Cat. No.: 173 006
Amount: 50 µg
Price:
$385.00
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| Cat. No. 173 006 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | full-length recombinant human GFAP (UniProt Id: P14136) |
| Reactivity |
Reacts with: human (P14136), rat (P47819), mouse (P03995). Other species not tested yet. |
| Specificity | Specific for GFAP, detects all isoforms. K.O. validated |
| Matching control protein/peptide | 173-0P |
| Remarks |
WB: Cat. nos. 173 002, 173 004 or 173 011 are recommended. |
| Data sheet | 173_006.pdf |
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Glial fibrillary acidic protein GFAP is a glial-specific member of the intermediate filament protein family. This group comprises cell type-specific filamentous proteins with similar structure and function as scaffold for cytoskeleton assembly and maintenance.
Frequently, neural stem cells also express GFAP. In addition many types of brain tumors, probably derived from astrocytic cells, heavily express GFAP. This protein is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and others.
Point-mutations in the GFAP gene have been correlated to Alexander disease, a fatal leukoencephalopathy that leads to the dysmyelination or demyelination of the central nervous system.