Cat. No.: 111 113
Amount: 50 µg
Price:
$375.00
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| Cat. No. 111 113 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to AA 58 to 72 from rat SNAP25B (UniProt Id: P60881-1) |
| Reactivity |
Reacts with: rat (P60881-1), mouse (P60879-1). Other species not tested yet. |
| Specificity | Specific for SNAP 25B, no cross-reactivity to SNAP 25A. K.O. validated PubMed: 31024034 |
| Data sheet | 111_113.pdf |
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SNAP25 (synaptosome-associated protein of 25 kDa) is a highly conserved protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 is the target of Botulinum neurotoxin A and E which cleave off 9 and 26 amino acids, respectively, from the C-terminus.
SNAP25 is part of the exocytotic fusion complex (v-SNARE) of neurons where it assembles with syntaxin1 and synaptobrevin. It is abundantly localized on the neuronal plasmalemma and on recycling vesicles including synaptic vesicles. It is also expressed in neuroendocrine cells. There are two splice-variants, SNAP25A and 25B.