Cat. No.: 144 103
Amount: 50 µg
Price:
$375.00
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| Cat. No. 144 103 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 2 to 265 from rat Mint1 (UniProt Id: O35430) |
| Reactivity |
Reacts with: rat (O35430), mouse (B2RUJ5). Other species not tested yet. |
| Matching control protein/peptide | 144-1P |
| Data sheet | 144_103.pdf |
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Mints (also referred to as X11-like proteins) are adaptor-proteins that consist of divergent N-terminal sequences and conserved C-terminal PTB and PDZ domains.
Three isoforms (Mint 1, 2 and 3) have been described. Mint 1 exclusively binds to the synaptic protein CASK via its N-terminal sequence. Munc18-1 has been shown to be an interaction partner of Mint 1 and 2. The more C-terminal located PTB and PDZ domains present in all Mint isoforms bind to widely distributed proteins like APP, presenilins and Ca2+ channels.
A Mint 1 knock out had no obvious effect on brain achitecture and development, nor was synaptic plasticity in excitatory synapses affected. In inhibitory synapses of knock out strains the release of gamma-aminobutyric acid (GABA) was impaired.