Cat. No.: 180 103
Amount: 50 µg
Price:
$375.00
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| Cat. No. 180 103 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 828 to 979 from rat GluK5 (UniProt Id: Q63273) |
| Reactivity |
Reacts with: rat (Q63273), mouse (Q61626). Other species not tested yet. |
| Matching control protein/peptide | 180-1P |
| Remarks |
IHC-Fr: Antibody requires Clarke liquid fixation (1 vol. acetic acid, 6 vol. ethanol, 15 min at RT). |
| Data sheet | 180_103.pdf |
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Ionotropic glutamate receptors (iGluRs) mediate rapid excitatory neurotransmission in the mammalian CNS. They can be subdivided into three major groups, the AMPA/GluA, NMDA/GluN, and kainate/GluK receptors (KARs) (1, 2).
mRNAs coding for glutamate receptors are substrates for an adenosine deaminase acting on RNA (ADAR) that increases the diversity of these proteins (3). KARs can be found at pre- and postsynaptic sites and are composed of five different subunits: GluK1, GluK2 and GluK3 can form homomeric receptors whereas GluK4 and GluK5 form heteromeric receptors with GluK1-3 (4).