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Home > Products > 119-2P

SV2 C peptide - 119-2P

SV2s are highly glycosylated synaptic vesicle proteins with homology to transmembrane transporters
control peptide
Cat. No.: 119-2P
Amount: 100 µg
Price: $105.00
Cat. No. 119-2P 100 µg peptide, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Control peptides should be stored at -20°C when still lyophilized!
Applications
 
Immunogen Synthetic peptide corresponding to AA 2 to 16 from rat SV2C (UniProt Id: Q9Z2I6)
Recommended dilution Optimal concentrations should be determined by the end-user.
Matching antibodies 119 202, 119 203, 119 204
Remarks

This control peptide consists of the synthetic peptide (aa 2-16 of rat SV2 C) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of peptide needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.
Data sheet 119-2p.pdf
Cat. No.: 119-2P
Amount: 100 µg
Price: $105.00
Background
SV2s (synaptic vesicle protein 2) are integral membrane glycoproteins present in all synaptic vesicles. They have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2 A, SV2 B and SV2 C. SV2 A is expressed ubiquitously throughout the brain and is probably involved in the maintenance of a pool of synaptic vesicles competent for calcium- stimulated exocytosis. SV2 B has a more restricted distribution with varying degrees of coexpression with SV2 A. SV2 C is more closely related to SV2 A but shows a very restricted expression pattern. The highest expression levels were observed in phylogenetically old brain areas like pallidum, the midbrain and the olfactory bulb. SV2 expression has also been observed in other organs. In kidney it localizes to podocytes.
Protocols
OTHER
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