Cat. No.: 191 002
Amount: 200 µl
Price:
$355.00
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| Cat. No. 191 002 |
200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: not recommended IHC: not recommended IHC-P: not tested yet |
| Immunogen | Recombinant protein corresponding to residues near the carboxy terminus of mouse mGluR1-α (UniProt Id: P97772) |
| Reactivity |
Reacts with: rat (P23385), mouse (P97772). Other species not tested yet. |
| Specificity | Specific for mGluR1-α |
| Matching control protein/peptide | 191-0P |
| Data sheet | 191_002.pdf |
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Glutamate is the main excitatory neurotransmitter in the vertebrate nervous system and regulates a number of cellular signaling pathways. In addition to the ionotropic glutamate receptors of the NMDA, AMPA and kainate type, eight metabotropic receptors (mGluR1-8) have been described so far (1). This receptor family can be subdivided into three groups (2): Group I receptors (mGluR1, mGluR5) are activated by dihydroxyphenylglycine (DHPG) (3), group II receptors (mGluR2, mGluR3) by dicarboxycyclopropylglycine (DCG-IV), and group III receptors (mGluR4, mGluR6, mGluR7, mGluR8) by aminophosphonobutyrate (L-AP4) (4).