Tau protein - 314-1P

Tau is a neuronal microtubule associated protein

control protein

Cat. No.: 314-1P

Amount: 100 µg

Price: $105.00

Cat. No. 314-1P	100 µg protein, lyophilized. For reconstitution add 100 µl H₂O to get a 1mg/ml solution in TBS. Then aliquot and store at -20°C to -80°C until use. Control proteins should be stored at +4°C when still lyophilized. Do not freeze!
Applications
Immunogen	Recombinant protein corresponding to AA 1 to 44 from human TauE (UniProt Id: P10636-7)
Recommended dilution	Optimal concentrations should be determined by the end-user.
Remarks	This control protein consists of the recombinant protein (aa 1 - 44 of human tau) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of protein needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.
Data sheet	314-1p.pdf

Cat. No.: 314-1P

Amount: 100 µg

Price: $105.00

Background

There are two major classes of heat stable microtubule associated proteins (MAPS): MAP 2 (280 kD), and tau (55-65 kD). Both protein classes are involved in the regulation of microtubule polymerization in cells. Tau is a neuronal protein that mainly localizes to axons. Hyperphosphorylated tau has been shown to be a major element of paired helical filaments in Alzheimer's disease.

1 ) Thies E et al., J. Neurosci. (2007)
2 ) Avila J et al., J. Biomed. Biotechnol. (2006)
3 ) Duka T et al., FASEB J. (2006)
4 ) Black MM et al., J. Neurosci. (1996)
5 ) Mandell JW et al., J. Neurosci. (1996)
6 ) Hirokawa N et al., J. Cell Biol. (1988)
7 ) Connolly JA et al., Proc. Natl. Acad. Sci. U.S.A. (1977)
8 ) Witman GB et al., Proc. Natl. Acad. Sci. U.S.A. (1976)

Protocols

OTHER

Preadsorbtion

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