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Neuroligin1/2/3/4 antibody cytoplasmic domain - 129 213 K.O.

Neuroligins are postsynaptic cell adhesion molecules
Rabbit polyclonal purified antibody
Cat. No.: 129 213
Amount: 50 µg
Price: $375.00
Cat. No. 129 213 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: not tested yet
IHC-P: not tested yet
Immunogen Synthetic peptide corresponding to AA 826 to 843 from mouse Neuroligin1 (UniProt Id: Q99K10)
Reactivity Reacts with: rat (Q62765, Q62888, Q62889, ), mouse (Q99K10, Q69ZK9, Q8BYM5, B0F2B4).
Other species not tested yet.
Specificity Recognizes neuroligin 1, 2, 3 and 4. K.O. validated
Data sheet 129_213.pdf

References for Neuroligin1/2/3/4 - 129 213

MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 129 213 WB, IP; tested species: mouse
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 129 213 WB, IP; tested species: mouse
Cat. No.: 129 213
Amount: 50 µg
Price: $375.00
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 129 213 WB, IP; tested species: mouse
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 129 213 WB, IP; tested species: mouse
Background

Neuroligins form a family of postsynaptic cell surface molecules that interact with β-neurexins. They are 110-120 kDa polypeptides with homology to acetylcholine esterase. Neuroligin1 and neuroligin3 are specifically localized to post-synaptic densities of excitatory synapses whereas neuroligin2 is found exclusively on inhibitory synapses.
Mutations in neuroligin3 and neuroligin4 have been implicated with a rare, heritable form of autism.