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Home > Products > 272 103

Glycine transporter1 antibody - 272 103

Glycine transporters are transmembrane proteins involved in the removal of extracellular glycine
Rabbit polyclonal purified antibody
Cat. No.: 272 103
Amount: 50 µg
Price: $380.00
Cat. No. 272 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) (see remarks) gallery  
IP: not tested yet
ICC: not tested yet
IHC: 1 : 1000 up to 1 : 2000 gallery  
IHC-P: 1 : 500 up to 1 : 1000 gallery  
Immunogen Recombinant protein corresponding to AA 649 to 692 from mouse Glycine transporter1 (UniProt Id: P28571)
Reactivity Reacts with: rat (P28572), mouse (P28571).
Other species not tested yet.
Remarks

WB:  Glycine transporter 1 aggregates after boiling, making it necessary to run SDS-PAGE with non-boiled samples.
Data sheet 272_103.pdf

References for Glycine transporter1 - 272 103

GlyT1 Encephalopathy: Characterization of presumably disease causing GlyT1 mutations.
Hauf K, Barsch L, Bauer D, Buchert R, Armbruster A, Frauenfeld L, Grasshoff U, Eulenburg V
Neurochemistry international (2020) : 104813. 272 103 WB, ICC; tested species: human
GlyT1 Encephalopathy: Characterization of presumably disease causing GlyT1 mutations.
Hauf K, Barsch L, Bauer D, Buchert R, Armbruster A, Frauenfeld L, Grasshoff U, Eulenburg V
Neurochemistry international (2020) : 104813. 272 103 WB, ICC; tested species: human
Vigabatrin-Induced Retinal Functional Alterations and Second-Order Neuron Plasticity in C57BL/6J Mice.
Chan K, Hoon M, Pattnaik BR, Ver Hoeve JN, Wahlgren B, Gloe S, Williams J, Wetherbee B, Kiland JA, Vogel KR, Jansen E, et al.
Investigative ophthalmology & visual science (2020) 612: 17. 272 103 IHC; tested species: mouse
Opposing effects of an atypical glycinergic and substance P transmission on interpeduncular nucleus plasticity.
Melani R, Von Itter R, Jing D, Koppensteiner P, Ninan I
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2019) : . 272 103 IHC; tested species: mouse
Cat. No.: 272 103
Amount: 50 µg
Price: $380.00
GlyT1 Encephalopathy: Characterization of presumably disease causing GlyT1 mutations.
Hauf K, Barsch L, Bauer D, Buchert R, Armbruster A, Frauenfeld L, Grasshoff U, Eulenburg V
Neurochemistry international (2020) : 104813. 272 103 WB, ICC; tested species: human
GlyT1 Encephalopathy: Characterization of presumably disease causing GlyT1 mutations.
Hauf K, Barsch L, Bauer D, Buchert R, Armbruster A, Frauenfeld L, Grasshoff U, Eulenburg V
Neurochemistry international (2020) : 104813. 272 103 WB, ICC; tested species: human
Vigabatrin-Induced Retinal Functional Alterations and Second-Order Neuron Plasticity in C57BL/6J Mice.
Chan K, Hoon M, Pattnaik BR, Ver Hoeve JN, Wahlgren B, Gloe S, Williams J, Wetherbee B, Kiland JA, Vogel KR, Jansen E, et al.
Investigative ophthalmology & visual science (2020) 612: 17. 272 103 IHC; tested species: mouse
Opposing effects of an atypical glycinergic and substance P transmission on interpeduncular nucleus plasticity.
Melani R, Von Itter R, Jing D, Koppensteiner P, Ninan I
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2019) : . 272 103 IHC; tested species: mouse
WB
IHC
IHC-P
Background
Glycine is the major inhibitory neurotransmitter in the spinal cord and brainstem. Two differentially expressed glycine transporters, GLYT 1 and GLYT 2, regulate the extracellular concentration of this neuroactive amino acid in the synaptic cleft.
GLYT 1 is expressed in both neurons as well as in glia with high expression levels in the main olfactory bulb, cerebellum, brainstem and spinal cord and low expression in other brain regions. It has been hypothesized to regulate glycine levels in NMDA receptor-mediated neurotransmission.
GLYT 2 shows an axonal localization and is mainly expressed in spinal cord, brain-stem and cerebellum.