Cat. No.: 331 003
Amount: 50 µg
Price:
$375.00
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| Cat. No. 331 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: not tested yet IHC: not tested yet IHC-P: not tested yet |
| Immunogen | Synthetic peptide corresponding to AA 1 to 15 from mouse MARK2 (UniProt Id: Q05512) |
| Reactivity |
Reacts with: rat (O08679), mouse (Q05512). Other species not tested yet. |
| Specificity | Specific for MARK 2, epitope is present in all four isoforms. |
| Data sheet | 331_003.pdf |
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The microtubule-affinity regulating kinase 2 (MARK 2), also referred to as Par-1b and EMK 1, was originally discovered by its ability to phosphorylate tau and related microtubule-associated proteins. It is involved in the regulation of many cellular processes like determination of polarity, intracellular signal transduction, transport, and cytoskeletal stability. Four isoforms are known so far.
MARK 2 has also been identified as an upstream regulator of PTEN-induced kinase 1 (PINK 1), a mitochondria-targeted serine/threonine kinase. Disbalanced functions of these proteins are connected to neurodegenerative disorders like Alzheimer's and Parkinson's disease.