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Home > Products > 126 303

Munc13-3 antibody - 126 303 K.O.

Munc13 proteins are the mammalian homologues of the C. elegans unc-13 gene essential for exocytosis
Rabbit polyclonal purified antibody
Cat. No.: 126 303
Amount: 50 µg
Price: $375.00
Cat. No. 126 303 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 22 to 332 from rat Munc13-3 (UniProt Id: Q62770)
Reactivity Reacts with: rat (Q62770), mouse (Q8K0T7).
Other species not tested yet.
Specificity K.O. validated
Data sheet 126_303.pdf

References for Munc13-3 - 126 303

Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in trappc9-linked brain developmental syndrome.
Li Y, Muhammad U, Sapp E, Ke Y, Wang Z, Boudi A, DiFiglia M, Li X
JCI insight (2024) : . 126 303 WB; tested species: mouse
Chronic social isolation stress during peri-adolescence alters presynaptic dopamine terminal dynamics via augmentation in accumbal dopamine availability.
Karkhanis AN, Leach AC, Yorgason JT, Uneri A, Barth S, Niere F, Alexander NJ, Weiner JL, McCool BA, Raab-Graham KF, Ferris MJ, et al.
ACS chemical neuroscience (2018) : . 126 303 WB; tested species: rat
Cat. No.: 126 303
Amount: 50 µg
Price: $375.00
Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in trappc9-linked brain developmental syndrome.
Li Y, Muhammad U, Sapp E, Ke Y, Wang Z, Boudi A, DiFiglia M, Li X
JCI insight (2024) : . 126 303 WB; tested species: mouse
Chronic social isolation stress during peri-adolescence alters presynaptic dopamine terminal dynamics via augmentation in accumbal dopamine availability.
Karkhanis AN, Leach AC, Yorgason JT, Uneri A, Barth S, Niere F, Alexander NJ, Weiner JL, McCool BA, Raab-Graham KF, Ferris MJ, et al.
ACS chemical neuroscience (2018) : . 126 303 WB; tested species: rat
WB
Background
Munc 13s are homologues of the C. elegans unc-13 gene product. Three brain specific isoforms, Munc 13-1, -13-2, and -13-3 are expressed in rat where they localize to presynaptic terminals. All three isoforms share multiple regulatory domains that may mediate phorbol ester and diacylglycerol binding.
Munc13-1 shows the broadest expression pattern and is found in cortex, cerebellum, olfactory bulb and hippocampus. Munc 13-2 is mainly expressed in cortex and hippocampus whereas Munc 13-3 exhibits highest expression levels in cerebellum and pons. Munc13-1 interacts directly with a putative coiled coil domain in the N-terminal part of syntaxin and is involved in synaptic vesicle priming. For Munc13-2 an additional ubiquitously expressed N-terminal splice variant (ubMunc 13-2) has been described.
Munc 13-3 has been shown to be involved in the regulation of cerebellar synaptic transmission and motor learning.