Cat. No.: 402 015
Amount: 50 µg
Price:
$460.00
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| Cat. No. 402 015 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: not tested yet IHC: 1 : 500 up to 1 : 1000 (see remarks) gallery IHC-P: not recommended |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of rat Kv1.2 (UniProt Id: P63142) |
| Reactivity |
Reacts with: rat (P63142), mouse (P63141). Other species not tested yet. |
| Remarks |
IHC: Heat-mediated antigen retrieval (in citrate buffer pH 6) can be applied to increase signal strength. |
| Data sheet | 402_015.pdf |
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A high diversity of K+ channels is formed in the nervous system by heteromeric assembly of subunits encoded by a large number of K+ channel genes. They play an important role in regulating the level of neuronal excitability.
Deletion of Kv 1.2 is lethal in mice and mutations lead to severe consequences including epileptic encephalopathy, intellectual disability and episodic ataxia in humans.