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Home > Products > 231 002

Kv2.1 antibody - 231 002

Kv2.1 is one of the major Kv components in brain and cortex
Rabbit polyclonal antiserum
Cat. No.: 231 002
Amount: 200 µl
Price: $355.00
Cat. No. 231 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: not tested yet
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 532 to 857 from rat Kv2.1 (UniProt Id: P15387)
Reactivity Reacts with: rat (P15387), mouse (Q03717).
Other species not tested yet.
Matching control protein/peptide 231-0P
Data sheet 231_002.pdf

References for Kv2.1 - 231 002

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, et al.
Science (New York, N.Y.) (2020) 3676477: 528-537. 231 002 IHC; tested species: mouse
Cat. No.: 231 002
Amount: 200 µl
Price: $355.00
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, et al.
Science (New York, N.Y.) (2020) 3676477: 528-537. 231 002 IHC; tested species: mouse
WB
ICC
Background
Voltage-gated potassium (Kv) channels regulate many aspects of neuronal excitability like shaping of action potentials or modulating of spike patterns.
Mammalian neurons express more than 20 different Kv subunits that can be subdivided into 12 families. Heteromeric assembly of four subunits and differential phosphorylation of Kv channels give rise to a huge molecular and functional diversity.
The Kv 2 subfamily comprising Kv 2.1 (DRK 1, Kcnb 1) and Kv 2.2 (CDRK, Kcnb 2) is a unique exception since they do not form heterodimers. Kv 2.1 is found in large clusters on the soma and proximal dendrites of pyramidal neurons.
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