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Home > Products > 195 006

Parvalbumin antibody - 195 006

Parvalbumin is calcium binding protein specific for a subpopulation of GABAergic interneurones
Chicken polyclonal IgY fraction
Cat. No.: 195 006
Amount: 200 µl
Price: $365.00
Cat. No. 195 006 200 µl antibody, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet (see remarks)
IP: yes
ICC: not tested yet
IHC: 1 : 500 gallery  
IHC-P: 1 : 200 gallery  

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.
Immunogen Full-length recombinant rat Parvalbumin (UniProt Id: P02625)
Reactivity Reacts with: rat (P02625), mouse (P32848).
Other species not tested yet.
Matching control protein/peptide 195-0P
Remarks

WB: The rabbit polyclonal antiserum (cat. no. 195 002) is recommended for westernblotting. Due to its small size, a tricine gel should be used.
Data sheet 195_006.pdf

References for Parvalbumin - 195 006

Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2.
Mueller-Buehl C, Reinhard J, Roll L, Bader V, Winklhofer KF, Faissner A
Frontiers in cell and developmental biology (2022) 10: 886527. 195 006 WB, IHC; tested species: mouse
Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice.
Chelini G, Mirzapourdelavar H, Durning P, Baidoe-Ansah D, Sethi MK, O'Donovan SM, Klengel T, Balasco L, Berciu C, Boyer-Boiteau A, McCullumsmith R, et al.
Cell reports (2024) 435: 114112. 195 006 ICC; tested species: mouse
The antipsychotic drugs olanzapine and haloperidol modify network connectivity and spontaneous activity of neural networks in vitro.
Dzyubenko E, Juckel G, Faissner A
Scientific reports (2017) 71: 11609. 195 006 ICC; tested species: mouse
Creation of a novel CRISPR-generated allele to express HA epitope-tagged C1QL1 and improved methods for its detection at synapses.
Cheung HW, Schouw AD, Altunay ZM, Maddox JW, Kresic LC, McAllister BC, Caro K, Alam S, Huang A, Pijewski RS, Lee A, et al.
FEBS letters (2024) : . 195 006 IHC; tested species: mouse
Calretinin-Expressing Synapses Show Improved Synaptic Efficacy with Reduced Asynchronous Release during High-Rate Activity.
Zhang C, Wang M, Lin S, Xie R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) 4213: 2729-2742. 195 006 IHC; tested species: mouse
Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2.
Mueller-Buehl C, Reinhard J, Roll L, Bader V, Winklhofer KF, Faissner A
Frontiers in cell and developmental biology (2022) 10: 886527. 195 006 WB, IHC; tested species: mouse
C1ql1 is expressed in adult outer hair cells of the cochlea in a tonotopic gradient.
Biswas J, Pijewski RS, Makol R, Miramontes TG, Thompson BL, Kresic LC, Burghard AL, Oliver DL, Martinelli DC
PloS one (2021) 165: e0251412. 195 006 IHC; tested species: mouse
Anoctamin 2-chloride channels reduce simple spike activity and mediate inhibition at elevated calcium concentration in cerebellar Purkinje cells.
Auer F, Franco Taveras E, Klein U, Kesenheimer C, Fleischhauer D, Möhrlen F, Frings S
PloS one (2021) 163: e0247801. 195 006 IHC; tested species: mouse
Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis.
Wilke JBH, Hindermann M, Berghoff SA, Zihsler S, Arinrad S, Ronnenberg A, Barnkothe N, Steixner-Kumar AA, Röglin S, Stöcker W, Hollmann M, et al.
Molecular psychiatry (2021) : . 195 006 IHC; tested species: mouse
Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice.
Strackeljan L, Baczynska E, Cangalaya C, Baidoe-Ansah D, Wlodarczyk J, Kaushik R, Dityatev A
Cells (2021) 108: . 195 006 IHC; tested species: mouse
Spatial Expression Pattern of the Major Ca2+-Buffer Proteins in Mouse Retinal Ganglion Cells.
Kovács-Öller T, Szarka G, Tengölics ÁJ, Ganczer A, Balogh B, Szabó-Meleg E, Nyitrai M, Völgyi B
Cells (2020) 94: . 195 006 IHC; tested species: mouse
Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits.
Exposito-Alonso D, Osório C, Bernard C, Pascual-García S, Del Pino I, Marín O, Rico B
eLife (2020) 9: . 195 006 IHC; tested species: mouse
Npas1+-Nkx2.1+ Neurons Are an Integral Part of the Cortico-pallido-cortical Loop.
Abecassis ZA, Berceau BL, Win PH, García D, Xenias HS, Cui Q, Pamukcu A, Cherian S, Hernández VM, Chon U, Lim BK, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 404: 743-768. 195 006 IHC; tested species: mouse
Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus But Leaves Cortical Layering and Behavior Unaffected.
Pahle J, Muhia M, Wagener RJ, Tippmann A, Bock HH, Graw J, Herz J, Staiger JF, Drakew A, Kneussel M, Rune GM, et al.
Cerebral cortex (New York, N.Y. : 1991) (2019) : . 195 006 IHC; tested species: mouse
Increased Excitability and Reduced Excitatory Synaptic Input Into Fast-Spiking CA2 Interneurons After Enzymatic Attenuation of Extracellular Matrix.
Hayani H, Song I, Dityatev A
Frontiers in cellular neuroscience (2018) 12: 149. 195 006 IHC; tested species: mouse
Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.
Favuzzi E, Marques-Smith A, Deogracias R, Winterflood CM, Sánchez-Aguilera A, Mantoan L, Maeso P, Fernandes C, Ewers H, Rico B
Neuron (2017) 953: 639-655.e10. 195 006 IHC; tested species: mouse
Cat. No.: 195 006
Amount: 200 µl
Price: $365.00
Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2.
Mueller-Buehl C, Reinhard J, Roll L, Bader V, Winklhofer KF, Faissner A
Frontiers in cell and developmental biology (2022) 10: 886527. 195 006 WB, IHC; tested species: mouse
Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice.
Chelini G, Mirzapourdelavar H, Durning P, Baidoe-Ansah D, Sethi MK, O'Donovan SM, Klengel T, Balasco L, Berciu C, Boyer-Boiteau A, McCullumsmith R, et al.
Cell reports (2024) 435: 114112. 195 006 ICC; tested species: mouse
The antipsychotic drugs olanzapine and haloperidol modify network connectivity and spontaneous activity of neural networks in vitro.
Dzyubenko E, Juckel G, Faissner A
Scientific reports (2017) 71: 11609. 195 006 ICC; tested species: mouse
Creation of a novel CRISPR-generated allele to express HA epitope-tagged C1QL1 and improved methods for its detection at synapses.
Cheung HW, Schouw AD, Altunay ZM, Maddox JW, Kresic LC, McAllister BC, Caro K, Alam S, Huang A, Pijewski RS, Lee A, et al.
FEBS letters (2024) : . 195 006 IHC; tested species: mouse
Calretinin-Expressing Synapses Show Improved Synaptic Efficacy with Reduced Asynchronous Release during High-Rate Activity.
Zhang C, Wang M, Lin S, Xie R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) 4213: 2729-2742. 195 006 IHC; tested species: mouse
Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2.
Mueller-Buehl C, Reinhard J, Roll L, Bader V, Winklhofer KF, Faissner A
Frontiers in cell and developmental biology (2022) 10: 886527. 195 006 WB, IHC; tested species: mouse
C1ql1 is expressed in adult outer hair cells of the cochlea in a tonotopic gradient.
Biswas J, Pijewski RS, Makol R, Miramontes TG, Thompson BL, Kresic LC, Burghard AL, Oliver DL, Martinelli DC
PloS one (2021) 165: e0251412. 195 006 IHC; tested species: mouse
Anoctamin 2-chloride channels reduce simple spike activity and mediate inhibition at elevated calcium concentration in cerebellar Purkinje cells.
Auer F, Franco Taveras E, Klein U, Kesenheimer C, Fleischhauer D, Möhrlen F, Frings S
PloS one (2021) 163: e0247801. 195 006 IHC; tested species: mouse
Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis.
Wilke JBH, Hindermann M, Berghoff SA, Zihsler S, Arinrad S, Ronnenberg A, Barnkothe N, Steixner-Kumar AA, Röglin S, Stöcker W, Hollmann M, et al.
Molecular psychiatry (2021) : . 195 006 IHC; tested species: mouse
Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice.
Strackeljan L, Baczynska E, Cangalaya C, Baidoe-Ansah D, Wlodarczyk J, Kaushik R, Dityatev A
Cells (2021) 108: . 195 006 IHC; tested species: mouse
Spatial Expression Pattern of the Major Ca2+-Buffer Proteins in Mouse Retinal Ganglion Cells.
Kovács-Öller T, Szarka G, Tengölics ÁJ, Ganczer A, Balogh B, Szabó-Meleg E, Nyitrai M, Völgyi B
Cells (2020) 94: . 195 006 IHC; tested species: mouse
Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits.
Exposito-Alonso D, Osório C, Bernard C, Pascual-García S, Del Pino I, Marín O, Rico B
eLife (2020) 9: . 195 006 IHC; tested species: mouse
Npas1+-Nkx2.1+ Neurons Are an Integral Part of the Cortico-pallido-cortical Loop.
Abecassis ZA, Berceau BL, Win PH, García D, Xenias HS, Cui Q, Pamukcu A, Cherian S, Hernández VM, Chon U, Lim BK, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 404: 743-768. 195 006 IHC; tested species: mouse
Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus But Leaves Cortical Layering and Behavior Unaffected.
Pahle J, Muhia M, Wagener RJ, Tippmann A, Bock HH, Graw J, Herz J, Staiger JF, Drakew A, Kneussel M, Rune GM, et al.
Cerebral cortex (New York, N.Y. : 1991) (2019) : . 195 006 IHC; tested species: mouse
Increased Excitability and Reduced Excitatory Synaptic Input Into Fast-Spiking CA2 Interneurons After Enzymatic Attenuation of Extracellular Matrix.
Hayani H, Song I, Dityatev A
Frontiers in cellular neuroscience (2018) 12: 149. 195 006 IHC; tested species: mouse
Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.
Favuzzi E, Marques-Smith A, Deogracias R, Winterflood CM, Sánchez-Aguilera A, Mantoan L, Maeso P, Fernandes C, Ewers H, Rico B
Neuron (2017) 953: 639-655.e10. 195 006 IHC; tested species: mouse
IHC
IHC
IHC
IHC-P
Background

Parvalbumin is a small, acidic calcium binding protein and belongs to the family of EF hand proteins. The protein is found in skeletal muscle and the brain of vertebrates where it locates to a specific population of GABAergic interneurons. This subset of neurons may contribute to maintaining the balance between excitation and inhibition in the cortex and the hippocampus.
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