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Home > Products > 421 002

MDGA1 antibody - 421 002 K.O.

MDGA1 is an IgSF protein involved in neural development
Rabbit polyclonal antiserum
Cat. No.: 421 002
Amount: 200 µl
Price: $355.00
Cat. No. 421 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery  
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 19 to 917 from mouse MDGA1 (UniProt Id: Q0PMG2)
Reactivity Reacts with: mouse (Q0PMG2).
Other species not tested yet.
Specificity K.O. validated PubMed: 35532105
Data sheet 421_002.pdf

References for MDGA1 - 421 002

Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, et al.
Communications biology (2024) 71: 1157. 421 002 WB, IHC-Fr; KO verified; tested species: mouse
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1.
Blumenreich S, Ben-Yashar DP, Shalit T, Kupervaser M, Milenkovic I, Joseph T, Futerman AH
Journal of neurochemistry (2024) 1681: 52-65. 421 002 WB, IHC; KD verified; tested species: rat
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1.
Blumenreich S, Ben-Yashar DP, Shalit T, Kupervaser M, Milenkovic I, Joseph T, Futerman AH
Journal of neurochemistry (2024) 1681: 52-65. 421 002 WB, IHC; KD verified; tested species: rat
Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, et al.
Communications biology (2024) 71: 1157. 421 002 WB, IHC-Fr; KO verified; tested species: mouse
Cat. No.: 421 002
Amount: 200 µl
Price: $355.00
Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, et al.
Communications biology (2024) 71: 1157. 421 002 WB, IHC-Fr; KO verified; tested species: mouse
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1.
Blumenreich S, Ben-Yashar DP, Shalit T, Kupervaser M, Milenkovic I, Joseph T, Futerman AH
Journal of neurochemistry (2024) 1681: 52-65. 421 002 WB, IHC; KD verified; tested species: rat
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1.
Blumenreich S, Ben-Yashar DP, Shalit T, Kupervaser M, Milenkovic I, Joseph T, Futerman AH
Journal of neurochemistry (2024) 1681: 52-65. 421 002 WB, IHC; KD verified; tested species: rat
Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, et al.
Communications biology (2024) 71: 1157. 421 002 WB, IHC-Fr; KO verified; tested species: mouse
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Background

MAM domain GPI anchor 1 and 2 proteins (MDGA1 and MDGA2) are Ig superfamily adhesion molecules composed of six IG domains, a fibronectin III domain, a MAM domain, and a GPI anchor.

MDGAs are required for radial migration and positioning of cortical neurons making it a useful layer and area specific marker during neural development.

They play a role in the formation or maintenance of Neuroligin2 positive inhibitory synapses.