Cat. No.: 169 002
Amount: 200 µl
Price:
$355.00
|
|
|
| Cat. No. 169 002 |
200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: not recommended IHC: not recommended IHC-P: not tested yet |
| Immunogen | Recombinant protein corresponding to AA 313 to 461 from mouse Liprin-α3 (UniProt Id: P60469) |
| Reactivity |
Reacts with: human (O75145), rat (Q91Z79), mouse (P60469). No signal: zebrafish. Other species not tested yet. |
| Specificity | This antibody probably cross reacts to isoforms 1, 2, 4, due to sequence homologies. |
| Matching control protein/peptide | 169-0P |
| Data sheet | 169_002.pdf |
|
|
The liprin-α/Syd 2 protein family was initially identified as binding partners of the LAR family of receptor protein-tyrosine phosphatases.
Liprin-α proteins are multidomain proteins which are involved in the development of presynaptic active zones. Four isoforms of liprin-α have been described, so far and all of them interact with the RIM binding partners ERC 1b and ERC 2.
All four isoforms of liprin-α have also been identified as members of the MALS complex composed of CASK, Mint1 and Velis. This complex has been reported to be crucial for synaptic vesicle exocytosis.