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Home > Products > 105 123

Synaptotagmin2 antibody cytoplasmic domain - 105 123

Synaptotagmin2 is an alternative Ca2+-sensor for neurotransmitter release
Rabbit polyclonal purified antibody
Cat. No.: 105 123
Amount: 50 µg
Price: $375.00
Cat. No. 105 123 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: yes
IHC: not tested yet
IHC-P: not tested yet
Immunogen Synthetic peptide corresponding to AA 406 to 422 from rat Synaptotagmin2 (UniProt Id: P29101)
Reactivity Reacts with: human (Q8N9I0), rat (P29101), mouse (P46097).
Other species not tested yet.
Matching control protein/peptide 105-12P
Data sheet 105_123.pdf

References for Synaptotagmin2 - 105 123

SV2B defines a subpopulation of synaptic vesicles.
Paulussen I, Beckert H, Musial TF, Gschossmann LJ, Wolf J, Schmitt M, Clasadonte J, Mairet-Coello G, Wolff C, Schoch S, Dietrich D, et al.
Journal of molecular cell biology (2023) : . 105 123 WB; tested species: mouse
Paroxysmal and cognitive phenotypes in Prrt2 mutant mice.
Robertson L, Featherby T, Howell S, Hughes J, Thomas P
Genes, brain, and behavior (2019) : e12566. 105 123 WB; tested species: mouse
Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carré D, Kalinichev M, Lezmi S, Mir I, et al.
Science advances (2019) 51: eaau7196. 105 123 WB; tested species: mouse
Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.
Culver BP, Savas JN, Park SK, Choi JH, Zheng S, Zeitlin SO, Yates JR, Tanese N
The Journal of biological chemistry (2012) 28726: 21599-614. 105 123 WB
Novel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detection.
Whitemarsh RC, Strathman MJ, Chase LG, Stankewicz C, Tepp WH, Johnson EA, Pellett S
Toxicological sciences : an official journal of the Society of Toxicology (2012) 1262: 426-35. 105 123 WB
Human Induced Pluripotent Stem Cell Derived Neuronal Cells Cultured on Chemically-Defined Hydrogels for Sensitive In Vitro Detection of Botulinum Neurotoxin.
Pellett S, Schwartz MP, Tepp WH, Josephson R, Scherf JM, Pier CL, Thomson JA, Murphy WL, Johnson EA
Scientific reports (2015) 5: 14566. 105 123 ICC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 105 123 ICC; tested species: rat
Calcium is Reduced in Presynaptic Mitochondria of Motor Nerve Terminals during Neurotransmission in SMA Mice.
Lopez-Manzaneda M, Franco-Espin J, Tejero R, Cano R, Tabares L
Human molecular genetics (2021) : . 105 123 IHC; tested species: mouse
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 105 123 IHC; tested species: rat
Loss of β2-laminin alters calcium sensitivity and voltage-gated calcium channel maturation of neurotransmission at the neuromuscular junction.
Chand KK, Lee KM, Schenning MP, Lavidis NA, Noakes PG
The Journal of physiology (2015) 5931: 245-65. 105 123 IHC
Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses.
Johnson SL, Franz C, Kuhn S, Furness DN, Rüttiger L, Münkner S, Rivolta MN, Seward EP, Herschman HR, Engel J, Knipper M, et al.
Nature neuroscience (2010) 131: 45-52. 105 123 IHC
Spatial proteomics in neurons at single-protein resolution.
Unterauer EM, Shetab Boushehri S, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, et al.
Cell (2024) 1877: 1785-1800.e16. 105 123 DNA-PAINT; tested species: rat
Cat. No.: 105 123
Amount: 50 µg
Price: $375.00
SV2B defines a subpopulation of synaptic vesicles.
Paulussen I, Beckert H, Musial TF, Gschossmann LJ, Wolf J, Schmitt M, Clasadonte J, Mairet-Coello G, Wolff C, Schoch S, Dietrich D, et al.
Journal of molecular cell biology (2023) : . 105 123 WB; tested species: mouse
Paroxysmal and cognitive phenotypes in Prrt2 mutant mice.
Robertson L, Featherby T, Howell S, Hughes J, Thomas P
Genes, brain, and behavior (2019) : e12566. 105 123 WB; tested species: mouse
Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carré D, Kalinichev M, Lezmi S, Mir I, et al.
Science advances (2019) 51: eaau7196. 105 123 WB; tested species: mouse
Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.
Culver BP, Savas JN, Park SK, Choi JH, Zheng S, Zeitlin SO, Yates JR, Tanese N
The Journal of biological chemistry (2012) 28726: 21599-614. 105 123 WB
Novel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detection.
Whitemarsh RC, Strathman MJ, Chase LG, Stankewicz C, Tepp WH, Johnson EA, Pellett S
Toxicological sciences : an official journal of the Society of Toxicology (2012) 1262: 426-35. 105 123 WB
Human Induced Pluripotent Stem Cell Derived Neuronal Cells Cultured on Chemically-Defined Hydrogels for Sensitive In Vitro Detection of Botulinum Neurotoxin.
Pellett S, Schwartz MP, Tepp WH, Josephson R, Scherf JM, Pier CL, Thomson JA, Murphy WL, Johnson EA
Scientific reports (2015) 5: 14566. 105 123 ICC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 105 123 ICC; tested species: rat
Calcium is Reduced in Presynaptic Mitochondria of Motor Nerve Terminals during Neurotransmission in SMA Mice.
Lopez-Manzaneda M, Franco-Espin J, Tejero R, Cano R, Tabares L
Human molecular genetics (2021) : . 105 123 IHC; tested species: mouse
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 105 123 IHC; tested species: rat
Loss of β2-laminin alters calcium sensitivity and voltage-gated calcium channel maturation of neurotransmission at the neuromuscular junction.
Chand KK, Lee KM, Schenning MP, Lavidis NA, Noakes PG
The Journal of physiology (2015) 5931: 245-65. 105 123 IHC
Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses.
Johnson SL, Franz C, Kuhn S, Furness DN, Rüttiger L, Münkner S, Rivolta MN, Seward EP, Herschman HR, Engel J, Knipper M, et al.
Nature neuroscience (2010) 131: 45-52. 105 123 IHC
Spatial proteomics in neurons at single-protein resolution.
Unterauer EM, Shetab Boushehri S, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, et al.
Cell (2024) 1877: 1785-1800.e16. 105 123 DNA-PAINT; tested species: rat
WB
Background

Synaptotagmin2 is an integral membrane glycoprotein of neuronal synaptic vesicles. It is very similar to synaptotagmin1 but shows a partly complementary expression pattern in the CNS. Synaptotagmin2 lacks a CAMK II/PKC phosphorylation site which is present in synaptotagmin1.
Recently synaptotagmin2 has been shown to be an alternative Ca2+ sensor for fast secretion.
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