Cat. No.: 111 004
Amount: 100 µl
Price:
$365.00
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| Cat. No. 111 004 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: yes ICC: not tested yet IHC: not tested yet IHC-P: not tested yet |
| Immunogen | Synthetic peptide corresponding to AA 192 to 206 from human SNAP25 (UniProt Id: P60880) |
| Reactivity |
Reacts with: human (P60880), rat (P60881), mouse (P60879), hamster, chicken, goldfish, zebrafish. Other species not tested yet. |
| Matching control protein/peptide | 111-0P |
| Data sheet | 111_004.pdf |
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SNAP25 (synaptosome-associated protein of 25 kD) is a highly conserved protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 is the target of Botulinum neurotoxins A and E which cleave off 9 and 26 amino acids, respectively, from the C-terminus.
SNAP25 is part of the exocytotic fusion complex (v-SNARE) of neurons where it assembles with syntaxin1 and synaptobrevin. It is abundantly localized on the neuronal plasmalemma and on recycling vesicles including synaptic vesicles. It is also expressed in neuroendocrine cells. There are two splice-variants, SNAP25A and 25B.