Cat. No.: 118 002
Amount: 200 µl
Price:
$355.00
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| Cat. No. 118 002 |
200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not recommended ICC: not tested yet IHC: yes IHC-P: not tested yet |
| Immunogen | Synthetic peptide corresponding to AA 671 to 684 from rat Rabphilin3a (UniProt Id: P47709) |
| Reactivity |
Reacts with: human (Q9Y2J0), rat (P47709), mouse (P47708), cow. Other species not tested yet. |
| Matching control protein/peptide | 118-0P |
| Data sheet | 118_002.pdf |
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Rabphilin 3a is a putative effector protein for the low molecular weight GTP-binding protein rab 3. Rab 3 occurs in four isoforms (Rab 3a, b, c and d), all of which probably bind to rabphilin 3a when in the GTP-bound form.
Rabphilin 3a contains an N-terminal Zn2+-finger sequence that is essential for binding rab 3, and two C-terminal C2 - domains that may bind Ca2+. It does not have a transmembrane region.
Rabphilin 3a is primarily expressed in neurons where it is localized to synaptic vesicles. It is probably recruited to synaptic vesicles by rab 3a and 3c. The structure of rabphilin 3a and its interaction with rab 3 suggests that it may be a Ca2+ sensor on synaptic vesicles that is recruited to synaptic vesicles as a function of GTP by rab 3.