Cat. No.: 119 111BT
Amount: 100 µg
Price:
$465.00
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| Cat. No. 119 111BT |
100 µg purified IgG, lyophilized, labeled with Biotin.
Biotin is a small vitamin B complex molecule. Its small size minimizes interference with antibody binding sites and allows for efficient conjugation without compromising antibody functionality. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: yes ICC: not recommended IHC: not recommended IHC-P: not tested yet |
| Label | biotin |
| Clone | 246E8 |
| Subtype | IgG2b (κ light chain) |
| Immunogen | Synthetic peptide corresponding to AA 2 to 17 from rat SV2B (UniProt Id: Q63564) |
| Reactivity |
Reacts with: human (Q7L1I2), rat (Q63564), mouse (Q8BG39). Other species not tested yet. |
| Matching control protein/peptide | 119-1P |
| Remarks |
WB: SV2 B aggregates after boiling, making it necessary to run SDS-PAGE with non-boiled samples. |
| Data sheet | 119_111bt.pdf |
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SV2s (synaptic vesicle protein 2) are integral membrane glycoproteins present in all synaptic vesicles. They have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2 A, SV2 B and SV2 C. SV2 A is expressed ubiquitously throughout the brain and is probably involved in the maintenance of a pool of synaptic vesicles competent for calcium- stimulated exocytosis. SV2 B has a more restricted distribution with varying degrees of coexpression with SV2 A. SV2 C is more closely related to SV2 A but shows a very restricted expression pattern. The highest expression levels were observed in phylogenetically old brain areas like pallidum, the midbrain and the olfactory bulb. SV2 expression has also been observed in other organs. In kidney it localizes to podocytes.