Tailor-made Antibodies
and Tools for Life Science
quick order | cart
?
|
login
Home|||||Technical Support
Home > Products > 231-0P

Kv2.1 protein - 231-0P

Kv2.1 is one of the major Kv components in brain and cortex
control protein
Cat. No.: 231-0P
Amount: 100 µg
Price: $105.00
Cat. No. 231-0P 100 µg protein, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in TBS. Then aliquot and store at -20°C to -80°C until use.
Control proteins should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
Immunogen Recombinant protein corresponding to AA 532 to 857 from rat Kv2.1 (UniProt Id: P15387)
Recommended dilution Optimal concentrations should be determined by the end-user.
Matching antibodies 231 002
Remarks

This control protein consists of the recombinant mouse Kv 2.1 (aa 532 - 857) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of protein needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.
Data sheet 231-0p.pdf
Cat. No.: 231-0P
Amount: 100 µg
Price: $105.00
Background
Voltage-gated potassium (Kv) channels regulate many aspects of neuronal excitability like shaping of action potentials or modulating of spike patterns.
Mammalian neurons express more than 20 different Kv subunits that can be subdivided into 12 families. Heteromeric assembly of four subunits and differential phosphorylation of Kv channels give rise to a huge molecular and functional diversity.
The Kv 2 subfamily comprising Kv 2.1 (DRK 1, Kcnb 1) and Kv 2.2 (CDRK, Kcnb 2) is a unique exception since they do not form heterodimers. Kv 2.1 is found in large clusters on the soma and proximal dendrites of pyramidal neurons.
Protocols
OTHER
Other products for this target