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Synapsin1 antibody - 106 103 K.O.

Synapsins are peripheral synaptic vesicle proteins and substrate for several protein kinases
Rabbit polyclonal purified antibody
Cat. No.: 106 103
Amount: 50 µg
Price: $380.00
Cat. No. 106 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.

Immunogen Synthetic peptide corresponding to AA 445 to 462 from mouse Synapsin1 (UniProt Id: O88935)
Reactivity Reacts with: human (P17600), rat (P09951), mouse (O88935), pig, zebrafish.
Other species not tested yet.
Specificity Specific for synapsins 1a and 1b, no cross-reactivity to synapsin 2a/b. K.O. validated
Matching control protein/peptide 106-1P
Data sheet 106_103.pdf

References for Synapsin1 - 106 103

Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease.
Choi BJ, Park MH, Park KH, Han WH, Yoon HJ, Jung HY, Hong JY, Chowdhury MR, Kim KY, Lee J, Song IS, et al.
Nature communications (2023) 141: 1631. 106 103 WB; tested species: mouse
Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity.
Wen J, Zellner A, Braun NC, Bajaj T, Gassen NC, Peitz M, Brüstle O
Translational psychiatry (2023) 131: 143. 106 103 WB; tested species: human
Multiplexed mRNA analysis of brain-derived extracellular vesicles upon experimental stroke in mice reveals increased mRNA content with potential relevance to inflammation and recovery processes.
Bub A, Brenna S, Alawi M, Kügler P, Gui Y, Kretz O, Altmeppen H, Magnus T, Puig B
Cellular and molecular life sciences : CMLS (2022) 796: 329. 106 103 WB; tested species: mouse
Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin.
Weiss FD, Calderon L, Wang YF, Georgieva R, Guo Y, Cvetesic N, Kaur M, Dharmalingam G, Krantz ID, Lenhard B, Fisher AG, et al.
Nature communications (2021) 121: 2919. 106 103 WB; tested species: mouse
Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells.
Park D, Wu Y, Lee SE, Kim G, Jeong S, Milovanovic D, Camilli P, Chang S
Nature communications (2021) 121: 263. 106 103 WB; tested species: cos cells
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
Lee JY, Han SH, Park MH, Song IS, Choi MK, Yu E, Park CM, Kim HJ, Kim SH, Schuchman EH, Jin HK, et al.
Nature communications (2020) 111: 2358. 106 103 WB; tested species: mouse
miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease.
Readhead B, Haure-Mirande JV, Mastroeni D, Audrain M, Fanutza T, Kim SH, Blitzer RD, Gandy S, Dudley JT, Ehrlich ME
Acta neuropathologica (2020) 1403: 295-315. 106 103 WB; tested species: mouse
Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies.
Alten B, Zhou Q, Shin OH, Esquivies L, Lin PY, White KI, Sun R, Chung WK, Monteggia LM, Brunger AT, Kavalali ET, et al.
Neuron (2020) : . 106 103 WB; tested species: mouse
Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR.
Wang J, Chen Y, Zhang C, Xiang Z, Ding J, Han X
Journal of hazardous materials (2019) 373: 504-518. 106 103 WB, ICC; tested species: mouse
Soluble Aβ1-42increases the heterogeneity in synaptic vesicle pool size among synapses by suppressing intersynaptic vesicle sharing.
Park D, Chang S
Molecular brain (2018) 111: 10. 106 103 WB; tested species: rat
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, et al.
Nature communications (2018) 91: 1479. 106 103 WB, IHC; tested species: mouse
CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.
Lehrman EK, Wilton DK, Litvina EY, Welsh CA, Chang ST, Frouin A, Walker AJ, Heller MD, Umemori H, Chen C, Stevens B, et al.
Neuron (2018) 1001: 120-134.e6. 106 103 WB; tested species: mouse
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 106 103 WB
Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
Biesemann C, Grønborg M, Luquet E, Wichert SP, Bernard V, Bungers SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, et al.
The EMBO journal (2014) 332: 157-70. 106 103 WB; tested species: mouse
Functional specificity of liquid-liquid phase separation at the synapse.
Guzikowski NJ, Kavalali ET
Nature communications (2024) 151: 10103. 106 103 ICC; tested species: rat
Human Pluripotent Stem Cell-Derived Astrocyte Functionality Compares Favorably with Primary Rat Astrocytes.
Lendemeijer B, Unkel M, Smeenk H, Mossink B, Hijazi S, Gordillo-Sampedro S, Shpak G, Slump DE, van den Hout MCGN, van IJcken WFJ, Bindels EMJ, et al.
eNeuro (2024) 119: . 106 103 ICC; tested species: human
Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons.
Mohd Rafiq N, Fujise K, Rosenfeld MS, Xu P, De Camilli P
Proceedings of the National Academy of Sciences of the United States of America (2024) 12117: e2318943121. 106 103 ICC; tested species: human
Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease.
Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, et al.
Journal of neurochemistry (2023) : . 106 103 ICC; tested species: mouse
Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging.
Uzay B, Houcek A, Ma ZZ, Konradi C, Monteggia LM, Kavalali ET
Cell reports (2023) 422: 112042. 106 103 ICC; tested species: human,rat
Axonal plasticity in response to active forces generated through magnetic nano-pulling.
Falconieri A, De Vincentiis S, Cappello V, Convertino D, Das R, Ghignoli S, Figoli S, Luin S, Català-Castro F, Marchetti L, Borello U, et al.
Cell reports (2022) 421: 111912. 106 103 ICC; tested species: mouse
Analysis of tripartite Synaptotagmin-1-SNARE-complexin-1 complexes in solution.
Jaczynska K, Esquivies L, Pfuetzner RA, Alten B, Brewer KD, Zhou Q, Kavalali ET, Brunger AT, Rizo J
FEBS open bio (2022) : . 106 103 ICC; tested species: rat
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5. 106 103 ICC; tested species: rat
Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural Models.
Bauer L, Lendemeijer B, Leijten L, Embregts CWE, Rockx B, Kushner SA, de Vrij FMS, van Riel D
mSphere (2021) 63: e0027021. 106 103 ICC; tested species: human
Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles.
Vilcaes AA, Chanaday NL, Kavalali ET
Neuron (2021) 1096: 971-983.e5. 106 103 ICC; tested species: mouse,rat
Optogenetic manipulation of cellular communication using engineered myosin motors.
Zhang Z, Denans N, Liu Y, Zhulyn O, Rosenblatt HD, Wernig M, Barna M
Nature cell biology (2021) 232: 198-208. 106 103 ICC; tested species: mouse
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response.
Wang C, Zhang M, Garcia G, Tian E, Cui Q, Chen X, Sun G, Wang J, Arumugaswami V, Shi Y
Cell stem cell (2021) 282: 331-342.e5. 106 103 ICC; tested species: human
Neurotherapeutic Potential of Cervus elaphus Sibericus on Axon Regeneration and Growth Cone Reformation after H2O2-Induced Injury in Rat Primary Cortical Neurons.
Hong JY, Lee J, Kim H, Jeon WJ, Yeo C, Choi BR, Yoon JE, Shin JY, Kim JY, Ha IH
Biology (2021) 109: . 106 103 ICC; tested species: rat
Single synapse glutamate imaging reveals multiple levels of release mode regulation in mammalian synapses.
Farsi Z, Walde M, Klementowicz AE, Paraskevopoulou F, Woehler A
iScience (2021) 241: 101909. 106 103 ICC; tested species: rat
Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK.
Zieger HL, Kunde SA, Rademacher N, Schmerl B, Shoichet SA
Scientific reports (2020) 101: 5709. 106 103 ICC; tested species: rat
Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR.
Wang J, Chen Y, Zhang C, Xiang Z, Ding J, Han X
Journal of hazardous materials (2019) 373: 504-518. 106 103 WB, ICC; tested species: mouse
Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.
Gerth F, Jäpel M, Sticht J, Kuropka B, Schmitt XJ, Driller JH, Loll B, Wahl MC, Pagel K, Haucke V, Freund C, et al.
Structure (London, England : 1993) (2019) : . 106 103 ICC; tested species: mouse
Diverse reprogramming codes for neuronal identity.
Tsunemoto R, Lee S, Szűcs A, Chubukov P, Sokolova I, Blanchard JW, Eade KT, Bruggemann J, Wu C, Torkamani A, Sanna PP, et al.
Nature (2018) : . 106 103 ICC; tested species: mouse
Morphology of mitochondria in spatially restricted axons revealed by cryo-electron tomography.
Fischer TD, Dash PK, Liu J, Waxham MN
PLoS biology (2018) 169: e2006169. 106 103 ICC; tested species: rat
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, et al.
Stem cell reports (2017) 96: 1745-1753. 106 103 ICC
Assay of Calcium Transients and Synapses in Rat Hippocampal Neurons by Kinetic Image Cytometry and High-Content Analysis: An In Vitro Model System for Postchemotherapy Cognitive Impairment.
McDonough PM, Prigozhina NL, Basa RCB, Price JH
Assay and drug development technologies (2017) 155: 220-236. 106 103 ICC; tested species: rat
Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome.
Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 361: 142-52. 106 103 ICC
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM
The Journal of biological chemistry (2013) 28814: 9634-47. 106 103 ICC
Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice.
Itoh N, Itoh Y, Meyer CE, Suen TT, Cortez-Delgado D, Rivera Lomeli M, Wendin S, Somepalli SS, Golden LC, MacKenzie-Graham A, Voskuhl RR, et al.
Nature communications (2023) 141: 6044. 106 103 IHC; tested species: mouse
Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer's tau pathology.
Huang S, Zhang Z, Cao J, Yu Y, Pei G
Signal transduction and targeted therapy (2022) 71: 176. 106 103 IHC; tested species: human
Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms.
Shi Y, Andhey PS, Ising C, Wang K, Snipes LL, Boyer K, Lawson S, Yamada K, Qin W, Manis M, Serrano JR, et al.
Neuron (2021) 10915: 2413-2426.e7. 106 103 IHC; tested species: mouse
Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson's disease.
Stemick J, Gauer C, Wihan J, Moceri S, Xiang W, von Hörsten S, Kohl Z, Winkler J
Brain research (2020) 1748: 147119. 106 103 IHC; tested species: rat
Glycine Receptor Autoantibodies Impair Receptor Function and Induce Motor Dysfunction.
Rauschenberger V, von Wardenburg N, Schaefer N, Ogino K, Hirata H, Lillesaar C, Kluck CJ, Meinck HM, Borrmann M, Weishaupt A, Doppler K, et al.
Annals of neurology (2020) 883: 544-561. 106 103 IHC; tested species: zebrafish
Cell-Specific Markers for the Identification of Retinal Cells and Subcellular Organelles by Immunofluorescence Microscopy.
Molday LL, Cheng CL, Molday RS
Methods in molecular biology (Clifton, N.J.) (2019) 1834: 293-310. 106 103 IHC; tested species: mouse
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, et al.
Nature communications (2018) 91: 1479. 106 103 WB, IHC; tested species: mouse
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS.
López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, et al.
Neuron (2018) : . 106 103 IHC; tested species: mouse
Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice.
Freria CM, Hall JC, Wei P, Guan Z, McTigue DM, Popovich PG
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3713: 3568-3587. 106 103 IHC; tested species: mouse
Cat. No.: 106 103
Amount: 50 µg
Price: $380.00
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease.
Choi BJ, Park MH, Park KH, Han WH, Yoon HJ, Jung HY, Hong JY, Chowdhury MR, Kim KY, Lee J, Song IS, et al.
Nature communications (2023) 141: 1631. 106 103 WB; tested species: mouse
Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity.
Wen J, Zellner A, Braun NC, Bajaj T, Gassen NC, Peitz M, Brüstle O
Translational psychiatry (2023) 131: 143. 106 103 WB; tested species: human
Multiplexed mRNA analysis of brain-derived extracellular vesicles upon experimental stroke in mice reveals increased mRNA content with potential relevance to inflammation and recovery processes.
Bub A, Brenna S, Alawi M, Kügler P, Gui Y, Kretz O, Altmeppen H, Magnus T, Puig B
Cellular and molecular life sciences : CMLS (2022) 796: 329. 106 103 WB; tested species: mouse
Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin.
Weiss FD, Calderon L, Wang YF, Georgieva R, Guo Y, Cvetesic N, Kaur M, Dharmalingam G, Krantz ID, Lenhard B, Fisher AG, et al.
Nature communications (2021) 121: 2919. 106 103 WB; tested species: mouse
Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells.
Park D, Wu Y, Lee SE, Kim G, Jeong S, Milovanovic D, Camilli P, Chang S
Nature communications (2021) 121: 263. 106 103 WB; tested species: cos cells
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
Lee JY, Han SH, Park MH, Song IS, Choi MK, Yu E, Park CM, Kim HJ, Kim SH, Schuchman EH, Jin HK, et al.
Nature communications (2020) 111: 2358. 106 103 WB; tested species: mouse
miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease.
Readhead B, Haure-Mirande JV, Mastroeni D, Audrain M, Fanutza T, Kim SH, Blitzer RD, Gandy S, Dudley JT, Ehrlich ME
Acta neuropathologica (2020) 1403: 295-315. 106 103 WB; tested species: mouse
Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies.
Alten B, Zhou Q, Shin OH, Esquivies L, Lin PY, White KI, Sun R, Chung WK, Monteggia LM, Brunger AT, Kavalali ET, et al.
Neuron (2020) : . 106 103 WB; tested species: mouse
Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR.
Wang J, Chen Y, Zhang C, Xiang Z, Ding J, Han X
Journal of hazardous materials (2019) 373: 504-518. 106 103 WB, ICC; tested species: mouse
Soluble Aβ1-42increases the heterogeneity in synaptic vesicle pool size among synapses by suppressing intersynaptic vesicle sharing.
Park D, Chang S
Molecular brain (2018) 111: 10. 106 103 WB; tested species: rat
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, et al.
Nature communications (2018) 91: 1479. 106 103 WB, IHC; tested species: mouse
CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.
Lehrman EK, Wilton DK, Litvina EY, Welsh CA, Chang ST, Frouin A, Walker AJ, Heller MD, Umemori H, Chen C, Stevens B, et al.
Neuron (2018) 1001: 120-134.e6. 106 103 WB; tested species: mouse
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 106 103 WB
Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
Biesemann C, Grønborg M, Luquet E, Wichert SP, Bernard V, Bungers SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, et al.
The EMBO journal (2014) 332: 157-70. 106 103 WB; tested species: mouse
Functional specificity of liquid-liquid phase separation at the synapse.
Guzikowski NJ, Kavalali ET
Nature communications (2024) 151: 10103. 106 103 ICC; tested species: rat
Human Pluripotent Stem Cell-Derived Astrocyte Functionality Compares Favorably with Primary Rat Astrocytes.
Lendemeijer B, Unkel M, Smeenk H, Mossink B, Hijazi S, Gordillo-Sampedro S, Shpak G, Slump DE, van den Hout MCGN, van IJcken WFJ, Bindels EMJ, et al.
eNeuro (2024) 119: . 106 103 ICC; tested species: human
Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons.
Mohd Rafiq N, Fujise K, Rosenfeld MS, Xu P, De Camilli P
Proceedings of the National Academy of Sciences of the United States of America (2024) 12117: e2318943121. 106 103 ICC; tested species: human
Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease.
Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, et al.
Journal of neurochemistry (2023) : . 106 103 ICC; tested species: mouse
Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging.
Uzay B, Houcek A, Ma ZZ, Konradi C, Monteggia LM, Kavalali ET
Cell reports (2023) 422: 112042. 106 103 ICC; tested species: human,rat
Axonal plasticity in response to active forces generated through magnetic nano-pulling.
Falconieri A, De Vincentiis S, Cappello V, Convertino D, Das R, Ghignoli S, Figoli S, Luin S, Català-Castro F, Marchetti L, Borello U, et al.
Cell reports (2022) 421: 111912. 106 103 ICC; tested species: mouse
Analysis of tripartite Synaptotagmin-1-SNARE-complexin-1 complexes in solution.
Jaczynska K, Esquivies L, Pfuetzner RA, Alten B, Brewer KD, Zhou Q, Kavalali ET, Brunger AT, Rizo J
FEBS open bio (2022) : . 106 103 ICC; tested species: rat
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5. 106 103 ICC; tested species: rat
Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural Models.
Bauer L, Lendemeijer B, Leijten L, Embregts CWE, Rockx B, Kushner SA, de Vrij FMS, van Riel D
mSphere (2021) 63: e0027021. 106 103 ICC; tested species: human
Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles.
Vilcaes AA, Chanaday NL, Kavalali ET
Neuron (2021) 1096: 971-983.e5. 106 103 ICC; tested species: mouse,rat
Optogenetic manipulation of cellular communication using engineered myosin motors.
Zhang Z, Denans N, Liu Y, Zhulyn O, Rosenblatt HD, Wernig M, Barna M
Nature cell biology (2021) 232: 198-208. 106 103 ICC; tested species: mouse
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response.
Wang C, Zhang M, Garcia G, Tian E, Cui Q, Chen X, Sun G, Wang J, Arumugaswami V, Shi Y
Cell stem cell (2021) 282: 331-342.e5. 106 103 ICC; tested species: human
Neurotherapeutic Potential of Cervus elaphus Sibericus on Axon Regeneration and Growth Cone Reformation after H2O2-Induced Injury in Rat Primary Cortical Neurons.
Hong JY, Lee J, Kim H, Jeon WJ, Yeo C, Choi BR, Yoon JE, Shin JY, Kim JY, Ha IH
Biology (2021) 109: . 106 103 ICC; tested species: rat
Single synapse glutamate imaging reveals multiple levels of release mode regulation in mammalian synapses.
Farsi Z, Walde M, Klementowicz AE, Paraskevopoulou F, Woehler A
iScience (2021) 241: 101909. 106 103 ICC; tested species: rat
Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK.
Zieger HL, Kunde SA, Rademacher N, Schmerl B, Shoichet SA
Scientific reports (2020) 101: 5709. 106 103 ICC; tested species: rat
Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR.
Wang J, Chen Y, Zhang C, Xiang Z, Ding J, Han X
Journal of hazardous materials (2019) 373: 504-518. 106 103 WB, ICC; tested species: mouse
Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.
Gerth F, Jäpel M, Sticht J, Kuropka B, Schmitt XJ, Driller JH, Loll B, Wahl MC, Pagel K, Haucke V, Freund C, et al.
Structure (London, England : 1993) (2019) : . 106 103 ICC; tested species: mouse
Diverse reprogramming codes for neuronal identity.
Tsunemoto R, Lee S, Szűcs A, Chubukov P, Sokolova I, Blanchard JW, Eade KT, Bruggemann J, Wu C, Torkamani A, Sanna PP, et al.
Nature (2018) : . 106 103 ICC; tested species: mouse
Morphology of mitochondria in spatially restricted axons revealed by cryo-electron tomography.
Fischer TD, Dash PK, Liu J, Waxham MN
PLoS biology (2018) 169: e2006169. 106 103 ICC; tested species: rat
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, et al.
Stem cell reports (2017) 96: 1745-1753. 106 103 ICC
Assay of Calcium Transients and Synapses in Rat Hippocampal Neurons by Kinetic Image Cytometry and High-Content Analysis: An In Vitro Model System for Postchemotherapy Cognitive Impairment.
McDonough PM, Prigozhina NL, Basa RCB, Price JH
Assay and drug development technologies (2017) 155: 220-236. 106 103 ICC; tested species: rat
Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome.
Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 361: 142-52. 106 103 ICC
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM
The Journal of biological chemistry (2013) 28814: 9634-47. 106 103 ICC
Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice.
Itoh N, Itoh Y, Meyer CE, Suen TT, Cortez-Delgado D, Rivera Lomeli M, Wendin S, Somepalli SS, Golden LC, MacKenzie-Graham A, Voskuhl RR, et al.
Nature communications (2023) 141: 6044. 106 103 IHC; tested species: mouse
Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer's tau pathology.
Huang S, Zhang Z, Cao J, Yu Y, Pei G
Signal transduction and targeted therapy (2022) 71: 176. 106 103 IHC; tested species: human
Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms.
Shi Y, Andhey PS, Ising C, Wang K, Snipes LL, Boyer K, Lawson S, Yamada K, Qin W, Manis M, Serrano JR, et al.
Neuron (2021) 10915: 2413-2426.e7. 106 103 IHC; tested species: mouse
Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson's disease.
Stemick J, Gauer C, Wihan J, Moceri S, Xiang W, von Hörsten S, Kohl Z, Winkler J
Brain research (2020) 1748: 147119. 106 103 IHC; tested species: rat
Glycine Receptor Autoantibodies Impair Receptor Function and Induce Motor Dysfunction.
Rauschenberger V, von Wardenburg N, Schaefer N, Ogino K, Hirata H, Lillesaar C, Kluck CJ, Meinck HM, Borrmann M, Weishaupt A, Doppler K, et al.
Annals of neurology (2020) 883: 544-561. 106 103 IHC; tested species: zebrafish
Cell-Specific Markers for the Identification of Retinal Cells and Subcellular Organelles by Immunofluorescence Microscopy.
Molday LL, Cheng CL, Molday RS
Methods in molecular biology (Clifton, N.J.) (2019) 1834: 293-310. 106 103 IHC; tested species: mouse
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, et al.
Nature communications (2018) 91: 1479. 106 103 WB, IHC; tested species: mouse
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS.
López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, et al.
Neuron (2018) : . 106 103 IHC; tested species: mouse
Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice.
Freria CM, Hall JC, Wei P, Guan Z, McTigue DM, Popovich PG
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3713: 3568-3587. 106 103 IHC; tested species: mouse
Background

Synapsins are neuron-specific phosphoproteins that are exclusively associated with small synaptic vesicles, with little or no expression in other tissues including neuroendocrine cells. In mammals, three distinct synapsin genes (synapsin1, 2, and 3) encode more than eight neuronal isoforms.
Synapsin1 is one of the most specific markers of synapses throughout the central and peripheral nervous system. In addition to synaptic nerve terminals, the protein is also present in certain sensory nerve endings. It is expressed in two splice variants (synapsin 1a and synapsin 1b). Synapsin1 interacts with vesicle membranes as well as with actin and spectrin.
Synapsin2 is expressed in the nervous system and also two splice variants were described so far, while synapsin3 shows a more restricted expression pattern and is mainly found in the hypocampus.
Synapsins are major phosphoproteins and are substrates for several protein kinases such as PKA, CaMK I and CaMK II. Synapsin1 is widely used as reference substrate for calmodulin-dependent protein kinases.