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Home > Products > 129 202

Neuroligin2 antibody - 129 202 K.O.

Neuroligins are postsynaptic cell adhesion molecules
Rabbit polyclonal antiserum
Cat. No.: 129 202
Amount: 200 µl
Price: $355.00
Cat. No. 129 202 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not recommended (see remarks)
IHC: not recommended
IHC-P: not tested yet
Immunogen Synthetic peptide corresponding to AA 732 to 749 and 750 to 767 from rat Neuroligin2 (UniProt Id: Q62888)
Reactivity Reacts with: human (Q8NFZ4), rat (Q62888), mouse (Q69ZK9), monkey, ape, cow.
Other species not tested yet.
Specificity K.O. validated
Remarks

ICC: The affinity purified antibody (cat. no. 129 203) is highly recommended for ICC.
Data sheet 129_202.pdf

References for Neuroligin2 - 129 202

Phosphorylation of neuroligin-2 by PKA regulates its cell surface abundance and synaptic stabilization.
Halff EF, Hannan S, Kwanthongdee J, Lesept F, Smart TG, Kittler JT
Science signaling (2022) 15739: eabg2505. 129 202 WB; tested species: rat
PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex.
McEachern EP, Coley AA, Yang SS, Gao WJ
Neuropharmacology (2020) 179: 108277. 129 202 WB, IP; tested species: mouse
Chemico-genetic discovery of astrocytic control of inhibition in vivo.
Takano T, Wallace JT, Baldwin KT, Purkey AM, Uezu A, Courtland JL, Soderblom EJ, Shimogori T, Maness PF, Eroglu C, Soderling SH, et al.
Nature (2020) : . 129 202 WB; tested species: mouse
LAR-RPTPs Directly Interact with Neurexins to Coordinate Bidirectional Assembly of Molecular Machineries.
Han KA, Kim YJ, Yoon TH, Kim H, Bae S, Um JW, Choi SY, Ko J
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 129 202 WB; tested species: rat
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.
Xu ZX, Kim GH, Tan JW, Riso AE, Sun Y, Xu EY, Liao GY, Xu H, Lee SH, Do NY, Lee CH, et al.
Nature communications (2020) 111: 1797. 129 202 WB; tested species: mouse
A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.
Mastro TL, Preza A, Basu S, Chattarji S, Till SM, Kind PC, Kennedy MB
eLife (2020) 9: . 129 202 WB; tested species: rat
SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling.
Halff EF, Szulc BR, Lesept F, Kittler JT
Cell reports (2019) 299: 2599-2607.e6. 129 202 WB; tested species: rat
Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.
Davenport EC, Szulc BR, Drew J, Taylor J, Morgan T, Higgs NF, López-Doménech G, Kittler JT
Cell reports (2019) 268: 2037-2051.e6. 129 202 WB; tested species: mouse
A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation.
Letellier M, Szíber Z, Chamma I, Saphy C, Papasideri I, Tessier B, Sainlos M, Czöndör K, Thoumine O
Nature communications (2018) 91: 3979. 129 202 WB; tested species: rat
GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation.
Jiang DY, Wu Z, Forsyth CT, Hu Y, Yee SP, Chen G
Molecular brain (2018) 111: 31. 129 202 WB; tested species: mouse
Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1/Neuroligin-2 Complex.
Kim JA, Kim D, Won SY, Han KA, Park D, Cho E, Yun N, An HJ, Um JW, Kim E, Lee JO, et al.
Neuron (2017) 946: 1121-1131.e6. 129 202 WB; tested species: rat
Assembly rules for GABAA receptor complexes in the brain.
Martenson JS, Yamasaki T, Chaudhury NH, Albrecht D, Tomita S
eLife (2017) 6: . 129 202 WB; tested species: mouse
Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins.
Smith KR, Jones KA, Kopeikina KJ, Burette AC, Copits BA, Yoon S, Forrest MP, Fawcett-Patel JM, Hanley JG, Weinberg RJ, Swanson GT, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3746: 11127-11139. 129 202 WB; tested species: rat
GARLH Family Proteins Stabilize GABAA Receptors at Synapses.
Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S
Neuron (2017) 935: 1138-1152.e6. 129 202 WB; tested species: mouse
A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density.
Walkup WG, Mastro TL, Schenker LT, Vielmetter J, Hu R, Iancu A, Reghunathan M, Bannon BD, Kennedy MB
eLife (2016) 5: . 129 202 WB; tested species: mouse
GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses.
Fuchs C, Abitbol K, Burden JJ, Mercer A, Brown L, Iball J, Anne Stephenson F, Thomson AM, Jovanovic JN
The European journal of neuroscience (2013) 388: 3146-58. 129 202 WB; tested species: rat
An unexpected role of neuroligin-2 in regulating KCC2 and GABA functional switch.
Sun C, Zhang L, Chen G
Molecular brain (2013) 6: 23. 129 202 WB
PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex.
McEachern EP, Coley AA, Yang SS, Gao WJ
Neuropharmacology (2020) 179: 108277. 129 202 WB, IP; tested species: mouse
Cat. No.: 129 202
Amount: 200 µl
Price: $355.00
Phosphorylation of neuroligin-2 by PKA regulates its cell surface abundance and synaptic stabilization.
Halff EF, Hannan S, Kwanthongdee J, Lesept F, Smart TG, Kittler JT
Science signaling (2022) 15739: eabg2505. 129 202 WB; tested species: rat
PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex.
McEachern EP, Coley AA, Yang SS, Gao WJ
Neuropharmacology (2020) 179: 108277. 129 202 WB, IP; tested species: mouse
Chemico-genetic discovery of astrocytic control of inhibition in vivo.
Takano T, Wallace JT, Baldwin KT, Purkey AM, Uezu A, Courtland JL, Soderblom EJ, Shimogori T, Maness PF, Eroglu C, Soderling SH, et al.
Nature (2020) : . 129 202 WB; tested species: mouse
LAR-RPTPs Directly Interact with Neurexins to Coordinate Bidirectional Assembly of Molecular Machineries.
Han KA, Kim YJ, Yoon TH, Kim H, Bae S, Um JW, Choi SY, Ko J
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 129 202 WB; tested species: rat
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.
Xu ZX, Kim GH, Tan JW, Riso AE, Sun Y, Xu EY, Liao GY, Xu H, Lee SH, Do NY, Lee CH, et al.
Nature communications (2020) 111: 1797. 129 202 WB; tested species: mouse
A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.
Mastro TL, Preza A, Basu S, Chattarji S, Till SM, Kind PC, Kennedy MB
eLife (2020) 9: . 129 202 WB; tested species: rat
SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling.
Halff EF, Szulc BR, Lesept F, Kittler JT
Cell reports (2019) 299: 2599-2607.e6. 129 202 WB; tested species: rat
Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.
Davenport EC, Szulc BR, Drew J, Taylor J, Morgan T, Higgs NF, López-Doménech G, Kittler JT
Cell reports (2019) 268: 2037-2051.e6. 129 202 WB; tested species: mouse
A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation.
Letellier M, Szíber Z, Chamma I, Saphy C, Papasideri I, Tessier B, Sainlos M, Czöndör K, Thoumine O
Nature communications (2018) 91: 3979. 129 202 WB; tested species: rat
GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation.
Jiang DY, Wu Z, Forsyth CT, Hu Y, Yee SP, Chen G
Molecular brain (2018) 111: 31. 129 202 WB; tested species: mouse
Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1/Neuroligin-2 Complex.
Kim JA, Kim D, Won SY, Han KA, Park D, Cho E, Yun N, An HJ, Um JW, Kim E, Lee JO, et al.
Neuron (2017) 946: 1121-1131.e6. 129 202 WB; tested species: rat
Assembly rules for GABAA receptor complexes in the brain.
Martenson JS, Yamasaki T, Chaudhury NH, Albrecht D, Tomita S
eLife (2017) 6: . 129 202 WB; tested species: mouse
Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins.
Smith KR, Jones KA, Kopeikina KJ, Burette AC, Copits BA, Yoon S, Forrest MP, Fawcett-Patel JM, Hanley JG, Weinberg RJ, Swanson GT, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3746: 11127-11139. 129 202 WB; tested species: rat
GARLH Family Proteins Stabilize GABAA Receptors at Synapses.
Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S
Neuron (2017) 935: 1138-1152.e6. 129 202 WB; tested species: mouse
A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density.
Walkup WG, Mastro TL, Schenker LT, Vielmetter J, Hu R, Iancu A, Reghunathan M, Bannon BD, Kennedy MB
eLife (2016) 5: . 129 202 WB; tested species: mouse
GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses.
Fuchs C, Abitbol K, Burden JJ, Mercer A, Brown L, Iball J, Anne Stephenson F, Thomson AM, Jovanovic JN
The European journal of neuroscience (2013) 388: 3146-58. 129 202 WB; tested species: rat
An unexpected role of neuroligin-2 in regulating KCC2 and GABA functional switch.
Sun C, Zhang L, Chen G
Molecular brain (2013) 6: 23. 129 202 WB
PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex.
McEachern EP, Coley AA, Yang SS, Gao WJ
Neuropharmacology (2020) 179: 108277. 129 202 WB, IP; tested species: mouse
WB
Background

Neuroligins form a family of postsynaptic cell surface molecules that interact with β-neurexins. They are 110-120 kDa polypeptides with homology to acetylcholine esterase. Neuroligin1 and neuroligin3 are specifically localized to post-synaptic densities of excitatory synapses whereas neuroligin2 is found exclusively on inhibitory synapses.
Mutations in neuroligin3 and neuroligin4 have been implicated with a rare, heritable form of autism.
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