Cat. No.: 183 003
Amount: 50 µg
Price:
$375.00
|
|
|
| Cat. No. 183 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 1067 to 1139 from rat Tomosyn1 (UniProt Id: Q9WU70) |
| Reactivity |
Reacts with: human (Q5T5C0, Q9Y2K9), rat (Q9WU70), mouse (Q8K400, Q5DQR4), cow. Other species not tested yet. |
| Specificity | Cross-reacts with tomosyn 2 due to sequence homology. |
| Matching control protein/peptide | 183-0P |
| Data sheet | 183_003.pdf |
|
|
SNARE proteins play crucial roles in vesicle transport by catalyzing membrane fusion events. Several proteins like the Munc 18s and tomosyn 1 (syntaxin 1A binding protein 5) interact with the neuronal plasmalemma located SNARE protein syntaxin 1a and modulate neurotransmitter release at synaptic nerve terminals.
Tomosyn 1 contains a C-terminal synaptobrevin-like R-SNARE motif that can form a stable ternary complex with syntaxin 1A and SNAP 25.
Another isoform, tomosyn 2 (syntaxin 1A binding protein 5 like), has also been described.