Cat. No.: 116 102
Amount: 200 µl
Price:
$355.00
|
|
|
| Cat. No. 116 102 |
200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: not tested yet IHC: not tested yet IHC-P: not tested yet |
| Immunogen | Recombinant protein corresponding to AA 1 to 593 from mouse Munc18-2 (UniProt Id: Q64324) |
| Reactivity |
Reacts with: rat (Q62753), mouse (Q64324). Other species not tested yet. |
| Specificity | Specific for Munc 18-2 with weak cross-reactivity to Munc18-1 and 3. |
| Remarks |
This antibody detects two smaller bands (possible degradation products) of unkown identity. |
| Data sheet | 116_102.pdf |
|
|
Munc 18 is an abundant neuronal protein that tightly binds to the synaptic fusion protein syntaxin 1. It is highly homologous to the C. elegans unc-18 gene product, and weakly related to the yeast sec1, sly1, and slp1 genes.
There are three munc 18 isoforms in mammals. Munc 18-1 or 18a, also referred to as rb-sec1, n-sec1, stxbp1 and p67, is primarily expressed in neurons. Munc 18-2 or 18b, also referred to as stxbp2, and Munc 18-3 or 18c are expressed ubiquitously.