Tailor-made Antibodies
and Tools for Life Science
quick order | cart
?
|
login
Home|||||Technical Support
Home > Products > 295 004

Myelin basic protein antibody - 295 004

MBP is a major component of the myelin sheath
Guinea pig polyclonal antiserum
Cat. No.: 295 004
Amount: 100 µl
Price: $365.00
Cat. No. 295 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not recommended
ICC: not tested yet
IHC: 1 : 500 (see remarks) gallery  
IHC-P: not tested yet
Immunogen Synthetic peptide corresponding to AA 105 to 115 from rat MBP (UniProt Id: P02688)
Reactivity Reacts with: human (P02686), rat (P02688), mouse (P04370).
Other species not tested yet.
Specificity Specific for MBP. Epitope is present in all splice variants.
Matching control protein/peptide 295-0P
Remarks

IHC: Heat-mediated antigen retrieval (in citrate buffer pH 6) is required for immunohistochemical staining.
Data sheet 295_004.pdf

References for Myelin basic protein - 295 004

Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.
Shariq M, Sahasrabuddhe V, Krishna S, Radha S, Nruthyathi , Bellampalli R, Dwivedi A, Cheramangalam R, Reizis B, Hébert J, Ghosh HS, et al.
Science advances (2021) 721: . 295 004 IHC; tested species: mouse
Immunosignals of Oligodendrocyte Markers and Myelin-Associated Proteins Are Critically Affected after Experimental Stroke in Wild-Type and Alzheimer Modeling Mice of Different Ages.
Michalski D, Keck AL, Grosche J, Martens H, Härtig W
Frontiers in cellular neuroscience (2018) 12: 23. 295 004 IHC; tested species: mouse
Cat. No.: 295 004
Amount: 100 µl
Price: $365.00
Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.
Shariq M, Sahasrabuddhe V, Krishna S, Radha S, Nruthyathi , Bellampalli R, Dwivedi A, Cheramangalam R, Reizis B, Hébert J, Ghosh HS, et al.
Science advances (2021) 721: . 295 004 IHC; tested species: mouse
Immunosignals of Oligodendrocyte Markers and Myelin-Associated Proteins Are Critically Affected after Experimental Stroke in Wild-Type and Alzheimer Modeling Mice of Different Ages.
Michalski D, Keck AL, Grosche J, Martens H, Härtig W
Frontiers in cellular neuroscience (2018) 12: 23. 295 004 IHC; tested species: mouse
WB
IHC
Background
The myelin sheath is a multi-layered membrane composed of several proteins like PLP, claudin 11 and myelin basic protein (MBP) which is specific for the nervous system. MBP functions as an insulator and increases the velocity of axonal impulse conduction.
MBP can be subdivided into the classic group consisting of isoforms 4 to 14 and the non-classic group of MBP comprising the Golli MBPs (isoforms 1 to 3). Differential splicing events and optional posttranslational modifications give rise to a wide spectrum of isomers with potentially specialized functions.
Other products for this target