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Home > Products > 105 223

Synaptotagmin2 antibody luminal domain - 105 223

Synaptotagmin2 is an alternative Ca2+-sensor for neurotransmitter release
Rabbit polyclonal purified antibody
Cat. No.: 105 223
Amount: 50 µg
Price: $460.00
Cat. No. 105 223 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 100 (see remarks) gallery  
IHC: 1 : 500 gallery  
IHC-P: not tested yet
Immunogen Synthetic peptide corresponding to AA 1 to 11 from mouse Synaptotagmin2 (UniProt Id: P46097)
Reactivity Reacts with: rat (P29101), mouse (P46097).
Other species not tested yet.
Remarks

ICC: This antibody is intended to be used for direct labeling of recycling synapses in primary neuronal cultures.
Data sheet 105_223.pdf

References for Synaptotagmin2 - 105 223

The proteomic landscape of synaptic diversity across brain regions and cell types.
van Oostrum M, Blok TM, Giandomenico SL, Tom Dieck S, Tushev G, Fürst N, Langer JD, Schuman EM
Cell (2023) 18624: 5411-5427.e23. 105 223 IHC; tested species: mouse
The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.
Wen L, Yang X, Wu Z, Fu S, Zhan Y, Chen Z, Bi D, Shen Y
Cell reports (2023) 424: 112349. 105 223 IHC; tested species: mouse
Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome.
Gu F, Parada I, Yang T, Longo FM, Prince DA
Proceedings of the National Academy of Sciences of the United States of America (2022) 1197: . 105 223 IHC; tested species: mouse
Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition.
Dubey M, Pascual-Garcia M, Helmes K, Wever DD, Hamada MS, Kushner SA, Kole MHP
eLife (2022) 11: . 105 223 IHC; tested species: mouse
ROCK/PKA inhibition rescues hippocampal hyperexcitability and GABAergic neuron alterations in Oligophrenin-1 Knock-out mouse model of X-linked intellectual disability.
Busti I, Allegra M, Spalletti C, Panzi C, Restani L, Billuart P, Caleo M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 105 223 IHC; tested species: mouse
Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain.
Park J, Park SJ, Kim S
Molecular brain (2019) 121: 58. 105 223 IHC; tested species: mouse
Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.
Beurg M, Michalski N, Safieddine S, Bouleau Y, Schneggenburger R, Chapman ER, Petit C, Dulon D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3040: 13281-90. 105 223 IHC; tested species: rat
Cat. No.: 105 223
Amount: 50 µg
Price: $460.00
The proteomic landscape of synaptic diversity across brain regions and cell types.
van Oostrum M, Blok TM, Giandomenico SL, Tom Dieck S, Tushev G, Fürst N, Langer JD, Schuman EM
Cell (2023) 18624: 5411-5427.e23. 105 223 IHC; tested species: mouse
The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.
Wen L, Yang X, Wu Z, Fu S, Zhan Y, Chen Z, Bi D, Shen Y
Cell reports (2023) 424: 112349. 105 223 IHC; tested species: mouse
Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome.
Gu F, Parada I, Yang T, Longo FM, Prince DA
Proceedings of the National Academy of Sciences of the United States of America (2022) 1197: . 105 223 IHC; tested species: mouse
Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition.
Dubey M, Pascual-Garcia M, Helmes K, Wever DD, Hamada MS, Kushner SA, Kole MHP
eLife (2022) 11: . 105 223 IHC; tested species: mouse
ROCK/PKA inhibition rescues hippocampal hyperexcitability and GABAergic neuron alterations in Oligophrenin-1 Knock-out mouse model of X-linked intellectual disability.
Busti I, Allegra M, Spalletti C, Panzi C, Restani L, Billuart P, Caleo M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 105 223 IHC; tested species: mouse
Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain.
Park J, Park SJ, Kim S
Molecular brain (2019) 121: 58. 105 223 IHC; tested species: mouse
Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.
Beurg M, Michalski N, Safieddine S, Bouleau Y, Schneggenburger R, Chapman ER, Petit C, Dulon D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3040: 13281-90. 105 223 IHC; tested species: rat
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ICC
IHC
IHC
IHC
Background

Synaptotagmin2 is an integral membrane glycoprotein of neuronal synaptic vesicles. It is very similar to synaptotagmin1 but shows a partly complementary expression pattern in the CNS. Synaptotagmin2 lacks a CAMK II/PKC phosphorylation site which is present in synaptotagmin1.
Recently synaptotagmin2 has been shown to be an alternative Ca2+ sensor for fast secretion.
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