
A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation.
Oorschot V, de Wit H, Annaert WG, Klumperman J
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (2002) 508: 1067-80. 101 002 EM
A phosphorylation site regulates sorting of the vesicular acetylcholine transporter to dense core vesicles.
Krantz DE, Waites C, Oorschot V, Liu Y, Wilson RI, Tan PK, Klumperman J, Edwards RH
The Journal of cell biology (2000) 1492: 379-96. 101 002 ICC, EM
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 101 002 ELISA
Background

Synaptophysin 1, also referred to as p38-1, is a membrane glycoprotein of synaptic vesicles that is ubiquitously expressed in all neurons and in many endocrine cells. It is currently the most widely used marker for nerve terminals and probably the best marker for the pathologist in differentiating neuroendocrine tumors.
Synaptophysin 1 has four transmembrane domains with both N- and C-terminus facing the cytoplasm. It binds to synaptobrevin 1 and synaptobrevin 2 in detergent extracts but its function has not been elucidated completely. It forms a complex with dynamin at high Ca2+ concentration suggesting an involvement in synaptic vesicle endocytosis. As typical for synaptic vesicle proteins, synaptophysin 1 represents a small protein family with two additonal members, synaptoporin (synaptophysin 2) and panthophysin. Like synaptophysin 1, synaptoporin is widely expressed in neurons and colocalizes with synaptophysin 1 on synaptic vesicles whereas panthophysin is expressed in all tissues.