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SERT antibody - 340 003 K.O.

SERT translocates serotonin back from the synaptic cleft into the presynaptic neuron
Rabbit polyclonal purified antibody
Cat. No.: 340 003
Amount: 50 µg
Price: $375.00
Cat. No. 340 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 up to 1 : 5000 gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 up to 1 : 1000 gallery  
IHC-P: 1 : 200 up to 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 77 from mouse SERT (UniProt Id: Q60857)
Reactivity Reacts with: rat (P31652), mouse (Q60857).
Other species not tested yet.
Specificity K.O. validated PubMed: 28362488
Data sheet 340_003.pdf

References for SERT - 340 003

Sex and brain region-specific regulation of serotonin transporter activity in synaptosomes in guanine nucleotide-binding protein G(q) alpha knockout mice.
Haase J, Jones AKC, Mc Veigh CJ, Brown E, Clarke G, Ahnert-Hilger G
Journal of neurochemistry (2021) : . 340 003 WB; tested species: mouse
TNFα-dependent anhedonia and upregulation of hippocampal serotonin transporter activity in a mouse model of collagen-induced arthritis.
Brown E, Mc Veigh CJ, Santos L, Gogarty M, Müller HK, Elfving B, Brayden DJ, Haase J
Neuropharmacology (2018) : . 340 003 WB; tested species: mouse
Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice.
Cataldi S, Follett J, Fox JD, Tatarnikov I, Kadgien C, Gustavsson EK, Khinda J, Milnerwood AJ, Farrer MJ
NPJ Parkinson's disease (2018) 4: 27. 340 003 WB; tested species: mouse
Serotonin Transporter Associated Protein Complexes Are Enriched in Synaptic Vesicle Proteins and Proteins Involved in Energy Metabolism and Ion Homeostasis.
Haase J, Grudzinska-Goebel J, Müller HK, Münster-Wandowski A, Chow E, Wynne K, Farsi Z, Zander JF, Ahnert-Hilger G
ACS chemical neuroscience (2017) 85: 1101-1116. 340 003 WB, EM; KO verified; tested species: mouse,rat
Fluoxetine reverses early-life stress-induced depressive-like behaviors and region-specific alterations of monoamine transporters in female mice.
Zheng JY, Li XX, Liu X, Zhang CC, Sun YX, Ma YN, Wang HL, Su YA, Si TM, Li JT
Pharmacology, biochemistry, and behavior (2024) 237: 173722. 340 003 IHC; tested species: mouse
Enoxaparin promotes functional recovery after spinal cord injury by antagonizing PTPRσ.
Ito S, Ozaki T, Morozumi M, Imagama S, Kadomatsu K, Sakamoto K
Experimental neurology (2021) 340: 113679. 340 003 IHC; tested species: rat
The development of synaptic transmission is time-locked to early social behaviors in rats.
Naskar S, Narducci R, Balzani E, Cwetsch AW, Tucci V, Cancedda L
Nature communications (2019) 101: 1195. 340 003 IHC; tested species: rat
Serotonin Transporter Associated Protein Complexes Are Enriched in Synaptic Vesicle Proteins and Proteins Involved in Energy Metabolism and Ion Homeostasis.
Haase J, Grudzinska-Goebel J, Müller HK, Münster-Wandowski A, Chow E, Wynne K, Farsi Z, Zander JF, Ahnert-Hilger G
ACS chemical neuroscience (2017) 85: 1101-1116. 340 003 WB, EM; KO verified; tested species: mouse,rat
Cat. No.: 340 003
Amount: 50 µg
Price: $375.00
Sex and brain region-specific regulation of serotonin transporter activity in synaptosomes in guanine nucleotide-binding protein G(q) alpha knockout mice.
Haase J, Jones AKC, Mc Veigh CJ, Brown E, Clarke G, Ahnert-Hilger G
Journal of neurochemistry (2021) : . 340 003 WB; tested species: mouse
TNFα-dependent anhedonia and upregulation of hippocampal serotonin transporter activity in a mouse model of collagen-induced arthritis.
Brown E, Mc Veigh CJ, Santos L, Gogarty M, Müller HK, Elfving B, Brayden DJ, Haase J
Neuropharmacology (2018) : . 340 003 WB; tested species: mouse
Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice.
Cataldi S, Follett J, Fox JD, Tatarnikov I, Kadgien C, Gustavsson EK, Khinda J, Milnerwood AJ, Farrer MJ
NPJ Parkinson's disease (2018) 4: 27. 340 003 WB; tested species: mouse
Serotonin Transporter Associated Protein Complexes Are Enriched in Synaptic Vesicle Proteins and Proteins Involved in Energy Metabolism and Ion Homeostasis.
Haase J, Grudzinska-Goebel J, Müller HK, Münster-Wandowski A, Chow E, Wynne K, Farsi Z, Zander JF, Ahnert-Hilger G
ACS chemical neuroscience (2017) 85: 1101-1116. 340 003 WB, EM; KO verified; tested species: mouse,rat
Fluoxetine reverses early-life stress-induced depressive-like behaviors and region-specific alterations of monoamine transporters in female mice.
Zheng JY, Li XX, Liu X, Zhang CC, Sun YX, Ma YN, Wang HL, Su YA, Si TM, Li JT
Pharmacology, biochemistry, and behavior (2024) 237: 173722. 340 003 IHC; tested species: mouse
Enoxaparin promotes functional recovery after spinal cord injury by antagonizing PTPRσ.
Ito S, Ozaki T, Morozumi M, Imagama S, Kadomatsu K, Sakamoto K
Experimental neurology (2021) 340: 113679. 340 003 IHC; tested species: rat
The development of synaptic transmission is time-locked to early social behaviors in rats.
Naskar S, Narducci R, Balzani E, Cwetsch AW, Tucci V, Cancedda L
Nature communications (2019) 101: 1195. 340 003 IHC; tested species: rat
Serotonin Transporter Associated Protein Complexes Are Enriched in Synaptic Vesicle Proteins and Proteins Involved in Energy Metabolism and Ion Homeostasis.
Haase J, Grudzinska-Goebel J, Müller HK, Münster-Wandowski A, Chow E, Wynne K, Farsi Z, Zander JF, Ahnert-Hilger G
ACS chemical neuroscience (2017) 85: 1101-1116. 340 003 WB, EM; KO verified; tested species: mouse,rat
WB
ICC
IHC
IHC-P
Background
This serotonin transporter (SERT), also referred to as 5HTT and Slc6a4, is a monoamine transporter protein that transports serotonin back from the synaptic cleft into the presynaptic neuron to terminate the action of this neurotransmitter.
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