Cat. No.: 163 004
Amount: 100 µl
Price:
$370.00
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| Cat. No. 163 004 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to residues near the central region of mouse Synaptopodin. (UniProt Id: Q8CC35) |
| Reactivity |
Reacts with: rat (Q9Z327), mouse (Q8CC35), human (Q8N3V7). Other species not tested yet. |
| Specificity | This antibody detects the renal Synpo-long and the neuronal Synpo-short isofoms but is negativ for the T-variant. K.O. validated PubMed: 28922860 |
| Matching control protein/peptide | 163-0P |
| Remarks |
WB: The antibody is less sensitive than the rabbit antiserum (cat. no. 163 002). |
| Data sheet | 163_004.pdf |
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Synaptopodin is the founding member of a class of proline-rich actin-associated proteins and has been originally identified in podocytes of renal glomeruli (1, 2). In brain it localizes to the post-synaptic density (PSD) and the spine aparatus (1). In humans, three isoforms of synaptopodin with a distinct expression profile have been identified, neuronal Synpo-short, renal Synpo-long and Synpo-T. All three isoforms interact with alpha-actinin and induce alpha-actinin-induced actin filaments (3).
Synaptopodin deficient mice lack the dendritic spine apparatus and exhibit impaired activity-dependent long-term synaptic plasticity (4).