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Home > Products > 224 411

GABA-A receptor beta3 antibody - 224 411

GABA-A receptors are involved in inhibitory neurotransmission
Mouse monoclonal purified IgG
Cat. No.: 224 411
Amount: 100 µg
Price: $415.00
Cat. No. 224 411 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 500 up to 1 : 1000 (AP staining) (see remarks) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 100 up to 1 : 500 (see remarks) gallery  
IHC-P: not tested yet
Clone 261F6
Subtype IgG2a (κ light chain)
Immunogen Recombinant protein corresponding to AA 390 to 429 from rat GABA-A receptor β3 (UniProt Id: P63079)
Reactivity Reacts with: rat (P63079), mouse (P63080).
Other species not tested yet.
Remarks

WB: Less sensitive compared to the polyclonal antibodies (224 403 and 224 404).
IHC: This antibody requires antigen retrieval with pepsin according to:
Lorincz A & Nusser Z (2008).
 
Data sheet 224_411.pdf

References for GABA-A receptor beta3 - 224 411

The Autism-Related Protein PX-RICS Mediates GABAergic Synaptic Plasticity in Hippocampal Neurons and Emotional Learning in Mice.
Nakamura T, Sakaue F, Nasu-Nishimura Y, Takeda Y, Matsuura K, Akiyama T
EBioMedicine (2018) : . 224 411 WB; tested species: mouse
Cat. No.: 224 411
Amount: 100 µg
Price: $415.00
The Autism-Related Protein PX-RICS Mediates GABAergic Synaptic Plasticity in Hippocampal Neurons and Emotional Learning in Mice.
Nakamura T, Sakaue F, Nasu-Nishimura Y, Takeda Y, Matsuura K, Akiyama T
EBioMedicine (2018) : . 224 411 WB; tested species: mouse
WB
ICC
IHC
Background

Gamma-aminobutyric acid type A (GABA-A) receptors mediate the majority of inhibitory neurotransmission in the brain. These receptor proteins are ligand gated chloride ion channels and consist of a pentameric combination of different subunits (alpha, beta, gamma, delta, epsilon and rho). The resulting heterogenous population of GABA-A receptor subtypes are expressed throughout the brain with specific cellular and subcellular expression patterns.
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