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Synaptotagmin11 antibody - 270 003 K.D.

Synaptotagmin11 is potentially involved in Parkinson´s desease and schizophrenia
Rabbit polyclonal purified antibody
Cat. No.: 270 003
Amount: 50 µg
Price: $380.00
Cat. No. 270 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 gallery  
IP: not tested yet
ICC: 1 : 500
IHC: not tested yet
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 70 to 154 from mouse Synaptotagmin11 (UniProt Id: Q9R0N3)
Reactivity Reacts with: rat (O08835), mouse (Q9R0N3).
Other species not tested yet.
Specificity K.D. validated PubMed: 28686317
Matching control protein/peptide 270-0P
Data sheet 270_003.pdf

References for Synaptotagmin11 - 270 003

Synaptotagmin-11 facilitates assembly of a presynaptic signaling complex in post-Golgi cargo vesicles.
Trovò L, Kouvaros S, Schwenk J, Fernandez-Fernandez D, Fritzius T, Rem PD, Früh S, Gassmann M, Fakler B, Bischofberger J, Bettler B, et al.
EMBO reports (2024) : . 270 003 WB, ICC; tested species: mouse,human
Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology.
Ng XY, Wu Y, Lin Y, Yaqoob SM, Greene LE, De Camilli P, Cao M
NPJ Parkinson's disease (2023) 91: 26. 270 003 WB; tested species: mouse
Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in microglia.
Du C, Wang Y, Zhang F, Yan S, Guan Y, Gong X, Zhang T, Cui X, Wang X, Zhang CX
Glia (2017) 6510: 1656-1667. 270 003 WB; KD verified; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 270 003 ICC, WB
Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.
Sreetama SC, Takano T, Nedergaard M, Simon SM, Jaiswal JK
Cell death and differentiation (2016) 234: 596-607. 270 003 WB, ICC; tested species: mouse
Synaptotagmin-11 facilitates assembly of a presynaptic signaling complex in post-Golgi cargo vesicles.
Trovò L, Kouvaros S, Schwenk J, Fernandez-Fernandez D, Fritzius T, Rem PD, Früh S, Gassmann M, Fakler B, Bischofberger J, Bettler B, et al.
EMBO reports (2024) : . 270 003 WB, ICC; tested species: mouse,human
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 270 003 ICC, WB
Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.
Sreetama SC, Takano T, Nedergaard M, Simon SM, Jaiswal JK
Cell death and differentiation (2016) 234: 596-607. 270 003 WB, ICC; tested species: mouse
Activity-dependent formation of a vesicular inhibitory amino acid transporter gradient in the superior olivary complex of NMRI mice.
Ebbers L, Weber M, Nothwang HG
BMC neuroscience (2017) 181: 75. 270 003 IHC; tested species: mouse
Cat. No.: 270 003
Amount: 50 µg
Price: $380.00
Synaptotagmin-11 facilitates assembly of a presynaptic signaling complex in post-Golgi cargo vesicles.
Trovò L, Kouvaros S, Schwenk J, Fernandez-Fernandez D, Fritzius T, Rem PD, Früh S, Gassmann M, Fakler B, Bischofberger J, Bettler B, et al.
EMBO reports (2024) : . 270 003 WB, ICC; tested species: mouse,human
Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology.
Ng XY, Wu Y, Lin Y, Yaqoob SM, Greene LE, De Camilli P, Cao M
NPJ Parkinson's disease (2023) 91: 26. 270 003 WB; tested species: mouse
Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in microglia.
Du C, Wang Y, Zhang F, Yan S, Guan Y, Gong X, Zhang T, Cui X, Wang X, Zhang CX
Glia (2017) 6510: 1656-1667. 270 003 WB; KD verified; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 270 003 ICC, WB
Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.
Sreetama SC, Takano T, Nedergaard M, Simon SM, Jaiswal JK
Cell death and differentiation (2016) 234: 596-607. 270 003 WB, ICC; tested species: mouse
Synaptotagmin-11 facilitates assembly of a presynaptic signaling complex in post-Golgi cargo vesicles.
Trovò L, Kouvaros S, Schwenk J, Fernandez-Fernandez D, Fritzius T, Rem PD, Früh S, Gassmann M, Fakler B, Bischofberger J, Bettler B, et al.
EMBO reports (2024) : . 270 003 WB, ICC; tested species: mouse,human
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 270 003 ICC, WB
Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.
Sreetama SC, Takano T, Nedergaard M, Simon SM, Jaiswal JK
Cell death and differentiation (2016) 234: 596-607. 270 003 WB, ICC; tested species: mouse
Activity-dependent formation of a vesicular inhibitory amino acid transporter gradient in the superior olivary complex of NMRI mice.
Ebbers L, Weber M, Nothwang HG
BMC neuroscience (2017) 181: 75. 270 003 IHC; tested species: mouse
WB
Background

Up to now at least 17 synaptotagmins have been identified. Synaptotagmin11, a close relative of synaptotagmin4, is mainly expressed in the brain. It is composed of a vesicular, a transmembrane and two C2 domains. Only the C2B domain is able to bind calcium. In the C2A domain one of the calcium binding aspartates has been substituted for serine leading to a loss of its binding capabilities.
Synaptotagmin11 has been shown to localize mainly to excitatory and inhibitory presynaptic terminals.
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